Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJJ1_LEIMA

TriTrypDb:

LmjF.05.0120 , LMJLV39_050006100 , LMJSD75_050006100

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QJJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJJ1

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008175	tRNA methyltransferase activity	5	1
GO:0008176	tRNA (guanine-N7-)-methyltransferase activity	7	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016423	tRNA (guanine) methyltransferase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140098	catalytic activity, acting on RNA	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.587
CLV_NRD_NRD_1	112	114	PF00675	0.453
CLV_NRD_NRD_1	201	203	PF00675	0.409
CLV_NRD_NRD_1	255	257	PF00675	0.544
CLV_NRD_NRD_1	284	286	PF00675	0.619
CLV_NRD_NRD_1	3	5	PF00675	0.651
CLV_NRD_NRD_1	311	313	PF00675	0.524
CLV_NRD_NRD_1	320	322	PF00675	0.407
CLV_PCSK_FUR_1	282	286	PF00082	0.664
CLV_PCSK_KEX2_1	112	114	PF00082	0.447

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N8	Leptomonas seymouri	67%	100%
A0A1X0P3K8	Trypanosomatidae	41%	98%
A0A3S5H5F9	Leishmania donovani	97%	100%
A0A3S5ISB0	Trypanosoma rangeli	49%	100%
A4H458	Leishmania braziliensis	87%	100%
A4HSE1	Leishmania infantum	97%	100%
C9ZPX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AKB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5AUY0	Trypanosoma cruzi	44%	100%

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