Putative paraflagellar rod component par4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component par4, putative

Species:

Leishmania major

UniProt:

Q4QJJ9_LEIMA

TriTrypDb:

LmjF.05.0040 , LMJLV39_050005300 , LMJSD75_050005300

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

Q4QJJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJJ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.511
CLV_C14_Caspase3-7	539	543	PF00656	0.563
CLV_NRD_NRD_1	220	222	PF00675	0.538
CLV_NRD_NRD_1	239	241	PF00675	0.437
CLV_NRD_NRD_1	43	45	PF00675	0.510
CLV_NRD_NRD_1	569	571	PF00675	0.594
CLV_NRD_NRD_1	69	71	PF00675	0.561
CLV_PCSK_KEX2_1	171	173	PF00082	0.628
CLV_PCSK_KEX2_1	238	240	PF00082	0.523
CLV_PCSK_KEX2_1	325	327	PF00082	0.570
CLV_PCSK_KEX2_1	43	45	PF00082	0.526
CLV_PCSK_KEX2_1	549	551	PF00082	0.512
CLV_PCSK_KEX2_1	69	71	PF00082	0.582
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.627
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.550
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.570
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.607
CLV_PCSK_SKI1_1	103	107	PF00082	0.556
CLV_PCSK_SKI1_1	201	205	PF00082	0.614
CLV_PCSK_SKI1_1	222	226	PF00082	0.556
CLV_PCSK_SKI1_1	295	299	PF00082	0.535
CLV_PCSK_SKI1_1	326	330	PF00082	0.537
CLV_PCSK_SKI1_1	465	469	PF00082	0.637
CLV_PCSK_SKI1_1	476	480	PF00082	0.581
CLV_PCSK_SKI1_1	510	514	PF00082	0.635
CLV_PCSK_SKI1_1	560	564	PF00082	0.531
DOC_MAPK_gen_1	15	23	PF00069	0.562
DOC_MAPK_gen_1	221	229	PF00069	0.599
DOC_MAPK_gen_1	510	518	PF00069	0.640
DOC_MAPK_gen_1	531	540	PF00069	0.552
DOC_MAPK_gen_1	568	575	PF00069	0.462
DOC_PP1_RVXF_1	366	372	PF00149	0.453
DOC_USP7_UBL2_3	302	306	PF12436	0.558
DOC_USP7_UBL2_3	5	9	PF12436	0.618
LIG_14-3-3_CanoR_1	221	227	PF00244	0.544
LIG_14-3-3_CanoR_1	251	259	PF00244	0.618
LIG_14-3-3_CanoR_1	568	574	PF00244	0.485
LIG_Actin_WH2_2	460	478	PF00022	0.662
LIG_Actin_WH2_2	505	521	PF00022	0.640
LIG_Actin_WH2_2	534	551	PF00022	0.568
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_CaM_IQ_9	541	557	PF13499	0.577
LIG_Clathr_ClatBox_1	112	116	PF01394	0.484
LIG_FHA_1	296	302	PF00498	0.561
LIG_FHA_1	570	576	PF00498	0.464
LIG_FHA_2	253	259	PF00498	0.589
LIG_FHA_2	267	273	PF00498	0.583
LIG_FHA_2	436	442	PF00498	0.629
LIG_FHA_2	444	450	PF00498	0.487
LIG_FHA_2	519	525	PF00498	0.596
LIG_FHA_2	559	565	PF00498	0.600
LIG_FHA_2	99	105	PF00498	0.516
LIG_Integrin_isoDGR_2	378	380	PF01839	0.581
LIG_LIR_Gen_1	364	374	PF02991	0.452
LIG_LIR_Gen_1	458	467	PF02991	0.655
LIG_LIR_Nem_3	364	369	PF02991	0.447
LIG_LIR_Nem_3	458	464	PF02991	0.628
LIG_NRBOX	225	231	PF00104	0.607
LIG_NRBOX	353	359	PF00104	0.474
LIG_PCNA_yPIPBox_3	216	230	PF02747	0.576
LIG_PCNA_yPIPBox_3	349	358	PF02747	0.582
LIG_Rb_LxCxE_1	353	370	PF01857	0.354
LIG_SH2_STAP1	241	245	PF00017	0.551
LIG_SH2_STAP1	432	436	PF00017	0.579
LIG_SH2_STAP1	92	96	PF00017	0.591
LIG_SH2_STAT3	134	137	PF00017	0.616
LIG_SH2_STAT3	432	435	PF00017	0.554
LIG_SH2_STAT3	92	95	PF00017	0.590
LIG_SH2_STAT5	134	137	PF00017	0.493
LIG_SH2_STAT5	307	310	PF00017	0.449
LIG_SUMO_SIM_anti_2	500	507	PF11976	0.438
LIG_SUMO_SIM_anti_2	536	543	PF11976	0.546
LIG_SUMO_SIM_par_1	500	507	PF11976	0.438
LIG_TRAF2_1	255	258	PF00917	0.522
