LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

UDP-galactose transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
UDP-galactose transporter
Gene product:
UDP-galactose transporter
Species:
Leishmania major
UniProt:
Q5QHQ6_LEIMA
TriTrypDb:
LmjF.18.0400 , LMJLV39_180009400 , LMJSD75_180009300 *
Length:
561

Annotations

LeishMANIAdb annotations

Homologous to animal UDP-N-acetylglucosamine, UDP-galactose and CMP-sialic acid transporters. Only expanded in the Leptomonas lineage. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 7
GO:0005737 cytoplasm 2 2
GO:0016020 membrane 2 7
GO:0031090 organelle membrane 3 7
GO:0098588 bounding membrane of organelle 4 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

Q5QHQ6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q5QHQ6

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0006811 monoatomic ion transport 4 2
GO:0006820 monoatomic anion transport 5 2
GO:0009987 cellular process 1 2
GO:0015711 organic anion transport 5 2
GO:0015780 nucleotide-sugar transmembrane transport 3 2
GO:0015931 nucleobase-containing compound transport 5 2
GO:0034220 monoatomic ion transmembrane transport 3 2
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 2
GO:0071702 organic substance transport 4 3
GO:0071705 nitrogen compound transport 4 2
GO:0072334 UDP-galactose transmembrane transport 5 2
GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 4 2
GO:0098656 monoatomic anion transmembrane transport 4 2
GO:1901264 carbohydrate derivative transport 5 2
GO:0008643 carbohydrate transport 5 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 7
GO:0005338 nucleotide-sugar transmembrane transporter activity 4 7
GO:0005459 UDP-galactose transmembrane transporter activity 6 2
GO:0015136 sialic acid transmembrane transporter activity 4 2
GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 5 7
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 7
GO:0022857 transmembrane transporter activity 2 7
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 284 288 PF00656 0.346
CLV_MEL_PAP_1 27 33 PF00089 0.308
CLV_NRD_NRD_1 108 110 PF00675 0.475
CLV_NRD_NRD_1 154 156 PF00675 0.459
CLV_NRD_NRD_1 231 233 PF00675 0.493
CLV_NRD_NRD_1 240 242 PF00675 0.358
CLV_NRD_NRD_1 311 313 PF00675 0.333
CLV_NRD_NRD_1 32 34 PF00675 0.330
CLV_NRD_NRD_1 73 75 PF00675 0.386
CLV_PCSK_KEX2_1 154 156 PF00082 0.459
CLV_PCSK_KEX2_1 233 235 PF00082 0.485
CLV_PCSK_KEX2_1 240 242 PF00082 0.375
CLV_PCSK_KEX2_1 259 261 PF00082 0.204
CLV_PCSK_KEX2_1 73 75 PF00082 0.386
CLV_PCSK_PC1ET2_1 233 235 PF00082 0.404
CLV_PCSK_PC1ET2_1 259 261 PF00082 0.346
CLV_PCSK_SKI1_1 234 238 PF00082 0.466
CLV_PCSK_SKI1_1 240 244 PF00082 0.349
CLV_PCSK_SKI1_1 402 406 PF00082 0.346
CLV_PCSK_SKI1_1 474 478 PF00082 0.563
DEG_SPOP_SBC_1 404 408 PF00917 0.539
DOC_CYCLIN_yClb1_LxF_4 275 281 PF00134 0.411
DOC_CYCLIN_yCln2_LP_2 265 271 PF00134 0.389
DOC_MAPK_gen_1 259 267 PF00069 0.526
DOC_MAPK_MEF2A_6 259 267 PF00069 0.533
DOC_MAPK_MEF2A_6 405 413 PF00069 0.546
DOC_MAPK_MEF2A_6 533 540 PF00069 0.252
DOC_MAPK_MEF2A_6 55 62 PF00069 0.546
DOC_MAPK_MEF2A_6 88 96 PF00069 0.699
DOC_MAPK_NFAT4_5 260 268 PF00069 0.546
DOC_MAPK_NFAT4_5 533 541 PF00069 0.252
DOC_MAPK_NFAT4_5 55 63 PF00069 0.530
DOC_PP1_RVXF_1 446 452 PF00149 0.405
DOC_PP2B_LxvP_1 265 268 PF13499 0.411
DOC_PP2B_LxvP_1 334 337 PF13499 0.436
DOC_PP4_FxxP_1 421 424 PF00568 0.411
DOC_PP4_FxxP_1 454 457 PF00568 0.346
DOC_USP7_MATH_1 11 15 PF00917 0.375
DOC_USP7_MATH_1 337 341 PF00917 0.319
DOC_USP7_MATH_1 426 430 PF00917 0.402
DOC_USP7_MATH_1 76 80 PF00917 0.671
DOC_WW_Pin1_4 132 137 PF00397 0.767
DOC_WW_Pin1_4 312 317 PF00397 0.530
DOC_WW_Pin1_4 405 410 PF00397 0.539
DOC_WW_Pin1_4 452 457 PF00397 0.305
LIG_14-3-3_CanoR_1 232 237 PF00244 0.706
LIG_14-3-3_CanoR_1 240 246 PF00244 0.473
LIG_14-3-3_CanoR_1 33 37 PF00244 0.452
LIG_14-3-3_CanoR_1 338 344 PF00244 0.280
LIG_BIR_II_1 1 5 PF00653 0.517
LIG_BIR_III_4 165 169 PF00653 0.783
LIG_BRCT_BRCA1_1 396 400 PF00533 0.436
LIG_BRCT_BRCA1_1 536 540 PF00533 0.485
LIG_BRCT_BRCA1_1 550 554 PF00533 0.309
LIG_BRCT_BRCA1_2 396 402 PF00533 0.436
LIG_eIF4E_1 42 48 PF01652 0.546
LIG_FHA_1 140 146 PF00498 0.767
LIG_FHA_1 260 266 PF00498 0.546
LIG_FHA_1 295 301 PF00498 0.369
LIG_FHA_1 324 330 PF00498 0.411
LIG_FHA_1 339 345 PF00498 0.325
LIG_FHA_1 353 359 PF00498 0.334
LIG_FHA_1 408 414 PF00498 0.530
LIG_FHA_1 42 48 PF00498 0.546
LIG_FHA_1 485 491 PF00498 0.411
LIG_FHA_2 197 203 PF00498 0.686
LIG_LIR_Apic_2 419 424 PF02991 0.411
LIG_LIR_Gen_1 247 257 PF02991 0.496
LIG_LIR_Gen_1 392 403 PF02991 0.436
LIG_LIR_Gen_1 487 496 PF02991 0.411
LIG_LIR_Gen_1 551 559 PF02991 0.493
LIG_LIR_LC3C_4 14 17 PF02991 0.428
LIG_LIR_LC3C_4 23 27 PF02991 0.400
LIG_LIR_Nem_3 235 239 PF02991 0.687
LIG_LIR_Nem_3 392 398 PF02991 0.411
LIG_LIR_Nem_3 487 491 PF02991 0.350
LIG_LIR_Nem_3 551 557 PF02991 0.479
LIG_LIR_Nem_3 66 72 PF02991 0.642
LIG_MLH1_MIPbox_1 396 400 PF16413 0.436
LIG_NRBOX 495 501 PF00104 0.358
LIG_NRP_CendR_1 560 561 PF00754 0.517
LIG_PCNA_PIPBox_1 242 251 PF02747 0.536
LIG_Pex14_1 488 492 PF04695 0.389
LIG_Pex14_2 266 270 PF04695 0.513
LIG_Rb_pABgroove_1 182 190 PF01858 0.648
LIG_REV1ctd_RIR_1 234 245 PF16727 0.479
LIG_REV1ctd_RIR_1 475 485 PF16727 0.336
LIG_SH2_CRK 395 399 PF00017 0.411
LIG_SH2_CRK 440 444 PF00017 0.363
LIG_SH2_CRK 470 474 PF00017 0.310
LIG_SH2_NCK_1 395 399 PF00017 0.436
LIG_SH2_NCK_1 440 444 PF00017 0.419
LIG_SH2_STAP1 395 399 PF00017 0.436
LIG_SH2_STAP1 482 486 PF00017 0.330
LIG_SH2_STAP1 507 511 PF00017 0.546
LIG_SH2_STAP1 534 538 PF00017 0.252
LIG_SH2_STAT5 197 200 PF00017 0.712
LIG_SH2_STAT5 249 252 PF00017 0.584
LIG_SH2_STAT5 399 402 PF00017 0.546
LIG_SH2_STAT5 470 473 PF00017 0.338
LIG_SH3_3 134 140 PF00018 0.741
LIG_SH3_3 164 170 PF00018 0.782
LIG_SH3_3 189 195 PF00018 0.650
LIG_SH3_3 222 228 PF00018 0.748
LIG_SH3_3 469 475 PF00018 0.330
LIG_SUMO_SIM_anti_2 14 20 PF11976 0.410
LIG_SUMO_SIM_anti_2 23 29 PF11976 0.409
LIG_SUMO_SIM_anti_2 517 524 PF11976 0.389
LIG_SUMO_SIM_anti_2 93 98 PF11976 0.696
LIG_SUMO_SIM_par_1 23 29 PF11976 0.411
LIG_SUMO_SIM_par_1 321 326 PF11976 0.402
LIG_SUMO_SIM_par_1 95 103 PF11976 0.705
LIG_TRAF2_1 123 126 PF00917 0.765
LIG_UBA3_1 499 506 PF00899 0.389
LIG_WRC_WIRS_1 554 559 PF05994 0.518
MOD_CK1_1 135 141 PF00069 0.753
MOD_CK1_1 146 152 PF00069 0.680
MOD_CK1_1 251 257 PF00069 0.536
MOD_CK1_1 32 38 PF00069 0.452
MOD_CK1_1 321 327 PF00069 0.308
MOD_CK1_1 375 381 PF00069 0.373
MOD_CK1_1 389 395 PF00069 0.393
MOD_Cter_Amidation 310 313 PF01082 0.363
MOD_GlcNHglycan 148 151 PF01048 0.583
MOD_GlcNHglycan 207 210 PF01048 0.619
MOD_GlcNHglycan 253 256 PF01048 0.363
MOD_GlcNHglycan 377 380 PF01048 0.486
MOD_GlcNHglycan 388 391 PF01048 0.371
MOD_GlcNHglycan 523 526 PF01048 0.411
MOD_GlcNHglycan 528 531 PF01048 0.411
MOD_GSK3_1 131 138 PF00069 0.770
MOD_GSK3_1 139 146 PF00069 0.721
MOD_GSK3_1 171 178 PF00069 0.773
MOD_GSK3_1 244 251 PF00069 0.520
MOD_GSK3_1 294 301 PF00069 0.431
MOD_GSK3_1 386 393 PF00069 0.392
MOD_GSK3_1 403 410 PF00069 0.546
MOD_N-GLC_1 146 151 PF02516 0.503
MOD_N-GLC_1 205 210 PF02516 0.501
MOD_NEK2_1 143 148 PF00069 0.756
MOD_NEK2_1 248 253 PF00069 0.525
MOD_NEK2_1 299 304 PF00069 0.411
MOD_NEK2_1 343 348 PF00069 0.299
MOD_NEK2_1 352 357 PF00069 0.319
MOD_NEK2_1 391 396 PF00069 0.411
MOD_NEK2_1 526 531 PF00069 0.411
MOD_NEK2_2 409 414 PF00069 0.546
MOD_PIKK_1 292 298 PF00454 0.411
MOD_PK_1 100 106 PF00069 0.638
MOD_PKA_1 232 238 PF00069 0.597
MOD_PKA_1 259 265 PF00069 0.546
MOD_PKA_2 259 265 PF00069 0.546
MOD_PKA_2 29 35 PF00069 0.546
MOD_PKA_2 337 343 PF00069 0.319
MOD_PKA_2 375 381 PF00069 0.252
MOD_Plk_1 100 106 PF00069 0.650
MOD_Plk_1 534 540 PF00069 0.252
MOD_Plk_4 11 17 PF00069 0.401
MOD_Plk_4 20 26 PF00069 0.423
MOD_Plk_4 244 250 PF00069 0.508
MOD_Plk_4 253 259 PF00069 0.500
MOD_Plk_4 318 324 PF00069 0.381
MOD_Plk_4 394 400 PF00069 0.413
MOD_Plk_4 416 422 PF00069 0.400
MOD_Plk_4 426 432 PF00069 0.411
MOD_Plk_4 43 49 PF00069 0.546
MOD_ProDKin_1 132 138 PF00069 0.767
MOD_ProDKin_1 312 318 PF00069 0.530
MOD_ProDKin_1 405 411 PF00069 0.539
MOD_ProDKin_1 452 458 PF00069 0.305
MOD_SUMO_rev_2 102 111 PF00179 0.657
TRG_DiLeu_BaEn_1 93 98 PF01217 0.696
TRG_ENDOCYTIC_2 239 242 PF00928 0.546
TRG_ENDOCYTIC_2 249 252 PF00928 0.545
TRG_ENDOCYTIC_2 395 398 PF00928 0.411
TRG_ENDOCYTIC_2 440 443 PF00928 0.363
TRG_ENDOCYTIC_2 470 473 PF00928 0.328
TRG_ENDOCYTIC_2 482 485 PF00928 0.399
TRG_ER_diArg_1 153 155 PF00400 0.658
TRG_ER_diArg_1 231 234 PF00400 0.682
TRG_ER_diArg_1 239 241 PF00400 0.574
TRG_ER_diArg_1 72 74 PF00400 0.582
TRG_NES_CRM1_1 51 66 PF08389 0.619
TRG_NLS_MonoExtN_4 230 236 PF00514 0.607

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVQ8 Leptomonas seymouri 52% 100%
A0A3S7WUS3 Leishmania donovani 85% 100%
A4H9E4 Leishmania braziliensis 62% 100%
A4HXR5 Leishmania infantum 86% 100%
E9ARH7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS