Thiol-dependent reductase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thiol-dependent reductase 1

Species:

Leishmania major

UniProt:

Q70GE8_LEIMA

TriTrypDb:

LmjF.33.0240 , LMJLV39_330008400 , LMJSD75_330008100

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q70GE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q70GE8

PDB structure(s): 4ags_A , 4ags_B , 4ags_C

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	3
GO:0015035	protein-disulfide reductase activity	3	6
GO:0015036	disulfide oxidoreductase activity	4	6
GO:0015038	glutathione disulfide oxidoreductase activity	5	3
GO:0016209	antioxidant activity	1	3
GO:0016491	oxidoreductase activity	2	6
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	6
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	6
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	4	3
GO:0019153	protein-disulfide reductase (glutathione) activity	4	6
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0045174	glutathione dehydrogenase (ascorbate) activity	2	3
GO:0050661	NADP binding	4	2
GO:0070402	NADPH binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2
GO:0005515	protein binding	2	1
GO:0042802	identical protein binding	3	1
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.389
CLV_NRD_NRD_1	252	254	PF00675	0.513
CLV_NRD_NRD_1	445	447	PF00675	0.579
CLV_PCSK_FUR_1	443	447	PF00082	0.594
CLV_PCSK_KEX2_1	125	127	PF00082	0.411
CLV_PCSK_KEX2_1	377	379	PF00082	0.436
CLV_PCSK_KEX2_1	445	447	PF00082	0.629
CLV_PCSK_KEX2_1	65	67	PF00082	0.474
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.411
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.436
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.458
CLV_PCSK_PC7_1	441	447	PF00082	0.583
CLV_PCSK_SKI1_1	170	174	PF00082	0.410
CLV_PCSK_SKI1_1	4	8	PF00082	0.455
CLV_PCSK_SKI1_1	427	431	PF00082	0.457
CLV_PCSK_SKI1_1	66	70	PF00082	0.474
DEG_SCF_FBW7_2	283	289	PF00400	0.513
DOC_CKS1_1	283	288	PF01111	0.411
DOC_CYCLIN_RxL_1	1	11	PF00134	0.479
DOC_MAPK_DCC_7	52	60	PF00069	0.411
DOC_MAPK_MEF2A_6	52	60	PF00069	0.411
DOC_PP1_RVXF_1	187	193	PF00149	0.280
DOC_WW_Pin1_4	202	207	PF00397	0.563
DOC_WW_Pin1_4	282	287	PF00397	0.411
LIG_14-3-3_CanoR_1	198	202	PF00244	0.480
LIG_Actin_WH2_2	156	172	PF00022	0.474
LIG_APCC_ABBA_1	239	244	PF00400	0.480
LIG_APCC_ABBA_1	262	267	PF00400	0.280
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_BRCT_BRCA1_1	235	239	PF00533	0.436
LIG_EH1_1	331	339	PF00400	0.513
LIG_eIF4E_1	332	338	PF01652	0.513
LIG_FHA_1	257	263	PF00498	0.376
LIG_FHA_1	307	313	PF00498	0.508
LIG_FHA_1	55	61	PF00498	0.441
LIG_FHA_2	154	160	PF00498	0.513
LIG_FHA_2	430	436	PF00498	0.592
LIG_GBD_Chelix_1	34	42	PF00786	0.474
LIG_Integrin_RGD_1	314	316	PF01839	0.588
LIG_LIR_Gen_1	30	38	PF02991	0.501
LIG_LIR_Gen_1	401	412	PF02991	0.417
LIG_LIR_Nem_3	213	218	PF02991	0.551
LIG_LIR_Nem_3	236	242	PF02991	0.514
LIG_LIR_Nem_3	267	273	PF02991	0.422
LIG_LIR_Nem_3	30	34	PF02991	0.501
LIG_LIR_Nem_3	401	407	PF02991	0.400
LIG_MYND_3	55	59	PF01753	0.513
LIG_PCNA_TLS_4	96	103	PF02747	0.513
LIG_Pex14_2	396	400	PF04695	0.496
LIG_PTB_Apo_2	326	333	PF02174	0.513
LIG_PTB_Phospho_1	326	332	PF10480	0.513
LIG_REV1ctd_RIR_1	371	382	PF16727	0.513
LIG_SH2_CRK	235	239	PF00017	0.519
LIG_SH2_CRK	271	275	PF00017	0.529
LIG_SH2_CRK	31	35	PF00017	0.474
LIG_SH2_CRK	46	50	PF00017	0.436
LIG_SH2_GRB2like	235	238	PF00017	0.441
LIG_SH2_GRB2like	273	276	PF00017	0.436
LIG_SH2_NCK_1	31	35	PF00017	0.397
LIG_SH2_PTP2	273	276	PF00017	0.436
LIG_SH2_SRC	135	138	PF00017	0.381
LIG_SH2_SRC	273	276	PF00017	0.436
LIG_SH2_STAP1	235	239	PF00017	0.513
LIG_SH2_STAP1	31	35	PF00017	0.516
LIG_SH2_STAP1	404	408	PF00017	0.441
LIG_SH2_STAT5	135	138	PF00017	0.388
LIG_SH2_STAT5	150	153	PF00017	0.388
LIG_SH2_STAT5	273	276	PF00017	0.490
LIG_SH2_STAT5	300	303	PF00017	0.387
LIG_SH2_STAT5	332	335	PF00017	0.416
LIG_SH2_STAT5	77	80	PF00017	0.369
LIG_SH2_STAT5	9	12	PF00017	0.467
LIG_SH3_3	257	263	PF00018	0.492
LIG_SUMO_SIM_anti_2	159	164	PF11976	0.358
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.388
LIG_TRAF2_1	432	435	PF00917	0.580
LIG_TYR_ITIM	233	238	PF00017	0.519
LIG_TYR_ITIM	29	34	PF00017	0.474
LIG_UBA3_1	386	394	PF00899	0.420
MOD_CK2_1	197	203	PF00069	0.402
MOD_CK2_1	429	435	PF00069	0.558
MOD_Cter_Amidation	375	378	PF01082	0.436
MOD_GlcNHglycan	10	13	PF01048	0.397
MOD_GlcNHglycan	121	124	PF01048	0.502
MOD_GlcNHglycan	221	224	PF01048	0.597
MOD_GlcNHglycan	286	289	PF01048	0.513
MOD_GlcNHglycan	399	403	PF01048	0.447
MOD_GlcNHglycan	79	83	PF01048	0.555
MOD_GlcNHglycan	92	95	PF01048	0.473
MOD_GSK3_1	197	204	PF00069	0.370
MOD_N-GLC_1	142	147	PF02516	0.515
MOD_NEK2_1	78	83	PF00069	0.488
MOD_NEK2_1	8	13	PF00069	0.426
MOD_NEK2_1	89	94	PF00069	0.413
MOD_PIKK_1	291	297	PF00454	0.438
MOD_PKA_2	197	203	PF00069	0.366
MOD_PKA_2	276	282	PF00069	0.355
MOD_PKA_2	51	57	PF00069	0.369
MOD_Plk_1	153	159	PF00069	0.421
MOD_Plk_4	336	342	PF00069	0.521
MOD_Plk_4	68	74	PF00069	0.476
MOD_ProDKin_1	202	208	PF00069	0.562
MOD_ProDKin_1	282	288	PF00069	0.411
MOD_SUMO_for_1	348	351	PF00179	0.441
MOD_SUMO_rev_2	346	350	PF00179	0.462
TRG_DiLeu_BaEn_1	307	312	PF01217	0.401
TRG_DiLeu_BaEn_2	321	327	PF01217	0.513
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.513
TRG_ENDOCYTIC_2	179	182	PF00928	0.369
TRG_ENDOCYTIC_2	215	218	PF00928	0.577
TRG_ENDOCYTIC_2	235	238	PF00928	0.183
TRG_ENDOCYTIC_2	271	274	PF00928	0.440
TRG_ENDOCYTIC_2	31	34	PF00928	0.474
TRG_ENDOCYTIC_2	404	407	PF00928	0.374
TRG_ENDOCYTIC_2	46	49	PF00928	0.382
TRG_ER_diArg_1	245	248	PF00400	0.411
TRG_ER_diArg_1	440	443	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IX62	Bodo saltans	40%	94%
A0A0S4KHM5	Bodo saltans	40%	93%
A0A1X0P247	Trypanosomatidae	46%	100%
A0A3S7X699	Leishmania donovani	96%	100%
A0A422NGA2	Trypanosoma rangeli	51%	100%
A4HJ18	Leishmania braziliensis	81%	100%
A4I8P2	Leishmania infantum	96%	100%
E9B3K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DBY4	Trypanosoma cruzi	48%	100%