TPR_MLP1_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJK2_LEIMA

TriTrypDb:

LmjF.05.0010 , LMJLV39_050005000 , LMJSD75_050005000

Length:

915

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	2
GO:0000922	spindle pole	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.541
CLV_C14_Caspase3-7	264	268	PF00656	0.569
CLV_C14_Caspase3-7	73	77	PF00656	0.534
CLV_C14_Caspase3-7	909	913	PF00656	0.513
CLV_NRD_NRD_1	322	324	PF00675	0.524
CLV_NRD_NRD_1	363	365	PF00675	0.671
CLV_NRD_NRD_1	45	47	PF00675	0.421
CLV_NRD_NRD_1	620	622	PF00675	0.478
CLV_NRD_NRD_1	741	743	PF00675	0.610
CLV_NRD_NRD_1	756	758	PF00675	0.434
CLV_NRD_NRD_1	782	784	PF00675	0.608
CLV_NRD_NRD_1	802	804	PF00675	0.339
CLV_NRD_NRD_1	825	827	PF00675	0.539
CLV_NRD_NRD_1	97	99	PF00675	0.440
CLV_PCSK_FUR_1	780	784	PF00082	0.472
CLV_PCSK_KEX2_1	269	271	PF00082	0.487
CLV_PCSK_KEX2_1	283	285	PF00082	0.460
CLV_PCSK_KEX2_1	322	324	PF00082	0.617
CLV_PCSK_KEX2_1	45	47	PF00082	0.421
CLV_PCSK_KEX2_1	741	743	PF00082	0.645
CLV_PCSK_KEX2_1	756	758	PF00082	0.434
CLV_PCSK_KEX2_1	769	771	PF00082	0.485
CLV_PCSK_KEX2_1	782	784	PF00082	0.464
CLV_PCSK_KEX2_1	802	804	PF00082	0.436
CLV_PCSK_KEX2_1	825	827	PF00082	0.489
CLV_PCSK_KEX2_1	904	906	PF00082	0.562
CLV_PCSK_KEX2_1	97	99	PF00082	0.530
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.595
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.576
CLV_PCSK_PC1ET2_1	769	771	PF00082	0.591
CLV_PCSK_PC1ET2_1	802	804	PF00082	0.579
CLV_PCSK_PC1ET2_1	904	906	PF00082	0.562
CLV_PCSK_SKI1_1	137	141	PF00082	0.475
CLV_PCSK_SKI1_1	360	364	PF00082	0.525
CLV_PCSK_SKI1_1	414	418	PF00082	0.502
CLV_PCSK_SKI1_1	421	425	PF00082	0.542
CLV_PCSK_SKI1_1	48	52	PF00082	0.519
CLV_PCSK_SKI1_1	588	592	PF00082	0.697
CLV_PCSK_SKI1_1	622	626	PF00082	0.431
CLV_PCSK_SKI1_1	706	710	PF00082	0.514
CLV_PCSK_SKI1_1	729	733	PF00082	0.583
CLV_PCSK_SKI1_1	770	774	PF00082	0.464
CLV_PCSK_SKI1_1	808	812	PF00082	0.432
CLV_PCSK_SKI1_1	83	87	PF00082	0.470
CLV_Separin_Metazoa	618	622	PF03568	0.419
DEG_Nend_UBRbox_2	1	3	PF02207	0.559
DOC_ANK_TNKS_1	74	81	PF00023	0.350
DOC_CDC14_PxL_1	897	905	PF14671	0.669
DOC_MAPK_gen_1	204	211	PF00069	0.544
DOC_MAPK_gen_1	269	277	PF00069	0.449
DOC_MAPK_gen_1	322	328	PF00069	0.515
DOC_MAPK_gen_1	45	51	PF00069	0.449
DOC_MAPK_gen_1	56	67	PF00069	0.438
DOC_MAPK_gen_1	663	671	PF00069	0.502
DOC_MAPK_gen_1	741	751	PF00069	0.463
DOC_MAPK_gen_1	882	890	PF00069	0.606
DOC_MAPK_MEF2A_6	167	174	PF00069	0.460
DOC_MAPK_MEF2A_6	270	279	PF00069	0.471
