Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

dynein light chain, putative

Species:

Leishmania major

UniProt:

Q4QJJ6_LEIMA

TriTrypDb:

LmjF.05.0070 , LMJLV39_050005600 , LMJSD75_050005600

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005868	cytoplasmic dynein complex	4	2
GO:0005874	microtubule	6	10
GO:0005875	microtubule associated complex	2	10
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10
GO:0099512	supramolecular fiber	4	10
GO:0099513	polymeric cytoskeletal fiber	5	10
GO:0110165	cellular anatomical entity	1	10
GO:1902494	catalytic complex	2	10

Expansion

Sequence features

Q4QJJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJJ6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045505	dynein intermediate chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	44	46	PF00082	0.274
CLV_PCSK_KEX2_1	49	51	PF00082	0.257
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.274
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.277
CLV_PCSK_PC7_1	45	51	PF00082	0.304
DOC_USP7_UBL2_3	16	20	PF12436	0.526
LIG_FHA_1	30	36	PF00498	0.472
LIG_LIR_Nem_3	78	82	PF02991	0.471
LIG_SH2_PTP2	74	77	PF00017	0.477
LIG_SH2_SRC	74	77	PF00017	0.499
LIG_SH2_STAT5	5	8	PF00017	0.488
LIG_SH2_STAT5	74	77	PF00017	0.466
LIG_WRC_WIRS_1	63	68	PF05994	0.477
MOD_CK1_1	65	71	PF00069	0.459
MOD_NEK2_1	6	11	PF00069	0.478
MOD_NEK2_1	86	91	PF00069	0.459
MOD_Plk_1	6	12	PF00069	0.549
MOD_Plk_2-3	31	37	PF00069	0.477
MOD_Plk_4	62	68	PF00069	0.459
MOD_Plk_4	80	86	PF00069	0.459
MOD_SUMO_for_1	43	46	PF00179	0.459
TRG_DiLeu_BaEn_1	21	26	PF01217	0.520
TRG_ENDOCYTIC_2	5	8	PF00928	0.524
TRG_ENDOCYTIC_2	51	54	PF00928	0.473
TRG_ENDOCYTIC_2	74	77	PF00928	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0W1	Leptomonas seymouri	48%	100%
A0A0N1I1Z7	Leptomonas seymouri	46%	100%
A0A0N1PBY8	Leptomonas seymouri	80%	100%
A0A0N1PCF1	Leptomonas seymouri	31%	85%
A0A0N1PCX2	Leptomonas seymouri	33%	81%
A0A0S4IS05	Bodo saltans	47%	100%
A0A0S4IUR3	Bodo saltans	49%	100%
A0A0S4J005	Bodo saltans	35%	69%
A0A0S4J1R8	Bodo saltans	51%	100%
A0A0S4JE57	Bodo saltans	42%	100%
A0A0S4JH61	Bodo saltans	51%	72%
A0A0S4JKR9	Bodo saltans	36%	90%
A0A0S4JQ28	Bodo saltans	60%	100%
A0A1X0P6I9	Trypanosomatidae	29%	76%
A0A1X0P8I8	Trypanosomatidae	37%	81%
A0A3Q8IDB7	Leishmania donovani	34%	81%
A0A3Q8IDX2	Leishmania donovani	41%	100%
A0A3R7KXV2	Trypanosoma rangeli	38%	81%
A0A3S5H7E1	Leishmania donovani	51%	100%
A0A3S5H7R1	Leishmania donovani	48%	100%
A0A3S7WNY4	Leishmania donovani	99%	100%
A0A3S7WTY9	Leishmania donovani	30%	81%
A0A422NC25	Trypanosoma rangeli	44%	84%
A4F4L4	Sus scrofa	33%	87%
A4H453	Leishmania braziliensis	89%	100%
A4H8L8	Leishmania braziliensis	29%	81%
A4HA47	Leishmania braziliensis	32%	81%
A4HDX3	Leishmania braziliensis	48%	100%
A4HGR7	Leishmania braziliensis	40%	100%
A4HK04	Leishmania braziliensis	48%	100%
A4HSD6	Leishmania infantum	99%	100%
A4HWY9	Leishmania infantum	29%	81%
A4HYB3	Leishmania infantum	34%	81%
A4I168	Leishmania infantum	51%	100%
A4I3U2	Leishmania infantum	41%	100%
A4I7I7	Leishmania infantum	48%	100%
C9ZPY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
D0A0N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	70%
D0A2J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	81%
D0A5F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A5K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AKB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AQQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	81%
E9AS46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	81%
E9AXA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9B034	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B2E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
O02414	Heliocidaris crassispina	51%	100%
O94111	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	53%	97%
O96015	Homo sapiens	33%	87%
O96860	Drosophila melanogaster	48%	100%
P61273	Macaca fascicularis	49%	100%
P61285	Bos taurus	49%	100%
P63167	Homo sapiens	49%	100%
P63168	Mus musculus	49%	100%
P63169	Oryctolagus cuniculus	49%	100%
P63170	Rattus norvegicus	49%	100%
Q02647	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	99%
Q21557	Caenorhabditis elegans	31%	100%
Q22799	Caenorhabditis elegans	51%	100%
Q24117	Drosophila melanogaster	48%	100%
Q32KN5	Bos taurus	33%	87%
Q39579	Chlamydomonas reinhardtii	31%	76%
Q39580	Chlamydomonas reinhardtii	47%	100%
Q3MHR3	Bos taurus	51%	100%
Q4Q5R2	Leishmania major	49%	100%
Q4Q852	Leishmania major	41%	100%
Q4QA70	Leishmania major	51%	100%
Q4QDC0	Leishmania major	34%	100%
Q4QES6	Leishmania major	29%	81%
Q6BZF8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	37%	100%
Q6CWX4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	35%	100%
Q6FUJ0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	38%	100%
Q759T0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	38%	100%
Q78P75	Rattus norvegicus	51%	100%
Q86A88	Dictyostelium discoideum	49%	100%
Q94748	Schistosoma mansoni	43%	100%
Q94758	Schistosoma mansoni	39%	100%
Q96FJ2	Homo sapiens	51%	100%
Q9D0M5	Mus musculus	51%	100%
Q9DCM4	Mus musculus	33%	87%
Q9UR05	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
V5AV01	Trypanosoma cruzi	66%	100%
V5BSX5	Trypanosoma cruzi	51%	100%
V5BV95	Trypanosoma cruzi	38%	81%
V5BXL9	Trypanosoma cruzi	44%	100%