Rrp15p-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rrp15p, putative

Species:

Leishmania major

UniProt:

Q4QJJ5_LEIMA

TriTrypDb:

LmjF.05.0080 , LMJLV39_050005700 , LMJSD75_050005700

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QJJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJJ5

Function

Biological processes
Term	Name	Level	Count
GO:0000460	maturation of 5.8S rRNA	9	2
GO:0000470	maturation of LSU-rRNA	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.277
CLV_PCSK_KEX2_1	22	24	PF00082	0.385
CLV_PCSK_KEX2_1	34	36	PF00082	0.288
CLV_PCSK_KEX2_1	93	95	PF00082	0.325
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.385
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.337
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.358
CLV_PCSK_SKI1_1	172	176	PF00082	0.277
CLV_PCSK_SKI1_1	188	192	PF00082	0.266
CLV_PCSK_SKI1_1	19	23	PF00082	0.409
CLV_PCSK_SKI1_1	83	87	PF00082	0.331
DOC_MAPK_gen_1	142	151	PF00069	0.360
DOC_MAPK_gen_1	22	32	PF00069	0.271
DOC_MAPK_gen_1	80	88	PF00069	0.389
DOC_USP7_MATH_1	121	125	PF00917	0.400
DOC_USP7_MATH_1	65	69	PF00917	0.462
DOC_USP7_UBL2_3	178	182	PF12436	0.281
DOC_USP7_UBL2_3	34	38	PF12436	0.331
DOC_WW_Pin1_4	33	38	PF00397	0.466
LIG_14-3-3_CanoR_1	107	115	PF00244	0.320
LIG_14-3-3_CanoR_1	142	147	PF00244	0.267
LIG_Actin_WH2_2	183	198	PF00022	0.200
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_FHA_1	146	152	PF00498	0.266
LIG_FHA_2	50	56	PF00498	0.362
LIG_Integrin_RGD_1	6	8	PF01839	0.585
LIG_MAD2	96	104	PF02301	0.331
LIG_SH2_STAP1	139	143	PF00017	0.266
LIG_UBA3_1	154	163	PF00899	0.281
MOD_CDK_SPK_2	33	38	PF00069	0.331
MOD_CK1_1	145	151	PF00069	0.325
MOD_CK1_1	53	59	PF00069	0.397
MOD_CK2_1	105	111	PF00069	0.279
MOD_CK2_1	49	55	PF00069	0.343
MOD_GlcNHglycan	164	167	PF01048	0.349
MOD_GlcNHglycan	55	58	PF01048	0.380
MOD_GlcNHglycan	74	77	PF01048	0.465
MOD_GSK3_1	154	161	PF00069	0.366
MOD_GSK3_1	49	56	PF00069	0.335
MOD_LATS_1	127	133	PF00433	0.200
MOD_NEK2_1	154	159	PF00069	0.266
MOD_NEK2_1	195	200	PF00069	0.421
MOD_PIKK_1	121	127	PF00454	0.363
MOD_PIKK_1	195	201	PF00454	0.371
MOD_PK_1	142	148	PF00069	0.325
MOD_PKA_1	162	168	PF00069	0.383
MOD_PKA_1	172	178	PF00069	0.236
MOD_PKA_2	106	112	PF00069	0.321
MOD_PKA_2	195	201	PF00069	0.371
MOD_PKA_2	53	59	PF00069	0.427
MOD_Plk_4	28	34	PF00069	0.438
MOD_ProDKin_1	33	39	PF00069	0.466
MOD_SUMO_for_1	92	95	PF00179	0.200
MOD_SUMO_rev_2	165	175	PF00179	0.305
TRG_DiLeu_BaEn_1	181	186	PF01217	0.265
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.293
TRG_ER_diArg_1	141	144	PF00400	0.266
TRG_NLS_MonoExtN_4	14	20	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	129	134	PF00026	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYI7	Leptomonas seymouri	76%	99%
A0A0S4JT37	Bodo saltans	46%	90%
A0A1X0P2H2	Trypanosomatidae	50%	86%
A0A3R7MSE6	Trypanosoma rangeli	58%	95%
A0A3S7WP07	Leishmania donovani	95%	100%
A4H454	Leishmania braziliensis	87%	100%
A4HSD7	Leishmania infantum	95%	100%
C9ZPX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	92%
E9AKB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BJH6	Trypanosoma cruzi	52%	95%