LeishMANIAdb
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Galactofuranosyltransferase LPG1-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Galactofuranosyltransferase LPG1-like protein
Gene product:
beta-galactofuranosyltransferase-like protein
Species:
Leishmania major
UniProt:
Q6XFB5_LEIMA
TriTrypDb:
LmjF.33.0300 , LMJLV39_330009600 * , LMJSD75_330009300 *
Length:
460

Annotations

LeishMANIAdb annotations

A large family of glycosyltransferases expanded in parazitic kinetoplastids (and even more in T cruzi). Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 36
NetGPI no yes: 0, no: 36
Cellular components
Term Name Level Count
GO:0016020 membrane 2 14
GO:0110165 cellular anatomical entity 1 14

Expansion

Sequence features

Q6XFB5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q6XFB5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 37
GO:0016740 transferase activity 2 37
GO:0016757 glycosyltransferase activity 3 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 38 42 PF00656 0.307
CLV_NRD_NRD_1 16 18 PF00675 0.441
CLV_NRD_NRD_1 186 188 PF00675 0.601
CLV_NRD_NRD_1 417 419 PF00675 0.596
CLV_NRD_NRD_1 436 438 PF00675 0.536
CLV_NRD_NRD_1 458 460 PF00675 0.599
CLV_PCSK_KEX2_1 16 18 PF00082 0.404
CLV_PCSK_KEX2_1 186 188 PF00082 0.601
CLV_PCSK_KEX2_1 2 4 PF00082 0.555
CLV_PCSK_KEX2_1 417 419 PF00082 0.588
CLV_PCSK_KEX2_1 436 438 PF00082 0.536
CLV_PCSK_PC1ET2_1 2 4 PF00082 0.376
CLV_PCSK_SKI1_1 162 166 PF00082 0.481
CLV_PCSK_SKI1_1 17 21 PF00082 0.406
CLV_PCSK_SKI1_1 282 286 PF00082 0.551
CLV_PCSK_SKI1_1 315 319 PF00082 0.436
CLV_PCSK_SKI1_1 377 381 PF00082 0.594
CLV_PCSK_SKI1_1 437 441 PF00082 0.488
DEG_APCC_DBOX_1 15 23 PF00400 0.410
DEG_APCC_DBOX_1 376 384 PF00400 0.400
DEG_Nend_UBRbox_1 1 4 PF02207 0.580
DEG_SCF_FBW7_1 233 240 PF00400 0.252
DOC_MAPK_DCC_7 167 177 PF00069 0.220
DOC_MAPK_gen_1 16 22 PF00069 0.210
DOC_MAPK_MEF2A_6 406 413 PF00069 0.399
DOC_PP1_RVXF_1 15 22 PF00149 0.203
DOC_PP2B_PxIxI_1 172 178 PF00149 0.332
DOC_PP4_FxxP_1 393 396 PF00568 0.352
DOC_USP7_MATH_1 136 140 PF00917 0.408
DOC_USP7_MATH_1 343 347 PF00917 0.461
DOC_WW_Pin1_4 10 15 PF00397 0.671
DOC_WW_Pin1_4 233 238 PF00397 0.406
DOC_WW_Pin1_4 383 388 PF00397 0.342
LIG_14-3-3_CanoR_1 226 230 PF00244 0.346
LIG_14-3-3_CanoR_1 250 255 PF00244 0.331
LIG_14-3-3_CanoR_1 3 12 PF00244 0.564
LIG_14-3-3_CanoR_1 74 82 PF00244 0.416
LIG_Actin_WH2_2 119 136 PF00022 0.373
LIG_BRCT_BRCA1_1 320 324 PF00533 0.245
LIG_deltaCOP1_diTrp_1 301 307 PF00928 0.389
LIG_deltaCOP1_diTrp_1 370 375 PF00928 0.365
LIG_deltaCOP1_diTrp_1 97 104 PF00928 0.361
LIG_FHA_1 125 131 PF00498 0.411
LIG_FHA_1 234 240 PF00498 0.310
LIG_FHA_1 30 36 PF00498 0.317
LIG_FHA_1 424 430 PF00498 0.421
LIG_FHA_1 76 82 PF00498 0.359
LIG_FHA_2 452 458 PF00498 0.347
LIG_FHA_2 62 68 PF00498 0.397
LIG_IRF3_LxIS_1 237 242 PF10401 0.230
LIG_LIR_Gen_1 95 105 PF02991 0.333
LIG_LIR_Nem_3 171 177 PF02991 0.249
LIG_LIR_Nem_3 293 299 PF02991 0.266
LIG_LIR_Nem_3 321 327 PF02991 0.342
LIG_LIR_Nem_3 386 391 PF02991 0.365
LIG_LIR_Nem_3 95 101 PF02991 0.341
LIG_Pex14_2 174 178 PF04695 0.318
LIG_Pex14_2 324 328 PF04695 0.412
LIG_PTB_Apo_2 308 315 PF02174 0.208
LIG_REV1ctd_RIR_1 325 334 PF16727 0.247
LIG_SH2_CRK 197 201 PF00017 0.394
LIG_SH2_NCK_1 349 353 PF00017 0.226
LIG_SH2_NCK_1 37 41 PF00017 0.330
LIG_SH2_PTP2 192 195 PF00017 0.200
LIG_SH2_SRC 114 117 PF00017 0.352
LIG_SH2_SRC 192 195 PF00017 0.205
LIG_SH2_STAP1 153 157 PF00017 0.250
LIG_SH2_STAP1 251 255 PF00017 0.259
LIG_SH2_STAP1 303 307 PF00017 0.224
LIG_SH2_STAP1 349 353 PF00017 0.376
LIG_SH2_STAT3 116 119 PF00017 0.375
LIG_SH2_STAT3 303 306 PF00017 0.215
LIG_SH2_STAT5 114 117 PF00017 0.348
LIG_SH2_STAT5 183 186 PF00017 0.367
LIG_SH2_STAT5 188 191 PF00017 0.336
LIG_SH2_STAT5 192 195 PF00017 0.306
LIG_SH2_STAT5 299 302 PF00017 0.296
LIG_SH3_3 52 58 PF00018 0.509
LIG_SH3_3 87 93 PF00018 0.372
LIG_SH3_5 364 368 PF00018 0.359
LIG_SUMO_SIM_anti_2 281 287 PF11976 0.371
LIG_SUMO_SIM_anti_2 30 35 PF11976 0.320
LIG_SUMO_SIM_par_1 24 30 PF11976 0.190
LIG_SUMO_SIM_par_1 32 38 PF11976 0.195
LIG_SUMO_SIM_par_1 409 415 PF11976 0.246
LIG_SUMO_SIM_par_1 92 97 PF11976 0.258
LIG_TRAF2_1 122 125 PF00917 0.233
LIG_TRAF2_1 209 212 PF00917 0.373
LIG_TRAF2_1 64 67 PF00917 0.248
LIG_TYR_ITIM 195 200 PF00017 0.212
LIG_WRC_WIRS_1 251 256 PF05994 0.247
LIG_WRC_WIRS_1 314 319 PF05994 0.308
MOD_CDC14_SPxK_1 13 16 PF00782 0.633
MOD_CDK_SPxK_1 10 16 PF00069 0.650
MOD_CDK_SPxxK_3 10 17 PF00069 0.502
MOD_CK1_1 232 238 PF00069 0.308
MOD_CK1_1 430 436 PF00069 0.269
MOD_CK2_1 119 125 PF00069 0.196
MOD_CK2_1 250 256 PF00069 0.284
MOD_CK2_1 61 67 PF00069 0.300
MOD_Cter_Amidation 415 418 PF01082 0.475
MOD_GlcNHglycan 320 323 PF01048 0.641
MOD_GlcNHglycan 383 386 PF01048 0.593
MOD_GlcNHglycan 448 451 PF01048 0.552
MOD_GSK3_1 124 131 PF00069 0.416
MOD_GSK3_1 225 232 PF00069 0.384
MOD_GSK3_1 233 240 PF00069 0.342
MOD_GSK3_1 313 320 PF00069 0.317
MOD_GSK3_1 417 424 PF00069 0.329
MOD_GSK3_1 427 434 PF00069 0.391
MOD_GSK3_1 446 453 PF00069 0.510
MOD_N-GLC_1 119 124 PF02516 0.488
MOD_N-GLC_1 427 432 PF02516 0.555
MOD_NEK2_1 229 234 PF00069 0.383
MOD_NEK2_1 239 244 PF00069 0.254
MOD_NEK2_1 27 32 PF00069 0.273
MOD_NEK2_1 278 283 PF00069 0.260
MOD_NEK2_1 317 322 PF00069 0.342
MOD_NEK2_1 423 428 PF00069 0.390
MOD_NEK2_1 431 436 PF00069 0.332
MOD_NEK2_1 446 451 PF00069 0.387
MOD_NEK2_1 69 74 PF00069 0.392
MOD_NEK2_2 225 230 PF00069 0.408
MOD_PK_1 417 423 PF00069 0.456
MOD_PKA_1 417 423 PF00069 0.424
MOD_PKA_2 225 231 PF00069 0.334
MOD_PKA_2 249 255 PF00069 0.306
MOD_PKA_2 417 423 PF00069 0.428
MOD_PKB_1 248 256 PF00069 0.248
MOD_Plk_1 124 130 PF00069 0.396
MOD_Plk_1 427 433 PF00069 0.262
MOD_Plk_4 427 433 PF00069 0.400
MOD_Plk_4 82 88 PF00069 0.221
MOD_ProDKin_1 10 16 PF00069 0.669
MOD_ProDKin_1 233 239 PF00069 0.387
MOD_ProDKin_1 383 389 PF00069 0.344
MOD_SUMO_rev_2 367 374 PF00179 0.361
TRG_DiLeu_BaEn_1 125 130 PF01217 0.226
TRG_DiLeu_BaLyEn_6 138 143 PF01217 0.389
TRG_ENDOCYTIC_2 114 117 PF00928 0.381
TRG_ENDOCYTIC_2 192 195 PF00928 0.383
TRG_ENDOCYTIC_2 197 200 PF00928 0.395
TRG_ENDOCYTIC_2 251 254 PF00928 0.295
TRG_ER_diArg_1 111 114 PF00400 0.289
TRG_ER_diArg_1 186 188 PF00400 0.398
TRG_ER_diArg_1 248 251 PF00400 0.308
TRG_ER_diArg_1 417 419 PF00400 0.403
TRG_ER_diArg_1 435 437 PF00400 0.390
TRG_Pf-PMV_PEXEL_1 141 145 PF00026 0.607
TRG_Pf-PMV_PEXEL_1 208 212 PF00026 0.620
TRG_Pf-PMV_PEXEL_1 74 79 PF00026 0.523

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P269 Leptomonas seymouri 29% 100%
A0A0N1PC27 Leptomonas seymouri 67% 100%
A0A0N1PES8 Leptomonas seymouri 31% 100%
A0A1X0NWK3 Trypanosomatidae 36% 100%
A0A1X0NWM3 Trypanosomatidae 36% 100%
A0A3Q8IHI5 Leishmania donovani 27% 70%
A0A3R7N1J7 Trypanosoma rangeli 35% 100%
A0A3S5H7D9 Leishmania donovani 32% 100%
A0A3S7WZK8 Leishmania donovani 29% 86%
A0A3S7X6F1 Leishmania donovani 94% 100%
A4HDU8 Leishmania braziliensis 32% 100%
A4HER0 Leishmania braziliensis 28% 69%
A4HL36 Leishmania braziliensis 30% 80%
A4I143 Leishmania infantum 32% 100%
A4I1Y7 Leishmania infantum 29% 86%
A4I8P7 Leishmania infantum 94% 100%
E9AHM5 Leishmania infantum 27% 77%
E9AXX9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AY34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 86%
E9B3H7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 78%
E9B3L0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q05889 Leishmania donovani 32% 100%
Q4Q9D9 Leishmania major 28% 100%
Q9NC61 Leishmania major 30% 100%
V5AJW5 Trypanosoma cruzi 36% 100%
V5AM55 Trypanosoma cruzi 38% 100%
V5AR28 Trypanosoma cruzi 38% 100%
V5ASN8 Trypanosoma cruzi 36% 100%
V5AUJ2 Trypanosoma cruzi 37% 100%
V5B2H2 Trypanosoma cruzi 37% 100%
V5B4V1 Trypanosoma cruzi 36% 100%
V5B8H6 Trypanosoma cruzi 36% 100%
V5BB47 Trypanosoma cruzi 37% 100%
V5BRK8 Trypanosoma cruzi 37% 100%
V5BXG8 Trypanosoma cruzi 36% 100%
V5DD11 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS