Putative translation elongation factor 1-beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation elongation factor 1-beta, putative

Species:

Leishmania major

UniProt:

Q66NE2_LEIMA

TriTrypDb:

LmjF.36.1430 , LMJLV39_360020400 , LMJSD75_360020400

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 22

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	3
GO:0005853	eukaryotic translation elongation factor 1 complex	2	21
GO:0032991	protein-containing complex	1	21
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q66NE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q66NE2

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009059	macromolecule biosynthetic process	4	3
GO:0009987	cellular process	1	3
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	21
GO:0003746	translation elongation factor activity	4	21
GO:0005085	guanyl-nucleotide exchange factor activity	3	3
GO:0005488	binding	1	21
GO:0008135	translation factor activity, RNA binding	3	21
GO:0030234	enzyme regulator activity	2	3
GO:0030695	GTPase regulator activity	4	3
GO:0045182	translation regulator activity	1	21
GO:0060589	nucleoside-triphosphatase regulator activity	3	3
GO:0090079	translation regulator activity, nucleic acid binding	2	21
GO:0097159	organic cyclic compound binding	2	21
GO:0098772	molecular function regulator activity	1	3
GO:0140677	molecular function activator activity	2	3
GO:0140678	molecular function inhibitor activity	2	3
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	102	106	PF00082	0.620
CLV_PCSK_SKI1_1	108	112	PF00082	0.599
CLV_PCSK_SKI1_1	116	120	PF00082	0.531
CLV_PCSK_SKI1_1	65	69	PF00082	0.719
DOC_MAPK_gen_1	171	179	PF00069	0.353
DOC_USP7_MATH_1	124	128	PF00917	0.409
DOC_USP7_MATH_1	15	19	PF00917	0.437
DOC_USP7_UBL2_3	111	115	PF12436	0.602
DOC_USP7_UBL2_3	116	120	PF12436	0.563
DOC_WW_Pin1_4	18	23	PF00397	0.484
LIG_14-3-3_CanoR_1	10	15	PF00244	0.462
LIG_14-3-3_CanoR_1	46	51	PF00244	0.491
LIG_APCC_ABBA_1	91	96	PF00400	0.592
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_BRCT_BRCA1_1	126	130	PF00533	0.348
LIG_CaM_IQ_9	38	54	PF13499	0.411
LIG_Clathr_ClatBox_1	176	180	PF01394	0.336
LIG_FHA_1	136	142	PF00498	0.348
LIG_FHA_2	1	7	PF00498	0.584
LIG_FHA_2	95	101	PF00498	0.593
LIG_Integrin_isoDGR_2	8	10	PF01839	0.446
LIG_PCNA_yPIPBox_3	37	46	PF02747	0.434
LIG_Pex14_2	16	20	PF04695	0.508
LIG_Pex14_2	30	34	PF04695	0.405
LIG_PTB_Apo_2	28	35	PF02174	0.361
LIG_SUMO_SIM_par_1	136	142	PF11976	0.337
LIG_SUMO_SIM_par_1	175	182	PF11976	0.336
LIG_TRAF2_1	84	87	PF00917	0.686
LIG_TRAF2_1	97	100	PF00917	0.572
LIG_UBA3_1	128	133	PF00899	0.443
LIG_UBA3_1	176	183	PF00899	0.332
MOD_CK1_1	18	24	PF00069	0.489
MOD_CK2_1	94	100	PF00069	0.616
MOD_GlcNHglycan	17	20	PF01048	0.486
MOD_GlcNHglycan	184	187	PF01048	0.361
MOD_NEK2_1	33	38	PF00069	0.396
MOD_PIKK_1	10	16	PF00454	0.430
MOD_PKA_1	65	71	PF00069	0.557
MOD_Plk_1	135	141	PF00069	0.341
MOD_Plk_2-3	199	205	PF00069	0.348
MOD_Plk_4	124	130	PF00069	0.356
MOD_Plk_4	46	52	PF00069	0.511
MOD_ProDKin_1	18	24	PF00069	0.486
MOD_SUMO_for_1	118	121	PF00179	0.551
MOD_SUMO_rev_2	112	118	PF00179	0.528
MOD_SUMO_rev_2	126	134	PF00179	0.315
MOD_SUMO_rev_2	154	164	PF00179	0.336
MOD_SUMO_rev_2	180	185	PF00179	0.336
MOD_SUMO_rev_2	96	104	PF00179	0.663
TRG_DiLeu_BaEn_4	100	106	PF01217	0.586
TRG_NLS_MonoExtC_3	115	120	PF00514	0.594
TRG_NLS_MonoExtN_4	115	120	PF00514	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W7	Leptomonas seymouri	82%	100%
A0A0N1HZF7	Leptomonas seymouri	61%	89%
A0A0S4JC29	Bodo saltans	70%	100%
A0A0S4JK70	Bodo saltans	55%	86%
A0A1X0P9D3	Trypanosomatidae	74%	100%
A0A1X0PA37	Trypanosomatidae	62%	92%
A0A3Q8IVV7	Leishmania donovani	98%	100%
A0A3R7MFZ8	Trypanosoma rangeli	70%	100%
A0A3S5H7W1	Leishmania donovani	62%	88%
A0A422N8N9	Trypanosoma rangeli	62%	93%
A4HAJ1	Leishmania braziliensis	61%	100%
A4HAJ3	Leishmania braziliensis	64%	68%
A4HAJ7	Leishmania braziliensis	58%	88%
A4HP03	Leishmania braziliensis	89%	100%
A4I9P1	Leishmania infantum	62%	88%
A4IDB2	Leishmania infantum	98%	100%
D0A2X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9ASR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B4Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	86%
O70251	Mus musculus	39%	94%
O74173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	99%
O81918	Beta vulgaris	37%	91%
O96827	Drosophila melanogaster	42%	95%
P12262	Artemia salina	37%	100%
P24534	Homo sapiens	39%	94%
P29522	Bombyx mori	43%	95%
P29692	Homo sapiens	43%	75%
P29693	Xenopus laevis	45%	80%
P30151	Xenopus laevis	41%	93%
P32192	Artemia salina	56%	89%
P34460	Caenorhabditis elegans	41%	99%
P34826	Oryctolagus cuniculus	39%	94%
P34827	Trypanosoma cruzi	63%	95%
P48006	Arabidopsis thaliana	38%	91%
P57776	Mus musculus	47%	75%
P78590	Candida albicans (strain WO-1)	33%	99%
P93447	Spuriopimpinella brachycarpa	37%	93%
Q40680	Oryza sativa subsp. japonica	34%	92%
Q40682	Oryza sativa subsp. japonica	37%	93%
Q4Q3C1	Leishmania major	66%	100%
Q4R3D4	Macaca fascicularis	42%	75%
Q5E983	Bos taurus	38%	94%
Q68FR9	Rattus norvegicus	48%	75%
Q69BZ7	Penicillium citrinum	33%	93%
Q6DET9	Xenopus tropicalis	37%	93%
Q84WM9	Arabidopsis thaliana	35%	93%
Q9GRF8	Dictyostelium discoideum	41%	98%
Q9SI20	Arabidopsis thaliana	38%	91%
Q9YGQ1	Gallus gallus	40%	94%