UDP-galactopyranose mutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-galactopyranose mutase

Species:

Leishmania major

UniProt:

Q5EEK0_LEIMA

TriTrypDb:

LmjF.18.0200 , LMJLV39_180007400 , LMJSD75_180007300

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q5EEK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q5EEK0

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006778	porphyrin-containing compound metabolic process	5	2
GO:0006779	porphyrin-containing compound biosynthetic process	6	2
GO:0006783	heme biosynthetic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0033013	tetrapyrrole metabolic process	4	2
GO:0033014	tetrapyrrole biosynthetic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0042168	heme metabolic process	3	2
GO:0042440	pigment metabolic process	2	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046148	pigment biosynthetic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004729	oxygen-dependent protoporphyrinogen oxidase activity	5	2
GO:0008767	UDP-galactopyranose mutase activity	4	7
GO:0016491	oxidoreductase activity	2	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	2
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	2
GO:0016853	isomerase activity	2	7
GO:0016866	intramolecular transferase activity	3	7
GO:0070818	protoporphyrinogen oxidase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	478	480	PF00675	0.476
CLV_PCSK_KEX2_1	192	194	PF00082	0.441
CLV_PCSK_KEX2_1	478	480	PF00082	0.476
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.427
CLV_PCSK_SKI1_1	244	248	PF00082	0.312
CLV_PCSK_SKI1_1	383	387	PF00082	0.350
CLV_PCSK_SKI1_1	44	48	PF00082	0.268
CLV_PCSK_SKI1_1	50	54	PF00082	0.237
DEG_SPOP_SBC_1	301	305	PF00917	0.316
DOC_ANK_TNKS_1	141	148	PF00023	0.316
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.206
DOC_MAPK_FxFP_2	204	207	PF00069	0.273
DOC_MAPK_gen_1	184	191	PF00069	0.406
DOC_MAPK_gen_1	403	410	PF00069	0.453
DOC_MAPK_MEF2A_6	159	167	PF00069	0.352
DOC_MAPK_RevD_3	178	193	PF00069	0.296
DOC_PP2B_LxvP_1	288	291	PF13499	0.273
DOC_PP4_FxxP_1	152	155	PF00568	0.273
DOC_PP4_FxxP_1	204	207	PF00568	0.273
DOC_USP7_MATH_1	123	127	PF00917	0.206
DOC_USP7_MATH_1	258	262	PF00917	0.412
DOC_USP7_MATH_1	283	287	PF00917	0.397
DOC_USP7_MATH_1	98	102	PF00917	0.341
DOC_USP7_UBL2_3	217	221	PF12436	0.407
LIG_14-3-3_CanoR_1	383	388	PF00244	0.319
LIG_14-3-3_CanoR_1	483	487	PF00244	0.504
LIG_Actin_WH2_2	13	28	PF00022	0.273
LIG_Actin_WH2_2	367	385	PF00022	0.436
LIG_BIR_II_1	1	5	PF00653	0.503
LIG_BRCT_BRCA1_1	140	144	PF00533	0.393
LIG_CSL_BTD_1	93	96	PF09270	0.352
LIG_CtBP_PxDLS_1	317	321	PF00389	0.273
LIG_deltaCOP1_diTrp_1	194	204	PF00928	0.273
LIG_deltaCOP1_diTrp_1	85	94	PF00928	0.296
LIG_FHA_1	168	174	PF00498	0.268
LIG_FHA_1	210	216	PF00498	0.291
LIG_FHA_1	241	247	PF00498	0.406
LIG_FHA_1	260	266	PF00498	0.406
LIG_FHA_1	303	309	PF00498	0.273
LIG_FHA_1	382	388	PF00498	0.460
LIG_FHA_2	371	377	PF00498	0.320
LIG_FHA_2	462	468	PF00498	0.440
LIG_IRF3_LxIS_1	71	77	PF10401	0.341
LIG_LIR_Apic_2	150	155	PF02991	0.265
LIG_LIR_Apic_2	203	207	PF02991	0.273
LIG_LIR_Gen_1	255	264	PF02991	0.278
LIG_LIR_Gen_1	322	333	PF02991	0.273
LIG_LIR_Gen_1	351	360	PF02991	0.302
LIG_LIR_Gen_1	396	406	PF02991	0.473
LIG_LIR_Gen_1	63	72	PF02991	0.273
LIG_LIR_Gen_1	77	85	PF02991	0.273
LIG_LIR_Nem_3	255	259	PF02991	0.278
LIG_LIR_Nem_3	322	328	PF02991	0.273
LIG_LIR_Nem_3	339	344	PF02991	0.273
LIG_LIR_Nem_3	351	357	PF02991	0.297
LIG_LIR_Nem_3	426	431	PF02991	0.460
LIG_LIR_Nem_3	63	68	PF02991	0.273
LIG_LIR_Nem_3	77	82	PF02991	0.273
LIG_LIR_Nem_3	91	97	PF02991	0.250
LIG_MAD2	5	13	PF02301	0.319
LIG_SH2_CRK	256	260	PF00017	0.292
LIG_SH2_CRK	366	370	PF00017	0.281
LIG_SH2_NCK_1	441	445	PF00017	0.397
LIG_SH2_STAP1	256	260	PF00017	0.273
LIG_SH2_STAT3	97	100	PF00017	0.273
LIG_SH2_STAT5	139	142	PF00017	0.376
LIG_SH2_STAT5	327	330	PF00017	0.273
LIG_SH2_STAT5	67	70	PF00017	0.273
LIG_SH3_3	124	130	PF00018	0.206
LIG_SH3_3	466	472	PF00018	0.379
LIG_SH3_3	92	98	PF00018	0.275
LIG_SUMO_SIM_anti_2	384	389	PF11976	0.228
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.244
LIG_SUMO_SIM_par_1	355	361	PF11976	0.273
LIG_TYR_ITIM	254	259	PF00017	0.273
LIG_TYR_ITIM	364	369	PF00017	0.296
LIG_UBA3_1	22	26	PF00899	0.319
LIG_UBA3_1	307	313	PF00899	0.341
MOD_CK1_1	209	215	PF00069	0.362
MOD_CK2_1	370	376	PF00069	0.322
MOD_GlcNHglycan	1	4	PF01048	0.511
MOD_GlcNHglycan	208	211	PF01048	0.402
MOD_GlcNHglycan	283	286	PF01048	0.409
MOD_GlcNHglycan	90	93	PF01048	0.386
MOD_GSK3_1	240	247	PF00069	0.445
MOD_GSK3_1	279	286	PF00069	0.417
MOD_GSK3_1	461	468	PF00069	0.410
MOD_GSK3_1	482	489	PF00069	0.509
MOD_GSK3_1	74	81	PF00069	0.341
MOD_N-GLC_1	200	205	PF02516	0.282
MOD_NEK2_1	259	264	PF00069	0.282
MOD_NEK2_1	300	305	PF00069	0.273
MOD_NEK2_1	358	363	PF00069	0.341
MOD_NEK2_1	42	47	PF00069	0.288
MOD_NEK2_1	482	487	PF00069	0.425
MOD_NEK2_2	200	205	PF00069	0.319
MOD_NEK2_2	336	341	PF00069	0.273
MOD_PIKK_1	358	364	PF00454	0.393
MOD_PKA_2	110	116	PF00069	0.455
MOD_PKA_2	234	240	PF00069	0.365
MOD_PKA_2	336	342	PF00069	0.273
MOD_PKA_2	482	488	PF00069	0.511
MOD_PKA_2	83	89	PF00069	0.273
MOD_Plk_1	200	206	PF00069	0.273
MOD_Plk_1	446	452	PF00069	0.310
MOD_Plk_1	465	471	PF00069	0.369
MOD_Plk_2-3	252	258	PF00069	0.316
MOD_Plk_4	336	342	PF00069	0.273
MOD_Plk_4	370	376	PF00069	0.285
MOD_Plk_4	383	389	PF00069	0.249
MOD_Plk_4	446	452	PF00069	0.310
MOD_Plk_4	83	89	PF00069	0.273
MOD_SUMO_rev_2	43	52	PF00179	0.279
TRG_ENDOCYTIC_2	216	219	PF00928	0.338
TRG_ENDOCYTIC_2	256	259	PF00928	0.273
TRG_ENDOCYTIC_2	366	369	PF00928	0.273
TRG_ENDOCYTIC_2	65	68	PF00928	0.273
TRG_ER_diArg_1	291	294	PF00400	0.341
TRG_ER_diArg_1	433	436	PF00400	0.307
TRG_NES_CRM1_1	377	391	PF08389	0.335
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0X8	Leptomonas seymouri	74%	100%
A0A0S4J0D0	Bodo saltans	53%	100%
A0A1X0P6P6	Trypanosomatidae	59%	100%
A0A3S5H724	Leishmania donovani	96%	100%
A0A422NWN4	Trypanosoma rangeli	61%	100%
A4H9C5	Leishmania braziliensis	86%	100%
A4HXP6	Leishmania infantum	96%	100%
E9ARF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BLY6	Trypanosoma cruzi	60%	100%