Putative amino acid permease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Polyamine transporter 1

Species:

Leishmania major

UniProt:

Q5C8V6_LEIMA

TriTrypDb:

LmjF.14.0320 , LMJLV39_140008300 , LMJSD75_140008300

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q5C8V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q5C8V6

Function

Biological processes
Term	Name	Level	Count
GO:0000296	spermine transport	6	2
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0009987	cellular process	1	2
GO:0015695	organic cation transport	5	2
GO:0015846	polyamine transport	5	2
GO:0015847	putrescine transport	6	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0098655	monoatomic cation transmembrane transport	4	2
GO:1902047	polyamine transmembrane transport	3	2
GO:1903710	spermine transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015101	organic cation transmembrane transporter activity	5	2
GO:0015203	polyamine transmembrane transporter activity	3	9
GO:0015489	putrescine transmembrane transporter activity	4	2
GO:0015606	spermidine transmembrane transporter activity	4	2
GO:0022857	transmembrane transporter activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	552	556	PF00656	0.706
CLV_C14_Caspase3-7	616	620	PF00656	0.655
CLV_NRD_NRD_1	304	306	PF00675	0.306
CLV_NRD_NRD_1	61	63	PF00675	0.434
CLV_NRD_NRD_1	73	75	PF00675	0.357
CLV_NRD_NRD_1	793	795	PF00675	0.581
CLV_NRD_NRD_1	80	82	PF00675	0.467
CLV_NRD_NRD_1	86	88	PF00675	0.390
CLV_PCSK_FUR_1	59	63	PF00082	0.482
CLV_PCSK_KEX2_1	304	306	PF00082	0.245
CLV_PCSK_KEX2_1	61	63	PF00082	0.423
CLV_PCSK_KEX2_1	73	75	PF00082	0.362
CLV_PCSK_KEX2_1	80	82	PF00082	0.337
CLV_PCSK_KEX2_1	86	88	PF00082	0.390
CLV_PCSK_SKI1_1	264	268	PF00082	0.271
CLV_PCSK_SKI1_1	304	308	PF00082	0.313
CLV_PCSK_SKI1_1	360	364	PF00082	0.504
CLV_PCSK_SKI1_1	447	451	PF00082	0.268
CLV_PCSK_SKI1_1	48	52	PF00082	0.413
DEG_APCC_DBOX_1	94	102	PF00400	0.504
DEG_Nend_UBRbox_1	1	4	PF02207	0.739
DEG_ODPH_VHL_1	209	222	PF01847	0.261
DEG_SPOP_SBC_1	234	238	PF00917	0.276
DEG_SPOP_SBC_1	742	746	PF00917	0.659
DOC_CKS1_1	410	415	PF01111	0.268
DOC_CYCLIN_RxL_1	444	454	PF00134	0.268
DOC_CYCLIN_yCln2_LP_2	410	416	PF00134	0.360
DOC_CYCLIN_yCln2_LP_2	465	471	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	482	488	PF00134	0.268
DOC_CYCLIN_yCln2_LP_2	583	589	PF00134	0.615
DOC_MAPK_DCC_7	409	419	PF00069	0.360
DOC_MAPK_gen_1	56	66	PF00069	0.693
DOC_MAPK_JIP1_4	467	473	PF00069	0.471
DOC_MAPK_MEF2A_6	264	271	PF00069	0.471
DOC_MAPK_MEF2A_6	309	316	PF00069	0.462
DOC_MAPK_MEF2A_6	59	68	PF00069	0.674
DOC_MAPK_NFAT4_5	309	317	PF00069	0.445
DOC_PP1_RVXF_1	270	277	PF00149	0.503
DOC_PP2B_LxvP_1	583	586	PF13499	0.653
DOC_PP2B_LxvP_1	587	590	PF13499	0.634
DOC_PP2B_LxvP_1	759	762	PF13499	0.705
DOC_PP2B_PxIxI_1	414	420	PF00149	0.360
DOC_USP7_MATH_1	155	159	PF00917	0.438
DOC_USP7_MATH_1	172	176	PF00917	0.438
DOC_USP7_MATH_1	328	332	PF00917	0.268
DOC_USP7_MATH_1	497	501	PF00917	0.246
DOC_USP7_MATH_1	549	553	PF00917	0.628
DOC_USP7_MATH_1	592	596	PF00917	0.710
DOC_USP7_MATH_1	599	603	PF00917	0.733
DOC_USP7_MATH_1	620	624	PF00917	0.713
DOC_USP7_MATH_1	655	659	PF00917	0.666
DOC_USP7_MATH_1	665	669	PF00917	0.599
DOC_USP7_MATH_1	700	704	PF00917	0.698
DOC_USP7_MATH_1	708	712	PF00917	0.664
DOC_USP7_MATH_1	724	728	PF00917	0.697
DOC_USP7_MATH_1	763	767	PF00917	0.796
DOC_WW_Pin1_4	409	414	PF00397	0.268
DOC_WW_Pin1_4	661	666	PF00397	0.720
DOC_WW_Pin1_4	719	724	PF00397	0.747
DOC_WW_Pin1_4	743	748	PF00397	0.736
DOC_WW_Pin1_4	750	755	PF00397	0.691
DOC_WW_Pin1_4	769	774	PF00397	0.724
DOC_WW_Pin1_4	778	783	PF00397	0.705
LIG_14-3-3_CanoR_1	612	621	PF00244	0.683
LIG_14-3-3_CanoR_1	95	104	PF00244	0.471
LIG_Actin_WH2_2	57	75	PF00022	0.658
LIG_APCC_ABBAyCdc20_2	264	270	PF00400	0.471
LIG_BIR_III_4	619	623	PF00653	0.683
LIG_BRCT_BRCA1_1	258	262	PF00533	0.471
LIG_BRCT_BRCA1_1	429	433	PF00533	0.249
LIG_deltaCOP1_diTrp_1	357	364	PF00928	0.283
LIG_eIF4E_1	444	450	PF01652	0.268
LIG_FHA_1	128	134	PF00498	0.268
LIG_FHA_1	180	186	PF00498	0.461
LIG_FHA_1	380	386	PF00498	0.268
LIG_FHA_1	432	438	PF00498	0.363
LIG_FHA_1	475	481	PF00498	0.474
LIG_FHA_1	669	675	PF00498	0.672
LIG_FHA_1	73	79	PF00498	0.585
LIG_FHA_1	783	789	PF00498	0.679
LIG_FHA_1	98	104	PF00498	0.360
LIG_FHA_2	614	620	PF00498	0.667
LIG_FHA_2	720	726	PF00498	0.683
LIG_LIR_Gen_1	175	184	PF02991	0.440
LIG_LIR_Gen_1	278	288	PF02991	0.456
LIG_LIR_Gen_1	430	439	PF02991	0.302
LIG_LIR_Gen_1	518	526	PF02991	0.428
LIG_LIR_Nem_3	175	179	PF02991	0.440
LIG_LIR_Nem_3	182	187	PF02991	0.441
LIG_LIR_Nem_3	192	196	PF02991	0.452
LIG_LIR_Nem_3	278	283	PF02991	0.451
LIG_LIR_Nem_3	284	290	PF02991	0.460
LIG_LIR_Nem_3	317	322	PF02991	0.268
LIG_LIR_Nem_3	357	361	PF02991	0.242
LIG_LIR_Nem_3	430	436	PF02991	0.237
LIG_LIR_Nem_3	461	465	PF02991	0.544
LIG_LIR_Nem_3	518	524	PF02991	0.331
LIG_LIR_Nem_3	666	672	PF02991	0.685
LIG_LYPXL_yS_3	193	196	PF13949	0.438
LIG_LYPXL_yS_3	462	465	PF13949	0.504
LIG_MYND_2	747	751	PF01753	0.651
LIG_NRBOX	445	451	PF00104	0.300
LIG_PDZ_Class_1	798	803	PF00595	0.666
LIG_Pex14_1	139	143	PF04695	0.360
LIG_Pex14_1	276	280	PF04695	0.504
LIG_Pex14_2	104	108	PF04695	0.273
LIG_Pex14_2	258	262	PF04695	0.467
LIG_PTB_Apo_2	187	194	PF02174	0.438
LIG_PTB_Phospho_1	187	193	PF10480	0.438
LIG_SH2_CRK	452	456	PF00017	0.268
LIG_SH2_CRK	469	473	PF00017	0.438
LIG_SH2_CRK	521	525	PF00017	0.565
LIG_SH2_GRB2like	287	290	PF00017	0.438
LIG_SH2_NCK_1	287	291	PF00017	0.438
LIG_SH2_NCK_1	469	473	PF00017	0.484
LIG_SH2_PTP2	268	271	PF00017	0.487
LIG_SH2_PTP2	322	325	PF00017	0.360
LIG_SH2_SRC	268	271	PF00017	0.482
LIG_SH2_SRC	287	290	PF00017	0.399
LIG_SH2_STAP1	200	204	PF00017	0.504
LIG_SH2_STAP1	452	456	PF00017	0.268
LIG_SH2_STAT3	200	203	PF00017	0.504
LIG_SH2_STAT3	634	637	PF00017	0.687
LIG_SH2_STAT5	268	271	PF00017	0.487
LIG_SH2_STAT5	319	322	PF00017	0.266
LIG_SH2_STAT5	444	447	PF00017	0.268
LIG_SH2_STAT5	521	524	PF00017	0.495
LIG_SH3_1	794	800	PF00018	0.661
LIG_SH3_3	297	303	PF00018	0.438
LIG_SH3_3	460	466	PF00018	0.427
LIG_SH3_3	478	484	PF00018	0.364
LIG_SH3_3	659	665	PF00018	0.747
LIG_SH3_3	776	782	PF00018	0.631
LIG_SH3_3	793	799	PF00018	0.639
LIG_SUMO_SIM_anti_2	250	256	PF11976	0.360
LIG_SUMO_SIM_anti_2	421	428	PF11976	0.365
LIG_SUMO_SIM_anti_2	477	484	PF11976	0.312
LIG_SUMO_SIM_anti_2	641	650	PF11976	0.610
LIG_SUMO_SIM_par_1	312	318	PF11976	0.368
LIG_SxIP_EBH_1	409	420	PF03271	0.360
LIG_TRAF2_1	565	568	PF00917	0.718
LIG_TRAF2_1	625	628	PF00917	0.688
LIG_TRAF2_1	711	714	PF00917	0.741
LIG_TYR_ITIM	266	271	PF00017	0.487
LIG_TYR_ITIM	450	455	PF00017	0.268
LIG_TYR_ITIM	460	465	PF00017	0.504
LIG_UBA3_1	251	260	PF00899	0.261
LIG_WRC_WIRS_1	173	178	PF05994	0.449
LIG_WRC_WIRS_1	184	189	PF05994	0.421
MOD_CK1_1	281	287	PF00069	0.462
MOD_CK1_1	421	427	PF00069	0.300
MOD_CK1_1	435	441	PF00069	0.300
MOD_CK1_1	474	480	PF00069	0.493
MOD_CK1_1	493	499	PF00069	0.238
MOD_CK1_1	515	521	PF00069	0.296
MOD_CK1_1	556	562	PF00069	0.726
MOD_CK1_1	602	608	PF00069	0.717
MOD_CK1_1	649	655	PF00069	0.698
MOD_CK1_1	664	670	PF00069	0.707
MOD_CK1_1	766	772	PF00069	0.676
MOD_CK1_1	8	14	PF00069	0.796
MOD_CK1_1	97	103	PF00069	0.337
MOD_CK2_1	708	714	PF00069	0.738
MOD_CK2_1	719	725	PF00069	0.734
MOD_DYRK1A_RPxSP_1	771	775	PF00069	0.674
MOD_GlcNHglycan	123	126	PF01048	0.442
MOD_GlcNHglycan	159	162	PF01048	0.238
MOD_GlcNHglycan	330	333	PF01048	0.268
MOD_GlcNHglycan	369	372	PF01048	0.362
MOD_GlcNHglycan	495	498	PF01048	0.503
MOD_GlcNHglycan	514	517	PF01048	0.446
MOD_GlcNHglycan	540	543	PF01048	0.431
MOD_GlcNHglycan	551	554	PF01048	0.446
MOD_GlcNHglycan	555	558	PF01048	0.431
MOD_GlcNHglycan	570	573	PF01048	0.368
MOD_GlcNHglycan	6	10	PF01048	0.518
MOD_GlcNHglycan	649	652	PF01048	0.524
MOD_GlcNHglycan	702	705	PF01048	0.563
MOD_GlcNHglycan	710	713	PF01048	0.513
MOD_GlcNHglycan	714	717	PF01048	0.509
MOD_GlcNHglycan	725	729	PF01048	0.540
MOD_GlcNHglycan	733	736	PF01048	0.540
MOD_GlcNHglycan	776	779	PF01048	0.475
MOD_GlcNHglycan	785	788	PF01048	0.442
MOD_GSK3_1	151	158	PF00069	0.456
MOD_GSK3_1	179	186	PF00069	0.449
MOD_GSK3_1	375	382	PF00069	0.268
MOD_GSK3_1	421	428	PF00069	0.399
MOD_GSK3_1	431	438	PF00069	0.355
MOD_GSK3_1	471	478	PF00069	0.583
MOD_GSK3_1	486	493	PF00069	0.277
MOD_GSK3_1	549	556	PF00069	0.594
MOD_GSK3_1	599	606	PF00069	0.775
MOD_GSK3_1	657	664	PF00069	0.651
MOD_GSK3_1	708	715	PF00069	0.735
MOD_GSK3_1	729	736	PF00069	0.722
MOD_GSK3_1	763	770	PF00069	0.671
MOD_GSK3_1	774	781	PF00069	0.719
MOD_LATS_1	3	9	PF00433	0.659
MOD_N-GLC_1	189	194	PF02516	0.238
MOD_N-GLC_1	553	558	PF02516	0.484
MOD_N-GLC_1	647	652	PF02516	0.538
MOD_N-GLC_1	788	793	PF02516	0.478
MOD_NEK2_1	163	168	PF00069	0.496
MOD_NEK2_1	314	319	PF00069	0.268
MOD_NEK2_1	374	379	PF00069	0.309
MOD_NEK2_1	418	423	PF00069	0.269
MOD_NEK2_1	425	430	PF00069	0.266
MOD_NEK2_1	431	436	PF00069	0.235
MOD_NEK2_1	439	444	PF00069	0.243
MOD_NEK2_1	490	495	PF00069	0.393
MOD_NEK2_1	593	598	PF00069	0.605
MOD_NEK2_1	656	661	PF00069	0.739
MOD_NEK2_1	731	736	PF00069	0.683
MOD_NEK2_1	790	795	PF00069	0.682
MOD_NEK2_2	665	670	PF00069	0.612
MOD_PIKK_1	23	29	PF00454	0.667
MOD_PIKK_1	604	610	PF00454	0.659
MOD_PIKK_1	620	626	PF00454	0.600
MOD_PKA_1	397	403	PF00069	0.438
MOD_PKA_2	568	574	PF00069	0.604
MOD_PKA_2	599	605	PF00069	0.668
MOD_PKA_2	72	78	PF00069	0.616
MOD_PKA_2	94	100	PF00069	0.447
MOD_PKB_1	685	693	PF00069	0.740
MOD_Plk_1	189	195	PF00069	0.438
MOD_Plk_1	431	437	PF00069	0.267
MOD_Plk_1	553	559	PF00069	0.599
MOD_Plk_1	678	684	PF00069	0.690
MOD_Plk_4	172	178	PF00069	0.445
MOD_Plk_4	179	185	PF00069	0.429
MOD_Plk_4	235	241	PF00069	0.399
MOD_Plk_4	250	256	PF00069	0.360
MOD_Plk_4	315	321	PF00069	0.260
MOD_Plk_4	418	424	PF00069	0.273
MOD_Plk_4	432	438	PF00069	0.229
MOD_Plk_4	439	445	PF00069	0.320
MOD_Plk_4	451	457	PF00069	0.192
MOD_Plk_4	490	496	PF00069	0.361
MOD_Plk_4	515	521	PF00069	0.300
MOD_Plk_4	593	599	PF00069	0.629
MOD_ProDKin_1	409	415	PF00069	0.268
MOD_ProDKin_1	661	667	PF00069	0.719
MOD_ProDKin_1	719	725	PF00069	0.747
MOD_ProDKin_1	743	749	PF00069	0.736
MOD_ProDKin_1	750	756	PF00069	0.689
MOD_ProDKin_1	769	775	PF00069	0.722
MOD_ProDKin_1	778	784	PF00069	0.706
MOD_SUMO_rev_2	45	50	PF00179	0.626
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.360
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.289
TRG_ENDOCYTIC_2	193	196	PF00928	0.461
TRG_ENDOCYTIC_2	268	271	PF00928	0.482
TRG_ENDOCYTIC_2	287	290	PF00928	0.399
TRG_ENDOCYTIC_2	361	364	PF00928	0.268
TRG_ENDOCYTIC_2	452	455	PF00928	0.268
TRG_ENDOCYTIC_2	462	465	PF00928	0.515
TRG_ENDOCYTIC_2	521	524	PF00928	0.557
TRG_ER_diArg_1	303	305	PF00400	0.445
TRG_ER_diArg_1	58	61	PF00400	0.618
TRG_ER_diArg_1	682	685	PF00400	0.732
TRG_ER_diArg_1	72	74	PF00400	0.564
TRG_ER_diArg_1	79	81	PF00400	0.586
TRG_ER_diArg_1	85	87	PF00400	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U3	Leptomonas seymouri	64%	99%
A0A3R7M6P3	Trypanosoma rangeli	61%	100%
A0A3S7WSV4	Leishmania donovani	95%	100%
A4H7J1	Leishmania braziliensis	78%	100%
A4HVX4	Leishmania infantum	95%	100%
E9APM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DDZ5	Trypanosoma cruzi	60%	100%