Putative MP18 RNA editing complex protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MP18 RNA editing complex protein, putative

Species:

Leishmania major

UniProt:

Q6T456_LEIMA

TriTrypDb:

LmjF.36.0700 , LMJLV39_360012700 , LMJSD75_360012600

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0031019	mitochondrial mRNA editing complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0045293	mRNA editing complex	3	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q6T456

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q6T456

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003697	single-stranded DNA binding	5	8
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004519	endonuclease activity	5	2
GO:0005488	binding	1	8
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.453
CLV_NRD_NRD_1	188	190	PF00675	0.513
CLV_NRD_NRD_1	3	5	PF00675	0.599
CLV_PCSK_KEX2_1	188	190	PF00082	0.513
CLV_PCSK_KEX2_1	3	5	PF00082	0.599
DEG_Nend_Nbox_1	1	3	PF02207	0.619
DOC_MAPK_MEF2A_6	165	174	PF00069	0.375
DOC_PP2B_PxIxI_1	169	175	PF00149	0.416
DOC_USP7_MATH_1	10	14	PF00917	0.517
DOC_USP7_MATH_1	20	24	PF00917	0.705
DOC_USP7_MATH_1	209	213	PF00917	0.594
DOC_USP7_MATH_1	35	39	PF00917	0.593
DOC_WW_Pin1_4	187	192	PF00397	0.600
DOC_WW_Pin1_4	3	8	PF00397	0.473
LIG_14-3-3_CanoR_1	12	18	PF00244	0.637
LIG_14-3-3_CanoR_1	138	147	PF00244	0.419
LIG_FHA_1	103	109	PF00498	0.398
LIG_FHA_1	16	22	PF00498	0.521
LIG_FHA_1	197	203	PF00498	0.655
LIG_FHA_1	88	94	PF00498	0.441
LIG_FHA_2	104	110	PF00498	0.457
LIG_Integrin_isoDGR_2	150	152	PF01839	0.373
LIG_SH2_PTP2	171	174	PF00017	0.394
LIG_SH2_STAT5	168	171	PF00017	0.383
LIG_SH2_STAT5	92	95	PF00017	0.460
LIG_SH3_1	188	194	PF00018	0.577
LIG_SH3_3	171	177	PF00018	0.362
LIG_SH3_3	188	194	PF00018	0.517
MOD_CK1_1	13	19	PF00069	0.557
MOD_CK1_1	190	196	PF00069	0.588
MOD_CK1_1	222	228	PF00069	0.716
MOD_CK1_1	29	35	PF00069	0.564
MOD_CK1_1	46	52	PF00069	0.613
MOD_GlcNHglycan	211	214	PF01048	0.676
MOD_GlcNHglycan	22	25	PF01048	0.635
MOD_GlcNHglycan	220	224	PF01048	0.670
MOD_GlcNHglycan	48	51	PF01048	0.696
MOD_GlcNHglycan	52	55	PF01048	0.651
MOD_GlcNHglycan	68	71	PF01048	0.667
MOD_GSK3_1	15	22	PF00069	0.607
MOD_GSK3_1	221	228	PF00069	0.785
MOD_GSK3_1	24	31	PF00069	0.784
MOD_GSK3_1	44	51	PF00069	0.667
MOD_GSK3_1	62	69	PF00069	0.701
MOD_GSK3_1	99	106	PF00069	0.354
MOD_NEK2_1	101	106	PF00069	0.370
MOD_NEK2_1	64	69	PF00069	0.669
MOD_PIKK_1	22	28	PF00454	0.563
MOD_PIKK_1	222	228	PF00454	0.671
MOD_PIKK_1	96	102	PF00454	0.349
MOD_PK_1	72	78	PF00069	0.487
MOD_Plk_4	179	185	PF00069	0.422
MOD_Plk_4	77	83	PF00069	0.371
MOD_ProDKin_1	187	193	PF00069	0.602
MOD_ProDKin_1	3	9	PF00069	0.475
TRG_ENDOCYTIC_2	129	132	PF00928	0.425
TRG_ENDOCYTIC_2	166	169	PF00928	0.402
TRG_ENDOCYTIC_2	171	174	PF00928	0.335
TRG_ER_diArg_1	152	155	PF00400	0.404
TRG_ER_diArg_1	2	4	PF00400	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM19	Leptomonas seymouri	78%	100%
A0A0S4JZ11	Bodo saltans	62%	100%
A0A3S7XAD1	Leishmania donovani	93%	100%
A4HNT0	Leishmania braziliensis	78%	100%
A4ICR4	Leishmania infantum	94%	100%
E9ASJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%