LeishMANIAdb
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RNA editing complex protein MP61

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RNA editing complex protein MP61
Gene product:
RNA editing complex protein MP61
Species:
Leishmania major
UniProt:
Q6T449_LEIMA
TriTrypDb:
LmjF.36.1050 , LMJLV39_360016200 * , LMJSD75_360016200 *
Length:
587

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q6T449
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q6T449

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006396 RNA processing 6 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004518 nuclease activity 4 11
GO:0004519 endonuclease activity 5 11
GO:0004521 RNA endonuclease activity 5 11
GO:0004525 ribonuclease III activity 6 11
GO:0004540 RNA nuclease activity 4 11
GO:0016787 hydrolase activity 2 11
GO:0016788 hydrolase activity, acting on ester bonds 3 11
GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 6 11
GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 11
GO:0032296 double-stranded RNA-specific ribonuclease activity 5 11
GO:0140098 catalytic activity, acting on RNA 3 11
GO:0140640 catalytic activity, acting on a nucleic acid 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 305 309 PF00656 0.414
CLV_C14_Caspase3-7 550 554 PF00656 0.519
CLV_NRD_NRD_1 119 121 PF00675 0.503
CLV_NRD_NRD_1 144 146 PF00675 0.571
CLV_NRD_NRD_1 225 227 PF00675 0.381
CLV_NRD_NRD_1 228 230 PF00675 0.386
CLV_NRD_NRD_1 24 26 PF00675 0.690
CLV_NRD_NRD_1 27 29 PF00675 0.667
CLV_NRD_NRD_1 432 434 PF00675 0.765
CLV_NRD_NRD_1 525 527 PF00675 0.686
CLV_NRD_NRD_1 528 530 PF00675 0.681
CLV_NRD_NRD_1 57 59 PF00675 0.677
CLV_NRD_NRD_1 8 10 PF00675 0.663
CLV_NRD_NRD_1 85 87 PF00675 0.731
CLV_NRD_NRD_1 88 90 PF00675 0.736
CLV_PCSK_FUR_1 226 230 PF00082 0.395
CLV_PCSK_FUR_1 25 29 PF00082 0.531
CLV_PCSK_FUR_1 526 530 PF00082 0.609
CLV_PCSK_FUR_1 86 90 PF00082 0.804
CLV_PCSK_KEX2_1 119 121 PF00082 0.617
CLV_PCSK_KEX2_1 144 146 PF00082 0.499
CLV_PCSK_KEX2_1 156 158 PF00082 0.393
CLV_PCSK_KEX2_1 227 229 PF00082 0.400
CLV_PCSK_KEX2_1 23 25 PF00082 0.685
CLV_PCSK_KEX2_1 27 29 PF00082 0.659
CLV_PCSK_KEX2_1 432 434 PF00082 0.761
CLV_PCSK_KEX2_1 489 491 PF00082 0.555
CLV_PCSK_KEX2_1 525 527 PF00082 0.668
CLV_PCSK_KEX2_1 528 530 PF00082 0.660
CLV_PCSK_KEX2_1 7 9 PF00082 0.636
CLV_PCSK_KEX2_1 85 87 PF00082 0.731
CLV_PCSK_KEX2_1 88 90 PF00082 0.736
CLV_PCSK_PC1ET2_1 156 158 PF00082 0.393
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.433
CLV_PCSK_PC1ET2_1 489 491 PF00082 0.555
CLV_PCSK_PC1ET2_1 7 9 PF00082 0.718
CLV_PCSK_PC7_1 23 29 PF00082 0.433
CLV_PCSK_PC7_1 3 9 PF00082 0.652
CLV_PCSK_SKI1_1 144 148 PF00082 0.531
CLV_PCSK_SKI1_1 228 232 PF00082 0.465
CLV_PCSK_SKI1_1 235 239 PF00082 0.410
CLV_PCSK_SKI1_1 240 244 PF00082 0.412
CLV_PCSK_SKI1_1 275 279 PF00082 0.378
CLV_Separin_Metazoa 186 190 PF03568 0.396
CLV_Separin_Metazoa 568 572 PF03568 0.734
DEG_APCC_DBOX_1 227 235 PF00400 0.507
DEG_APCC_DBOX_1 503 511 PF00400 0.694
DEG_Nend_UBRbox_3 1 3 PF02207 0.712
DEG_SPOP_SBC_1 139 143 PF00917 0.526
DOC_ANK_TNKS_1 489 496 PF00023 0.686
DOC_CDC14_PxL_1 212 220 PF14671 0.416
DOC_CKS1_1 103 108 PF01111 0.732
DOC_CKS1_1 449 454 PF01111 0.539
DOC_CKS1_1 66 71 PF01111 0.704
DOC_CYCLIN_yClb1_LxF_4 404 410 PF00134 0.518
DOC_MAPK_DCC_7 9 19 PF00069 0.546
DOC_MAPK_gen_1 226 236 PF00069 0.389
DOC_MAPK_gen_1 400 409 PF00069 0.447
DOC_MAPK_gen_1 7 16 PF00069 0.708
DOC_MAPK_MEF2A_6 130 139 PF00069 0.548
DOC_MAPK_MEF2A_6 180 187 PF00069 0.385
DOC_MAPK_MEF2A_6 33 41 PF00069 0.562
DOC_MAPK_MEF2A_6 7 16 PF00069 0.625
DOC_MAPK_NFAT4_5 180 188 PF00069 0.385
DOC_MAPK_NFAT4_5 7 15 PF00069 0.626
DOC_PP1_RVXF_1 263 269 PF00149 0.409
DOC_PP2B_LxvP_1 100 103 PF13499 0.773
DOC_PP2B_LxvP_1 12 15 PF13499 0.662
DOC_PP2B_LxvP_1 572 575 PF13499 0.617
DOC_PP2B_PxIxI_1 132 138 PF00149 0.421
DOC_PP4_FxxP_1 66 69 PF00568 0.706
DOC_USP7_MATH_1 15 19 PF00917 0.586
DOC_USP7_MATH_1 452 456 PF00917 0.642
DOC_USP7_MATH_1 76 80 PF00917 0.559
DOC_WW_Pin1_4 102 107 PF00397 0.715
DOC_WW_Pin1_4 191 196 PF00397 0.422
DOC_WW_Pin1_4 322 327 PF00397 0.609
DOC_WW_Pin1_4 448 453 PF00397 0.676
DOC_WW_Pin1_4 52 57 PF00397 0.748
DOC_WW_Pin1_4 559 564 PF00397 0.659
DOC_WW_Pin1_4 65 70 PF00397 0.636
LIG_14-3-3_CanoR_1 205 212 PF00244 0.402
LIG_14-3-3_CanoR_1 571 575 PF00244 0.691
LIG_14-3-3_CanoR_1 8 13 PF00244 0.707
LIG_APCC_ABBA_1 147 152 PF00400 0.389
LIG_BIR_III_4 75 79 PF00653 0.633
LIG_BRCT_BRCA1_1 259 263 PF00533 0.443
LIG_BRCT_BRCA1_1 282 286 PF00533 0.528
LIG_DLG_GKlike_1 423 431 PF00625 0.683
LIG_eIF4E_1 369 375 PF01652 0.523
LIG_FHA_1 244 250 PF00498 0.454
LIG_FHA_1 355 361 PF00498 0.558
LIG_FHA_1 363 369 PF00498 0.532
LIG_FHA_1 422 428 PF00498 0.561
LIG_FHA_1 449 455 PF00498 0.737
LIG_FHA_1 456 462 PF00498 0.682
LIG_FHA_1 560 566 PF00498 0.682
LIG_FHA_2 192 198 PF00498 0.421
LIG_FHA_2 349 355 PF00498 0.505
LIG_FHA_2 481 487 PF00498 0.722
LIG_FHA_2 544 550 PF00498 0.584
LIG_FXI_DFP_1 150 154 PF00024 0.406
LIG_GBD_Chelix_1 336 344 PF00786 0.348
LIG_Integrin_RGD_1 433 435 PF01839 0.685
LIG_Integrin_RGDW_4 433 436 PF00362 0.685
LIG_LIR_Apic_2 440 446 PF02991 0.678
LIG_LIR_Apic_2 448 452 PF02991 0.582
LIG_LIR_Gen_1 121 129 PF02991 0.652
LIG_LIR_Gen_1 143 153 PF02991 0.425
LIG_LIR_Gen_1 200 211 PF02991 0.463
LIG_LIR_Gen_1 260 269 PF02991 0.422
LIG_LIR_Gen_1 298 304 PF02991 0.550
LIG_LIR_Gen_1 338 348 PF02991 0.503
LIG_LIR_Gen_1 482 493 PF02991 0.692
LIG_LIR_Nem_3 121 125 PF02991 0.615
LIG_LIR_Nem_3 148 153 PF02991 0.396
LIG_LIR_Nem_3 200 206 PF02991 0.428
LIG_LIR_Nem_3 260 266 PF02991 0.431
LIG_LIR_Nem_3 298 303 PF02991 0.512
LIG_LIR_Nem_3 338 344 PF02991 0.348
LIG_LIR_Nem_3 482 488 PF02991 0.595
LIG_NRBOX 229 235 PF00104 0.384
LIG_PCNA_yPIPBox_3 392 402 PF02747 0.516
LIG_PDZ_Class_3 582 587 PF00595 0.569
LIG_Pex14_2 118 122 PF04695 0.650
LIG_Pex14_2 146 150 PF04695 0.385
LIG_PTB_Apo_2 159 166 PF02174 0.403
LIG_SH2_CRK 443 447 PF00017 0.736
LIG_SH2_CRK 449 453 PF00017 0.714
LIG_SH2_GRB2like 485 488 PF00017 0.604
LIG_SH2_GRB2like 63 66 PF00017 0.705
LIG_SH2_NCK_1 443 447 PF00017 0.641
LIG_SH2_STAP1 369 373 PF00017 0.502
LIG_SH2_STAT5 191 194 PF00017 0.441
LIG_SH2_STAT5 232 235 PF00017 0.391
LIG_SH2_STAT5 276 279 PF00017 0.373
LIG_SH2_STAT5 347 350 PF00017 0.469
LIG_SH2_STAT5 369 372 PF00017 0.484
LIG_SH3_3 100 106 PF00018 0.652
LIG_SH3_3 451 457 PF00018 0.727
LIG_SUMO_SIM_anti_2 506 511 PF11976 0.698
LIG_SUMO_SIM_anti_2 68 75 PF11976 0.622
LIG_SUMO_SIM_par_1 135 143 PF11976 0.586
LIG_UBA3_1 230 238 PF00899 0.392
LIG_WRC_WIRS_1 244 249 PF05994 0.539
MOD_CDK_SPK_2 322 327 PF00069 0.609
MOD_CDK_SPK_2 559 564 PF00069 0.761
MOD_CDK_SPxK_1 52 58 PF00069 0.727
MOD_CDK_SPxxK_3 52 59 PF00069 0.526
MOD_CK1_1 123 129 PF00069 0.707
MOD_CK1_1 138 144 PF00069 0.491
MOD_CK1_1 254 260 PF00069 0.672
MOD_CK1_1 42 48 PF00069 0.697
MOD_CK1_1 448 454 PF00069 0.674
MOD_CK1_1 455 461 PF00069 0.516
MOD_CK1_1 466 472 PF00069 0.651
MOD_CK1_1 51 57 PF00069 0.643
MOD_CK1_1 558 564 PF00069 0.589
MOD_CK2_1 191 197 PF00069 0.493
MOD_CK2_1 543 549 PF00069 0.579
MOD_Cter_Amidation 56 59 PF01082 0.755
MOD_GlcNHglycan 126 129 PF01048 0.681
MOD_GlcNHglycan 256 259 PF01048 0.566
MOD_GlcNHglycan 33 36 PF01048 0.650
MOD_GlcNHglycan 41 44 PF01048 0.621
MOD_GlcNHglycan 413 416 PF01048 0.623
MOD_GlcNHglycan 454 457 PF01048 0.572
MOD_GlcNHglycan 557 560 PF01048 0.682
MOD_GSK3_1 120 127 PF00069 0.674
MOD_GSK3_1 135 142 PF00069 0.512
MOD_GSK3_1 243 250 PF00069 0.573