LIG_TRAF2_1	411	414	PF00917	0.621
LIG_TRAF2_1	522	525	PF00917	0.506
LIG_WRC_WIRS_1	273	278	PF05994	0.536
LIG_WRC_WIRS_1	440	445	PF05994	0.365
MOD_CK1_1	420	426	PF00069	0.598
MOD_CK1_1	493	499	PF00069	0.620
MOD_CK1_1	91	97	PF00069	0.583
MOD_CK2_1	252	258	PF00069	0.582
MOD_CK2_1	266	272	PF00069	0.505
MOD_CK2_1	307	313	PF00069	0.535
MOD_CK2_1	36	42	PF00069	0.544
MOD_CK2_1	408	414	PF00069	0.542
MOD_CK2_1	518	524	PF00069	0.578
MOD_CK2_1	551	557	PF00069	0.533
MOD_CK2_1	87	93	PF00069	0.523
MOD_Cter_Amidation	7	10	PF01082	0.714
MOD_GlcNHglycan	182	185	PF01048	0.585
MOD_GlcNHglycan	419	422	PF01048	0.620
MOD_GlcNHglycan	82	85	PF01048	0.539
MOD_GSK3_1	307	314	PF00069	0.477
MOD_GSK3_1	374	381	PF00069	0.350
MOD_GSK3_1	435	442	PF00069	0.505
MOD_GSK3_1	490	497	PF00069	0.567
MOD_GSK3_1	76	83	PF00069	0.556
MOD_GSK3_1	87	94	PF00069	0.581
MOD_N-GLC_1	222	227	PF02516	0.610
MOD_NEK2_1	167	172	PF00069	0.557
MOD_NEK2_1	266	271	PF00069	0.623
MOD_NEK2_1	344	349	PF00069	0.516
MOD_NEK2_1	443	448	PF00069	0.493
MOD_NEK2_1	518	523	PF00069	0.636
MOD_NEK2_2	558	563	PF00069	0.528
MOD_PIKK_1	252	258	PF00454	0.648
MOD_PIKK_1	266	272	PF00454	0.627
MOD_PIKK_1	326	332	PF00454	0.562
MOD_PIKK_1	344	350	PF00454	0.600
MOD_PIKK_1	91	97	PF00454	0.545
MOD_PKA_1	9	15	PF00069	0.671
MOD_PKA_2	127	133	PF00069	0.585
MOD_PKA_2	138	144	PF00069	0.591
MOD_PKA_2	180	186	PF00069	0.587
MOD_PKA_2	250	256	PF00069	0.567
MOD_PKA_2	493	499	PF00069	0.629
MOD_PKA_2	569	575	PF00069	0.614
MOD_PKA_2	79	85	PF00069	0.597
MOD_Plk_1	222	228	PF00069	0.610
MOD_Plk_1	494	500	PF00069	0.606
MOD_Plk_1	76	82	PF00069	0.540
MOD_Plk_1	87	93	PF00069	0.409
MOD_Plk_2-3	272	278	PF00069	0.619
MOD_Plk_2-3	88	94	PF00069	0.534
MOD_Plk_4	222	228	PF00069	0.558
MOD_Plk_4	367	373	PF00069	0.516
MOD_SUMO_for_1	113	116	PF00179	0.569
MOD_SUMO_for_1	276	279	PF00179	0.478
MOD_SUMO_for_1	456	459	PF00179	0.601
MOD_SUMO_for_1	512	515	PF00179	0.648
MOD_SUMO_for_1	562	565	PF00179	0.610
MOD_SUMO_rev_2	182	190	PF00179	0.543
MOD_SUMO_rev_2	214	224	PF00179	0.569
MOD_SUMO_rev_2	257	266	PF00179	0.552
MOD_SUMO_rev_2	289	297	PF00179	0.496
MOD_SUMO_rev_2	299	308	PF00179	0.521
MOD_SUMO_rev_2	542	551	PF00179	0.596
MOD_SUMO_rev_2	83	91	PF00179	0.581
TRG_DiLeu_BaEn_1	353	358	PF01217	0.484
TRG_DiLeu_BaEn_3	118	124	PF01217	0.613
TRG_DiLeu_BaEn_3	50	56	PF01217	0.551
TRG_DiLeu_BaEn_4	151	157	PF01217	0.614
TRG_DiLeu_BaEn_4	257	263	PF01217	0.533
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.506
TRG_ENDOCYTIC_2	461	464	PF00928	0.631
TRG_ER_diArg_1	239	241	PF00400	0.537
TRG_ER_diArg_1	450	453	PF00400	0.641
TRG_ER_diArg_1	530	533	PF00400	0.580
TRG_ER_diArg_1	69	71	PF00400	0.590
TRG_NES_CRM1_1	507	520	PF08389	0.592
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	560	564	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWW9	Leptomonas seymouri	49%	100%
A0A0S4JPX7	Bodo saltans	34%	99%
A0A1X0P3Y1	Trypanosomatidae	40%	100%
A0A3R7MZM3	Trypanosoma rangeli	40%	100%
A0A3S5H5F5	Leishmania donovani	95%	100%
A4H450	Leishmania braziliensis	79%	100%
A4HSC7	Leishmania infantum	95%	100%
C9ZPY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AKA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BJE7	Trypanosoma cruzi	40%	100%