RNA editing comple protein MP63

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing comple protein MP63

Species:

Leishmania major

UniProt:

Q6T448_LEIMA

TriTrypDb:

LmjF.36.6930 , LMJLV39_360084700 , LMJSD75_360084500

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q6T448

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q6T448

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.620
CLV_NRD_NRD_1	21	23	PF00675	0.637
CLV_NRD_NRD_1	260	262	PF00675	0.648
CLV_NRD_NRD_1	479	481	PF00675	0.609
CLV_NRD_NRD_1	5	7	PF00675	0.602
CLV_NRD_NRD_1	61	63	PF00675	0.586
CLV_PCSK_KEX2_1	137	139	PF00082	0.620
CLV_PCSK_KEX2_1	171	173	PF00082	0.573
CLV_PCSK_KEX2_1	21	23	PF00082	0.637
CLV_PCSK_KEX2_1	4	6	PF00082	0.600
CLV_PCSK_KEX2_1	479	481	PF00082	0.621
CLV_PCSK_KEX2_1	483	485	PF00082	0.617
CLV_PCSK_KEX2_1	603	605	PF00082	0.412
CLV_PCSK_KEX2_1	61	63	PF00082	0.536
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.620
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.574
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.631
CLV_PCSK_PC1ET2_1	603	605	PF00082	0.323
CLV_PCSK_PC7_1	17	23	PF00082	0.599
CLV_PCSK_PC7_1	479	485	PF00082	0.592
CLV_PCSK_SKI1_1	17	21	PF00082	0.613
CLV_PCSK_SKI1_1	262	266	PF00082	0.699
DEG_APCC_DBOX_1	16	24	PF00400	0.592
DOC_CKS1_1	123	128	PF01111	0.585
DOC_CKS1_1	283	288	PF01111	0.559
DOC_MAPK_MEF2A_6	151	158	PF00069	0.560
DOC_MAPK_MEF2A_6	269	276	PF00069	0.761
DOC_MAPK_RevD_3	47	62	PF00069	0.568
DOC_USP7_MATH_1	13	17	PF00917	0.687
DOC_USP7_MATH_1	189	193	PF00917	0.619
DOC_USP7_MATH_1	303	307	PF00917	0.723
DOC_USP7_MATH_1	347	351	PF00917	0.660
DOC_USP7_MATH_1	36	40	PF00917	0.628
DOC_USP7_MATH_1	365	369	PF00917	0.753
DOC_USP7_MATH_1	381	385	PF00917	0.533
DOC_USP7_MATH_1	415	419	PF00917	0.617
DOC_USP7_MATH_1	432	436	PF00917	0.485
DOC_USP7_MATH_1	504	508	PF00917	0.660
DOC_USP7_MATH_1	509	513	PF00917	0.661
DOC_USP7_MATH_1	587	591	PF00917	0.404
DOC_USP7_UBL2_3	140	144	PF12436	0.710
DOC_USP7_UBL2_3	225	229	PF12436	0.460
DOC_USP7_UBL2_3	265	269	PF12436	0.651
DOC_USP7_UBL2_3	599	603	PF12436	0.482
DOC_WW_Pin1_4	105	110	PF00397	0.622
DOC_WW_Pin1_4	122	127	PF00397	0.613
DOC_WW_Pin1_4	282	287	PF00397	0.557
DOC_WW_Pin1_4	293	298	PF00397	0.581
DOC_WW_Pin1_4	318	323	PF00397	0.601
DOC_WW_Pin1_4	327	332	PF00397	0.579
DOC_WW_Pin1_4	343	348	PF00397	0.603
DOC_WW_Pin1_4	374	379	PF00397	0.566
DOC_WW_Pin1_4	386	391	PF00397	0.541
DOC_WW_Pin1_4	393	398	PF00397	0.560
DOC_WW_Pin1_4	492	497	PF00397	0.525
DOC_WW_Pin1_4	500	505	PF00397	0.536
LIG_14-3-3_CanoR_1	367	375	PF00244	0.576
LIG_14-3-3_CanoR_1	511	521	PF00244	0.595
LIG_14-3-3_CanoR_1	566	575	PF00244	0.473
LIG_14-3-3_CanoR_1	604	612	PF00244	0.371
LIG_14-3-3_CanoR_1	62	68	PF00244	0.431
LIG_APCC_ABBA_1	593	598	PF00400	0.461
LIG_APCC_ABBAyCdc20_2	577	583	PF00400	0.400
LIG_BRCT_BRCA1_1	319	323	PF00533	0.648
LIG_BRCT_BRCA1_1	568	572	PF00533	0.509
LIG_CSK_EPIYA_1	196	200	PF00017	0.706
LIG_CtBP_PxDLS_1	496	500	PF00389	0.497
LIG_EH_1	207	211	PF12763	0.553
LIG_EH_1	256	260	PF12763	0.587
LIG_EVH1_2	387	391	PF00568	0.547
LIG_FHA_1	123	129	PF00498	0.710
LIG_FHA_1	279	285	PF00498	0.621
LIG_FHA_1	614	620	PF00498	0.374
LIG_FHA_2	222	228	PF00498	0.605
LIG_FHA_2	513	519	PF00498	0.671
LIG_LIR_Gen_1	512	522	PF02991	0.645
LIG_LIR_Nem_3	227	233	PF02991	0.588
LIG_LIR_Nem_3	245	250	PF02991	0.634
LIG_LIR_Nem_3	285	290	PF02991	0.568
LIG_LIR_Nem_3	346	351	PF02991	0.689
LIG_LIR_Nem_3	458	463	PF02991	0.389
LIG_LIR_Nem_3	512	517	PF02991	0.656
LIG_LIR_Nem_3	569	575	PF02991	0.372
LIG_LIR_Nem_3	578	584	PF02991	0.277
LIG_SH2_CRK	460	464	PF00017	0.320
LIG_SH2_STAP1	522	526	PF00017	0.600
LIG_SH2_STAP1	605	609	PF00017	0.432
LIG_SH3_1	484	490	PF00018	0.563
LIG_SH3_2	249	254	PF14604	0.643
LIG_SH3_3	115	121	PF00018	0.642
LIG_SH3_3	123	129	PF00018	0.689
LIG_SH3_3	198	204	PF00018	0.683
LIG_SH3_3	211	217	PF00018	0.640
LIG_SH3_3	246	252	PF00018	0.668
LIG_SH3_3	280	286	PF00018	0.608
LIG_SH3_3	316	322	PF00018	0.621
LIG_SH3_3	348	354	PF00018	0.670
LIG_SH3_3	372	378	PF00018	0.669
LIG_SH3_3	384	390	PF00018	0.536
LIG_SH3_3	433	439	PF00018	0.616
LIG_SH3_3	484	490	PF00018	0.548
LIG_SH3_3	609	615	PF00018	0.386
LIG_SH3_4	140	147	PF00018	0.599
LIG_SH3_4	520	527	PF00018	0.492
LIG_SUMO_SIM_par_1	159	168	PF11976	0.494
LIG_SUMO_SIM_par_1	495	500	PF11976	0.515
LIG_TRAF2_1	307	310	PF00917	0.755
LIG_TRAF2_2	98	103	PF00917	0.592
LIG_TYR_ITIM	579	584	PF00017	0.378
MOD_CK1_1	298	304	PF00069	0.628
MOD_CK1_1	317	323	PF00069	0.610
MOD_CK1_1	368	374	PF00069	0.758
MOD_CK1_1	396	402	PF00069	0.630
MOD_CK1_1	431	437	PF00069	0.643
MOD_CK1_1	512	518	PF00069	0.662
MOD_CK1_1	527	533	PF00069	0.260
MOD_CK1_1	555	561	PF00069	0.428
MOD_CK2_1	221	227	PF00069	0.686
MOD_CK2_1	303	309	PF00069	0.766
MOD_CK2_1	347	353	PF00069	0.570
MOD_CK2_1	415	421	PF00069	0.511
MOD_CK2_1	512	518	PF00069	0.517
MOD_CK2_1	555	561	PF00069	0.359
MOD_Cter_Amidation	477	480	PF01082	0.539
MOD_Cter_Amidation	481	484	PF01082	0.546
MOD_GlcNHglycan	193	196	PF01048	0.504
MOD_GlcNHglycan	305	308	PF01048	0.735
MOD_GlcNHglycan	33	36	PF01048	0.753
MOD_GlcNHglycan	367	370	PF01048	0.745
MOD_GlcNHglycan	38	41	PF01048	0.761
MOD_GlcNHglycan	383	386	PF01048	0.615
MOD_GlcNHglycan	400	404	PF01048	0.479
MOD_GlcNHglycan	417	420	PF01048	0.627
MOD_GlcNHglycan	430	433	PF01048	0.635
MOD_GlcNHglycan	436	439	PF01048	0.649
MOD_GlcNHglycan	507	510	PF01048	0.621
MOD_GlcNHglycan	511	514	PF01048	0.573
MOD_GlcNHglycan	55	58	PF01048	0.682
MOD_GlcNHglycan	554	557	PF01048	0.555
MOD_GlcNHglycan	568	571	PF01048	0.378
MOD_GlcNHglycan	606	609	PF01048	0.568
MOD_GlcNHglycan	86	89	PF01048	0.534
MOD_GSK3_1	278	285	PF00069	0.590
MOD_GSK3_1	310	317	PF00069	0.696
MOD_GSK3_1	343	350	PF00069	0.676
MOD_GSK3_1	365	372	PF00069	0.658
MOD_GSK3_1	427	434	PF00069	0.742
MOD_GSK3_1	444	451	PF00069	0.523
MOD_GSK3_1	500	507	PF00069	0.550
MOD_GSK3_1	535	542	PF00069	0.457
MOD_GSK3_1	571	578	PF00069	0.442
MOD_GSK3_1	594	601	PF00069	0.469
MOD_N-GLC_1	327	332	PF02516	0.586
MOD_N-GLC_1	455	460	PF02516	0.287
MOD_N-GLC_1	527	532	PF02516	0.374
MOD_N-GLC_1	53	58	PF02516	0.632
MOD_NEK2_1	177	182	PF00069	0.564
MOD_NEK2_1	31	36	PF00069	0.710
MOD_NEK2_1	398	403	PF00069	0.731
MOD_NEK2_1	427	432	PF00069	0.674
MOD_NEK2_1	499	504	PF00069	0.496
MOD_NEK2_1	505	510	PF00069	0.515
MOD_NEK2_1	546	551	PF00069	0.391
MOD_NEK2_1	575	580	PF00069	0.523
MOD_NEK2_1	63	68	PF00069	0.393
MOD_NEK2_2	347	352	PF00069	0.607
MOD_NEK2_2	587	592	PF00069	0.463
MOD_NEK2_2	68	73	PF00069	0.470
MOD_PIKK_1	103	109	PF00454	0.507
MOD_PIKK_1	598	604	PF00454	0.480
MOD_PK_1	160	166	PF00069	0.573
MOD_PKA_1	603	609	PF00069	0.307
MOD_PKA_2	189	195	PF00069	0.694
MOD_PKA_2	552	558	PF00069	0.520
MOD_PKA_2	565	571	PF00069	0.416
MOD_PKA_2	603	609	PF00069	0.391
MOD_Plk_1	455	461	PF00069	0.409
MOD_Plk_1	497	503	PF00069	0.629
MOD_Plk_1	527	533	PF00069	0.382
MOD_Plk_1	53	59	PF00069	0.627
MOD_Plk_4	119	125	PF00069	0.664
MOD_Plk_4	160	166	PF00069	0.550
MOD_Plk_4	178	184	PF00069	0.605
MOD_Plk_4	314	320	PF00069	0.684
MOD_Plk_4	546	552	PF00069	0.349
MOD_ProDKin_1	105	111	PF00069	0.622
MOD_ProDKin_1	122	128	PF00069	0.612
MOD_ProDKin_1	282	288	PF00069	0.559
MOD_ProDKin_1	293	299	PF00069	0.578
MOD_ProDKin_1	318	324	PF00069	0.600
MOD_ProDKin_1	327	333	PF00069	0.579
MOD_ProDKin_1	343	349	PF00069	0.606
MOD_ProDKin_1	374	380	PF00069	0.568
MOD_ProDKin_1	386	392	PF00069	0.546
MOD_ProDKin_1	393	399	PF00069	0.560
MOD_ProDKin_1	492	498	PF00069	0.523
MOD_ProDKin_1	500	506	PF00069	0.539
MOD_SUMO_rev_2	222	230	PF00179	0.605
MOD_SUMO_rev_2	512	521	PF00179	0.539
TRG_ENDOCYTIC_2	199	202	PF00928	0.601
TRG_ENDOCYTIC_2	460	463	PF00928	0.320
TRG_ENDOCYTIC_2	581	584	PF00928	0.377
TRG_ER_diArg_1	20	22	PF00400	0.588
TRG_ER_diArg_1	5	7	PF00400	0.609
TRG_ER_diArg_1	61	63	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.722
TRG_Pf-PMV_PEXEL_1	534	539	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D6	Leptomonas seymouri	54%	99%
A0A0S4KI33	Bodo saltans	38%	97%
A0A1X0NLZ8	Trypanosomatidae	39%	100%
A0A3S7XCC6	Leishmania donovani	92%	100%
A0A422NVX1	Trypanosoma rangeli	39%	100%
A4HQL4	Leishmania braziliensis	75%	100%
A4ICD3	Leishmania infantum	92%	100%
D0A3R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AUC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
V5DDW7	Trypanosoma cruzi	40%	100%