Putative translation elongation factor 1-beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation elongation factor 1-beta, putative

Species:

Leishmania major

UniProt:

Q66NE2_LEIMA

TriTrypDb:

LmjF.36.1430 , LMJLV39_360020400 , LMJSD75_360020400

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 22

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	3
GO:0005853	eukaryotic translation elongation factor 1 complex	2	21
GO:0032991	protein-containing complex	1	21
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

Q66NE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q66NE2

Function

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Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009059	macromolecule biosynthetic process	4	3
GO:0009987	cellular process	1	3
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	21
GO:0003746	translation elongation factor activity	4	21
GO:0005085	guanyl-nucleotide exchange factor activity	3	3
GO:0005488	binding	1	21
GO:0008135	translation factor activity, RNA binding	3	21
GO:0030234	enzyme regulator activity	2	3
GO:0030695	GTPase regulator activity	4	3
GO:0045182	translation regulator activity	1	21
GO:0060589	nucleoside-triphosphatase regulator activity	3	3
GO:0090079	translation regulator activity, nucleic acid binding	2	21

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	102	106	PF00082	0.620
CLV_PCSK_SKI1_1	108	112	PF00082	0.599
CLV_PCSK_SKI1_1	116	120	PF00082	0.531
CLV_PCSK_SKI1_1	65	69	PF00082	0.719
DOC_MAPK_gen_1	171	179	PF00069	0.353
DOC_USP7_MATH_1	124	128	PF00917	0.409
DOC_USP7_MATH_1	15	19	PF00917	0.437
DOC_USP7_UBL2_3	111	115	PF12436	0.602
DOC_USP7_UBL2_3	116	120	PF12436	0.563
DOC_WW_Pin1_4	18	23	PF00397	0.484

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W7	Leptomonas seymouri	82%	100%
A0A0N1HZF7	Leptomonas seymouri	61%	89%
A0A0S4JC29	Bodo saltans	70%	100%
A0A0S4JK70	Bodo saltans	55%	86%
A0A1X0P9D3	Trypanosomatidae	74%	100%
A0A1X0PA37	Trypanosomatidae	62%	92%
A0A3Q8IVV7	Leishmania donovani	98%	100%
A0A3R7MFZ8	Trypanosoma rangeli	70%	100%
A0A3S5H7W1	Leishmania donovani	62%	88%
A0A422N8N9	Trypanosoma rangeli	62%	93%

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