LeishMANIAdb
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Phosphodiesterase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphodiesterase
Gene product:
cAMP phosphodiesterase A, putative
Species:
Leishmania major
UniProt:
Q6S998_LEIMA
TriTrypDb:
LmjF.18.1090 , LMJLV39_180016400 * , LMJSD75_180016600
Length:
631

Annotations

LeishMANIAdb annotations

Phosphodiesterase, with probable N-terminal lipidation signal. Not embedded in membrane, like its homologs.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 6
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1

Expansion

Sequence features

Q6S998
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q6S998

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 13
GO:0009892 negative regulation of metabolic process 4 2
GO:0009987 cellular process 1 13
GO:0019222 regulation of metabolic process 3 2
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031324 negative regulation of cellular metabolic process 5 2
GO:0048519 negative regulation of biological process 3 2
GO:0048523 negative regulation of cellular process 4 2
GO:0050789 regulation of biological process 2 13
GO:0050794 regulation of cellular process 3 13
GO:0065007 biological regulation 1 13
GO:2000377 regulation of reactive oxygen species metabolic process 5 2
GO:2000378 negative regulation of reactive oxygen species metabolic process 6 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 13
GO:0004112 cyclic-nucleotide phosphodiesterase activity 6 13
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 7 13
GO:0005488 binding 1 13
GO:0008081 phosphoric diester hydrolase activity 5 13
GO:0016787 hydrolase activity 2 13
GO:0016788 hydrolase activity, acting on ester bonds 3 13
GO:0042578 phosphoric ester hydrolase activity 4 13
GO:0043167 ion binding 2 13
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 311 315 PF00656 0.490
CLV_NRD_NRD_1 204 206 PF00675 0.543
CLV_PCSK_KEX2_1 177 179 PF00082 0.577
CLV_PCSK_KEX2_1 408 410 PF00082 0.404
CLV_PCSK_PC1ET2_1 177 179 PF00082 0.584
CLV_PCSK_PC1ET2_1 408 410 PF00082 0.404
CLV_PCSK_SKI1_1 126 130 PF00082 0.489
CLV_PCSK_SKI1_1 141 145 PF00082 0.497
CLV_PCSK_SKI1_1 178 182 PF00082 0.638
CLV_PCSK_SKI1_1 262 266 PF00082 0.358
CLV_PCSK_SKI1_1 453 457 PF00082 0.298
DEG_APCC_DBOX_1 408 416 PF00400 0.353
DEG_APCC_DBOX_1 452 460 PF00400 0.341
DEG_Nend_Nbox_1 1 3 PF02207 0.444
DEG_SCF_FBW7_2 596 602 PF00400 0.366
DOC_CKS1_1 596 601 PF01111 0.366
DOC_CYCLIN_RxL_1 565 575 PF00134 0.371
DOC_MAPK_gen_1 251 261 PF00069 0.520
DOC_MAPK_gen_1 360 369 PF00069 0.410
DOC_MAPK_MEF2A_6 289 296 PF00069 0.577
DOC_PIKK_1 451 459 PF02985 0.404
DOC_PP4_FxxP_1 429 432 PF00568 0.404
DOC_SPAK_OSR1_1 612 616 PF12202 0.452
DOC_USP7_MATH_1 26 30 PF00917 0.467
DOC_USP7_MATH_1 309 313 PF00917 0.548
DOC_USP7_MATH_1 325 329 PF00917 0.324
DOC_USP7_MATH_1 554 558 PF00917 0.426
DOC_USP7_MATH_1 60 64 PF00917 0.611
DOC_USP7_MATH_1 80 84 PF00917 0.279
DOC_USP7_UBL2_3 196 200 PF12436 0.633
DOC_WW_Pin1_4 243 248 PF00397 0.684
DOC_WW_Pin1_4 267 272 PF00397 0.538
DOC_WW_Pin1_4 275 280 PF00397 0.592
DOC_WW_Pin1_4 572 577 PF00397 0.298
DOC_WW_Pin1_4 595 600 PF00397 0.446
LIG_14-3-3_CanoR_1 134 142 PF00244 0.425
LIG_14-3-3_CanoR_1 85 89 PF00244 0.431
LIG_APCC_ABBA_1 597 602 PF00400 0.326
LIG_BRCT_BRCA1_1 461 465 PF00533 0.346
LIG_BRCT_BRCA1_1 556 560 PF00533 0.311
LIG_BRCT_BRCA1_1 70 74 PF00533 0.468
LIG_deltaCOP1_diTrp_1 314 321 PF00928 0.356
LIG_deltaCOP1_diTrp_1 69 74 PF00928 0.451
LIG_FHA_1 127 133 PF00498 0.422
LIG_FHA_1 395 401 PF00498 0.301
LIG_FHA_2 133 139 PF00498 0.483
LIG_FHA_2 174 180 PF00498 0.577
LIG_FHA_2 233 239 PF00498 0.739
LIG_FHA_2 250 256 PF00498 0.602
LIG_FHA_2 29 35 PF00498 0.568
LIG_FHA_2 488 494 PF00498 0.305
LIG_FXI_DFP_1 426 430 PF00024 0.452
LIG_IBAR_NPY_1 382 384 PF08397 0.349
LIG_LIR_Apic_2 266 271 PF02991 0.525
LIG_LIR_Apic_2 428 432 PF02991 0.298
LIG_LIR_Gen_1 255 264 PF02991 0.535
LIG_LIR_Gen_1 347 357 PF02991 0.341
LIG_LIR_Gen_1 39 48 PF02991 0.371
LIG_LIR_Gen_1 462 473 PF02991 0.317
LIG_LIR_Gen_1 598 609 PF02991 0.413
LIG_LIR_Gen_1 69 77 PF02991 0.406
LIG_LIR_Nem_3 255 259 PF02991 0.505
LIG_LIR_Nem_3 315 321 PF02991 0.396
LIG_LIR_Nem_3 330 335 PF02991 0.537
LIG_LIR_Nem_3 34 40 PF02991 0.422
LIG_LIR_Nem_3 347 352 PF02991 0.275
LIG_LIR_Nem_3 598 604 PF02991 0.369
LIG_LIR_Nem_3 69 73 PF02991 0.381
LIG_MLH1_MIPbox_1 70 74 PF16413 0.470
LIG_Pex14_1 70 74 PF04695 0.364
LIG_Pex14_2 357 361 PF04695 0.375
LIG_PTB_Apo_2 467 474 PF02174 0.346
LIG_REV1ctd_RIR_1 71 79 PF16727 0.532
LIG_SH2_CRK 349 353 PF00017 0.351
LIG_SH2_GRB2like 384 387 PF00017 0.298
LIG_SH2_STAP1 160 164 PF00017 0.531
LIG_SH2_STAT5 142 145 PF00017 0.572
LIG_SH2_STAT5 332 335 PF00017 0.663
LIG_SH2_STAT5 445 448 PF00017 0.441
LIG_SH2_STAT5 48 51 PF00017 0.518
LIG_SH2_STAT5 506 509 PF00017 0.404
LIG_SH2_STAT5 549 552 PF00017 0.305
LIG_SH2_STAT5 595 598 PF00017 0.298
LIG_SH3_3 280 286 PF00018 0.457
LIG_Sin3_3 256 263 PF02671 0.412
LIG_SUMO_SIM_par_1 184 190 PF11976 0.617
LIG_TRAF2_1 227 230 PF00917 0.598
LIG_TRAF2_1 31 34 PF00917 0.647
LIG_UBA3_1 164 171 PF00899 0.600
LIG_UBA3_1 260 265 PF00899 0.361
LIG_WRC_WIRS_1 476 481 PF05994 0.371
MOD_CDK_SPxxK_3 275 282 PF00069 0.550
MOD_CK1_1 105 111 PF00069 0.665
MOD_CK1_1 297 303 PF00069 0.497
MOD_CK1_1 312 318 PF00069 0.393
MOD_CK1_1 334 340 PF00069 0.599
MOD_CK1_1 39 45 PF00069 0.462
MOD_CK1_1 518 524 PF00069 0.458
MOD_CK2_1 173 179 PF00069 0.547
MOD_CK2_1 232 238 PF00069 0.583
MOD_CK2_1 28 34 PF00069 0.537
MOD_CK2_1 370 376 PF00069 0.350
MOD_CK2_1 451 457 PF00069 0.316
MOD_CK2_1 460 466 PF00069 0.316
MOD_CK2_1 487 493 PF00069 0.332
MOD_GlcNHglycan 104 107 PF01048 0.637
MOD_GlcNHglycan 120 123 PF01048 0.359
MOD_GlcNHglycan 299 302 PF01048 0.527
MOD_GlcNHglycan 327 330 PF01048 0.487
MOD_GlcNHglycan 372 375 PF01048 0.443
MOD_GlcNHglycan 418 421 PF01048 0.443
MOD_GlcNHglycan 82 85 PF01048 0.540
MOD_GSK3_1 214 221 PF00069 0.625
MOD_GSK3_1 239 246 PF00069 0.779
MOD_GSK3_1 263 270 PF00069 0.385
MOD_GSK3_1 336 343 PF00069 0.484
MOD_GSK3_1 441 448 PF00069 0.328
MOD_GSK3_1 495 502 PF00069 0.491
MOD_GSK3_1 516 523 PF00069 0.366
MOD_GSK3_1 56 63 PF00069 0.568
MOD_GSK3_1 581 588 PF00069 0.438
MOD_GSK3_1 80 87 PF00069 0.417
MOD_LATS_1 439 445 PF00433 0.326
MOD_N-GLC_1 190 195 PF02516 0.639
MOD_N-GLC_1 249 254 PF02516 0.680
MOD_N-GLC_2 527 529 PF02516 0.492
MOD_NEK2_1 263 268 PF00069 0.389
MOD_NEK2_1 299 304 PF00069 0.559
MOD_NEK2_1 333 338 PF00069 0.554
MOD_NEK2_1 344 349 PF00069 0.330
MOD_NEK2_1 399 404 PF00069 0.330
MOD_NEK2_1 422 427 PF00069 0.452
MOD_NEK2_1 459 464 PF00069 0.381
MOD_NEK2_1 585 590 PF00069 0.404
MOD_NEK2_2 249 254 PF00069 0.659
MOD_NEK2_2 384 389 PF00069 0.311
MOD_NEK2_2 445 450 PF00069 0.346
MOD_NEK2_2 506 511 PF00069 0.276
MOD_PIKK_1 294 300 PF00454 0.472
MOD_PIKK_1 334 340 PF00454 0.647
MOD_PIKK_1 399 405 PF00454 0.461
MOD_PIKK_1 518 524 PF00454 0.457
MOD_PIKK_1 585 591 PF00454 0.424
MOD_PKA_2 133 139 PF00069 0.422
MOD_PKA_2 487 493 PF00069 0.301
MOD_PKA_2 84 90 PF00069 0.444
MOD_Plk_1 33 39 PF00069 0.562
MOD_Plk_1 375 381 PF00069 0.573
MOD_Plk_1 451 457 PF00069 0.343
MOD_Plk_1 515 521 PF00069 0.465
MOD_Plk_1 68 74 PF00069 0.550
MOD_Plk_2-3 133 139 PF00069 0.553
MOD_Plk_4 10 16 PF00069 0.394
MOD_Plk_4 126 132 PF00069 0.520
MOD_Plk_4 143 149 PF00069 0.363
MOD_Plk_4 20 26 PF00069 0.355
MOD_Plk_4 340 346 PF00069 0.372
MOD_Plk_4 44 50 PF00069 0.437
MOD_Plk_4 441 447 PF00069 0.349
MOD_Plk_4 460 466 PF00069 0.239
MOD_Plk_4 487 493 PF00069 0.298
MOD_Plk_4 69 75 PF00069 0.479
MOD_ProDKin_1 243 249 PF00069 0.678
MOD_ProDKin_1 267 273 PF00069 0.546
MOD_ProDKin_1 275 281 PF00069 0.587
MOD_ProDKin_1 572 578 PF00069 0.298
MOD_ProDKin_1 595 601 PF00069 0.446
MOD_SUMO_rev_2 105 111 PF00179 0.723
MOD_SUMO_rev_2 159 165 PF00179 0.614
MOD_SUMO_rev_2 619 623 PF00179 0.430
TRG_DiLeu_BaEn_2 572 578 PF01217 0.435
TRG_ENDOCYTIC_2 318 321 PF00928 0.371
TRG_ENDOCYTIC_2 332 335 PF00928 0.527
TRG_ENDOCYTIC_2 349 352 PF00928 0.217
TRG_ENDOCYTIC_2 40 43 PF00928 0.386
TRG_NES_CRM1_1 606 620 PF08389 0.366
TRG_Pf-PMV_PEXEL_1 267 272 PF00026 0.546
TRG_Pf-PMV_PEXEL_1 568 573 PF00026 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1Y4 Leptomonas seymouri 33% 89%
A0A0N1PG81 Leptomonas seymouri 66% 100%
A0A0S4KIW5 Bodo saltans 48% 100%
A0A1X0P701 Trypanosomatidae 49% 100%
A0A3Q8IB14 Leishmania donovani 96% 100%
A0A422P0P1 Trypanosoma rangeli 50% 100%
A4H9L9 Leishmania braziliensis 84% 100%
A4HXY3 Leishmania infantum 96% 100%
D0A5C4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9ARP6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5BNN7 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS