Protein kinase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcium/calmodulin-dependent protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QJJ0_LEIMA

TriTrypDb:

LmjF.05.0130 , LMJLV39_050006200 , LMJSD75_050006200

Length:

432

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Show entries

Cellular components
Term	Name	Level	Count
GO:0005964	phosphorylase kinase complex	7	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

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Expansion

Sequence features

Q4QJJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJJ0

Function

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Biological processes
Term	Name	Level	Count
GO:0000271	polysaccharide biosynthetic process	5	1
GO:0005975	carbohydrate metabolic process	3	1
GO:0005976	polysaccharide metabolic process	4	1
GO:0005977	glycogen metabolic process	6	1
GO:0005978	glycogen biosynthetic process	7	1
GO:0006073	obsolete cellular glucan metabolic process	5	1
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006112	energy reserve metabolic process	5	1
GO:0006468	protein phosphorylation	5	14
GO:0006793	phosphorus metabolic process	3	14

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003824	catalytic activity	1	14
GO:0004672	protein kinase activity	3	14
GO:0004674	protein serine/threonine kinase activity	4	11
GO:0004683	calmodulin-dependent protein kinase activity	5	1
GO:0004689	phosphorylase kinase activity	6	1
GO:0005488	binding	1	14
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1
GO:0005524	ATP binding	5	14

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.337
CLV_PCSK_KEX2_1	179	181	PF00082	0.360
CLV_PCSK_KEX2_1	58	60	PF00082	0.346
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.422
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.346
CLV_PCSK_SKI1_1	129	133	PF00082	0.377
CLV_PCSK_SKI1_1	147	151	PF00082	0.158
CLV_PCSK_SKI1_1	164	168	PF00082	0.414
CLV_PCSK_SKI1_1	242	246	PF00082	0.401
CLV_PCSK_SKI1_1	303	307	PF00082	0.319

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S2	Leptomonas seymouri	29%	78%
A0A0N0P4J7	Leptomonas seymouri	27%	97%
A0A0N0P6T0	Leptomonas seymouri	29%	79%
A0A0N0P7D2	Leptomonas seymouri	26%	100%
A0A0N0P7K3	Leptomonas seymouri	27%	90%
A0A0N0P8H5	Leptomonas seymouri	27%	100%
A0A0N1HS61	Leptomonas seymouri	26%	100%
A0A0N1HTF0	Leptomonas seymouri	26%	68%
A0A0N1I0C1	Leptomonas seymouri	25%	97%
A0A0N1I1M7	Leptomonas seymouri	27%	67%

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