Alkyldihydroxyacetonephosphate synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alkyldihydroxyacetonephosphate synthase

Species:

Leishmania major

UniProt:

Q7YWB6_LEIMA

TriTrypDb:

LmjF.30.0120 , LMJLV39_300006300 , LMJSD75_300006300

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q7YWB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q7YWB6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006662	glycerol ether metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0008611	ether lipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0018904	ether metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0046485	ether lipid metabolic process	4	2
GO:0046504	glycerol ether biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0097384	cellular lipid biosynthetic process	4	2
GO:1901503	ether biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008609	alkylglycerone-phosphate synthase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	8
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0071949	FAD binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.410
CLV_NRD_NRD_1	193	195	PF00675	0.260
CLV_NRD_NRD_1	391	393	PF00675	0.374
CLV_PCSK_KEX2_1	193	195	PF00082	0.288
CLV_PCSK_KEX2_1	391	393	PF00082	0.273
CLV_PCSK_KEX2_1	527	529	PF00082	0.279
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.279
CLV_PCSK_SKI1_1	206	210	PF00082	0.389
CLV_PCSK_SKI1_1	269	273	PF00082	0.243
CLV_PCSK_SKI1_1	379	383	PF00082	0.280
CLV_PCSK_SKI1_1	46	50	PF00082	0.356
CLV_PCSK_SKI1_1	472	476	PF00082	0.243
CLV_PCSK_SKI1_1	520	524	PF00082	0.302
CLV_PCSK_SKI1_1	527	531	PF00082	0.298
CLV_Separin_Metazoa	151	155	PF03568	0.177
DEG_APCC_DBOX_1	391	399	PF00400	0.446
DEG_SCF_FBW7_1	276	283	PF00400	0.363
DEG_SPOP_SBC_1	361	365	PF00917	0.370
DOC_CKS1_1	270	275	PF01111	0.243
DOC_CKS1_1	277	282	PF01111	0.356
DOC_CYCLIN_RxL_1	46	53	PF00134	0.460
DOC_CYCLIN_RxL_1	599	609	PF00134	0.519
DOC_CYCLIN_yClb1_LxF_4	49	55	PF00134	0.457
DOC_CYCLIN_yClb5_NLxxxL_5	49	55	PF00134	0.478
DOC_MAPK_gen_1	183	190	PF00069	0.248
DOC_MAPK_gen_1	193	201	PF00069	0.235
DOC_MAPK_gen_1	391	398	PF00069	0.279
DOC_MAPK_gen_1	46	54	PF00069	0.328
DOC_MAPK_gen_1	599	608	PF00069	0.436
DOC_MAPK_MEF2A_6	158	166	PF00069	0.243
DOC_MAPK_MEF2A_6	183	192	PF00069	0.248
DOC_MAPK_MEF2A_6	391	400	PF00069	0.226
DOC_MAPK_MEF2A_6	514	523	PF00069	0.368
DOC_PP1_RVXF_1	15	21	PF00149	0.383
DOC_PP1_RVXF_1	404	410	PF00149	0.412
DOC_PP1_RVXF_1	602	609	PF00149	0.517
DOC_USP7_MATH_1	248	252	PF00917	0.265
DOC_USP7_MATH_1	280	284	PF00917	0.386
DOC_USP7_MATH_1	552	556	PF00917	0.286
DOC_USP7_MATH_1	616	620	PF00917	0.486
