MP99

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

MP99

Gene product:

mitochondrial protein 99, putative

Species:

Leishmania major

UniProt:

Q6T444_LEIMA

TriTrypDb:

LmjF.03.0620 , LMJLV39_030011500 , LMJSD75_030011600

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016604	nuclear body	2	2
GO:0016605	PML body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q6T444

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q6T444

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003697	single-stranded DNA binding	5	2
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	2
GO:0008081	phosphoric diester hydrolase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0070259	tyrosyl-DNA phosphodiesterase activity	4	2
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.514
CLV_C14_Caspase3-7	488	492	PF00656	0.722
CLV_NRD_NRD_1	107	109	PF00675	0.457
CLV_NRD_NRD_1	111	113	PF00675	0.425
CLV_NRD_NRD_1	131	133	PF00675	0.217
CLV_NRD_NRD_1	137	139	PF00675	0.436
CLV_NRD_NRD_1	287	289	PF00675	0.544
CLV_NRD_NRD_1	552	554	PF00675	0.557
CLV_PCSK_KEX2_1	107	109	PF00082	0.427
CLV_PCSK_KEX2_1	131	133	PF00082	0.495
CLV_PCSK_KEX2_1	137	139	PF00082	0.498
CLV_PCSK_KEX2_1	287	289	PF00082	0.465
CLV_PCSK_SKI1_1	131	135	PF00082	0.561
CLV_PCSK_SKI1_1	238	242	PF00082	0.504
CLV_PCSK_SKI1_1	349	353	PF00082	0.568
DEG_APCC_DBOX_1	111	119	PF00400	0.484
DEG_APCC_DBOX_1	292	300	PF00400	0.495
DEG_APCC_DBOX_1	368	376	PF00400	0.498
DEG_Nend_Nbox_1	1	3	PF02207	0.674
DOC_ANK_TNKS_1	607	614	PF00023	0.554
DOC_CKS1_1	166	171	PF01111	0.535
DOC_CKS1_1	178	183	PF01111	0.392
DOC_CKS1_1	315	320	PF01111	0.512
DOC_CYCLIN_RxL_1	107	120	PF00134	0.415
DOC_MAPK_gen_1	454	464	PF00069	0.561
DOC_MAPK_MEF2A_6	293	301	PF00069	0.342
DOC_PP1_RVXF_1	111	118	PF00149	0.436
DOC_PP1_RVXF_1	347	354	PF00149	0.584
DOC_PP2B_LxvP_1	200	203	PF13499	0.627
DOC_USP7_MATH_1	111	115	PF00917	0.412
DOC_USP7_MATH_1	337	341	PF00917	0.599
DOC_USP7_MATH_1	434	438	PF00917	0.689
DOC_USP7_MATH_1	571	575	PF00917	0.687
DOC_USP7_MATH_2	535	541	PF00917	0.486
DOC_WW_Pin1_4	146	151	PF00397	0.386
DOC_WW_Pin1_4	165	170	PF00397	0.494
DOC_WW_Pin1_4	177	182	PF00397	0.398
DOC_WW_Pin1_4	232	237	PF00397	0.397
DOC_WW_Pin1_4	314	319	PF00397	0.477
DOC_WW_Pin1_4	397	402	PF00397	0.613
DOC_WW_Pin1_4	425	430	PF00397	0.500
DOC_WW_Pin1_4	493	498	PF00397	0.534
LIG_14-3-3_CanoR_1	112	116	PF00244	0.339
LIG_14-3-3_CanoR_1	142	152	PF00244	0.459
LIG_14-3-3_CanoR_1	238	244	PF00244	0.540
LIG_14-3-3_CanoR_1	347	352	PF00244	0.601
LIG_14-3-3_CanoR_1	371	376	PF00244	0.448
LIG_14-3-3_CanoR_1	43	47	PF00244	0.585
LIG_14-3-3_CanoR_1	457	464	PF00244	0.525
LIG_14-3-3_CanoR_1	530	535	PF00244	0.588
LIG_14-3-3_CanoR_1	553	559	PF00244	0.495
LIG_14-3-3_CanoR_1	99	105	PF00244	0.488
LIG_Actin_WH2_2	255	271	PF00022	0.604
LIG_APCC_ABBAyCdc20_2	349	355	PF00400	0.564
LIG_BRCT_BRCA1_1	113	117	PF00533	0.427
LIG_BRCT_BRCA1_1	349	353	PF00533	0.517
LIG_BRCT_BRCA1_1	597	601	PF00533	0.469
LIG_Clathr_ClatBox_1	296	300	PF01394	0.271
LIG_CSL_BTD_1	426	429	PF09270	0.608
LIG_DLG_GKlike_1	371	378	PF00625	0.438
LIG_eIF4E_1	79	85	PF01652	0.561
LIG_FHA_1	101	107	PF00498	0.495
LIG_FHA_1	178	184	PF00498	0.511
LIG_FHA_1	195	201	PF00498	0.364
LIG_FHA_1	216	222	PF00498	0.440
LIG_FHA_1	292	298	PF00498	0.337
LIG_FHA_1	3	9	PF00498	0.722
LIG_FHA_1	306	312	PF00498	0.404
LIG_FHA_1	411	417	PF00498	0.491
LIG_FHA_1	441	447	PF00498	0.687
LIG_FHA_1	466	472	PF00498	0.484
LIG_FHA_1	508	514	PF00498	0.452
LIG_FHA_1	543	549	PF00498	0.499
LIG_FHA_1	553	559	PF00498	0.480
LIG_FHA_1	576	582	PF00498	0.674
LIG_FHA_1	637	643	PF00498	0.554
LIG_FHA_1	79	85	PF00498	0.470
LIG_FHA_2	160	166	PF00498	0.552
LIG_FHA_2	212	218	PF00498	0.523
LIG_FHA_2	403	409	PF00498	0.552
LIG_FHA_2	504	510	PF00498	0.382
LIG_FHA_2	514	520	PF00498	0.399
LIG_FHA_2	531	537	PF00498	0.508
LIG_LIR_Apic_2	491	497	PF02991	0.599
LIG_LIR_Gen_1	226	237	PF02991	0.389
LIG_LIR_Gen_1	258	268	PF02991	0.423
LIG_LIR_Gen_1	317	327	PF02991	0.454
LIG_LIR_Nem_3	204	208	PF02991	0.665
LIG_LIR_Nem_3	226	232	PF02991	0.407
LIG_LIR_Nem_3	235	240	PF02991	0.430
LIG_LIR_Nem_3	258	264	PF02991	0.431
LIG_LIR_Nem_3	317	322	PF02991	0.443
LIG_LIR_Nem_3	453	458	PF02991	0.578
LIG_LIR_Nem_3	5	10	PF02991	0.494
LIG_LIR_Nem_3	50	55	PF02991	0.424
LIG_LIR_Nem_3	615	619	PF02991	0.442
LIG_NRBOX	114	120	PF00104	0.493
LIG_NRBOX	263	269	PF00104	0.612
LIG_NRBOX	297	303	PF00104	0.462
LIG_NRBOX	374	380	PF00104	0.490
LIG_PCNA_PIPBox_1	1	10	PF02747	0.687
LIG_PCNA_yPIPBox_3	553	563	PF02747	0.558
LIG_PTAP_UEV_1	338	343	PF05743	0.515
LIG_SH2_STAP1	139	143	PF00017	0.548
LIG_SH2_STAT5	153	156	PF00017	0.453
LIG_SH2_STAT5	191	194	PF00017	0.503
LIG_SH2_STAT5	326	329	PF00017	0.454
LIG_SH2_STAT5	469	472	PF00017	0.483
LIG_SH2_STAT5	494	497	PF00017	0.530
LIG_SH2_STAT5	528	531	PF00017	0.526
LIG_SH2_STAT5	7	10	PF00017	0.712
LIG_SH2_STAT5	79	82	PF00017	0.516
LIG_SH3_3	175	181	PF00018	0.467
LIG_SH3_3	200	206	PF00018	0.595
LIG_SH3_3	219	225	PF00018	0.487
LIG_SH3_3	336	342	PF00018	0.694
LIG_SH3_3	388	394	PF00018	0.636
LIG_SUMO_SIM_anti_2	294	300	PF11976	0.409
LIG_SUMO_SIM_par_1	191	197	PF11976	0.432
LIG_SUMO_SIM_par_1	294	300	PF11976	0.268
LIG_SUMO_SIM_par_1	448	453	PF11976	0.620
LIG_SUMO_SIM_par_1	509	514	PF11976	0.460
LIG_SUMO_SIM_par_1	66	71	PF11976	0.484
LIG_TRAF2_1	254	257	PF00917	0.481
LIG_TRAF2_1	566	569	PF00917	0.607
LIG_UBA3_1	105	113	PF00899	0.412
LIG_Vh1_VBS_1	548	566	PF01044	0.544
MOD_CDC14_SPxK_1	496	499	PF00782	0.536
MOD_CDK_SPxK_1	232	238	PF00069	0.456
MOD_CDK_SPxK_1	493	499	PF00069	0.581
MOD_CK1_1	146	152	PF00069	0.380
MOD_CK1_1	209	215	PF00069	0.470
MOD_CK1_1	25	31	PF00069	0.755
MOD_CK1_1	438	444	PF00069	0.720
MOD_CK1_1	540	546	PF00069	0.481
MOD_CK1_1	647	653	PF00069	0.642
MOD_CK1_1	668	674	PF00069	0.806
MOD_CK2_1	159	165	PF00069	0.582
MOD_CK2_1	251	257	PF00069	0.446
MOD_CK2_1	402	408	PF00069	0.582
MOD_CK2_1	503	509	PF00069	0.403
MOD_CK2_1	513	519	PF00069	0.396
MOD_Cter_Amidation	135	138	PF01082	0.510
MOD_GlcNHglycan	16	19	PF01048	0.722
MOD_GlcNHglycan	175	178	PF01048	0.415
MOD_GlcNHglycan	188	191	PF01048	0.337
MOD_GlcNHglycan	30	33	PF01048	0.768
MOD_GlcNHglycan	334	337	PF01048	0.592
MOD_GlcNHglycan	339	342	PF01048	0.565
MOD_GlcNHglycan	386	389	PF01048	0.553
MOD_GlcNHglycan	437	440	PF01048	0.756
MOD_GlcNHglycan	458	461	PF01048	0.426
MOD_GlcNHglycan	513	516	PF01048	0.438
MOD_GlcNHglycan	573	576	PF01048	0.701
MOD_GlcNHglycan	646	650	PF01048	0.616
MOD_GlcNHglycan	652	655	PF01048	0.654
MOD_GlcNHglycan	670	673	PF01048	0.757
MOD_GSK3_1	173	180	PF00069	0.525
MOD_GSK3_1	21	28	PF00069	0.752
MOD_GSK3_1	211	218	PF00069	0.533
MOD_GSK3_1	251	258	PF00069	0.436
MOD_GSK3_1	38	45	PF00069	0.326
MOD_GSK3_1	421	428	PF00069	0.555
MOD_GSK3_1	434	441	PF00069	0.525
MOD_GSK3_1	465	472	PF00069	0.486
MOD_GSK3_1	489	496	PF00069	0.558
MOD_GSK3_1	503	510	PF00069	0.441
MOD_GSK3_1	569	576	PF00069	0.639
MOD_GSK3_1	634	641	PF00069	0.521
MOD_GSK3_1	644	651	PF00069	0.606
MOD_N-GLC_1	238	243	PF02516	0.402
MOD_N-GLC_1	446	451	PF02516	0.677
MOD_N-GLC_1	634	639	PF02516	0.601
MOD_NEK2_1	159	164	PF00069	0.527
MOD_NEK2_1	208	213	PF00069	0.582
MOD_NEK2_1	407	412	PF00069	0.402
MOD_NEK2_1	446	451	PF00069	0.640
MOD_NEK2_1	503	508	PF00069	0.432
MOD_NEK2_1	511	516	PF00069	0.355
MOD_NEK2_1	601	606	PF00069	0.566
MOD_NEK2_1	644	649	PF00069	0.670
MOD_NEK2_1	73	78	PF00069	0.488
MOD_NEK2_2	196	201	PF00069	0.338
MOD_NEK2_2	489	494	PF00069	0.633
MOD_PIKK_1	421	427	PF00454	0.595
MOD_PIKK_1	513	519	PF00454	0.547
MOD_PIKK_1	540	546	PF00454	0.596
MOD_PIKK_1	552	558	PF00454	0.513
MOD_PIKK_1	564	570	PF00454	0.618
MOD_PK_1	347	353	PF00069	0.608
MOD_PKA_2	111	117	PF00069	0.469
MOD_PKA_2	159	165	PF00069	0.544
MOD_PKA_2	42	48	PF00069	0.447
MOD_PKA_2	456	462	PF00069	0.556
MOD_PKA_2	552	558	PF00069	0.573
MOD_PKB_1	369	377	PF00069	0.404
MOD_Plk_1	209	215	PF00069	0.524
MOD_Plk_1	238	244	PF00069	0.400
MOD_Plk_1	407	413	PF00069	0.497
MOD_Plk_1	68	74	PF00069	0.420
MOD_Plk_4	100	106	PF00069	0.455
MOD_Plk_4	402	408	PF00069	0.517
MOD_Plk_4	446	452	PF00069	0.629
MOD_Plk_4	465	471	PF00069	0.446
MOD_Plk_4	489	495	PF00069	0.623
MOD_Plk_4	507	513	PF00069	0.396
MOD_Plk_4	68	74	PF00069	0.472
MOD_ProDKin_1	146	152	PF00069	0.386
MOD_ProDKin_1	165	171	PF00069	0.492
MOD_ProDKin_1	177	183	PF00069	0.394
MOD_ProDKin_1	232	238	PF00069	0.409
MOD_ProDKin_1	314	320	PF00069	0.475
MOD_ProDKin_1	397	403	PF00069	0.601
MOD_ProDKin_1	425	431	PF00069	0.512
MOD_ProDKin_1	493	499	PF00069	0.537
MOD_SUMO_for_1	623	626	PF00179	0.553
TRG_ENDOCYTIC_2	326	329	PF00928	0.454
TRG_ENDOCYTIC_2	616	619	PF00928	0.455
TRG_ER_diArg_1	106	108	PF00400	0.454
TRG_ER_diArg_1	131	133	PF00400	0.491
TRG_ER_diArg_1	137	139	PF00400	0.516
TRG_ER_diArg_1	287	289	PF00400	0.544
TRG_ER_diArg_1	368	371	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	546	550	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUJ3	Leptomonas seymouri	56%	100%
A0A0S4J9X6	Bodo saltans	33%	83%
A0A1X0P940	Trypanosomatidae	43%	75%
A0A3R7NI16	Trypanosoma rangeli	26%	73%
A0A3S5H550	Leishmania donovani	96%	100%
A0A422NMS5	Trypanosoma rangeli	42%	74%
A4H3M3	Leishmania braziliensis	77%	99%
C9ZRZ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	76%
D0A265	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	73%
E9AG51	Leishmania infantum	96%	100%
E9AJU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BPW5	Trypanosoma cruzi	26%	73%