Leucine-rich repeat protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJI8_LEIMA

TriTrypDb:

LmjF.05.0150 , LMJLV39_050006400 , LMJSD75_050006400

Length:

441

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	19
GO:0005929	cilium	4	17
GO:0042995	cell projection	2	17
GO:0043226	organelle	2	17
GO:0043227	membrane-bounded organelle	3	17
GO:0120025	plasma membrane bounded cell projection	3	17
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QJI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.387
CLV_NRD_NRD_1	377	379	PF00675	0.391
CLV_NRD_NRD_1	5	7	PF00675	0.626
CLV_PCSK_KEX2_1	377	379	PF00082	0.402
CLV_PCSK_SKI1_1	129	133	PF00082	0.348
CLV_PCSK_SKI1_1	157	161	PF00082	0.356
CLV_PCSK_SKI1_1	264	268	PF00082	0.319
CLV_PCSK_SKI1_1	31	35	PF00082	0.370
CLV_PCSK_SKI1_1	360	364	PF00082	0.386
CLV_PCSK_SKI1_1	378	382	PF00082	0.507
CLV_PCSK_SKI1_1	435	439	PF00082	0.450
CLV_PCSK_SKI1_1	49	53	PF00082	0.394
DOC_MAPK_gen_1	377	384	PF00069	0.508
DOC_MAPK_MEF2A_6	377	384	PF00069	0.508
DOC_USP7_MATH_1	109	113	PF00917	0.261
DOC_USP7_MATH_1	239	243	PF00917	0.347
DOC_USP7_MATH_1	273	277	PF00917	0.387
DOC_USP7_MATH_1	81	85	PF00917	0.345
DOC_USP7_UBL2_3	27	31	PF12436	0.486
DOC_USP7_UBL2_3	435	439	PF12436	0.506
DOC_WW_Pin1_4	116	121	PF00397	0.514
LIG_14-3-3_CanoR_1	129	135	PF00244	0.378
LIG_14-3-3_CanoR_1	223	229	PF00244	0.493
LIG_14-3-3_CanoR_1	264	272	PF00244	0.415
LIG_14-3-3_CanoR_1	360	366	PF00244	0.463
LIG_14-3-3_CanoR_1	377	381	PF00244	0.394
LIG_14-3-3_CanoR_1	87	95	PF00244	0.329
LIG_BIR_III_4	400	404	PF00653	0.657
LIG_BRCT_BRCA1_1	20	24	PF00533	0.367
LIG_FHA_1	172	178	PF00498	0.258
LIG_FHA_1	199	205	PF00498	0.334
LIG_FHA_1	216	222	PF00498	0.398
LIG_FHA_1	229	235	PF00498	0.286
LIG_FHA_1	320	326	PF00498	0.384
LIG_FHA_1	330	336	PF00498	0.407
LIG_FHA_1	357	363	PF00498	0.437
LIG_FHA_1	377	383	PF00498	0.416
LIG_FHA_1	385	391	PF00498	0.536
LIG_FHA_1	405	411	PF00498	0.669
LIG_FHA_1	412	418	PF00498	0.655
LIG_FHA_1	54	60	PF00498	0.370
LIG_FHA_2	158	164	PF00498	0.336
LIG_FHA_2	35	41	PF00498	0.496
LIG_FHA_2	63	69	PF00498	0.332
LIG_LIR_Gen_1	130	137	PF02991	0.326
LIG_LIR_Nem_3	130	135	PF02991	0.328
LIG_LIR_Nem_3	163	169	PF02991	0.263
LIG_LIR_Nem_3	253	259	PF02991	0.466
LIG_NRP_CendR_1	438	441	PF00754	0.467
LIG_SH2_STAT5	203	206	PF00017	0.402
LIG_SH2_STAT5	25	28	PF00017	0.424
LIG_SH2_STAT5	63	66	PF00017	0.260
LIG_SH3_3	8	14	PF00018	0.513
LIG_SUMO_SIM_anti_2	133	138	PF11976	0.396
LIG_SUMO_SIM_anti_2	332	338	PF11976	0.450
LIG_SUMO_SIM_par_1	379	388	PF11976	0.518
LIG_TRAF2_1	421	424	PF00917	0.428
MOD_CK1_1	215	221	PF00069	0.459
MOD_CK2_1	67	73	PF00069	0.349
MOD_GlcNHglycan	111	114	PF01048	0.319
MOD_GlcNHglycan	120	123	PF01048	0.457
MOD_GlcNHglycan	3	6	PF01048	0.719
MOD_GlcNHglycan	372	375	PF01048	0.513
MOD_GSK3_1	19	26	PF00069	0.362
MOD_GSK3_1	224	231	PF00069	0.398
MOD_GSK3_1	319	326	PF00069	0.349
MOD_GSK3_1	356	363	PF00069	0.425
MOD_GSK3_1	59	66	PF00069	0.357
MOD_GSK3_1	81	88	PF00069	0.530
MOD_LATS_1	376	382	PF00433	0.494
MOD_N-GLC_1	116	121	PF02516	0.464
MOD_N-GLC_1	127	132	PF02516	0.381
MOD_N-GLC_1	171	176	PF02516	0.393
MOD_N-GLC_1	239	244	PF02516	0.459
MOD_N-GLC_1	280	285	PF02516	0.354
MOD_N-GLC_1	95	100	PF02516	0.287
MOD_NEK2_1	147	152	PF00069	0.354
MOD_NEK2_1	238	243	PF00069	0.396
MOD_NEK2_1	280	285	PF00069	0.326
MOD_NEK2_1	329	334	PF00069	0.330
MOD_NEK2_1	34	39	PF00069	0.547
MOD_NEK2_1	59	64	PF00069	0.317
MOD_NEK2_1	67	72	PF00069	0.340
MOD_NEK2_1	85	90	PF00069	0.499
MOD_NEK2_1	95	100	PF00069	0.392
MOD_NEK2_2	127	132	PF00069	0.351
MOD_NEK2_2	273	278	PF00069	0.260
MOD_PIKK_1	212	218	PF00454	0.498
MOD_PIKK_1	67	73	PF00454	0.312
MOD_PIKK_1	87	93	PF00454	0.128
MOD_PK_1	29	35	PF00069	0.343
MOD_PKA_2	376	382	PF00069	0.404
MOD_Plk_1	127	133	PF00069	0.342
MOD_Plk_1	142	148	PF00069	0.282
MOD_Plk_1	157	163	PF00069	0.281
MOD_Plk_1	239	245	PF00069	0.391
MOD_Plk_4	142	148	PF00069	0.329
MOD_Plk_4	198	204	PF00069	0.381
MOD_Plk_4	239	245	PF00069	0.470
MOD_Plk_4	29	35	PF00069	0.506
MOD_Plk_4	59	65	PF00069	0.413
MOD_Plk_4	81	87	PF00069	0.437
MOD_ProDKin_1	116	122	PF00069	0.517
MOD_SUMO_for_1	16	19	PF00179	0.522
MOD_SUMO_rev_2	307	317	PF00179	0.407
TRG_DiLeu_BaEn_1	405	410	PF01217	0.600
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.335
TRG_ER_diLys_1	436	441	PF00400	0.568
TRG_NLS_MonoExtC_3	26	31	PF00514	0.517
TRG_NLS_MonoExtC_3	434	439	PF00514	0.497
TRG_NLS_MonoExtN_4	27	32	PF00514	0.387
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH0	Leptomonas seymouri	26%	94%
A0A0N1I317	Leptomonas seymouri	26%	100%
A0A0N1PD72	Leptomonas seymouri	71%	99%
A0A0S4IK39	Bodo saltans	25%	70%
A0A0S4IT30	Bodo saltans	26%	66%
A0A0S4JGH2	Bodo saltans	25%	100%
A0A0S4JL85	Bodo saltans	48%	100%
A0A0S4JPV3	Bodo saltans	28%	91%
A0A1X0NTY3	Trypanosomatidae	29%	98%
A0A1X0P364	Trypanosomatidae	52%	100%
A0A3Q8IDE6	Leishmania donovani	28%	100%
A0A3R7L7Y9	Trypanosoma rangeli	28%	99%
A0A3R7P015	Trypanosoma rangeli	52%	93%
A0A3S5H5G2	Leishmania donovani	97%	100%
A0A3S7WZL6	Leishmania donovani	28%	100%
A4H461	Leishmania braziliensis	88%	100%
A4HEQ6	Leishmania braziliensis	25%	100%
A4HFQ6	Leishmania braziliensis	28%	100%
A4HHW0	Leishmania braziliensis	27%	100%
A4HSD0	Leishmania infantum	97%	100%
A4I1Y5	Leishmania infantum	28%	100%
A4I2T1	Leishmania infantum	28%	100%
C9ZPX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
E9ADA9	Leishmania major	28%	100%
E9AKB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	93%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
P10775	Sus scrofa	24%	97%
Q4Q9E1	Leishmania major	27%	100%
Q4QBG0	Leishmania major	24%	100%
Q4V8D9	Rattus norvegicus	22%	100%
Q8IZ02	Homo sapiens	25%	95%
Q91VI7	Mus musculus	23%	97%
Q9DAM1	Mus musculus	23%	100%
Q9LE82	Arabidopsis thaliana	26%	82%
Q9M651	Arabidopsis thaliana	26%	81%
Q9VIW3	Drosophila melanogaster	28%	74%
V5BC66	Trypanosoma cruzi	28%	67%
V5BJF0	Trypanosoma cruzi	53%	89%
V5BPZ7	Trypanosoma cruzi	29%	98%