DOC_USP7_MATH_2	589	595	PF00917	0.488
DOC_USP7_UBL2_3	572	576	PF12436	0.389
DOC_USP7_UBL2_3	79	83	PF12436	0.418
DOC_WW_Pin1_4	269	274	PF00397	0.243
DOC_WW_Pin1_4	276	281	PF00397	0.355
DOC_WW_Pin1_4	400	405	PF00397	0.426
DOC_WW_Pin1_4	584	589	PF00397	0.438
DOC_WW_Pin1_4	69	74	PF00397	0.387
LIG_14-3-3_CanoR_1	185	191	PF00244	0.303
LIG_14-3-3_CanoR_1	206	211	PF00244	0.389
LIG_14-3-3_CanoR_1	357	361	PF00244	0.253
LIG_14-3-3_CanoR_1	372	377	PF00244	0.243
LIG_14-3-3_CanoR_1	391	396	PF00244	0.361
LIG_14-3-3_CanoR_1	528	534	PF00244	0.333
LIG_Actin_WH2_2	375	393	PF00022	0.242
LIG_AP2alpha_2	179	181	PF02296	0.380
LIG_APCC_ABBA_1	348	353	PF00400	0.243
LIG_EVH1_1	585	589	PF00568	0.458
LIG_FHA_1	171	177	PF00498	0.250
LIG_FHA_1	210	216	PF00498	0.343
LIG_FHA_1	272	278	PF00498	0.337
LIG_FHA_1	283	289	PF00498	0.514
LIG_FHA_1	306	312	PF00498	0.323
LIG_FHA_1	345	351	PF00498	0.290
LIG_FHA_1	412	418	PF00498	0.397
LIG_FHA_1	458	464	PF00498	0.247
LIG_FHA_1	535	541	PF00498	0.298
LIG_FHA_2	311	317	PF00498	0.518
LIG_FHA_2	431	437	PF00498	0.370
LIG_FHA_2	8	14	PF00498	0.558
LIG_LIR_Apic_2	321	326	PF02991	0.243
LIG_LIR_Apic_2	436	442	PF02991	0.223
LIG_LIR_Apic_2	555	560	PF02991	0.389
LIG_LIR_Gen_1	236	246	PF02991	0.277
LIG_LIR_Gen_1	329	340	PF02991	0.337
LIG_LIR_Gen_1	368	378	PF02991	0.177
LIG_LIR_Gen_1	452	462	PF02991	0.303
LIG_LIR_Gen_1	53	63	PF02991	0.368
LIG_LIR_Gen_1	605	616	PF02991	0.378
LIG_LIR_Nem_3	12	18	PF02991	0.347
LIG_LIR_Nem_3	236	242	PF02991	0.277
LIG_LIR_Nem_3	255	261	PF02991	0.243
LIG_LIR_Nem_3	298	304	PF02991	0.274
LIG_LIR_Nem_3	317	323	PF02991	0.434
LIG_LIR_Nem_3	329	335	PF02991	0.243
LIG_LIR_Nem_3	368	373	PF02991	0.343
LIG_LIR_Nem_3	452	457	PF02991	0.303
LIG_LIR_Nem_3	53	59	PF02991	0.466
LIG_MYND_1	69	73	PF01753	0.526
LIG_PDZ_Class_1	616	621	PF00595	0.544
LIG_Pex14_1	454	458	PF04695	0.243
LIG_Pex14_1	553	557	PF04695	0.243
LIG_Pex14_2	224	228	PF04695	0.308
LIG_Pex14_2	328	332	PF04695	0.307
LIG_REV1ctd_RIR_1	367	376	PF16727	0.291
LIG_SH2_CRK	15	19	PF00017	0.390
LIG_SH2_CRK	239	243	PF00017	0.277
LIG_SH2_CRK	421	425	PF00017	0.428
LIG_SH2_CRK	439	443	PF00017	0.157
LIG_SH2_NCK_1	439	443	PF00017	0.243
LIG_SH2_NCK_1	548	552	PF00017	0.258
LIG_SH2_SRC	237	240	PF00017	0.265
LIG_SH2_SRC	548	551	PF00017	0.258
LIG_SH2_SRC	56	59	PF00017	0.434
LIG_SH2_STAP1	336	340	PF00017	0.402
LIG_SH2_STAP1	464	468	PF00017	0.258
LIG_SH2_STAT5	237	240	PF00017	0.303
LIG_SH2_STAT5	323	326	PF00017	0.380
LIG_SH2_STAT5	336	339	PF00017	0.380
LIG_SH2_STAT5	443	446	PF00017	0.243
LIG_SH2_STAT5	506	509	PF00017	0.291
LIG_SH3_1	583	589	PF00018	0.417
LIG_SH3_3	159	165	PF00018	0.258
LIG_SH3_3	211	217	PF00018	0.258
LIG_SH3_3	267	273	PF00018	0.258
LIG_SH3_3	583	589	PF00018	0.408
LIG_SH3_3	67	73	PF00018	0.424
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.358
LIG_SUMO_SIM_anti_2	394	399	PF11976	0.284
LIG_SUMO_SIM_anti_2	561	567	PF11976	0.236
LIG_SUMO_SIM_par_1	186	191	PF11976	0.254
LIG_SUMO_SIM_par_1	197	202	PF11976	0.251
LIG_TYR_ITIM	546	551	PF00017	0.258
LIG_UBA3_1	152	158	PF00899	0.309
LIG_UBA3_1	521	527	PF00899	0.337
LIG_WRC_WIRS_1	207	212	PF05994	0.337
LIG_WRC_WIRS_1	325	330	PF05994	0.243
LIG_WRC_WIRS_1	378	383	PF05994	0.425
LIG_WRC_WIRS_1	506	511	PF05994	0.243
LIG_WW_3	587	591	PF00397	0.462
MOD_CDC14_SPxK_1	587	590	PF00782	0.448
MOD_CDK_SPxK_1	400	406	PF00069	0.231
MOD_CDK_SPxK_1	584	590	PF00069	0.434
MOD_CK1_1	297	303	PF00069	0.314
MOD_CK2_1	310	316	PF00069	0.524
MOD_CK2_1	377	383	PF00069	0.262
MOD_CK2_1	7	13	PF00069	0.584
MOD_CMANNOS	20	23	PF00535	0.297
MOD_GlcNHglycan	250	253	PF01048	0.243
MOD_GlcNHglycan	332	335	PF01048	0.291
MOD_GlcNHglycan	428	431	PF01048	0.234
MOD_GlcNHglycan	510	513	PF01048	0.349
MOD_GlcNHglycan	58	62	PF01048	0.478
MOD_GlcNHglycan	593	596	PF01048	0.560
MOD_GlcNHglycan	96	100	PF01048	0.474
MOD_GSK3_1	202	209	PF00069	0.320
MOD_GSK3_1	233	240	PF00069	0.251
MOD_GSK3_1	248	255	PF00069	0.243
MOD_GSK3_1	276	283	PF00069	0.385
MOD_GSK3_1	310	317	PF00069	0.269
MOD_GSK3_1	330	337	PF00069	0.258
MOD_GSK3_1	356	363	PF00069	0.253
MOD_GSK3_1	426	433	PF00069	0.211
MOD_GSK3_1	458	465	PF00069	0.277
MOD_GSK3_1	534	541	PF00069	0.277
MOD_N-GLC_1	170	175	PF02516	0.299
MOD_N-GLC_1	538	543	PF02516	0.246
MOD_N-GLC_1	591	596	PF02516	0.470
MOD_N-GLC_2	577	579	PF02516	0.237
MOD_NEK2_1	101	106	PF00069	0.431
MOD_NEK2_1	356	361	PF00069	0.335
MOD_NEK2_1	362	367	PF00069	0.282
MOD_NEK2_1	447	452	PF00069	0.282
MOD_NEK2_1	458	463	PF00069	0.272
MOD_NEK2_1	505	510	PF00069	0.243
MOD_NEK2_1	534	539	PF00069	0.277
MOD_PIKK_1	101	107	PF00454	0.419
MOD_PIKK_1	462	468	PF00454	0.389
MOD_PIKK_1	7	13	PF00454	0.434
MOD_PK_1	197	203	PF00069	0.255
MOD_PKA_1	391	397	PF00069	0.314
MOD_PKA_1	527	533	PF00069	0.314
MOD_PKA_2	202	208	PF00069	0.357
MOD_PKA_2	248	254	PF00069	0.246
MOD_PKA_2	356	362	PF00069	0.243
MOD_PKA_2	391	397	PF00069	0.349
MOD_PKA_2	527	533	PF00069	0.337
MOD_Plk_1	305	311	PF00069	0.319
MOD_Plk_1	458	464	PF00069	0.243
MOD_Plk_1	95	101	PF00069	0.455
MOD_Plk_4	233	239	PF00069	0.345
MOD_Plk_4	365	371	PF00069	0.310
MOD_Plk_4	377	383	PF00069	0.219
MOD_Plk_4	458	464	PF00069	0.296
MOD_ProDKin_1	269	275	PF00069	0.243
MOD_ProDKin_1	276	282	PF00069	0.356
MOD_ProDKin_1	400	406	PF00069	0.426
MOD_ProDKin_1	584	590	PF00069	0.446
MOD_ProDKin_1	69	75	PF00069	0.381
MOD_SUMO_for_1	309	312	PF00179	0.298
MOD_SUMO_rev_2	104	112	PF00179	0.469
MOD_SUMO_rev_2	312	319	PF00179	0.410
MOD_SUMO_rev_2	515	522	PF00179	0.259
TRG_ENDOCYTIC_2	122	125	PF00928	0.333
TRG_ENDOCYTIC_2	15	18	PF00928	0.355
TRG_ENDOCYTIC_2	239	242	PF00928	0.277
TRG_ENDOCYTIC_2	258	261	PF00928	0.243
TRG_ENDOCYTIC_2	421	424	PF00928	0.364
TRG_ENDOCYTIC_2	506	509	PF00928	0.243
TRG_ENDOCYTIC_2	548	551	PF00928	0.258
TRG_ENDOCYTIC_2	56	59	PF00928	0.466
TRG_ER_diArg_1	126	129	PF00400	0.339
TRG_ER_diArg_1	183	186	PF00400	0.270
TRG_ER_diArg_1	192	194	PF00400	0.212
TRG_ER_diArg_1	390	392	PF00400	0.264
TRG_NLS_MonoExtC_3	525	531	PF00514	0.314
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.527
TRG_PTS1	618	621	PF00515	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q0	Leptomonas seymouri	23%	100%
A0A0N1PEY1	Leptomonas seymouri	81%	100%
A0A0S4JV88	Bodo saltans	64%	98%
A0A1X0P026	Trypanosomatidae	22%	100%
A0A1X0P2J0	Trypanosomatidae	60%	100%
A0A3Q8IDH3	Leishmania donovani	23%	100%
A0A3Q8IDH5	Leishmania donovani	23%	100%
A0A3Q8IEJ5	Leishmania donovani	23%	100%
A0A3Q8IRN9	Leishmania donovani	96%	100%
A0A422N649	Trypanosoma rangeli	63%	100%
A4HFX9	Leishmania braziliensis	24%	100%
A4HHV7	Leishmania braziliensis	87%	100%
A4I0D2	Leishmania infantum	23%	100%
A4I309	Leishmania infantum	23%	100%
A4I481	Leishmania infantum	24%	100%
A4I507	Leishmania infantum	96%	100%
C9ZQF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
D4MUV9	Anaerostipes hadrus	23%	100%
E9ADI2	Leishmania major	22%	91%
E9ADN0	Leishmania major	24%	100%
E9AM50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AZA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B0D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
F1QXM5	Danio rerio	23%	100%
H6LBS1	Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)	24%	100%
O00116	Homo sapiens	31%	94%
O29853	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	23%	100%
O45218	Caenorhabditis elegans	31%	100%
O96759	Dictyostelium discoideum	37%	100%
O97157	Trypanosoma brucei brucei	60%	100%
P32891	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P94535	Bacillus subtilis (strain 168)	26%	100%
P97275	Cavia porcellus	31%	94%
Q12627	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q46911	Escherichia coli (strain K12)	24%	100%
Q4QB82	Leishmania major	23%	100%
Q7TNG8	Mus musculus	24%	100%
Q86WU2	Homo sapiens	23%	100%
Q8C0I1	Mus musculus	32%	96%
Q8X7S0	Escherichia coli O157:H7	24%	100%
Q94AX4	Arabidopsis thaliana	24%	100%
Q9EQR2	Rattus norvegicus	32%	96%
Q9V778	Drosophila melanogaster	31%	98%
V5BCB2	Trypanosoma cruzi	62%	100%