Putative RNA-editing complex protein MP81

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinetoplastid RNA editing protein 1, putative

Species:

Leishmania major

UniProt:

Q6T446_LEIMA

TriTrypDb:

LmjF.02.0410 , LMJLV39_020008900 , LMJSD75_020009000

Length:

989

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0031019	mitochondrial mRNA editing complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0045293	mRNA editing complex	3	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q6T446

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q6T446

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0070705	RNA nucleotide insertion	6	2
GO:0070706	RNA nucleotide deletion	6	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1900864	mitochondrial RNA modification	6	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045294	alpha-catenin binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.618
CLV_C14_Caspase3-7	375	379	PF00656	0.477
CLV_C14_Caspase3-7	39	43	PF00656	0.758
CLV_C14_Caspase3-7	742	746	PF00656	0.711
CLV_C14_Caspase3-7	845	849	PF00656	0.797
CLV_C14_Caspase3-7	907	911	PF00656	0.662
CLV_NRD_NRD_1	177	179	PF00675	0.745
CLV_NRD_NRD_1	253	255	PF00675	0.510
CLV_NRD_NRD_1	410	412	PF00675	0.544
CLV_NRD_NRD_1	459	461	PF00675	0.793
CLV_NRD_NRD_1	482	484	PF00675	0.696
CLV_NRD_NRD_1	603	605	PF00675	0.605
CLV_NRD_NRD_1	967	969	PF00675	0.547
CLV_PCSK_KEX2_1	129	131	PF00082	0.686
CLV_PCSK_KEX2_1	177	179	PF00082	0.745
CLV_PCSK_KEX2_1	252	254	PF00082	0.558
CLV_PCSK_KEX2_1	409	411	PF00082	0.691
CLV_PCSK_KEX2_1	458	460	PF00082	0.706
CLV_PCSK_KEX2_1	482	484	PF00082	0.696
CLV_PCSK_KEX2_1	603	605	PF00082	0.602
CLV_PCSK_KEX2_1	786	788	PF00082	0.660
CLV_PCSK_KEX2_1	967	969	PF00082	0.547
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.686
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.691
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.706
CLV_PCSK_PC1ET2_1	786	788	PF00082	0.627
CLV_PCSK_PC7_1	249	255	PF00082	0.538
CLV_PCSK_SKI1_1	603	607	PF00082	0.660
DEG_APCC_DBOX_1	116	124	PF00400	0.613
DEG_APCC_DBOX_1	602	610	PF00400	0.653
DEG_APCC_DBOX_1	769	777	PF00400	0.660
DEG_SPOP_SBC_1	162	166	PF00917	0.822
DEG_SPOP_SBC_1	300	304	PF00917	0.563
DOC_ANK_TNKS_1	446	453	PF00023	0.698
DOC_ANK_TNKS_1	481	488	PF00023	0.657
DOC_CKS1_1	9	14	PF01111	0.607
DOC_CYCLIN_yCln2_LP_2	616	619	PF00134	0.658
DOC_MAPK_DCC_7	418	426	PF00069	0.746
DOC_MAPK_DCC_7	929	939	PF00069	0.590
DOC_MAPK_HePTP_8	965	977	PF00069	0.606
DOC_MAPK_MEF2A_6	418	426	PF00069	0.746
DOC_MAPK_MEF2A_6	543	552	PF00069	0.669
DOC_MAPK_MEF2A_6	84	91	PF00069	0.657
DOC_MAPK_MEF2A_6	968	977	PF00069	0.495
DOC_PP2B_LxvP_1	171	174	PF13499	0.745
DOC_PP2B_LxvP_1	616	619	PF13499	0.681
DOC_PP2B_LxvP_1	89	92	PF13499	0.679
DOC_USP7_MATH_1	186	190	PF00917	0.715
DOC_USP7_MATH_1	342	346	PF00917	0.679
DOC_USP7_MATH_1	562	566	PF00917	0.674
DOC_USP7_MATH_1	568	572	PF00917	0.742
DOC_USP7_MATH_1	627	631	PF00917	0.680
DOC_USP7_MATH_1	668	672	PF00917	0.731
DOC_USP7_MATH_1	681	685	PF00917	0.683
DOC_USP7_MATH_1	791	795	PF00917	0.646
DOC_USP7_MATH_1	904	908	PF00917	0.690
DOC_USP7_UBL2_3	321	325	PF12436	0.669
DOC_WW_Pin1_4	359	364	PF00397	0.618
DOC_WW_Pin1_4	446	451	PF00397	0.697
DOC_WW_Pin1_4	466	471	PF00397	0.454
DOC_WW_Pin1_4	530	535	PF00397	0.610
DOC_WW_Pin1_4	576	581	PF00397	0.723
DOC_WW_Pin1_4	642	647	PF00397	0.699
DOC_WW_Pin1_4	8	13	PF00397	0.829
DOC_WW_Pin1_4	832	837	PF00397	0.794
LIG_14-3-3_CanoR_1	313	319	PF00244	0.796
LIG_14-3-3_CanoR_1	459	465	PF00244	0.684
LIG_14-3-3_CanoR_1	7	12	PF00244	0.803
LIG_14-3-3_CanoR_1	787	795	PF00244	0.695
LIG_14-3-3_CanoR_1	890	897	PF00244	0.465
LIG_14-3-3_CanoR_1	967	975	PF00244	0.513
LIG_APCC_ABBA_1	546	551	PF00400	0.671
LIG_BIR_III_2	190	194	PF00653	0.599
LIG_BIR_III_4	903	907	PF00653	0.696
LIG_BRCT_BRCA1_1	197	201	PF00533	0.592
LIG_BRCT_BRCA1_1	247	251	PF00533	0.469
LIG_BRCT_BRCA1_1	461	465	PF00533	0.569
LIG_BRCT_BRCA1_1	947	951	PF00533	0.530
LIG_Clathr_ClatBox_1	538	542	PF01394	0.525
LIG_CtBP_PxDLS_1	618	622	PF00389	0.667
LIG_deltaCOP1_diTrp_1	584	591	PF00928	0.751
LIG_deltaCOP1_diTrp_1	695	699	PF00928	0.503
LIG_deltaCOP1_diTrp_1	752	757	PF00928	0.529
LIG_EH_1	527	531	PF12763	0.645
LIG_EH_1	546	550	PF12763	0.672
LIG_FHA_1	1	7	PF00498	0.813
LIG_FHA_1	166	172	PF00498	0.737
LIG_FHA_1	227	233	PF00498	0.577
LIG_FHA_1	313	319	PF00498	0.711
LIG_FHA_1	360	366	PF00498	0.634
LIG_FHA_1	63	69	PF00498	0.653
LIG_FHA_1	632	638	PF00498	0.683
LIG_FHA_1	861	867	PF00498	0.499
LIG_FHA_1	878	884	PF00498	0.530
LIG_FHA_1	947	953	PF00498	0.430
LIG_FHA_2	139	145	PF00498	0.789
LIG_FHA_2	398	404	PF00498	0.644
LIG_FHA_2	511	517	PF00498	0.623
LIG_FHA_2	570	576	PF00498	0.813
LIG_FHA_2	740	746	PF00498	0.687
LIG_FHA_2	747	753	PF00498	0.588
LIG_FHA_2	788	794	PF00498	0.704
LIG_FHA_2	843	849	PF00498	0.791
LIG_FHA_2	866	872	PF00498	0.581
LIG_FHA_2	890	896	PF00498	0.631
LIG_Integrin_RGD_1	40	42	PF01839	0.717
LIG_LIR_Apic_2	523	529	PF02991	0.627
LIG_LIR_Gen_1	378	387	PF02991	0.541
LIG_LIR_Gen_1	462	473	PF02991	0.567
LIG_LIR_Gen_1	752	762	PF02991	0.635
LIG_LIR_Gen_1	793	803	PF02991	0.578
LIG_LIR_Nem_3	378	384	PF02991	0.538
LIG_LIR_Nem_3	462	468	PF02991	0.607
LIG_LIR_Nem_3	695	700	PF02991	0.559
LIG_LIR_Nem_3	752	758	PF02991	0.612
LIG_LIR_Nem_3	793	798	PF02991	0.667
LIG_LIR_Nem_3	969	975	PF02991	0.502
LIG_LIR_Nem_3	98	102	PF02991	0.675
LIG_LYPXL_yS_3	972	975	PF13949	0.486
LIG_MYND_1	475	479	PF01753	0.719
LIG_MYND_1	615	619	PF01753	0.657
LIG_MYND_1	93	97	PF01753	0.695
LIG_PDZ_Class_2	984	989	PF00595	0.616
LIG_Pex14_1	755	759	PF04695	0.627
LIG_Pex14_2	62	66	PF04695	0.651
LIG_PTAP_UEV_1	196	201	PF05743	0.564
LIG_SH2_CRK	596	600	PF00017	0.611
LIG_SH2_PTP2	974	977	PF00017	0.450
LIG_SH2_STAP1	292	296	PF00017	0.597
LIG_SH2_STAP1	63	67	PF00017	0.635
LIG_SH2_STAP1	700	704	PF00017	0.596
LIG_SH2_STAT5	724	727	PF00017	0.684
LIG_SH2_STAT5	885	888	PF00017	0.446
LIG_SH2_STAT5	974	977	PF00017	0.450
LIG_SH3_1	194	200	PF00018	0.657
LIG_SH3_2	35	40	PF14604	0.677
LIG_SH3_3	102	108	PF00018	0.690
LIG_SH3_3	190	196	PF00018	0.721
LIG_SH3_3	229	235	PF00018	0.557
LIG_SH3_3	278	284	PF00018	0.495
LIG_SH3_3	32	38	PF00018	0.690
LIG_SH3_3	362	368	PF00018	0.628
LIG_SH3_3	464	470	PF00018	0.676
LIG_SH3_3	542	548	PF00018	0.664
LIG_SH3_3	574	580	PF00018	0.817
LIG_SH3_3	612	618	PF00018	0.649
LIG_SH3_3	779	785	PF00018	0.599
LIG_SH3_3	94	100	PF00018	0.697
LIG_SH3_3	974	980	PF00018	0.472
LIG_SUMO_SIM_anti_2	423	428	PF11976	0.665
LIG_SUMO_SIM_anti_2	922	929	PF11976	0.509
LIG_SUMO_SIM_par_1	423	428	PF11976	0.665
LIG_SUMO_SIM_par_1	862	868	PF11976	0.596
LIG_TRAF2_1	256	259	PF00917	0.571
LIG_TRAF2_1	513	516	PF00917	0.628
LIG_UBA3_1	538	543	PF00899	0.528
LIG_WRC_WIRS_1	63	68	PF05994	0.698
MOD_CDK_SPK_2	359	364	PF00069	0.660
MOD_CDK_SPxxK_3	576	583	PF00069	0.667
MOD_CDK_SPxxK_3	642	649	PF00069	0.602
MOD_CDK_SPxxK_3	8	15	PF00069	0.742
MOD_CK1_1	10	16	PF00069	0.773
MOD_CK1_1	245	251	PF00069	0.478
MOD_CK1_1	272	278	PF00069	0.634
MOD_CK1_1	463	469	PF00069	0.698
MOD_CK1_1	579	585	PF00069	0.716
MOD_CK1_1	664	670	PF00069	0.727
MOD_CK1_1	794	800	PF00069	0.664
MOD_CK1_1	835	841	PF00069	0.728
MOD_CK1_1	893	899	PF00069	0.637
MOD_CK1_1	966	972	PF00069	0.530
MOD_CK2_1	138	144	PF00069	0.784
MOD_CK2_1	203	209	PF00069	0.815
MOD_CK2_1	510	516	PF00069	0.639
MOD_CK2_1	746	752	PF00069	0.739
MOD_CK2_1	787	793	PF00069	0.759
MOD_CK2_1	889	895	PF00069	0.608
MOD_GlcNHglycan	113	116	PF01048	0.718
MOD_GlcNHglycan	134	137	PF01048	0.722
MOD_GlcNHglycan	16	19	PF01048	0.578
MOD_GlcNHglycan	197	200	PF01048	0.684
MOD_GlcNHglycan	244	247	PF01048	0.518
MOD_GlcNHglycan	26	29	PF01048	0.701
MOD_GlcNHglycan	271	274	PF01048	0.690
MOD_GlcNHglycan	31	35	PF01048	0.710
MOD_GlcNHglycan	330	334	PF01048	0.667
MOD_GlcNHglycan	350	353	PF01048	0.673
MOD_GlcNHglycan	564	567	PF01048	0.787
MOD_GlcNHglycan	629	632	PF01048	0.772
MOD_GlcNHglycan	649	652	PF01048	0.762
MOD_GlcNHglycan	662	666	PF01048	0.648
MOD_GlcNHglycan	681	684	PF01048	0.665
MOD_GlcNHglycan	830	833	PF01048	0.698
MOD_GlcNHglycan	837	840	PF01048	0.737
MOD_GlcNHglycan	858	861	PF01048	0.608
MOD_GlcNHglycan	892	895	PF01048	0.650
MOD_GlcNHglycan	898	901	PF01048	0.679
MOD_GSK3_1	132	139	PF00069	0.737
MOD_GSK3_1	161	168	PF00069	0.729
MOD_GSK3_1	195	202	PF00069	0.753
MOD_GSK3_1	204	211	PF00069	0.718
MOD_GSK3_1	213	220	PF00069	0.685
MOD_GSK3_1	299	306	PF00069	0.621
MOD_GSK3_1	344	351	PF00069	0.654
MOD_GSK3_1	355	362	PF00069	0.605
MOD_GSK3_1	392	399	PF00069	0.587
MOD_GSK3_1	459	466	PF00069	0.693
MOD_GSK3_1	50	57	PF00069	0.796
MOD_GSK3_1	575	582	PF00069	0.717
MOD_GSK3_1	62	69	PF00069	0.740
MOD_GSK3_1	622	629	PF00069	0.745
MOD_GSK3_1	660	667	PF00069	0.682
MOD_GSK3_1	7	14	PF00069	0.736
MOD_GSK3_1	787	794	PF00069	0.670
MOD_GSK3_1	828	835	PF00069	0.767
MOD_GSK3_1	843	850	PF00069	0.725
MOD_GSK3_1	856	863	PF00069	0.528
MOD_GSK3_1	889	896	PF00069	0.662
MOD_LATS_1	647	653	PF00433	0.610
MOD_N-GLC_1	269	274	PF02516	0.632
MOD_N-GLC_1	890	895	PF02516	0.578
MOD_NEK2_1	163	168	PF00069	0.700
MOD_NEK2_1	201	206	PF00069	0.594
MOD_NEK2_1	24	29	PF00069	0.827
MOD_NEK2_1	355	360	PF00069	0.569
MOD_NEK2_1	62	67	PF00069	0.723
MOD_NEK2_1	865	870	PF00069	0.527
MOD_NEK2_1	877	882	PF00069	0.391
MOD_NEK2_1	946	951	PF00069	0.568
MOD_NEK2_2	167	172	PF00069	0.706
MOD_NEK2_2	344	349	PF00069	0.556
MOD_PIKK_1	477	483	PF00454	0.731
MOD_PKA_1	459	465	PF00069	0.793
MOD_PKA_1	786	792	PF00069	0.665
MOD_PKA_2	14	20	PF00069	0.665
MOD_PKA_2	154	160	PF00069	0.711
MOD_PKA_2	312	318	PF00069	0.716
MOD_PKA_2	366	372	PF00069	0.494
MOD_PKA_2	459	465	PF00069	0.756
MOD_PKA_2	50	56	PF00069	0.781
MOD_PKA_2	786	792	PF00069	0.665
MOD_PKA_2	889	895	PF00069	0.651
MOD_PKA_2	966	972	PF00069	0.530
MOD_PKB_1	130	138	PF00069	0.718
MOD_Plk_1	208	214	PF00069	0.732
MOD_Plk_1	515	521	PF00069	0.606
MOD_Plk_2-3	366	372	PF00069	0.475
MOD_Plk_2-3	748	754	PF00069	0.632
MOD_Plk_4	236	242	PF00069	0.626
MOD_Plk_4	420	426	PF00069	0.706
MOD_Plk_4	460	466	PF00069	0.693
MOD_Plk_4	617	623	PF00069	0.638
MOD_Plk_4	62	68	PF00069	0.653
MOD_Plk_4	860	866	PF00069	0.518
MOD_Plk_4	946	952	PF00069	0.463
MOD_ProDKin_1	359	365	PF00069	0.614
MOD_ProDKin_1	446	452	PF00069	0.696
MOD_ProDKin_1	466	472	PF00069	0.455
MOD_ProDKin_1	530	536	PF00069	0.606
MOD_ProDKin_1	576	582	PF00069	0.713
MOD_ProDKin_1	642	648	PF00069	0.693
MOD_ProDKin_1	8	14	PF00069	0.828
MOD_ProDKin_1	832	838	PF00069	0.795
MOD_SUMO_rev_2	288	297	PF00179	0.584
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.737
TRG_DiLeu_BaLyEn_6	612	617	PF01217	0.746
TRG_DiLeu_BaLyEn_6	705	710	PF01217	0.630
TRG_ENDOCYTIC_2	63	66	PF00928	0.602
TRG_ENDOCYTIC_2	638	641	PF00928	0.601
TRG_ENDOCYTIC_2	780	783	PF00928	0.586
TRG_ENDOCYTIC_2	972	975	PF00928	0.486
TRG_ER_diArg_1	251	254	PF00400	0.541
TRG_ER_diArg_1	410	412	PF00400	0.544
TRG_ER_diArg_1	459	461	PF00400	0.793
TRG_NES_CRM1_1	374	390	PF08389	0.553
TRG_NLS_MonoExtN_4	455	462	PF00514	0.799
TRG_Pf-PMV_PEXEL_1	476	481	PF00026	0.718
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.753

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0H5	Leptomonas seymouri	44%	93%
A0A3S5H4Z9	Leishmania donovani	89%	86%
A4H3D6	Leishmania braziliensis	66%	99%
A4HRN8	Leishmania infantum	89%	89%
E9AJK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	96%