DOC_MAPK_MEF2A_6	665	673	PF00069	0.611
DOC_PP1_RVXF_1	5	12	PF00149	0.470
DOC_USP7_MATH_1	100	104	PF00917	0.406
DOC_USP7_MATH_1	694	698	PF00917	0.459
DOC_USP7_MATH_1	725	729	PF00917	0.588
DOC_USP7_MATH_1	896	900	PF00917	0.561
DOC_USP7_UBL2_3	136	140	PF12436	0.510
DOC_USP7_UBL2_3	17	21	PF12436	0.438
DOC_USP7_UBL2_3	183	187	PF12436	0.535
DOC_USP7_UBL2_3	3	7	PF12436	0.488
DOC_USP7_UBL2_3	417	421	PF12436	0.344
DOC_USP7_UBL2_3	56	60	PF12436	0.410
DOC_USP7_UBL2_3	769	773	PF12436	0.659
DOC_USP7_UBL2_3	788	792	PF12436	0.385
DOC_USP7_UBL2_3	804	808	PF12436	0.353
DOC_WW_Pin1_4	883	888	PF00397	0.627
LIG_14-3-3_CanoR_1	162	170	PF00244	0.626
LIG_14-3-3_CanoR_1	225	233	PF00244	0.428
LIG_14-3-3_CanoR_1	26	31	PF00244	0.438
LIG_14-3-3_CanoR_1	364	373	PF00244	0.481
LIG_14-3-3_CanoR_1	569	577	PF00244	0.638
LIG_14-3-3_CanoR_1	621	627	PF00244	0.331
LIG_14-3-3_CanoR_1	684	688	PF00244	0.429
LIG_14-3-3_CanoR_1	762	766	PF00244	0.629
LIG_Actin_WH2_2	349	366	PF00022	0.538
LIG_Actin_WH2_2	633	651	PF00022	0.461
LIG_Actin_WH2_2	810	827	PF00022	0.512
LIG_Actin_WH2_2	890	906	PF00022	0.609
LIG_deltaCOP1_diTrp_1	344	347	PF00928	0.573
LIG_deltaCOP1_diTrp_1	498	506	PF00928	0.338
LIG_DLG_GKlike_1	533	541	PF00625	0.350
LIG_FHA_1	148	154	PF00498	0.578
LIG_FHA_1	519	525	PF00498	0.481
LIG_FHA_1	537	543	PF00498	0.441
LIG_FHA_1	56	62	PF00498	0.630
LIG_FHA_1	600	606	PF00498	0.575
LIG_FHA_1	672	678	PF00498	0.470
LIG_FHA_1	746	752	PF00498	0.370
LIG_FHA_1	870	876	PF00498	0.516
LIG_FHA_2	106	112	PF00498	0.569
LIG_FHA_2	225	231	PF00498	0.379
LIG_FHA_2	391	397	PF00498	0.515
LIG_FHA_2	623	629	PF00498	0.462
LIG_FHA_2	773	779	PF00498	0.542
LIG_LIR_Gen_1	346	356	PF02991	0.545
LIG_LIR_Gen_1	489	497	PF02991	0.521
LIG_LIR_Gen_1	764	772	PF02991	0.496
LIG_LIR_Nem_3	346	352	PF02991	0.555
LIG_LIR_Nem_3	489	495	PF02991	0.566
LIG_LIR_Nem_3	764	768	PF02991	0.491
LIG_NRBOX	750	756	PF00104	0.551
LIG_PCNA_PIPBox_1	655	664	PF02747	0.421
LIG_Pex14_1	345	349	PF04695	0.574
LIG_Pex14_1	846	850	PF04695	0.437
LIG_Pex14_2	495	499	PF04695	0.609
LIG_SH2_STAT3	128	131	PF00017	0.390
LIG_SH2_STAT5	650	653	PF00017	0.368
LIG_SH2_STAT5	679	682	PF00017	0.422
LIG_SUMO_SIM_par_1	248	253	PF11976	0.458
LIG_SUMO_SIM_par_1	395	403	PF11976	0.654
LIG_TRAF2_1	109	112	PF00917	0.481
LIG_TRAF2_1	393	396	PF00917	0.512
LIG_TRAF2_1	775	778	PF00917	0.466
LIG_WRC_WIRS_1	492	497	PF05994	0.435
LIG_WRC_WIRS_1	765	770	PF05994	0.473
MOD_CK1_1	176	182	PF00069	0.438
MOD_CK1_1	292	298	PF00069	0.556
MOD_CK1_1	366	372	PF00069	0.562
MOD_CK1_1	532	538	PF00069	0.434
MOD_CK1_1	571	577	PF00069	0.647
MOD_CK1_1	600	606	PF00069	0.634
MOD_CK1_1	675	681	PF00069	0.532
MOD_CK1_1	686	692	PF00069	0.417
MOD_CK1_1	764	770	PF00069	0.601
MOD_CK1_1	860	866	PF00069	0.516
MOD_CK1_1	869	875	PF00069	0.504
MOD_CK2_1	105	111	PF00069	0.569
MOD_CK2_1	176	182	PF00069	0.512
MOD_CK2_1	224	230	PF00069	0.447
MOD_CK2_1	347	353	PF00069	0.528
MOD_CK2_1	390	396	PF00069	0.491
MOD_CK2_1	436	442	PF00069	0.534
MOD_CK2_1	577	583	PF00069	0.507
MOD_CK2_1	591	597	PF00069	0.562
MOD_CK2_1	622	628	PF00069	0.431
MOD_CK2_1	638	644	PF00069	0.481
MOD_CK2_1	686	692	PF00069	0.520
MOD_CK2_1	694	700	PF00069	0.463
MOD_CK2_1	772	778	PF00069	0.511
MOD_CK2_1	816	822	PF00069	0.608
MOD_GlcNHglycan	30	33	PF01048	0.487
MOD_GlcNHglycan	366	369	PF01048	0.606
MOD_GlcNHglycan	432	436	PF01048	0.438
MOD_GlcNHglycan	438	441	PF01048	0.459
MOD_GlcNHglycan	570	573	PF01048	0.481
MOD_GlcNHglycan	592	596	PF01048	0.410
MOD_GlcNHglycan	602	605	PF01048	0.615
MOD_GlcNHglycan	700	704	PF01048	0.551
MOD_GSK3_1	112	119	PF00069	0.520
MOD_GSK3_1	157	164	PF00069	0.456
MOD_GSK3_1	211	218	PF00069	0.544
MOD_GSK3_1	283	290	PF00069	0.547
MOD_GSK3_1	343	350	PF00069	0.581
MOD_GSK3_1	529	536	PF00069	0.519
MOD_GSK3_1	671	678	PF00069	0.472
MOD_GSK3_1	683	690	PF00069	0.478
MOD_GSK3_1	708	715	PF00069	0.525
MOD_N-GLC_1	100	105	PF02516	0.515
MOD_N-GLC_1	597	602	PF02516	0.624
MOD_N-GLC_1	622	627	PF02516	0.326
MOD_N-GLC_1	712	717	PF02516	0.608
MOD_NEK2_1	191	196	PF00069	0.504
MOD_NEK2_1	219	224	PF00069	0.517
MOD_NEK2_1	233	238	PF00069	0.389
MOD_NEK2_1	289	294	PF00069	0.564
MOD_NEK2_1	326	331	PF00069	0.517
MOD_NEK2_1	347	352	PF00069	0.540
MOD_NEK2_1	363	368	PF00069	0.432
MOD_NEK2_1	537	542	PF00069	0.538
MOD_NEK2_1	591	596	PF00069	0.595
MOD_NEK2_1	599	604	PF00069	0.641
MOD_NEK2_1	671	676	PF00069	0.578
MOD_NEK2_2	694	699	PF00069	0.447
MOD_PIKK_1	138	144	PF00454	0.410
MOD_PIKK_1	161	167	PF00454	0.635
MOD_PIKK_1	176	182	PF00454	0.462
MOD_PIKK_1	287	293	PF00454	0.524
MOD_PIKK_1	326	332	PF00454	0.521
MOD_PIKK_1	400	406	PF00454	0.473
MOD_PIKK_1	537	543	PF00454	0.439
MOD_PIKK_1	571	577	PF00454	0.723
MOD_PIKK_1	83	89	PF00454	0.452
MOD_PK_1	866	872	PF00069	0.618
MOD_PKA_1	283	289	PF00069	0.567
MOD_PKA_1	364	370	PF00069	0.487
MOD_PKA_1	56	62	PF00069	0.471
MOD_PKA_2	161	167	PF00069	0.508
MOD_PKA_2	224	230	PF00069	0.648
MOD_PKA_2	283	289	PF00069	0.715
MOD_PKA_2	363	369	PF00069	0.492
MOD_PKA_2	532	538	PF00069	0.412
MOD_PKA_2	568	574	PF00069	0.626
MOD_PKA_2	577	583	PF00069	0.599
MOD_PKA_2	683	689	PF00069	0.410
MOD_PKA_2	761	767	PF00069	0.443
MOD_Plk_1	100	106	PF00069	0.517
MOD_Plk_1	116	122	PF00069	0.389
MOD_Plk_1	191	197	PF00069	0.406
MOD_Plk_1	219	225	PF00069	0.626
MOD_Plk_1	233	239	PF00069	0.470
MOD_Plk_1	324	330	PF00069	0.552
MOD_Plk_1	343	349	PF00069	0.531
MOD_Plk_1	518	524	PF00069	0.408
MOD_Plk_1	533	539	PF00069	0.419
MOD_Plk_1	597	603	PF00069	0.642
MOD_Plk_1	622	628	PF00069	0.450
MOD_Plk_1	699	705	PF00069	0.506
MOD_Plk_2-3	215	221	PF00069	0.456
MOD_Plk_2-3	638	644	PF00069	0.310
MOD_Plk_2-3	761	767	PF00069	0.584
MOD_Plk_4	191	197	PF00069	0.406
MOD_Plk_4	369	375	PF00069	0.457
MOD_Plk_4	491	497	PF00069	0.466
MOD_Plk_4	638	644	PF00069	0.466
MOD_Plk_4	672	678	PF00069	0.582
MOD_Plk_4	750	756	PF00069	0.513
MOD_ProDKin_1	883	889	PF00069	0.628
MOD_SUMO_for_1	135	138	PF00179	0.551
MOD_SUMO_for_1	268	271	PF00179	0.562
MOD_SUMO_for_1	768	771	PF00179	0.536
MOD_SUMO_rev_2	133	141	PF00179	0.433
MOD_SUMO_rev_2	168	177	PF00179	0.472
MOD_SUMO_rev_2	213	219	PF00179	0.490
MOD_SUMO_rev_2	329	338	PF00179	0.597
MOD_SUMO_rev_2	382	390	PF00179	0.603
MOD_SUMO_rev_2	410	419	PF00179	0.360
MOD_SUMO_rev_2	53	58	PF00179	0.431
MOD_SUMO_rev_2	702	711	PF00179	0.495
MOD_SUMO_rev_2	766	775	PF00179	0.485
MOD_SUMO_rev_2	800	810	PF00179	0.419
TRG_DiLeu_BaEn_1	305	310	PF01217	0.452
TRG_DiLeu_BaEn_1	376	381	PF01217	0.563
TRG_DiLeu_BaEn_1	386	391	PF01217	0.461
TRG_DiLeu_BaEn_2	475	481	PF01217	0.386
TRG_DiLeu_BaEn_2	553	559	PF01217	0.444
TRG_DiLeu_BaEn_4	396	402	PF01217	0.568
TRG_DiLeu_BaEn_4	656	662	PF01217	0.418
TRG_DiLeu_LyEn_5	305	310	PF01217	0.452
TRG_ENDOCYTIC_2	349	352	PF00928	0.545
TRG_ENDOCYTIC_2	845	848	PF00928	0.519
TRG_ER_diArg_1	321	323	PF00400	0.638
TRG_ER_diArg_1	44	46	PF00400	0.420
TRG_ER_diArg_1	629	632	PF00400	0.321
TRG_ER_diArg_1	755	757	PF00400	0.550
TRG_ER_diArg_1	824	826	PF00400	0.529
TRG_ER_diArg_1	96	98	PF00400	0.445
TRG_NES_CRM1_1	190	203	PF08389	0.521
TRG_NLS_Bipartite_1	802	819	PF00514	0.499
TRG_NLS_MonoExtC_3	814	820	PF00514	0.512
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P634	Leptomonas seymouri	50%	100%
A0A1X0P2I2	Trypanosomatidae	34%	99%
A0A3R7LAM9	Trypanosoma rangeli	32%	99%
A0A3S5H5F4	Leishmania donovani	91%	100%
A4H447	Leishmania braziliensis	74%	100%
A4HSC4	Leishmania infantum	90%	100%
C9ZPY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	99%
E9AKA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%