Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peroxisomal targeting signal 2 receptor

Species:

Leishmania major

UniProt:

Q4VQ66_LEIMA

TriTrypDb:

LmjF.29.0740 , LMJLV39_290012800 , LMJSD75_290012800

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005777	peroxisome	6	12
GO:0005782	peroxisomal matrix	6	2
GO:0005829	cytosol	2	2
GO:0005840	ribosome	5	12
GO:0020015	glycosome	7	2
GO:0031907	microbody lumen	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0032991	protein-containing complex	1	12
GO:0042579	microbody	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4VQ66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4VQ66

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006625	protein targeting to peroxisome	5	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006996	organelle organization	4	12
GO:0007031	peroxisome organization	5	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0015919	peroxisomal membrane transport	5	12
GO:0016043	cellular component organization	3	12
GO:0016558	protein import into peroxisome matrix	5	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0043574	peroxisomal transport	4	12
GO:0044743	protein transmembrane import into intracellular organelle	4	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0055085	transmembrane transport	2	12
GO:0065002	intracellular protein transmembrane transport	4	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0071806	protein transmembrane transport	3	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0072594	establishment of protein localization to organelle	4	12
GO:0072662	protein localization to peroxisome	6	12
GO:0072663	establishment of protein localization to peroxisome	5	12

Molecular functions
Term	Name	Level	Count
GO:0000268	peroxisome targeting sequence binding	5	12
GO:0005048	signal sequence binding	4	12
GO:0005053	peroxisome matrix targeting signal-2 binding	6	12
GO:0005488	binding	1	12
GO:0033218	amide binding	2	12
GO:0042277	peptide binding	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	233	235	PF00675	0.425
CLV_NRD_NRD_1	250	252	PF00675	0.254
CLV_PCSK_KEX2_1	233	235	PF00082	0.425
CLV_PCSK_KEX2_1	250	252	PF00082	0.254
CLV_PCSK_SKI1_1	192	196	PF00082	0.454
DEG_APCC_DBOX_1	191	199	PF00400	0.450
DOC_CYCLIN_yClb5_NLxxxL_5	89	98	PF00134	0.435
DOC_PP1_RVXF_1	248	255	PF00149	0.466
DOC_USP7_MATH_1	11	15	PF00917	0.414
DOC_USP7_MATH_1	114	118	PF00917	0.483
DOC_USP7_MATH_1	146	150	PF00917	0.410
DOC_USP7_MATH_1	190	194	PF00917	0.545
DOC_USP7_MATH_1	238	242	PF00917	0.486
DOC_USP7_MATH_1	306	310	PF00917	0.383
DOC_USP7_MATH_1	325	329	PF00917	0.619
DOC_USP7_MATH_1	355	359	PF00917	0.606
DOC_WW_Pin1_4	166	171	PF00397	0.539
DOC_WW_Pin1_4	186	191	PF00397	0.501
DOC_WW_Pin1_4	323	328	PF00397	0.460
DOC_WW_Pin1_4	364	369	PF00397	0.713
DOC_WW_Pin1_4	51	56	PF00397	0.454
LIG_14-3-3_CanoR_1	251	261	PF00244	0.521
LIG_BRCT_BRCA1_1	206	210	PF00533	0.515
LIG_BRCT_BRCA1_1	29	33	PF00533	0.456
LIG_BRCT_BRCA1_1	314	318	PF00533	0.461
LIG_BRCT_BRCA1_2	206	212	PF00533	0.515
LIG_CtBP_PxDLS_1	55	59	PF00389	0.488
LIG_deltaCOP1_diTrp_1	179	185	PF00928	0.454
LIG_FHA_1	21	27	PF00498	0.411
LIG_FHA_1	224	230	PF00498	0.458
LIG_FHA_1	324	330	PF00498	0.633
LIG_FHA_1	346	352	PF00498	0.659
LIG_FHA_2	150	156	PF00498	0.400
LIG_LIR_Gen_1	70	81	PF02991	0.377
LIG_LIR_Nem_3	155	160	PF02991	0.522
LIG_LIR_Nem_3	30	36	PF02991	0.478
LIG_LIR_Nem_3	315	321	PF02991	0.425
LIG_LIR_Nem_3	70	76	PF02991	0.445
LIG_MAD2	349	357	PF02301	0.703
LIG_MLH1_MIPbox_1	314	318	PF16413	0.461
LIG_NRP_CendR_1	370	373	PF00754	0.749
LIG_PCNA_PIPBox_1	150	159	PF02747	0.337
LIG_Pex14_2	69	73	PF04695	0.352
LIG_SH2_CRK	141	145	PF00017	0.465
LIG_SH2_NCK_1	161	165	PF00017	0.540
LIG_SH2_SRC	287	290	PF00017	0.428
LIG_SH2_STAP1	130	134	PF00017	0.428
LIG_SH2_STAP1	267	271	PF00017	0.449
LIG_SH2_STAT5	42	45	PF00017	0.377
LIG_SH3_1	16	22	PF00018	0.421
LIG_SH3_3	16	22	PF00018	0.458
LIG_SH3_3	232	238	PF00018	0.442
LIG_SH3_3	276	282	PF00018	0.430
LIG_SH3_3	324	330	PF00018	0.496
LIG_SH3_3	333	339	PF00018	0.552
LIG_SH3_3	340	346	PF00018	0.625
LIG_SH3_3	354	360	PF00018	0.612
LIG_SH3_3	362	368	PF00018	0.672
LIG_SUMO_SIM_anti_2	54	60	PF11976	0.458
LIG_SUMO_SIM_par_1	204	209	PF11976	0.454
LIG_TRAF2_1	152	155	PF00917	0.473
LIG_WRC_WIRS_1	1	6	PF05994	0.453
LIG_WW_3	339	343	PF00397	0.555
LIG_WW_3	367	371	PF00397	0.603
MOD_CDC14_SPxK_1	189	192	PF00782	0.543
MOD_CDC14_SPxK_1	367	370	PF00782	0.710
MOD_CDK_SPK_2	368	373	PF00069	0.742
MOD_CDK_SPxK_1	186	192	PF00069	0.542
MOD_CDK_SPxK_1	364	370	PF00069	0.708
MOD_CK1_1	117	123	PF00069	0.390
MOD_CK1_1	133	139	PF00069	0.371
MOD_CK1_1	14	20	PF00069	0.520
MOD_CK1_1	149	155	PF00069	0.287
MOD_CK1_1	169	175	PF00069	0.486
MOD_CK1_1	193	199	PF00069	0.326
MOD_CK1_1	328	334	PF00069	0.606
MOD_CK1_1	54	60	PF00069	0.494
MOD_CK2_1	149	155	PF00069	0.402
MOD_CMANNOS	182	185	PF00535	0.254
MOD_GlcNHglycan	122	125	PF01048	0.548
MOD_GlcNHglycan	130	133	PF01048	0.455
MOD_GlcNHglycan	141	144	PF01048	0.261
MOD_GlcNHglycan	176	179	PF01048	0.251
MOD_GlcNHglycan	219	222	PF01048	0.315
MOD_GlcNHglycan	264	267	PF01048	0.245
MOD_GlcNHglycan	308	311	PF01048	0.353
MOD_GlcNHglycan	313	317	PF01048	0.344
MOD_GlcNHglycan	37	40	PF01048	0.380
MOD_GSK3_1	130	137	PF00069	0.363
MOD_GSK3_1	162	169	PF00069	0.540
MOD_GSK3_1	174	181	PF00069	0.466
MOD_GSK3_1	186	193	PF00069	0.432
MOD_GSK3_1	253	260	PF00069	0.504
MOD_GSK3_1	308	315	PF00069	0.391
MOD_GSK3_1	364	371	PF00069	0.736
MOD_N-GLC_1	186	191	PF02516	0.486
MOD_NEK2_1	25	30	PF00069	0.397
MOD_NEK2_1	261	266	PF00069	0.471
MOD_NEK2_1	297	302	PF00069	0.372
MOD_NEK2_1	317	322	PF00069	0.428
MOD_NEK2_1	363	368	PF00069	0.678
MOD_NEK2_1	94	99	PF00069	0.524
MOD_NEK2_2	11	16	PF00069	0.416
MOD_NEK2_2	134	139	PF00069	0.367
MOD_PIKK_1	193	199	PF00454	0.310
MOD_PIKK_1	20	26	PF00454	0.411
MOD_PIKK_1	27	33	PF00454	0.390
MOD_PIKK_1	297	303	PF00454	0.496
MOD_PIKK_1	328	334	PF00454	0.635
MOD_PKA_2	125	131	PF00069	0.432
MOD_PKA_2	252	258	PF00069	0.525
MOD_PKB_1	251	259	PF00069	0.552
MOD_Plk_1	114	120	PF00069	0.480
MOD_Plk_1	134	140	PF00069	0.167
MOD_Plk_1	146	152	PF00069	0.424
MOD_Plk_1	223	229	PF00069	0.472
MOD_Plk_4	125	131	PF00069	0.408
MOD_Plk_4	146	152	PF00069	0.477
MOD_Plk_4	169	175	PF00069	0.466
MOD_Plk_4	257	263	PF00069	0.540
MOD_Plk_4	54	60	PF00069	0.458
MOD_ProDKin_1	166	172	PF00069	0.539
MOD_ProDKin_1	186	192	PF00069	0.507
MOD_ProDKin_1	323	329	PF00069	0.464
MOD_ProDKin_1	364	370	PF00069	0.697
MOD_ProDKin_1	51	57	PF00069	0.453
MOD_SUMO_for_1	144	147	PF00179	0.535
TRG_ENDOCYTIC_2	141	144	PF00928	0.527
TRG_ER_diArg_1	233	235	PF00400	0.427
TRG_ER_diArg_1	250	253	PF00400	0.455
TRG_ER_diArg_1	344	347	PF00400	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM97	Leptomonas seymouri	84%	100%
A0A0S4JHX6	Bodo saltans	52%	92%
A0A1X0P138	Trypanosomatidae	63%	100%
A0A3Q8IF18	Leishmania donovani	96%	100%
A0A3Q8IGC4	Leishmania donovani	25%	71%
A0A422NRU1	Trypanosoma rangeli	67%	100%
A4HDT7	Leishmania braziliensis	25%	71%
A4HH81	Leishmania braziliensis	90%	100%
A4I135	Leishmania infantum	25%	71%
A4I4C7	Leishmania infantum	96%	100%
B4HWV6	Drosophila sechellia	28%	89%
B4JWA1	Drosophila grimshawi	26%	91%
B4Q9T6	Drosophila simulans	28%	89%
C4YFX2	Candida albicans (strain WO-1)	23%	73%
C9ZL39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
D1ZEB4	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	23%	81%
E9AM04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	71%
O00628	Homo sapiens	33%	100%
O59894	Komagataella pastoris	29%	99%
P0CY34	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	73%
P39108	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	99%
P49177	Arabidopsis thaliana	24%	99%
P78798	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P93397	Nicotiana tabacum	24%	99%
P93398	Nicotiana tabacum	24%	99%
P93563	Solanum tuberosum	24%	99%
P97865	Mus musculus	34%	100%
Q17963	Caenorhabditis elegans	24%	99%
Q24572	Drosophila melanogaster	28%	87%
Q2UA71	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	23%	86%
Q40507	Nicotiana tabacum	25%	99%
Q4I7L0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	22%	86%
Q4QAA4	Leishmania major	25%	71%
Q4WEI5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	86%
Q54WA3	Dictyostelium discoideum	35%	100%
Q5E9I7	Bos taurus	25%	100%
Q5RFF8	Pongo abelii	24%	77%
Q6BK34	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	22%	90%
Q6P315	Xenopus tropicalis	29%	88%
Q75C99	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	88%
Q7RY30	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	82%
Q7S7N3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	22%	84%
Q7ZTY4	Danio rerio	28%	88%
Q8AVH1	Xenopus laevis	29%	88%
Q8R537	Cricetulus griseus	34%	100%
Q9BQA1	Homo sapiens	26%	100%
Q9M2Z2	Arabidopsis thaliana	25%	100%
Q9VPR4	Drosophila melanogaster	24%	76%
Q9XF57	Arabidopsis thaliana	37%	100%
V5BQ16	Trypanosoma cruzi	66%	100%