C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fip1 motif/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania major

UniProt:

Q4QJI4_LEIMA

TriTrypDb:

LmjF.05.0190 , LMJLV39_050006800 , LMJSD75_050006800

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	2
GO:0005849	mRNA cleavage factor complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	10
GO:0140513	nuclear protein-containing complex	2	2
GO:0005634	nucleus	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

Q4QJI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJI4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006378	mRNA polyadenylation	7	2
GO:0006379	mRNA cleavage	7	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0031123	RNA 3'-end processing	7	2
GO:0031124	mRNA 3'-end processing	8	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043631	RNA polyadenylation	6	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0098787	mRNA cleavage involved in mRNA processing	8	2
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.656
CLV_C14_Caspase3-7	336	340	PF00656	0.697
CLV_PCSK_KEX2_1	350	352	PF00082	0.655
CLV_PCSK_KEX2_1	72	74	PF00082	0.318
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.632
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.318
CLV_PCSK_PC7_1	346	352	PF00082	0.662
DEG_Nend_UBRbox_2	1	3	PF02207	0.575
DOC_CKS1_1	289	294	PF01111	0.666
DOC_MAPK_MEF2A_6	43	50	PF00069	0.515
DOC_PP4_FxxP_1	345	348	PF00568	0.668
DOC_USP7_MATH_1	267	271	PF00917	0.614
DOC_WW_Pin1_4	288	293	PF00397	0.734
DOC_WW_Pin1_4	303	308	PF00397	0.498
LIG_BIR_III_2	24	28	PF00653	0.660
LIG_BRCT_BRCA1_1	59	63	PF00533	0.567
LIG_BRCT_BRCA1_1	82	86	PF00533	0.330
LIG_FHA_1	112	118	PF00498	0.611
LIG_FHA_2	32	38	PF00498	0.653
LIG_LIR_Apic_2	343	348	PF02991	0.725
LIG_LIR_Nem_3	83	88	PF02991	0.294
LIG_LIR_Nem_3	92	98	PF02991	0.293
LIG_MLH1_MIPbox_1	82	86	PF16413	0.330
LIG_Pex14_2	86	90	PF04695	0.293
LIG_PTB_Apo_2	203	210	PF02174	0.513
LIG_PTB_Apo_2	84	91	PF02174	0.293
LIG_PTB_Phospho_1	203	209	PF10480	0.528
LIG_SH2_CRK	183	187	PF00017	0.777
LIG_SH2_CRK	290	294	PF00017	0.733
LIG_SH2_GRB2like	85	88	PF00017	0.293
LIG_SH2_NCK_1	290	294	PF00017	0.663
LIG_SH2_SRC	65	68	PF00017	0.318
LIG_SH2_STAP1	65	69	PF00017	0.384
LIG_SH2_STAT3	171	174	PF00017	0.708
LIG_SH2_STAT3	360	363	PF00017	0.705
LIG_SH2_STAT5	290	293	PF00017	0.665
LIG_SH2_STAT5	312	315	PF00017	0.714
LIG_SH2_STAT5	85	88	PF00017	0.319
LIG_SH2_STAT5	98	101	PF00017	0.295
LIG_SH3_1	183	189	PF00018	0.685
LIG_SH3_1	289	295	PF00018	0.668
LIG_SH3_1	346	352	PF00018	0.692
LIG_SH3_2	304	309	PF14604	0.705
LIG_SH3_3	183	189	PF00018	0.685
LIG_SH3_3	242	248	PF00018	0.662
LIG_SH3_3	289	295	PF00018	0.743
LIG_SH3_3	301	307	PF00018	0.640
LIG_SH3_3	346	352	PF00018	0.704
LIG_SH3_3	356	362	PF00018	0.646
LIG_SUMO_SIM_anti_2	66	71	PF11976	0.384
LIG_TRAF2_1	100	103	PF00917	0.384
LIG_TRAF2_1	131	134	PF00917	0.658
LIG_WRC_WIRS_1	314	319	PF05994	0.520
MOD_CDC14_SPxK_1	306	309	PF00782	0.523
MOD_CDK_SPxK_1	303	309	PF00069	0.522
MOD_CK1_1	338	344	PF00069	0.817
MOD_CK1_1	59	65	PF00069	0.629
MOD_GlcNHglycan	269	272	PF01048	0.792
MOD_GlcNHglycan	329	332	PF01048	0.728
MOD_GlcNHglycan	342	345	PF01048	0.746
MOD_GlcNHglycan	59	62	PF01048	0.631
MOD_GSK3_1	334	341	PF00069	0.643
MOD_N-GLC_1	111	116	PF02516	0.628
MOD_N-GLC_2	226	228	PF02516	0.222
MOD_NEK2_1	327	332	PF00069	0.663
MOD_Plk_1	105	111	PF00069	0.537
MOD_Plk_1	91	97	PF00069	0.295
MOD_Plk_4	105	111	PF00069	0.515
MOD_ProDKin_1	288	294	PF00069	0.731
MOD_ProDKin_1	303	309	PF00069	0.501
TRG_ENDOCYTIC_2	98	101	PF00928	0.293
TRG_NES_CRM1_1	37	51	PF08389	0.601
TRG_NLS_MonoCore_2	349	354	PF00514	0.693
TRG_NLS_MonoExtC_3	349	355	PF00514	0.716
TRG_NLS_MonoExtN_4	348	354	PF00514	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N7	Leptomonas seymouri	54%	100%
A0A0S4JNN9	Bodo saltans	33%	100%
A0A3S5H5G4	Leishmania donovani	89%	100%
A4H465	Leishmania braziliensis	80%	100%
A4HSD3	Leishmania infantum	89%	100%
C9ZPW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AKC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
V5BAD2	Trypanosoma cruzi	38%	100%