LeishMANIAdb
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Hypoxanthine phosphoribosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hypoxanthine phosphoribosyltransferase
Gene product:
hypoxanthine-guanine phosphoribosyltransferase
Species:
Leishmania donovani
UniProt:
Q7KLF3_LEIDO
TriTrypDb:
LdBPK_210980.1 , LdCL_210014800 , LDHU3_21.1150
Length:
211

Annotations

Annotations by Jardim et al.

Purine metabolism, Hypoxanthine-guanine phosphoribosyltransferase HGPRT

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0005777 peroxisome 6 1
GO:0005829 cytosol 2 1
GO:0020015 glycosome 7 1
GO:0020022 acidocalcisome 5 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

Q7KLF3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

PDB structure(s): 7cmj_A , 7cmj_B

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 6
GO:0006163 purine nucleotide metabolic process 5 6
GO:0006164 purine nucleotide biosynthetic process 6 6
GO:0006166 purine ribonucleoside salvage 5 6
GO:0006188 IMP biosynthetic process 8 6
GO:0006725 cellular aromatic compound metabolic process 3 6
GO:0006753 nucleoside phosphate metabolic process 4 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009058 biosynthetic process 2 6
GO:0009116 nucleoside metabolic process 4 6
GO:0009117 nucleotide metabolic process 5 6
GO:0009119 ribonucleoside metabolic process 5 6
GO:0009123 nucleoside monophosphate metabolic process 5 6
GO:0009124 nucleoside monophosphate biosynthetic process 6 6
GO:0009126 purine nucleoside monophosphate metabolic process 6 6
GO:0009127 purine nucleoside monophosphate biosynthetic process 7 6
GO:0009150 purine ribonucleotide metabolic process 6 6
GO:0009152 purine ribonucleotide biosynthetic process 7 6
GO:0009156 ribonucleoside monophosphate biosynthetic process 7 6
GO:0009161 ribonucleoside monophosphate metabolic process 6 6
GO:0009163 nucleoside biosynthetic process 5 6
GO:0009165 nucleotide biosynthetic process 6 6
GO:0009167 purine ribonucleoside monophosphate metabolic process 7 6
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 8 6
GO:0009259 ribonucleotide metabolic process 5 6
GO:0009260 ribonucleotide biosynthetic process 6 6
GO:0009987 cellular process 1 6
GO:0018130 heterocycle biosynthetic process 4 6
GO:0019438 aromatic compound biosynthetic process 4 6
GO:0019637 organophosphate metabolic process 3 6
GO:0019693 ribose phosphate metabolic process 4 6
GO:0032261 purine nucleotide salvage 5 6
GO:0032264 IMP salvage 7 6
GO:0034404 nucleobase-containing small molecule biosynthetic process 4 6
GO:0034641 cellular nitrogen compound metabolic process 3 6
GO:0034654 nucleobase-containing compound biosynthetic process 4 6
GO:0042278 purine nucleoside metabolic process 5 6
GO:0042451 purine nucleoside biosynthetic process 6 6
GO:0042455 ribonucleoside biosynthetic process 6 6
GO:0043094 cellular metabolic compound salvage 3 6
GO:0043101 purine-containing compound salvage 4 6
GO:0043173 nucleotide salvage 4 6
GO:0043174 nucleoside salvage 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0044249 cellular biosynthetic process 3 6
GO:0044271 cellular nitrogen compound biosynthetic process 4 6
GO:0044281 small molecule metabolic process 2 6
GO:0044283 small molecule biosynthetic process 3 6
GO:0046040 IMP metabolic process 7 6
GO:0046128 purine ribonucleoside metabolic process 6 6
GO:0046129 purine ribonucleoside biosynthetic process 7 6
GO:0046390 ribose phosphate biosynthetic process 5 6
GO:0046483 heterocycle metabolic process 3 6
GO:0055086 nucleobase-containing small molecule metabolic process 3 6
GO:0071704 organic substance metabolic process 2 6
GO:0072521 purine-containing compound metabolic process 4 6
GO:0072522 purine-containing compound biosynthetic process 5 6
GO:0090407 organophosphate biosynthetic process 4 6
GO:0106380 purine ribonucleotide salvage 6 6
GO:1901135 carbohydrate derivative metabolic process 3 6
GO:1901137 carbohydrate derivative biosynthetic process 4 6
GO:1901293 nucleoside phosphate biosynthetic process 5 6
GO:1901360 organic cyclic compound metabolic process 3 6
GO:1901362 organic cyclic compound biosynthetic process 4 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:1901566 organonitrogen compound biosynthetic process 4 6
GO:1901576 organic substance biosynthetic process 3 6
GO:1901657 glycosyl compound metabolic process 4 6
GO:1901659 glycosyl compound biosynthetic process 5 6
GO:0006144 purine nucleobase metabolic process 5 1
GO:0006177 GMP biosynthetic process 8 1
GO:0006178 guanine salvage 6 1
GO:0009112 nucleobase metabolic process 4 1
GO:0009113 purine nucleobase biosynthetic process 6 1
GO:0032263 GMP salvage 7 1
GO:0043096 purine nucleobase salvage 5 1
GO:0046037 GMP metabolic process 7 1
GO:0046098 guanine metabolic process 6 1
GO:0046099 guanine biosynthetic process 7 1
GO:0046100 hypoxanthine metabolic process 6 1
GO:0046112 nucleobase biosynthetic process 5 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 6
GO:0003824 catalytic activity 1 6
GO:0004422 hypoxanthine phosphoribosyltransferase activity 6 6
GO:0005488 binding 1 6
GO:0016740 transferase activity 2 6
GO:0016757 glycosyltransferase activity 3 6
GO:0016763 pentosyltransferase activity 4 6
GO:0036094 small molecule binding 2 6
GO:0043167 ion binding 2 6
GO:0043169 cation binding 3 6
GO:0046872 metal ion binding 4 6
GO:0052657 guanine phosphoribosyltransferase activity 6 6
GO:0097159 organic cyclic compound binding 2 6
GO:0106130 purine phosphoribosyltransferase activity 5 6
GO:1901265 nucleoside phosphate binding 3 6
GO:1901363 heterocyclic compound binding 2 6
GO:0000287 magnesium ion binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 111 115 PF00656 0.713
CLV_C14_Caspase3-7 126 130 PF00656 0.713
CLV_NRD_NRD_1 160 162 PF00675 0.513
CLV_NRD_NRD_1 17 19 PF00675 0.621
CLV_PCSK_KEX2_1 17 19 PF00082 0.684
CLV_PCSK_SKI1_1 107 111 PF00082 0.493
CLV_PCSK_SKI1_1 119 123 PF00082 0.308
CLV_PCSK_SKI1_1 139 143 PF00082 0.513
CLV_PCSK_SKI1_1 39 43 PF00082 0.458
CLV_PCSK_SKI1_1 49 53 PF00082 0.304
DOC_CYCLIN_RxL_1 104 114 PF00134 0.713
DOC_MAPK_gen_1 161 167 PF00069 0.702
DOC_PP1_RVXF_1 85 91 PF00149 0.713
DOC_USP7_UBL2_3 206 210 PF12436 0.684
DOC_USP7_UBL2_3 39 43 PF12436 0.630
DOC_WW_Pin1_4 4 9 PF00397 0.818
LIG_Actin_WH2_2 134 152 PF00022 0.713
LIG_BIR_II_1 1 5 PF00653 0.837
LIG_BRCT_BRCA1_1 67 71 PF00533 0.713
LIG_FHA_1 149 155 PF00498 0.713
LIG_FHA_1 70 76 PF00498 0.630
LIG_FHA_2 96 102 PF00498 0.630
LIG_LIR_Apic_2 202 207 PF02991 0.653
LIG_LIR_Nem_3 168 172 PF02991 0.647
LIG_LIR_Nem_3 188 193 PF02991 0.626
LIG_LIR_Nem_3 46 51 PF02991 0.693
LIG_LYPXL_yS_3 169 172 PF13949 0.713
LIG_PDZ_Class_1 206 211 PF00595 0.694
LIG_PTB_Apo_2 54 61 PF02174 0.658
LIG_PTB_Phospho_1 54 60 PF10480 0.658
LIG_SH2_NCK_1 204 208 PF00017 0.580
LIG_SH2_SRC 186 189 PF00017 0.507
LIG_SH2_STAP1 186 190 PF00017 0.507
LIG_SH2_STAT5 136 139 PF00017 0.713
LIG_SH2_STAT5 60 63 PF00017 0.713
LIG_SH3_3 164 170 PF00018 0.635
LIG_SH3_3 5 11 PF00018 0.752
LIG_SUMO_SIM_anti_2 151 156 PF11976 0.713
LIG_SUMO_SIM_par_1 108 115 PF11976 0.713
LIG_SUMO_SIM_par_1 120 126 PF11976 0.513
LIG_SUMO_SIM_par_1 150 156 PF11976 0.713
LIG_TYR_ITIM 167 172 PF00017 0.713
LIG_UBA3_1 137 145 PF00899 0.713
LIG_UBA3_1 61 66 PF00899 0.713
LIG_WRC_WIRS_1 48 53 PF05994 0.658
MOD_CK1_1 130 136 PF00069 0.713
MOD_CK1_1 148 154 PF00069 0.501
MOD_CK1_1 23 29 PF00069 0.487
MOD_CK1_1 4 10 PF00069 0.840
MOD_CK1_1 95 101 PF00069 0.572
MOD_CK2_1 186 192 PF00069 0.624
MOD_CK2_1 95 101 PF00069 0.602
MOD_Cter_Amidation 15 18 PF01082 0.695
MOD_Cter_Amidation 159 162 PF01082 0.458
MOD_GlcNHglycan 101 105 PF01048 0.399
MOD_GlcNHglycan 129 132 PF01048 0.513
MOD_GlcNHglycan 158 161 PF01048 0.458
MOD_GlcNHglycan 22 25 PF01048 0.623
MOD_GlcNHglycan 3 6 PF01048 0.687
MOD_GlcNHglycan 8 11 PF01048 0.672
MOD_GSK3_1 47 54 PF00069 0.663
MOD_GSK3_1 65 72 PF00069 0.551
MOD_GSK3_1 91 98 PF00069 0.586
MOD_NEK2_1 1 6 PF00069 0.669
MOD_NEK2_1 65 70 PF00069 0.621
MOD_PIKK_1 26 32 PF00454 0.698
MOD_PKA_2 112 118 PF00069 0.713
MOD_Plk_4 148 154 PF00069 0.713
MOD_Plk_4 23 29 PF00069 0.529
MOD_Plk_4 65 71 PF00069 0.635
MOD_ProDKin_1 4 10 PF00069 0.819
MOD_SUMO_for_1 199 202 PF00179 0.660
MOD_SUMO_for_1 86 89 PF00179 0.658
MOD_SUMO_rev_2 202 211 PF00179 0.599
TRG_ENDOCYTIC_2 169 172 PF00928 0.605
TRG_ENDOCYTIC_2 190 193 PF00928 0.551
TRG_ENDOCYTIC_2 48 51 PF00928 0.713
TRG_Pf-PMV_PEXEL_1 107 111 PF00026 0.513
TRG_Pf-PMV_PEXEL_1 191 195 PF00026 0.631
TRG_Pf-PMV_PEXEL_1 77 81 PF00026 0.513

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHW3 Leptomonas seymouri 34% 88%
A0A0N1PCR6 Leptomonas seymouri 78% 100%
A0A0S4JHI0 Bodo saltans 54% 99%
A0A0S4JLD9 Bodo saltans 52% 100%
A0A1X0NZ20 Trypanosomatidae 61% 100%
A0A1X0NZ92 Trypanosomatidae 37% 91%
A0A422N3N7 Trypanosoma rangeli 36% 92%
A0A422N3S1 Trypanosoma rangeli 60% 97%
A4HBT6 Leishmania braziliensis 82% 100%
A4HBT7 Leishmania braziliensis 34% 100%
A4II60 Xenopus tropicalis 31% 94%
A5A6I1 Pan troglodytes 34% 97%
D0A1D6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 90%
D0A1D7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
D0A1E6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AGU6 Leishmania infantum 100% 100%
E9AGU7 Leishmania infantum 34% 100%
E9AV58 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9AV59 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
O33799 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 38% 100%
O66821 Aquifex aeolicus (strain VF5) 34% 100%
O69537 Mycobacterium leprae (strain TN) 41% 100%
P00492 Homo sapiens 34% 97%
P00493 Mus musculus 34% 97%
P00494 Cricetulus griseus 34% 97%
P07833 Plasmodium falciparum (isolate K1 / Thailand) 27% 91%
P09383 Schistosoma mansoni 28% 74%
P0A5T1 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 42% 100%
P0A9M2 Escherichia coli (strain K12) 37% 100%
P0A9M3 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 37% 100%
P0A9M4 Shigella flexneri 37% 100%
P0DD40 Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) 39% 100%
P0DD41 Streptococcus pyogenes serotype M3 (strain SSI-1) 39% 100%
P18134 Vibrio harveyi 39% 100%
P20035 Plasmodium falciparum (isolate FCR-3 / Gambia) 27% 91%
P27605 Rattus norvegicus 34% 97%
P37171 Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) 40% 100%
P37472 Bacillus subtilis (strain 168) 40% 100%
P43152 Leishmania donovani 100% 100%
P45078 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 41% 100%
P47696 Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) 22% 100%
P47959 Meriones unguiculatus 34% 97%
P51900 Tritrichomonas foetus 34% 100%
P57291 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 37% 100%
P65827 Staphylococcus aureus (strain Mu50 / ATCC 700699) 35% 100%
P65828 Staphylococcus aureus (strain MW2) 35% 100%
P75119 Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) 25% 100%
P96794 Mycobacterium avium 39% 100%
P99085 Staphylococcus aureus (strain N315) 35% 100%
P9WHQ8 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 41% 100%
P9WHQ9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 42% 100%
Q02522 Lactococcus lactis subsp. lactis (strain IL1403) 46% 100%
Q07010 Trypanosoma brucei brucei 43% 100%
Q26997 Toxoplasma gondii 29% 92%
Q27541 Crithidia fasciculata 81% 100%
Q3SZ18 Bos taurus 35% 97%
Q45FY6 Sus scrofa 34% 97%
Q4QCC2 Leishmania major 34% 100%
Q4QCC3 Leishmania major 99% 100%
Q54NJ8 Dictyostelium discoideum 42% 100%
Q5HIG5 Staphylococcus aureus (strain COL) 35% 100%
Q5HRP4 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 37% 100%
Q5M216 Streptococcus thermophilus (strain CNRZ 1066) 38% 100%
Q5M6K8 Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) 38% 100%
Q5XEL6 Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) 39% 100%
Q64531 Mus spretus 34% 99%
Q6DCP3 Xenopus laevis 30% 94%
Q6GBX8 Staphylococcus aureus (strain MSSA476) 35% 100%
Q6GJG1 Staphylococcus aureus (strain MRSA252) 35% 100%
Q6LDD9 Macaca fascicularis 34% 97%
Q6WIT9 Canis lupus familiaris 34% 97%
Q7CNQ9 Streptococcus pyogenes serotype M18 (strain MGAS8232) 39% 100%
Q839B2 Enterococcus faecalis (strain ATCC 700802 / V583) 44% 100%
Q8CQV4 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 37% 100%
Q8DRP8 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 39% 100%
Q8DWM8 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) 36% 100%
Q8E2H3 Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) 38% 100%
Q8E7Y1 Streptococcus agalactiae serotype III (strain NEM316) 38% 100%
Q8K9U8 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 34% 100%
Q97TC4 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 39% 100%
Q9NRG1 Homo sapiens 35% 94%
Q9U6Y2 Leishmania donovani 34% 88%
Q9W719 Gallus gallus 33% 97%
V5DEL0 Trypanosoma cruzi 36% 69%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS