LeishMANIAdb
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Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ras-like small GTPases
Gene product:
ras-like small GTPases, putative
Species:
Leishmania major
UniProt:
Q4QJK0_LEIMA
TriTrypDb:
LmjF.05.0030 , LMJLV39_050005200 * , LMJSD75_050005200 *
Length:
195

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005783 endoplasmic reticulum 5 9
GO:0005794 Golgi apparatus 5 11
GO:0030117 membrane coat 3 2
GO:0030120 vesicle coat 4 2
GO:0030127 COPII vesicle coat 5 2
GO:0032991 protein-containing complex 1 2
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 11
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Expansion

Sequence features

Q4QJK0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJK0

Function

Biological processes
TermNameLevelCount
GO:0003400 regulation of COPII vesicle coating 6 2
GO:0006810 transport 3 11
GO:0006886 intracellular protein transport 4 11
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 2
GO:0006996 organelle organization 4 2
GO:0008104 protein localization 4 11
GO:0009987 cellular process 1 11
GO:0015031 protein transport 4 11
GO:0016043 cellular component organization 3 2
GO:0016050 vesicle organization 5 2
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0003924 GTPase activity 7 11
GO:0005488 binding 1 11
GO:0005525 GTP binding 5 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0017076 purine nucleotide binding 4 11
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 86 90 PF00656 0.278
CLV_NRD_NRD_1 78 80 PF00675 0.278
CLV_PCSK_KEX2_1 78 80 PF00082 0.278
CLV_PCSK_SKI1_1 22 26 PF00082 0.278
CLV_PCSK_SKI1_1 39 43 PF00082 0.278
DEG_MDM2_SWIB_1 4 11 PF02201 0.411
DOC_CYCLIN_RxL_1 19 29 PF00134 0.295
DOC_MAPK_gen_1 19 28 PF00069 0.278
DOC_MAPK_HePTP_8 16 28 PF00069 0.321
DOC_MAPK_MEF2A_6 19 28 PF00069 0.278
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P4P7 Leptomonas seymouri 29% 100%
A0A0N0P633 Leptomonas seymouri 33% 100%
A0A0N0P8D4 Leptomonas seymouri 33% 100%
A0A0N0P8Z3 Leptomonas seymouri 34% 100%
A0A0N1HS40 Leptomonas seymouri 40% 100%
A0A0N1HTN6 Leptomonas seymouri 31% 100%
A0A0N1I3A9 Leptomonas seymouri 30% 100%
A0A0N1I556 Leptomonas seymouri 33% 100%
A0A0N1I6N0 Leptomonas seymouri 32% 100%
A0A0N1IKF2 Leptomonas seymouri 95% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS