Elongation factor-1 gamma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

elongation factor-1 gamma

Species:

Leishmania major

UniProt:

Q66NE0_LEIMA

TriTrypDb:

LmjF.09.0970 , LMJLV39_090016000 , LMJSD75_090015600

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	yes	yes: 3
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q66NE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q66NE0

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003746	translation elongation factor activity	4	13
GO:0005488	binding	1	13
GO:0008135	translation factor activity, RNA binding	3	13
GO:0045182	translation regulator activity	1	13
GO:0090079	translation regulator activity, nucleic acid binding	2	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.427
CLV_NRD_NRD_1	324	326	PF00675	0.322
CLV_PCSK_KEX2_1	266	268	PF00082	0.322
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.322
CLV_PCSK_SKI1_1	147	151	PF00082	0.322
CLV_PCSK_SKI1_1	326	330	PF00082	0.322
CLV_PCSK_SKI1_1	395	399	PF00082	0.430
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.429
DOC_MAPK_gen_1	325	333	PF00069	0.322
DOC_MAPK_MEF2A_6	326	335	PF00069	0.322
DOC_PP2B_LxvP_1	5	8	PF13499	0.403
DOC_USP7_MATH_1	91	95	PF00917	0.470
DOC_USP7_UBL2_3	215	219	PF12436	0.635
DOC_USP7_UBL2_3	226	230	PF12436	0.623
DOC_USP7_UBL2_3	244	248	PF12436	0.707
DOC_USP7_UBL2_3	81	85	PF12436	0.501
DOC_WW_Pin1_4	110	115	PF00397	0.374
DOC_WW_Pin1_4	40	45	PF00397	0.384
DOC_WW_Pin1_4	48	53	PF00397	0.300
DOC_WW_Pin1_4	87	92	PF00397	0.430
LIG_14-3-3_CanoR_1	154	158	PF00244	0.340
LIG_14-3-3_CanoR_1	189	195	PF00244	0.322
LIG_BIR_III_2	253	257	PF00653	0.454
LIG_BIR_III_4	287	291	PF00653	0.315
LIG_BRCT_BRCA1_1	160	164	PF00533	0.391
LIG_CtBP_PxDLS_1	177	182	PF00389	0.391
LIG_deltaCOP1_diTrp_1	141	149	PF00928	0.322
LIG_deltaCOP1_diTrp_1	98	103	PF00928	0.383
LIG_EH1_1	328	336	PF00400	0.322
LIG_EVH1_2	256	260	PF00568	0.322
LIG_FHA_1	111	117	PF00498	0.384
LIG_FHA_1	146	152	PF00498	0.322
LIG_FHA_1	198	204	PF00498	0.408
LIG_FHA_1	272	278	PF00498	0.322
LIG_FHA_1	308	314	PF00498	0.322
LIG_FHA_1	381	387	PF00498	0.364
LIG_FHA_2	130	136	PF00498	0.459
LIG_FHA_2	154	160	PF00498	0.322
LIG_FHA_2	88	94	PF00498	0.466
LIG_LIR_Gen_1	289	298	PF02991	0.456
LIG_LIR_Gen_1	368	377	PF02991	0.411
LIG_LIR_Gen_1	98	108	PF02991	0.383
LIG_LIR_Nem_3	118	123	PF02991	0.197
LIG_LIR_Nem_3	2	6	PF02991	0.456
LIG_LIR_Nem_3	289	294	PF02991	0.331
LIG_LIR_Nem_3	345	349	PF02991	0.332
LIG_LIR_Nem_3	368	372	PF02991	0.402
LIG_LIR_Nem_3	98	103	PF02991	0.383
LIG_LYPXL_SIV_4	24	32	PF13949	0.391
LIG_Pex14_1	207	211	PF04695	0.583
LIG_Pex14_2	164	168	PF04695	0.322
LIG_SH2_CRK	191	195	PF00017	0.334
LIG_SH2_CRK	3	7	PF00017	0.405
LIG_SH2_GRB2like	25	28	PF00017	0.391
LIG_SH2_GRB2like	269	272	PF00017	0.322
LIG_SH2_NCK_1	25	29	PF00017	0.391
LIG_SH2_SRC	25	28	PF00017	0.391
LIG_SH2_STAP1	291	295	PF00017	0.322
LIG_SH2_STAT5	115	118	PF00017	0.391
LIG_SH2_STAT5	281	284	PF00017	0.322
LIG_SH2_STAT5	291	294	PF00017	0.322
LIG_SH2_STAT5	385	388	PF00017	0.375
LIG_SH2_STAT5	65	68	PF00017	0.535
LIG_SH3_3	274	280	PF00018	0.322
LIG_SH3_3	388	394	PF00018	0.410