MOD_GSK3_1 29 36 PF00069 0.724
MOD_GSK3_1 327 334 PF00069 0.420
MOD_GSK3_1 42 49 PF00069 0.665
MOD_GSK3_1 423 430 PF00069 0.702
MOD_GSK3_1 448 455 PF00069 0.582
MOD_GSK3_1 534 541 PF00069 0.650
MOD_GSK3_1 543 550 PF00069 0.579
MOD_GSK3_1 555 562 PF00069 0.642
MOD_GSK3_1 76 83 PF00069 0.558
MOD_N-GLC_1 161 166 PF02516 0.414
MOD_N-GLC_1 247 252 PF02516 0.615
MOD_N-GLC_2 2 4 PF02516 0.635
MOD_N-GLC_2 207 209 PF02516 0.551
MOD_NEK2_1 243 248 PF00069 0.523
MOD_NEK2_1 348 353 PF00069 0.552
MOD_NEK2_1 39 44 PF00069 0.658
MOD_NEK2_1 427 432 PF00069 0.624
MOD_NEK2_1 479 484 PF00069 0.690
MOD_NEK2_1 538 543 PF00069 0.708
MOD_NEK2_2 295 300 PF00069 0.572
MOD_NEK2_2 534 539 PF00069 0.532
MOD_PIKK_1 348 354 PF00454 0.551
MOD_PIKK_1 463 469 PF00454 0.660
MOD_PK_1 33 39 PF00069 0.562
MOD_PKA_1 8 14 PF00069 0.689
MOD_PKA_2 570 576 PF00069 0.692
MOD_PKA_2 8 14 PF00069 0.690
MOD_Plk_1 161 167 PF00069 0.418
MOD_Plk_1 505 511 PF00069 0.699
MOD_Plk_4 161 167 PF00069 0.394
MOD_Plk_4 336 342 PF00069 0.347
MOD_Plk_4 505 511 PF00069 0.623
MOD_Plk_4 68 74 PF00069 0.615
MOD_ProDKin_1 102 108 PF00069 0.711
MOD_ProDKin_1 191 197 PF00069 0.424
MOD_ProDKin_1 322 328 PF00069 0.605
MOD_ProDKin_1 448 454 PF00069 0.675
MOD_ProDKin_1 52 58 PF00069 0.749
MOD_ProDKin_1 559 565 PF00069 0.656
MOD_ProDKin_1 65 71 PF00069 0.635
MOD_SUMO_for_1 577 580 PF00179 0.679
TRG_AP2beta_CARGO_1 148 157 PF09066 0.409
TRG_DiLeu_BaEn_1 95 100 PF01217 0.706
TRG_DiLeu_BaEn_2 263 269 PF01217 0.521
TRG_DiLeu_BaLyEn_6 226 231 PF01217 0.537
TRG_ENDOCYTIC_2 314 317 PF00928 0.478
TRG_ENDOCYTIC_2 485 488 PF00928 0.579
TRG_ENDOCYTIC_2 63 66 PF00928 0.705
TRG_ER_diArg_1 118 120 PF00400 0.613
TRG_ER_diArg_1 144 146 PF00400 0.568
TRG_ER_diArg_1 22 25 PF00400 0.754
TRG_ER_diArg_1 226 229 PF00400 0.391
TRG_ER_diArg_1 525 528 PF00400 0.665
TRG_ER_diArg_1 8 10 PF00400 0.669
TRG_ER_diArg_1 85 88 PF00400 0.739
TRG_NLS_Bipartite_1 144 160 PF00514 0.403
TRG_NLS_MonoExtN_4 226 231 PF00514 0.392
TRG_Pf-PMV_PEXEL_1 372 376 PF00026 0.484

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3V7 Leptomonas seymouri 47% 99%
A0A1X0P9H0 Trypanosomatidae 47% 100%
A0A3R7KSN8 Trypanosoma rangeli 45% 100%
A0A3S7XAI5 Leishmania donovani 92% 100%
A4HNW5 Leishmania braziliensis 76% 98%
A4ICM9 Leishmania infantum 92% 100%
D0A2T3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9ASM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5BZU7 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS