Small myristoylated protein 3

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small myristoylated protein 4, putative

Species:

Leishmania major

UniProt:

Q5SDH3_LEIMA

TriTrypDb:

LmjF.20.1280 , LMJLV39_200019100 , LMJSD75_200019100

Length:

152

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: avilan@ula.ve
Publication title: Plasminogen binding proteins in secreted membrane vesicles of Leishmania mexicana
Publication 1st author(s): Figuera
Publication Identifier(s): 23178693
Host organism: -1
Interaction detection method(s): enzymatic linked imunosorbent assay
Interaction type: direct interaction
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: E9AUS1
ID(s) interactor B: P00747
Taxid interactor A: Leishmania mexicana
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 5
Forrest at al. (procyclic)	no	yes: 7
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 43
NetGPI	no	yes: 0, no: 43

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0097542	ciliary tip	2	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	1
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0060170	ciliary membrane	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2

Expansion

Sequence features

Q5SDH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q5SDH3

PDB structure(s): 1r75_A , 2fe0_A

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0009987	cellular process	1	2
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044000	movement in host	4	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044409	entry into host	5	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0044782	cilium organization	5	1
GO:0051701	biological process involved in interaction with host	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.313
CLV_NRD_NRD_1	126	128	PF00675	0.482
CLV_PCSK_KEX2_1	126	128	PF00082	0.501
CLV_PCSK_KEX2_1	131	133	PF00082	0.549
CLV_PCSK_KEX2_1	55	57	PF00082	0.524
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.556
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.504
CLV_PCSK_PC7_1	127	133	PF00082	0.490
CLV_PCSK_SKI1_1	132	136	PF00082	0.627
DOC_MAPK_gen_1	55	63	PF00069	0.455
DOC_MAPK_MEF2A_6	56	65	PF00069	0.452
DOC_PP1_RVXF_1	60	66	PF00149	0.436
DOC_USP7_UBL2_3	124	128	PF12436	0.543
DOC_USP7_UBL2_3	131	135	PF12436	0.584
LIG_APCC_ABBA_1	27	32	PF00400	0.493
LIG_APCC_ABBAyCdc20_2	26	32	PF00400	0.278
LIG_BRCT_BRCA1_1	46	50	PF00533	0.267
LIG_LIR_Apic_2	11	17	PF02991	0.574
LIG_LIR_Nem_3	47	51	PF02991	0.408
LIG_PCNA_yPIPBox_3	111	124	PF02747	0.379
LIG_PCNA_yPIPBox_3	33	41	PF02747	0.483
LIG_SH2_CRK	14	18	PF00017	0.547
LIG_SH2_STAP1	23	27	PF00017	0.465
LIG_SH2_STAT5	79	82	PF00017	0.429
MOD_CK1_1	15	21	PF00069	0.642
MOD_GlcNHglycan	14	17	PF01048	0.455
MOD_N-GLC_1	44	49	PF02516	0.414
MOD_N-GLC_2	52	54	PF02516	0.267
MOD_NEK2_1	12	17	PF00069	0.480
MOD_NEK2_1	147	152	PF00069	0.547
MOD_NEK2_1	75	80	PF00069	0.416
MOD_NMyristoyl	1	7	PF02799	0.659
MOD_PKA_2	12	18	PF00069	0.612
MOD_Plk_4	109	115	PF00069	0.473
MOD_Plk_4	75	81	PF00069	0.355
MOD_Plk_4	89	95	PF00069	0.376
MOD_SUMO_rev_2	125	133	PF00179	0.612
MOD_SUMO_rev_2	19	28	PF00179	0.270
MOD_SUMO_rev_2	47	57	PF00179	0.525
TRG_DiLeu_BaEn_1	32	37	PF01217	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y3	Leptomonas seymouri	41%	100%
A0A0N1HYV4	Leptomonas seymouri	42%	100%
A0A0N1I5S6	Leptomonas seymouri	72%	99%
A0A0N1PCZ0	Leptomonas seymouri	40%	100%
A0A0N1PE11	Leptomonas seymouri	34%	100%
A0A1X0NW79	Trypanosomatidae	47%	77%
A0A1X0NW95	Trypanosomatidae	43%	100%
A0A1X0NWH2	Trypanosomatidae	33%	100%
A0A1X0NWV3	Trypanosomatidae	47%	100%
A0A1X0NXT9	Trypanosomatidae	34%	100%
A0A1X0NYV3	Trypanosomatidae	41%	100%
A0A3Q8I9V9	Leishmania donovani	38%	100%
A0A3Q8IBM6	Leishmania donovani	31%	100%
A0A3Q8IDP8	Leishmania donovani	97%	100%
A0A3Q8IKN9	Leishmania donovani	41%	100%
A0A3S7WW23	Leishmania donovani	44%	100%
A0A3S7WZ86	Leishmania donovani	33%	100%
A0A422MSY8	Trypanosoma rangeli	45%	90%
A0A422MUY0	Trypanosoma rangeli	49%	100%
A4H7N9	Leishmania braziliensis	37%	100%
A4H7P0	Leishmania braziliensis	37%	100%
A4HEG7	Leishmania braziliensis	34%	100%
A4HW29	Leishmania infantum	38%	100%
A4HYW6	Leishmania infantum	31%	100%
A4HYX1	Leishmania infantum	97%	100%
A4HYX3	Leishmania infantum	44%	100%
A4HYX4	Leishmania infantum	41%	100%
A4I1M3	Leishmania infantum	33%	100%
E9AIH7	Leishmania braziliensis	37%	100%
E9AII3	Leishmania braziliensis	81%	100%
E9AII5	Leishmania braziliensis	42%	100%
E9AII6	Leishmania braziliensis	41%	100%
E9APT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AUR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AUS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AUS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AXQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
P84150	Leishmania major	32%	100%
Q4Q9R4	Leishmania major	35%	100%
Q4QFP8	Leishmania major	38%	100%
Q5SDH4	Leishmania major	44%	100%
Q5SDH5	Leishmania major	40%	100%