LIG_SH3_3	5	11	PF00018	0.515
LIG_SUMO_SIM_anti_2	200	205	PF11976	0.407
LIG_TRAF2_1	132	135	PF00917	0.454
LIG_TRAF2_1	243	246	PF00917	0.737
LIG_UBA3_1	72	81	PF00899	0.483
LIG_WRC_WIRS_1	117	122	PF05994	0.352
LIG_WRC_WIRS_1	343	348	PF05994	0.332
MOD_CDK_SPxxK_3	48	55	PF00069	0.340
MOD_CK1_1	58	64	PF00069	0.397
MOD_CK2_1	129	135	PF00069	0.421
MOD_CK2_1	87	93	PF00069	0.449
MOD_Cter_Amidation	227	230	PF01082	0.574
MOD_GlcNHglycan	12	15	PF01048	0.463
MOD_GlcNHglycan	127	130	PF01048	0.352
MOD_GlcNHglycan	80	84	PF01048	0.428
MOD_GSK3_1	125	132	PF00069	0.458
MOD_GSK3_1	267	274	PF00069	0.322
MOD_GSK3_1	87	94	PF00069	0.511
MOD_N-GLC_1	40	45	PF02516	0.375
MOD_N-GLC_1	48	53	PF02516	0.375
MOD_NEK2_1	116	121	PF00069	0.530
MOD_NEK2_1	133	138	PF00069	0.437
MOD_NEK2_1	190	195	PF00069	0.322
MOD_NEK2_1	66	71	PF00069	0.434
MOD_NEK2_1	92	97	PF00069	0.421
MOD_PIKK_1	92	98	PF00454	0.412
MOD_PKA_2	153	159	PF00069	0.322
MOD_Plk_1	133	139	PF00069	0.454
MOD_Plk_1	158	164	PF00069	0.391
MOD_Plk_1	92	98	PF00069	0.543
MOD_Plk_2-3	153	159	PF00069	0.322
MOD_Plk_4	190	196	PF00069	0.322
MOD_Plk_4	256	262	PF00069	0.438
MOD_Plk_4	342	348	PF00069	0.352
MOD_ProDKin_1	110	116	PF00069	0.307
MOD_ProDKin_1	40	46	PF00069	0.384
MOD_ProDKin_1	48	54	PF00069	0.300
MOD_ProDKin_1	87	93	PF00069	0.424
MOD_SUMO_for_1	243	246	PF00179	0.754
MOD_SUMO_rev_2	222	231	PF00179	0.779
MOD_SUMO_rev_2	239	249	PF00179	0.646
MOD_SUMO_rev_2	29	34	PF00179	0.332
MOD_SUMO_rev_2	365	375	PF00179	0.535
TRG_DiLeu_BaEn_2	144	150	PF01217	0.349
TRG_ENDOCYTIC_2	191	194	PF00928	0.334
TRG_ENDOCYTIC_2	25	28	PF00928	0.391
TRG_ENDOCYTIC_2	291	294	PF00928	0.322
TRG_ENDOCYTIC_2	3	6	PF00928	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSJ4	Leptomonas seymouri	79%	100%
A0A1X0NID9	Trypanosomatidae	68%	98%
A0A3Q8I8H5	Leishmania donovani	98%	100%
A0A3R7LEF5	Trypanosoma rangeli	61%	89%
A0A3S7WQR4	Leishmania donovani	98%	100%
A2Q127	Equus caballus	32%	92%
A4H5S5	Leishmania braziliensis	89%	100%
A4HU18	Leishmania infantum	98%	89%
A4HU19	Leishmania infantum	98%	100%
D0A9I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	87%
D0A9K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AMU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O04487	Arabidopsis thaliana	36%	98%
P12261	Artemia salina	29%	94%
P26641	Homo sapiens	32%	92%
P26642	Xenopus laevis	30%	93%
P29547	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	97%
P29694	Oryctolagus cuniculus	32%	92%
P34715	Trypanosoma cruzi	65%	98%
P36008	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	98%
P40921	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	99%
P54412	Caenorhabditis elegans	30%	100%
Q29387	Sus scrofa	32%	94%
Q3SZV3	Bos taurus	31%	92%
Q4R7H5	Macaca fascicularis	32%	92%
Q5Z627	Oryza sativa subsp. japonica	36%	97%
Q68FR6	Rattus norvegicus	32%	92%
Q6PE25	Danio rerio	32%	91%
Q6YW46	Oryza sativa subsp. japonica	37%	97%
Q90YC0	Carassius auratus	31%	91%
Q91375	Xenopus laevis	29%	92%
Q9D8N0	Mus musculus	32%	92%
Q9FUM1	Prunus avium	33%	96%
Q9FVT2	Arabidopsis thaliana	36%	98%
Q9NJH0	Drosophila melanogaster	30%	94%
Q9ZRI7	Oryza sativa subsp. japonica	36%	97%