LeishMANIAdb
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Cytosolic leucyl aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cytosolic leucyl aminopeptidase
Gene product:
cytosolic leucyl aminopeptidase
Species:
Leishmania major
UniProt:
Q7KF27_LEIMA
TriTrypDb:
LmjF.23.0950 , LMJLV39_230018700 , LMJSD75_230018900
Length:
565

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0005856 cytoskeleton 5 2
GO:0030863 cortical cytoskeleton 6 2
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

Q7KF27
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q7KF27

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0019538 protein metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004177 aminopeptidase activity 5 12
GO:0005488 binding 1 12
GO:0008233 peptidase activity 3 12
GO:0008235 metalloexopeptidase activity 5 12
GO:0008237 metallopeptidase activity 4 12
GO:0008238 exopeptidase activity 4 12
GO:0016787 hydrolase activity 2 12
GO:0030145 manganese ion binding 6 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0046914 transition metal ion binding 5 12
GO:0070006 metalloaminopeptidase activity 6 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 128 130 PF00675 0.402
CLV_NRD_NRD_1 203 205 PF00675 0.666
CLV_NRD_NRD_1 275 277 PF00675 0.368
CLV_NRD_NRD_1 3 5 PF00675 0.504
CLV_NRD_NRD_1 451 453 PF00675 0.250
CLV_NRD_NRD_1 87 89 PF00675 0.515
CLV_NRD_NRD_1 91 93 PF00675 0.736
CLV_NRD_NRD_1 98 100 PF00675 0.577
CLV_PCSK_FUR_1 201 205 PF00082 0.712
CLV_PCSK_KEX2_1 203 205 PF00082 0.669
CLV_PCSK_KEX2_1 3 5 PF00082 0.414
CLV_PCSK_KEX2_1 451 453 PF00082 0.268
CLV_PCSK_KEX2_1 98 100 PF00082 0.616
CLV_PCSK_PC7_1 199 205 PF00082 0.482
CLV_PCSK_SKI1_1 129 133 PF00082 0.472
CLV_PCSK_SKI1_1 276 280 PF00082 0.278
CLV_PCSK_SKI1_1 29 33 PF00082 0.551
CLV_PCSK_SKI1_1 3 7 PF00082 0.458
CLV_PCSK_SKI1_1 325 329 PF00082 0.235
CLV_PCSK_SKI1_1 397 401 PF00082 0.289
CLV_PCSK_SKI1_1 411 415 PF00082 0.201
DEG_APCC_DBOX_1 410 418 PF00400 0.380
DEG_COP1_1 252 259 PF00400 0.380
DEG_Nend_Nbox_1 1 3 PF02207 0.350
DOC_CYCLIN_yClb3_PxF_3 56 64 PF00134 0.403
DOC_CYCLIN_yCln2_LP_2 365 371 PF00134 0.235
DOC_MAPK_gen_1 29 38 PF00069 0.496
DOC_MAPK_gen_1 297 307 PF00069 0.290
DOC_MAPK_gen_1 429 437 PF00069 0.239
DOC_MAPK_MEF2A_6 300 307 PF00069 0.269
DOC_MAPK_MEF2A_6 32 40 PF00069 0.461
DOC_MAPK_MEF2A_6 360 369 PF00069 0.235
DOC_PP1_RVXF_1 323 330 PF00149 0.235
DOC_PP2B_LxvP_1 141 144 PF13499 0.465
DOC_PP2B_LxvP_1 365 368 PF13499 0.235
DOC_PP4_FxxP_1 518 521 PF00568 0.380
DOC_USP7_MATH_1 137 141 PF00917 0.442
DOC_USP7_MATH_1 314 318 PF00917 0.256
DOC_USP7_MATH_1 338 342 PF00917 0.235
DOC_USP7_UBL2_3 360 364 PF12436 0.300
DOC_USP7_UBL2_3 487 491 PF12436 0.294
DOC_USP7_UBL2_3 89 93 PF12436 0.543
DOC_WW_Pin1_4 454 459 PF00397 0.300
LIG_14-3-3_CanoR_1 160 167 PF00244 0.473
LIG_14-3-3_CanoR_1 315 323 PF00244 0.272
LIG_BIR_III_4 407 411 PF00653 0.235
LIG_Clathr_ClatBox_1 305 309 PF01394 0.250
LIG_CtBP_PxDLS_1 218 222 PF00389 0.414
LIG_EH1_1 550 558 PF00400 0.250
LIG_FHA_1 123 129 PF00498 0.310
LIG_FHA_1 18 24 PF00498 0.330
LIG_FHA_1 317 323 PF00498 0.292
LIG_FHA_1 398 404 PF00498 0.298
LIG_FHA_1 430 436 PF00498 0.275
LIG_FHA_1 439 445 PF00498 0.198
LIG_FHA_2 114 120 PF00498 0.333
LIG_FHA_2 148 154 PF00498 0.507
LIG_FHA_2 338 344 PF00498 0.212
LIG_FHA_2 40 46 PF00498 0.442
LIG_FHA_2 404 410 PF00498 0.235
LIG_FHA_2 74 80 PF00498 0.628
LIG_LIR_Apic_2 152 158 PF02991 0.439
LIG_LIR_Apic_2 475 481 PF02991 0.235
LIG_LIR_Apic_2 516 521 PF02991 0.380
LIG_LIR_Gen_1 302 311 PF02991 0.269
LIG_LIR_Gen_1 354 363 PF02991 0.256
LIG_LIR_Gen_1 522 533 PF02991 0.294
LIG_LIR_Gen_1 67 77 PF02991 0.455
LIG_LIR_LC3C_4 220 223 PF02991 0.386
LIG_LIR_LC3C_4 302 307 PF02991 0.180
LIG_LIR_Nem_3 299 304 PF02991 0.280
LIG_LIR_Nem_3 354 359 PF02991 0.256
LIG_LIR_Nem_3 522 528 PF02991 0.294
LIG_LIR_Nem_3 67 73 PF02991 0.432
LIG_MAD2 4 12 PF02301 0.489
LIG_Pex14_1 263 267 PF04695 0.380
LIG_Pex14_2 259 263 PF04695 0.294
LIG_Pex14_2 514 518 PF04695 0.235
LIG_Pex14_2 70 74 PF04695 0.551
LIG_SH2_CRK 155 159 PF00017 0.533
LIG_SH2_CRK 181 185 PF00017 0.367
LIG_SH2_NCK_1 543 547 PF00017 0.380
LIG_SH2_SRC 543 546 PF00017 0.380
LIG_SH2_STAP1 260 264 PF00017 0.292
LIG_SH2_STAT5 304 307 PF00017 0.256
LIG_SH2_STAT5 310 313 PF00017 0.243
LIG_SH2_STAT5 339 342 PF00017 0.212
LIG_SH2_STAT5 420 423 PF00017 0.294
LIG_SH3_3 151 157 PF00018 0.537
LIG_SH3_3 209 215 PF00018 0.581
LIG_SH3_3 53 59 PF00018 0.636
LIG_SUMO_SIM_anti_2 400 407 PF11976 0.250
LIG_SUMO_SIM_par_1 304 309 PF11976 0.293
LIG_SUMO_SIM_par_1 432 439 PF11976 0.237
LIG_UBA3_1 392 397 PF00899 0.329
MOD_CK1_1 191 197 PF00069 0.501
MOD_CK1_1 21 27 PF00069 0.485
MOD_CK1_1 316 322 PF00069 0.323
MOD_CK1_1 341 347 PF00069 0.250
MOD_CK1_1 391 397 PF00069 0.272
MOD_CK2_1 296 302 PF00069 0.294
MOD_CK2_1 337 343 PF00069 0.212
MOD_CK2_1 39 45 PF00069 0.446
MOD_CK2_1 403 409 PF00069 0.235
MOD_Cter_Amidation 90 93 PF01082 0.544
MOD_GlcNHglycan 185 188 PF01048 0.507
MOD_GlcNHglycan 193 196 PF01048 0.520
MOD_GlcNHglycan 316 319 PF01048 0.380
MOD_GlcNHglycan 458 461 PF01048 0.283
MOD_GlcNHglycan 52 56 PF01048 0.506
MOD_GlcNHglycan 89 92 PF01048 0.719
MOD_GSK3_1 13 20 PF00069 0.336
MOD_GSK3_1 313 320 PF00069 0.250
MOD_GSK3_1 337 344 PF00069 0.320
MOD_GSK3_1 351 358 PF00069 0.214
MOD_GSK3_1 383 390 PF00069 0.239
MOD_GSK3_1 69 76 PF00069 0.466
MOD_NEK2_1 122 127 PF00069 0.333
MOD_NEK2_1 173 178 PF00069 0.346
MOD_NEK2_1 30 35 PF00069 0.479
MOD_NEK2_1 462 467 PF00069 0.265
MOD_NEK2_1 73 78 PF00069 0.650
MOD_NEK2_1 87 92 PF00069 0.419
MOD_NEK2_2 113 118 PF00069 0.399
MOD_NEK2_2 137 142 PF00069 0.378
MOD_NEK2_2 355 360 PF00069 0.380
MOD_PIKK_1 468 474 PF00454 0.274
MOD_PKA_1 429 435 PF00069 0.300
MOD_PKA_2 296 302 PF00069 0.355
MOD_PKA_2 314 320 PF00069 0.148
MOD_PKA_2 87 93 PF00069 0.459
MOD_Plk_1 167 173 PF00069 0.410
MOD_Plk_2-3 147 153 PF00069 0.501
MOD_Plk_4 388 394 PF00069 0.301
MOD_Plk_4 416 422 PF00069 0.226
MOD_Plk_4 462 468 PF00069 0.394
MOD_Plk_4 69 75 PF00069 0.613
MOD_Plk_4 82 88 PF00069 0.420
MOD_ProDKin_1 454 460 PF00069 0.300
MOD_SUMO_rev_2 484 489 PF00179 0.269
TRG_ENDOCYTIC_2 181 184 PF00928 0.322
TRG_ENDOCYTIC_2 304 307 PF00928 0.250
TRG_ENDOCYTIC_2 339 342 PF00928 0.269
TRG_ENDOCYTIC_2 424 427 PF00928 0.300
TRG_ER_diArg_1 2 4 PF00400 0.505
TRG_ER_diArg_1 201 204 PF00400 0.713
TRG_NES_CRM1_1 366 379 PF08389 0.294

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6B6 Leptomonas seymouri 73% 100%
A0A0S4J9X5 Bodo saltans 54% 100%
A0A1X0NWS8 Trypanosomatidae 61% 91%
A0A3R7MFB6 Trypanosoma rangeli 55% 92%
A0A3S7WXR2 Leishmania donovani 96% 100%
A1UIA8 Mycobacterium sp. (strain KMS) 35% 100%
A1WUV1 Halorhodospira halophila (strain DSM 244 / SL1) 36% 100%
A3M1A8 Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) 37% 100%
A3Q1S2 Mycobacterium sp. (strain JLS) 35% 100%
A4HCW4 Leishmania braziliensis 89% 100%
A4I0E4 Leishmania infantum 96% 100%
A5IAU5 Legionella pneumophila (strain Corby) 38% 100%
A5VZ69 Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) 37% 100%
A6T0V4 Janthinobacterium sp. (strain Marseille) 36% 100%
A6V0T2 Pseudomonas aeruginosa (strain PA7) 38% 100%
A8EXL1 Rickettsia canadensis (strain McKiel) 40% 100%
A8F0Q0 Rickettsia massiliae (strain Mtu5) 38% 100%
B0KQK8 Pseudomonas putida (strain GB-1) 37% 100%
B0RVI0 Xanthomonas campestris pv. campestris (strain B100) 36% 100%
B0VDC8 Acinetobacter baumannii (strain AYE) 37% 100%
B1JBA9 Pseudomonas putida (strain W619) 38% 100%
B1VZN5 Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) 37% 100%
B1WR01 Crocosphaera subtropica (strain ATCC 51142 / BH68) 36% 100%
B2I1U0 Acinetobacter baumannii (strain ACICU) 37% 100%
B2JET5 Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815) 36% 100%
B2UTQ8 Helicobacter pylori (strain Shi470) 34% 100%
B3ED46 Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330) 40% 100%
B3Q9R8 Rhodopseudomonas palustris (strain TIE-1) 39% 100%
B3QNM5 Chlorobaculum parvum (strain DSM 263 / NCIMB 8327) 40% 100%
B3QVE8 Chloroherpeton thalassium (strain ATCC 35110 / GB-78) 37% 100%
B5EKZ2 Acidithiobacillus ferrooxidans (strain ATCC 53993 / BNL-5-31) 36% 100%
B5F9Q6 Aliivibrio fischeri (strain MJ11) 37% 100%
B5Z6U1 Helicobacter pylori (strain G27) 34% 100%
B6EMT2 Aliivibrio salmonicida (strain LFI1238) 37% 100%
B6JLF2 Helicobacter pylori (strain P12) 34% 100%
B7H1P9 Acinetobacter baumannii (strain AB307-0294) 37% 100%
B7I309 Acinetobacter baumannii (strain AB0057) 37% 100%
B7J5I9 Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455) 36% 100%
B7UVT6 Pseudomonas aeruginosa (strain LESB58) 38% 100%
C0QSL9 Persephonella marina (strain DSM 14350 / EX-H1) 34% 100%
C1DPG2 Azotobacter vinelandii (strain DJ / ATCC BAA-1303) 36% 100%
C3K6G5 Pseudomonas fluorescens (strain SBW25) 38% 100%
C5CCM4 Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230) 34% 100%
C6E543 Geobacter sp. (strain M21) 39% 100%
C9ZV91 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 84%
E9AWA7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O25294 Helicobacter pylori (strain ATCC 700392 / 26695) 34% 100%
O67868 Aquifex aeolicus (strain VF5) 35% 100%
O68822 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 38% 100%
O86436 Pseudomonas putida 37% 100%
P00727 Bos taurus 35% 100%
P28838 Homo sapiens 34% 100%
P28839 Sus scrofa 35% 100%
Q02RY8 Pseudomonas aeruginosa (strain UCBPP-PA14) 38% 100%
Q07LG0 Rhodopseudomonas palustris (strain BisA53) 39% 100%
Q0AB75 Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1) 36% 100%
Q0AIF5 Nitrosomonas eutropha (strain DSM 101675 / C91 / Nm57) 38% 100%
Q0SHL0 Rhodococcus jostii (strain RHA1) 36% 100%
Q15PX4 Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) 39% 100%
Q17W06 Helicobacter acinonychis (strain Sheeba) 34% 100%
Q1B6R7 Mycobacterium sp. (strain MCS) 35% 100%
Q1CTV6 Helicobacter pylori (strain HPAG1) 34% 100%
Q1H4U4 Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) 34% 100%
Q1I5F9 Pseudomonas entomophila (strain L48) 39% 100%
Q215R8 Rhodopseudomonas palustris (strain BisB18) 39% 100%
Q2JKL5 Synechococcus sp. (strain JA-2-3B'a(2-13)) 31% 100%
Q2YB18 Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71) 35% 100%
Q3B4B5 Chlorobium luteolum (strain DSM 273 / BCRC 81028 / 2530) 40% 100%
Q3KHM4 Pseudomonas fluorescens (strain Pf0-1) 37% 100%
Q47BG9 Dechloromonas aromatica (strain RCB) 37% 100%
Q4UKD7 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 38% 100%
Q4UQP6 Xanthomonas campestris pv. campestris (strain 8004) 36% 100%
Q5E7T8 Aliivibrio fischeri (strain ATCC 700601 / ES114) 37% 100%
Q5V9F0 Dictyostelium discoideum 35% 100%
Q5WTG8 Legionella pneumophila (strain Lens) 38% 100%
Q5X1Q9 Legionella pneumophila (strain Paris) 38% 100%
Q67NI4 Symbiobacterium thermophilum (strain T / IAM 14863) 34% 100%
Q68FS4 Rattus norvegicus 35% 100%
Q6LUW0 Photobacterium profundum (strain SS9) 38% 100%
Q6N5B9 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 39% 100%
Q72F03 Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) 33% 100%
Q73QZ3 Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) 36% 100%
Q73YK2 Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) 36% 100%
Q7M8W6 Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) 35% 100%
Q7NTY9 Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) 35% 100%
Q7UJ62 Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1) 33% 100%
Q7VAP4 Prochlorococcus marinus (strain SARG / CCMP1375 / SS120) 39% 100%
Q82AN2 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) 37% 100%
Q82X54 Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298) 38% 100%
Q87LG8 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 38% 100%
Q88P73 Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) 37% 100%
Q8KD74 Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) 38% 100%
Q8PCR4 Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) 36% 100%
Q984S1 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 38% 100%
Q9CPY7 Mus musculus 35% 100%
Q9PP04 Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) 33% 100%
Q9ZLR1 Helicobacter pylori (strain J99 / ATCC 700824) 34% 100%
V5BNS5 Trypanosoma cruzi 51% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS