Phenylalanine-4-hydroxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phenylalanine-4-hydroxylase

Species:

Leishmania major

UniProt:

Q6WRI4_LEIMA

TriTrypDb:

LmjF.28.1280 , LMJLV39_280020000 , LMJSD75_280019600

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q6WRI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q6WRI4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	5
GO:0006520	amino acid metabolic process	3	5
GO:0006558	L-phenylalanine metabolic process	5	2
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009072	aromatic amino acid metabolic process	4	5
GO:0009987	cellular process	1	5
GO:0019752	carboxylic acid metabolic process	5	5
GO:0043436	oxoacid metabolic process	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044281	small molecule metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901360	organic cyclic compound metabolic process	3	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1902221	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004497	monooxygenase activity	3	9
GO:0004505	phenylalanine 4-monooxygenase activity	5	6
GO:0005488	binding	1	9
GO:0005506	iron ion binding	6	9
GO:0016491	oxidoreductase activity	2	9
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	9
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	4	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.447
CLV_NRD_NRD_1	168	170	PF00675	0.249
CLV_NRD_NRD_1	349	351	PF00675	0.298
CLV_NRD_NRD_1	406	408	PF00675	0.298
CLV_NRD_NRD_1	429	431	PF00675	0.288
CLV_PCSK_FUR_1	165	169	PF00082	0.314
CLV_PCSK_KEX2_1	167	169	PF00082	0.249
CLV_PCSK_KEX2_1	349	351	PF00082	0.298
CLV_PCSK_KEX2_1	429	431	PF00082	0.291
CLV_PCSK_KEX2_1	447	449	PF00082	0.631
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.546
CLV_PCSK_SKI1_1	253	257	PF00082	0.268
CLV_PCSK_SKI1_1	262	266	PF00082	0.223
CLV_PCSK_SKI1_1	330	334	PF00082	0.314
CLV_PCSK_SKI1_1	6	10	PF00082	0.552
CLV_PCSK_SKI1_1	87	91	PF00082	0.350
DEG_APCC_DBOX_1	261	269	PF00400	0.514
DEG_Nend_Nbox_1	1	3	PF02207	0.573
DOC_CDC14_PxL_1	298	306	PF14671	0.514
DOC_CKS1_1	286	291	PF01111	0.447
DOC_MAPK_gen_1	165	174	PF00069	0.554
DOC_MAPK_gen_1	176	186	PF00069	0.465
DOC_MAPK_gen_1	36	46	PF00069	0.412
DOC_MAPK_MEF2A_6	39	48	PF00069	0.383
DOC_PP1_RVXF_1	331	337	PF00149	0.447
DOC_USP7_UBL2_3	32	36	PF12436	0.604
DOC_WW_Pin1_4	23	28	PF00397	0.400
DOC_WW_Pin1_4	231	236	PF00397	0.449
DOC_WW_Pin1_4	285	290	PF00397	0.447
DOC_WW_Pin1_4	382	387	PF00397	0.514
LIG_14-3-3_CanoR_1	195	200	PF00244	0.514
LIG_14-3-3_CanoR_1	271	279	PF00244	0.447
LIG_14-3-3_CanoR_1	39	45	PF00244	0.386
LIG_14-3-3_CanoR_1	429	435	PF00244	0.510
LIG_14-3-3_CterR_2	448	453	PF00244	0.593
LIG_APCC_ABBAyCdc20_2	4	10	PF00400	0.503
LIG_BRCT_BRCA1_1	260	264	PF00533	0.447
LIG_BRCT_BRCA1_1	337	341	PF00533	0.471
LIG_BRCT_BRCA1_1	4	8	PF00533	0.528
LIG_eIF4E_1	218	224	PF01652	0.514
LIG_FHA_1	232	238	PF00498	0.518
LIG_FHA_1	254	260	PF00498	0.466
LIG_FHA_1	274	280	PF00498	0.355
LIG_FHA_1	311	317	PF00498	0.514
LIG_FHA_1	86	92	PF00498	0.437
LIG_FHA_2	188	194	PF00498	0.447
LIG_FHA_2	258	264	PF00498	0.514
LIG_LIR_Apic_2	119	125	PF02991	0.363
LIG_LIR_Gen_1	198	209	PF02991	0.455
LIG_LIR_Gen_1	306	316	PF02991	0.451
LIG_LIR_Gen_1	438	446	PF02991	0.511
LIG_LIR_Gen_1	88	97	PF02991	0.412
LIG_LIR_Nem_3	198	204	PF02991	0.455
LIG_LIR_Nem_3	306	312	PF02991	0.451
LIG_LIR_Nem_3	390	395	PF02991	0.398
LIG_LIR_Nem_3	422	427	PF02991	0.449
LIG_LIR_Nem_3	438	442	PF02991	0.398
LIG_LIR_Nem_3	61	66	PF02991	0.380
LIG_LIR_Nem_3	88	93	PF02991	0.404
LIG_NRBOX	55	61	PF00104	0.369
LIG_PCNA_yPIPBox_3	406	418	PF02747	0.482
LIG_PDZ_Class_2	448	453	PF00595	0.593
LIG_Pex14_1	197	201	PF04695	0.514
LIG_SH2_CRK	216	220	PF00017	0.514
LIG_SH2_CRK	24	28	PF00017	0.405
LIG_SH2_CRK	392	396	PF00017	0.398
LIG_SH2_GRB2like	80	83	PF00017	0.608
LIG_SH2_NCK_1	24	28	PF00017	0.405
LIG_SH2_PTP2	218	221	PF00017	0.514
LIG_SH2_STAP1	274	278	PF00017	0.471
LIG_SH2_STAP1	337	341	PF00017	0.447
LIG_SH2_STAP1	427	431	PF00017	0.447
LIG_SH2_STAP1	66	70	PF00017	0.398
LIG_SH2_STAP1	80	84	PF00017	0.478
LIG_SH2_STAT3	274	277	PF00017	0.471
LIG_SH2_STAT5	189	192	PF00017	0.447
LIG_SH2_STAT5	218	221	PF00017	0.514
LIG_SH2_STAT5	278	281	PF00017	0.447
LIG_SH2_STAT5	287	290	PF00017	0.447
LIG_SH2_STAT5	396	399	PF00017	0.447
LIG_SH2_STAT5	421	424	PF00017	0.494
LIG_SH2_STAT5	96	99	PF00017	0.408
LIG_SH3_3	122	128	PF00018	0.316
LIG_SH3_3	149	155	PF00018	0.453
LIG_SH3_3	373	379	PF00018	0.447
LIG_SH3_3	59	65	PF00018	0.401
LIG_SUMO_SIM_par_1	220	225	PF11976	0.501
LIG_TRAF2_1	144	147	PF00917	0.514
LIG_TRAF2_1	190	193	PF00917	0.447
LIG_TRAF2_1	414	417	PF00917	0.501
LIG_TYR_ITIM	199	204	PF00017	0.501
LIG_UBA3_1	327	333	PF00899	0.514
LIG_WRPW_2	63	66	PF00400	0.363
MOD_CDK_SPxxK_3	231	238	PF00069	0.449
MOD_CK1_1	26	32	PF00069	0.469
MOD_CK1_1	47	53	PF00069	0.548
MOD_CK2_1	187	193	PF00069	0.447
MOD_CK2_1	357	363	PF00069	0.447
MOD_CK2_1	411	417	PF00069	0.501
MOD_Cter_Amidation	347	350	PF01082	0.298
MOD_GSK3_1	227	234	PF00069	0.477
MOD_GSK3_1	253	260	PF00069	0.514
MOD_GSK3_1	317	324	PF00069	0.471
MOD_GSK3_1	35	42	PF00069	0.487
MOD_GSK3_1	419	426	PF00069	0.456
MOD_GSK3_1	64	71	PF00069	0.562
MOD_N-GLC_1	187	192	PF02516	0.271
MOD_N-GLC_1	310	315	PF02516	0.249
MOD_N-GLC_1	68	73	PF02516	0.388
MOD_NEK2_1	137	142	PF00069	0.447
MOD_NEK2_1	2	7	PF00069	0.509
MOD_NEK2_1	229	234	PF00069	0.485
MOD_NEK2_1	273	278	PF00069	0.457
MOD_NEK2_1	312	317	PF00069	0.514
MOD_NEK2_1	44	49	PF00069	0.422
MOD_NEK2_1	446	451	PF00069	0.573
MOD_NEK2_2	16	21	PF00069	0.547
MOD_NEK2_2	419	424	PF00069	0.514
MOD_NEK2_2	85	90	PF00069	0.485
MOD_PIKK_1	273	279	PF00454	0.447
MOD_PIKK_1	310	316	PF00454	0.514
MOD_PIKK_1	412	418	PF00454	0.501
MOD_PIKK_1	68	74	PF00454	0.506
MOD_PK_1	64	70	PF00069	0.472
MOD_PKA_2	40	46	PF00069	0.468
MOD_Plk_1	137	143	PF00069	0.447
MOD_Plk_1	68	74	PF00069	0.397
MOD_Plk_1	98	104	PF00069	0.579
MOD_Plk_4	118	124	PF00069	0.383
MOD_Plk_4	419	425	PF00069	0.571
MOD_Plk_4	58	64	PF00069	0.564
MOD_ProDKin_1	23	29	PF00069	0.397
MOD_ProDKin_1	231	237	PF00069	0.449
MOD_ProDKin_1	285	291	PF00069	0.447
MOD_ProDKin_1	382	388	PF00069	0.514
MOD_SUMO_rev_2	29	38	PF00179	0.577
TRG_DiLeu_BaEn_1	55	60	PF01217	0.445
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.514
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.514
TRG_ENDOCYTIC_2	201	204	PF00928	0.489
TRG_ENDOCYTIC_2	216	219	PF00928	0.395
TRG_ENDOCYTIC_2	392	395	PF00928	0.398
TRG_ER_diArg_1	164	167	PF00400	0.514
TRG_ER_diArg_1	3	6	PF00400	0.566
TRG_ER_diArg_1	429	431	PF00400	0.488
TRG_NES_CRM1_1	292	306	PF08389	0.514
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A060X6Z0	Oncorhynchus mykiss	43%	93%
A0A0N1HZV2	Leptomonas seymouri	82%	100%
A0A0S4JDM5	Bodo saltans	56%	100%
A0A3S5H7J2	Leishmania donovani	98%	100%
A4HGH5	Leishmania braziliensis	91%	100%
A4I3K7	Leishmania infantum	98%	100%
A8X3V8	Caenorhabditis briggsae	45%	88%
B6DT73	Bodo saltans	56%	100%
E9AZU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O17446	Schistosoma mansoni	42%	97%
O42091	Anguilla anguilla	43%	93%
P00439	Homo sapiens	44%	100%
P04176	Rattus norvegicus	44%	100%
P04177	Rattus norvegicus	43%	91%
P07101	Homo sapiens	42%	86%
P09810	Rattus norvegicus	43%	100%
P11982	Phasianidae sp.	43%	92%
P16331	Mus musculus	44%	100%
P17276	Drosophila melanogaster	43%	100%
P17289	Bos taurus	42%	92%
P17290	Oryctolagus cuniculus	43%	100%
P17532	Mus musculus	44%	100%
P17752	Homo sapiens	44%	100%
P18459	Drosophila melanogaster	48%	78%
P24529	Mus musculus	43%	91%
P70080	Gallus gallus	44%	100%
P90925	Caenorhabditis elegans	45%	99%
P90986	Caenorhabditis elegans	46%	87%
Q0EAB8	Equus caballus	47%	92%
Q2HZ26	Macaca mulatta	47%	92%
Q2KIH7	Bos taurus	45%	100%
Q54XS1	Dictyostelium discoideum	47%	100%
Q76IQ3	Canis lupus familiaris	41%	92%
Q8CGU9	Rattus norvegicus	42%	93%
Q8CGV2	Mus musculus	41%	93%
Q8IWU9	Homo sapiens	47%	92%
Q92142	Xenopus laevis	42%	94%