Thialysine N6-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetyltransferase-like protein

Species:

Leishmania major

UniProt:

Q53HX3_LEIMA

TriTrypDb:

LmjF.36.2750 , LMJLV39_360036400 , LMJSD75_360036300

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q53HX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q53HX3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008080	N-acetyltransferase activity	6	2
GO:0016407	acetyltransferase activity	5	6
GO:0016410	N-acyltransferase activity	5	2
GO:0016740	transferase activity	2	6
GO:0016746	acyltransferase activity	3	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	9	11	PF00675	0.424
CLV_PCSK_KEX2_1	9	11	PF00082	0.403
CLV_PCSK_SKI1_1	107	111	PF00082	0.342
DOC_CYCLIN_RxL_1	101	111	PF00134	0.420
DOC_CYCLIN_RxL_1	84	93	PF00134	0.317
DOC_MAPK_gen_1	68	76	PF00069	0.331
LIG_14-3-3_CanoR_1	51	61	PF00244	0.303
LIG_14-3-3_CanoR_1	80	85	PF00244	0.314
LIG_BIR_II_1	1	5	PF00653	0.468
LIG_deltaCOP1_diTrp_1	131	139	PF00928	0.290
LIG_deltaCOP1_diTrp_1	148	158	PF00928	0.430
LIG_FHA_1	62	68	PF00498	0.331
LIG_LIR_Apic_2	131	135	PF02991	0.331
LIG_LIR_Nem_3	138	143	PF02991	0.331
LIG_PDZ_Class_2	153	158	PF00595	0.428
LIG_SH2_CRK	20	24	PF00017	0.363
LIG_SH2_NCK_1	29	33	PF00017	0.382
LIG_SH2_STAP1	143	147	PF00017	0.404
LIG_SH2_STAP1	20	24	PF00017	0.363
LIG_SH2_STAT5	90	93	PF00017	0.316
LIG_TRAF2_1	117	120	PF00917	0.338
MOD_GlcNHglycan	1	4	PF01048	0.639
MOD_GlcNHglycan	54	57	PF01048	0.314
MOD_NEK2_2	4	9	PF00069	0.500
MOD_PIKK_1	13	19	PF00454	0.398
MOD_PKA_2	79	85	PF00069	0.314
MOD_SUMO_for_1	117	120	PF00179	0.321
MOD_SUMO_rev_2	60	69	PF00179	0.331
TRG_ENDOCYTIC_2	20	23	PF00928	0.361
TRG_ER_diArg_1	8	10	PF00400	0.412
TRG_ER_diArg_1	84	87	PF00400	0.314
TRG_NES_CRM1_1	17	30	PF08389	0.367
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.189
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE86	Leptomonas seymouri	79%	100%
A0A3Q8IJ73	Leishmania donovani	95%	100%
A4HPE1	Leishmania braziliensis	88%	100%
A4ICI2	Leishmania infantum	96%	100%
O17731	Caenorhabditis elegans	30%	99%
P21673	Homo sapiens	35%	92%
P48026	Mus musculus	35%	92%
P49431	Mus saxicola	35%	92%
P79081	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	94%
Q01612	Mesocricetus auratus	34%	92%
Q28999	Sus scrofa	36%	92%
Q3T0Q0	Bos taurus	36%	92%
Q6P8J2	Mus musculus	34%	93%
Q7PCJ8	Bos taurus	38%	93%
Q7PCJ9	Sus scrofa	37%	93%
Q8AXL1	Gallus gallus	36%	92%
Q96F10	Homo sapiens	36%	93%
Q9JHW6	Cricetulus griseus	34%	92%
Q9ZV05	Arabidopsis thaliana	24%	69%
Q9ZV06	Arabidopsis thaliana	26%	67%