G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania major

UniProt:

Q4QJI3_LEIMA

TriTrypDb:

LmjF.05.0200 , LMJLV39_050006900 , LMJSD75_050006900

Length:

789

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJI3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0003924	GTPase activity	7	9
GO:0005488	binding	1	9
GO:0005525	GTP binding	5	9
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0019001	guanyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032561	guanyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.573
CLV_C14_Caspase3-7	523	527	PF00656	0.453
CLV_C14_Caspase3-7	651	655	PF00656	0.602
CLV_C14_Caspase3-7	66	70	PF00656	0.548
CLV_NRD_NRD_1	10	12	PF00675	0.506
CLV_NRD_NRD_1	147	149	PF00675	0.374
CLV_NRD_NRD_1	17	19	PF00675	0.478
CLV_NRD_NRD_1	21	23	PF00675	0.536
CLV_NRD_NRD_1	233	235	PF00675	0.388
CLV_NRD_NRD_1	312	314	PF00675	0.466
CLV_NRD_NRD_1	456	458	PF00675	0.220
CLV_NRD_NRD_1	501	503	PF00675	0.408
CLV_NRD_NRD_1	539	541	PF00675	0.393
CLV_NRD_NRD_1	701	703	PF00675	0.493
CLV_NRD_NRD_1	707	709	PF00675	0.491
CLV_NRD_NRD_1	766	768	PF00675	0.492
CLV_NRD_NRD_1	782	784	PF00675	0.628
CLV_PCSK_FUR_1	11	15	PF00082	0.549
CLV_PCSK_FUR_1	708	712	PF00082	0.511
CLV_PCSK_KEX2_1	10	12	PF00082	0.598
CLV_PCSK_KEX2_1	122	124	PF00082	0.402
CLV_PCSK_KEX2_1	13	15	PF00082	0.577
CLV_PCSK_KEX2_1	147	149	PF00082	0.372
CLV_PCSK_KEX2_1	21	23	PF00082	0.580
CLV_PCSK_KEX2_1	233	235	PF00082	0.388
CLV_PCSK_KEX2_1	339	341	PF00082	0.471
CLV_PCSK_KEX2_1	378	380	PF00082	0.544
CLV_PCSK_KEX2_1	456	458	PF00082	0.220
CLV_PCSK_KEX2_1	501	503	PF00082	0.408
CLV_PCSK_KEX2_1	538	540	PF00082	0.381
CLV_PCSK_KEX2_1	706	708	PF00082	0.525
CLV_PCSK_KEX2_1	710	712	PF00082	0.537
CLV_PCSK_KEX2_1	762	764	PF00082	0.500
CLV_PCSK_KEX2_1	766	768	PF00082	0.493
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.440
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.546
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.502
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.544
CLV_PCSK_PC1ET2_1	710	712	PF00082	0.554
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.500
CLV_PCSK_PC7_1	702	708	PF00082	0.565
CLV_PCSK_SKI1_1	13	17	PF00082	0.584
CLV_PCSK_SKI1_1	140	144	PF00082	0.484
CLV_PCSK_SKI1_1	158	162	PF00082	0.547
CLV_PCSK_SKI1_1	217	221	PF00082	0.399
CLV_PCSK_SKI1_1	25	29	PF00082	0.553
CLV_PCSK_SKI1_1	303	307	PF00082	0.568
CLV_PCSK_SKI1_1	308	312	PF00082	0.562
CLV_PCSK_SKI1_1	321	325	PF00082	0.591
CLV_PCSK_SKI1_1	340	344	PF00082	0.650
CLV_PCSK_SKI1_1	457	461	PF00082	0.220
CLV_PCSK_SKI1_1	505	509	PF00082	0.470
CLV_PCSK_SKI1_1	556	560	PF00082	0.332
CLV_PCSK_SKI1_1	752	756	PF00082	0.667
CLV_PCSK_SKI1_1	767	771	PF00082	0.488
DEG_APCC_DBOX_1	146	154	PF00400	0.392
DEG_APCC_DBOX_1	684	692	PF00400	0.520
DEG_APCC_DBOX_1	765	773	PF00400	0.585
DEG_SCF_FBW7_1	437	444	PF00400	0.420
DEG_SPOP_SBC_1	718	722	PF00917	0.485
DOC_CKS1_1	160	165	PF01111	0.356
DOC_CKS1_1	406	411	PF01111	0.458
DOC_CKS1_1	743	748	PF01111	0.660
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.505
DOC_MAPK_gen_1	216	222	PF00069	0.336
DOC_MAPK_gen_1	321	330	PF00069	0.509
DOC_MAPK_gen_1	443	452	PF00069	0.420
DOC_MAPK_gen_1	553	563	PF00069	0.334
DOC_MAPK_gen_1	766	774	PF00069	0.546
DOC_MAPK_MEF2A_6	180	188	PF00069	0.300
DOC_MAPK_MEF2A_6	556	563	PF00069	0.328
DOC_MAPK_MEF2A_6	726	734	PF00069	0.620
DOC_MAPK_NFAT4_5	556	564	PF00069	0.335
DOC_MAPK_RevD_3	326	340	PF00069	0.414
DOC_PP2B_LxvP_1	118	121	PF13499	0.334
DOC_PP2B_LxvP_1	324	327	PF13499	0.546
DOC_PP2B_LxvP_1	450	453	PF13499	0.420
DOC_USP7_MATH_1	267	271	PF00917	0.757
DOC_USP7_MATH_1	289	293	PF00917	0.546
DOC_USP7_MATH_1	372	376	PF00917	0.589
DOC_USP7_MATH_1	599	603	PF00917	0.685
DOC_USP7_MATH_1	678	682	PF00917	0.552
DOC_USP7_MATH_1	718	722	PF00917	0.485
DOC_USP7_UBL2_3	212	216	PF12436	0.498
DOC_USP7_UBL2_3	49	53	PF12436	0.571
DOC_USP7_UBL2_3	556	560	PF12436	0.426
DOC_USP7_UBL2_3	756	760	PF12436	0.551
DOC_WW_Pin1_4	159	164	PF00397	0.369
DOC_WW_Pin1_4	405	410	PF00397	0.397
DOC_WW_Pin1_4	437	442	PF00397	0.430
DOC_WW_Pin1_4	594	599	PF00397	0.616
DOC_WW_Pin1_4	742	747	PF00397	0.576
LIG_14-3-3_CanoR_1	147	151	PF00244	0.457
LIG_14-3-3_CanoR_1	197	205	PF00244	0.397
LIG_14-3-3_CanoR_1	47	56	PF00244	0.565
LIG_14-3-3_CanoR_1	680	684	PF00244	0.540
LIG_Actin_WH2_2	667	682	PF00022	0.444
LIG_APCC_ABBA_1	559	564	PF00400	0.335
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_BIR_III_2	666	670	PF00653	0.582
LIG_BIR_III_4	623	627	PF00653	0.720
LIG_Clathr_ClatBox_1	688	692	PF01394	0.504
LIG_deltaCOP1_diTrp_1	169	175	PF00928	0.338
LIG_deltaCOP1_diTrp_1	632	640	PF00928	0.476
LIG_FHA_1	447	453	PF00498	0.449
LIG_FHA_1	488	494	PF00498	0.421
LIG_FHA_1	56	62	PF00498	0.459
LIG_FHA_2	160	166	PF00498	0.355
LIG_FHA_2	272	278	PF00498	0.666
LIG_FHA_2	357	363	PF00498	0.508
LIG_FHA_2	381	387	PF00498	0.429
LIG_FHA_2	486	492	PF00498	0.379
LIG_FHA_2	623	629	PF00498	0.653
LIG_FHA_2	682	688	PF00498	0.442
LIG_FXI_DFP_1	637	641	PF00024	0.475
LIG_GBD_Chelix_1	528	536	PF00786	0.434
LIG_IBAR_NPY_1	332	334	PF08397	0.455
LIG_Integrin_RGD_1	243	245	PF01839	0.432
LIG_IRF3_LxIS_1	508	515	PF10401	0.391
LIG_LIR_Gen_1	110	118	PF02991	0.440
LIG_LIR_Gen_1	380	390	PF02991	0.424
LIG_LIR_Gen_1	392	401	PF02991	0.345
LIG_LIR_Gen_1	444	453	PF02991	0.420
LIG_LIR_Gen_1	564	574	PF02991	0.446
LIG_LIR_Gen_1	62	70	PF02991	0.475
LIG_LIR_Gen_1	634	641	PF02991	0.578
LIG_LIR_Gen_1	684	693	PF02991	0.517
LIG_LIR_Nem_3	110	114	PF02991	0.457
LIG_LIR_Nem_3	169	174	PF02991	0.304
LIG_LIR_Nem_3	199	204	PF02991	0.375
LIG_LIR_Nem_3	245	250	PF02991	0.340
LIG_LIR_Nem_3	380	385	PF02991	0.457
LIG_LIR_Nem_3	392	397	PF02991	0.428
LIG_LIR_Nem_3	444	450	PF02991	0.420
LIG_LIR_Nem_3	564	570	PF02991	0.437
LIG_LIR_Nem_3	62	67	PF02991	0.470
LIG_LIR_Nem_3	634	640	PF02991	0.577
LIG_LIR_Nem_3	681	686	PF02991	0.553
LIG_LYPXL_yS_3	417	420	PF13949	0.420
LIG_Pex14_1	236	240	PF04695	0.317
LIG_REV1ctd_RIR_1	247	256	PF16727	0.455
LIG_RPA_C_Fungi	692	704	PF08784	0.521
LIG_SH2_PTP2	569	572	PF00017	0.378
LIG_SH2_SRC	562	565	PF00017	0.338
LIG_SH2_SRC	569	572	PF00017	0.344
LIG_SH2_STAP1	164	168	PF00017	0.320
LIG_SH2_STAP1	334	338	PF00017	0.534
LIG_SH2_STAP1	658	662	PF00017	0.649
LIG_SH2_STAT3	588	591	PF00017	0.588
LIG_SH2_STAT5	204	207	PF00017	0.395
LIG_SH2_STAT5	239	242	PF00017	0.356
LIG_SH2_STAT5	562	565	PF00017	0.456
LIG_SH2_STAT5	566	569	PF00017	0.380
LIG_SH2_STAT5	673	676	PF00017	0.601
LIG_SH2_STAT5	75	78	PF00017	0.607
LIG_SH3_3	118	124	PF00018	0.347
LIG_SH3_3	327	333	PF00018	0.484
LIG_SH3_3	381	387	PF00018	0.418
LIG_SH3_3	412	418	PF00018	0.259
LIG_SH3_3	567	573	PF00018	0.410
LIG_SH3_3	747	753	PF00018	0.648
LIG_SH3_4	758	765	PF00018	0.582
LIG_SUMO_SIM_anti_2	182	189	PF11976	0.293
LIG_SUMO_SIM_par_1	735	745	PF11976	0.619
LIG_TRAF2_1	299	302	PF00917	0.647
LIG_TRAF2_1	610	613	PF00917	0.668
LIG_TRAF2_1	614	617	PF00917	0.770
LIG_TRAF2_1	631	634	PF00917	0.604
LIG_TRAF2_1	70	73	PF00917	0.553
LIG_TRAF2_2	387	392	PF00917	0.338
LIG_TYR_ITIM	415	420	PF00017	0.257
LIG_WRC_WIRS_1	468	473	PF05994	0.354
LIG_WW_1	573	576	PF00397	0.400
MOD_CDK_SPxK_1	437	443	PF00069	0.257
MOD_CDK_SPxxK_3	159	166	PF00069	0.357
MOD_CK1_1	470	476	PF00069	0.385
MOD_CK1_1	681	687	PF00069	0.504
MOD_CK2_1	128	134	PF00069	0.383
MOD_CK2_1	159	165	PF00069	0.376
MOD_CK2_1	196	202	PF00069	0.274
MOD_CK2_1	208	214	PF00069	0.491
MOD_CK2_1	356	362	PF00069	0.514
MOD_CK2_1	51	57	PF00069	0.448
MOD_CK2_1	524	530	PF00069	0.390
MOD_CK2_1	622	628	PF00069	0.698
MOD_CK2_1	681	687	PF00069	0.453
MOD_Cter_Amidation	19	22	PF01082	0.535
MOD_GlcNHglycan	130	133	PF01048	0.419
MOD_GlcNHglycan	250	253	PF01048	0.372
MOD_GlcNHglycan	31	35	PF01048	0.554
MOD_GlcNHglycan	335	339	PF01048	0.475
MOD_GlcNHglycan	374	377	PF01048	0.496
MOD_GlcNHglycan	437	440	PF01048	0.262
MOD_GlcNHglycan	594	597	PF01048	0.603
MOD_GlcNHglycan	602	605	PF01048	0.669
MOD_GlcNHglycan	641	644	PF01048	0.591
MOD_GlcNHglycan	651	654	PF01048	0.671
MOD_GSK3_1	112	119	PF00069	0.437
MOD_GSK3_1	204	211	PF00069	0.430
MOD_GSK3_1	222	229	PF00069	0.325
MOD_GSK3_1	267	274	PF00069	0.641
MOD_GSK3_1	401	408	PF00069	0.454
MOD_GSK3_1	437	444	PF00069	0.276
MOD_GSK3_1	467	474	PF00069	0.353
MOD_GSK3_1	47	54	PF00069	0.496
MOD_GSK3_1	485	492	PF00069	0.376
MOD_GSK3_1	9	16	PF00069	0.485
MOD_LATS_1	312	318	PF00433	0.581
MOD_N-GLC_1	128	133	PF02516	0.337
MOD_N-GLC_1	222	227	PF02516	0.326
MOD_N-GLC_1	512	517	PF02516	0.374
MOD_N-GLC_1	656	661	PF02516	0.525
MOD_NEK2_1	1	6	PF00069	0.495
MOD_NEK2_1	114	119	PF00069	0.470
MOD_NEK2_1	248	253	PF00069	0.418
MOD_NEK2_1	471	476	PF00069	0.411
MOD_NEK2_1	493	498	PF00069	0.436
MOD_NEK2_1	512	517	PF00069	0.374
MOD_NEK2_1	679	684	PF00069	0.544
MOD_NEK2_1	9	14	PF00069	0.448
MOD_PIKK_1	47	53	PF00454	0.563
MOD_PKA_1	13	19	PF00069	0.485
MOD_PKA_1	709	715	PF00069	0.526
MOD_PKA_2	146	152	PF00069	0.455
MOD_PKA_2	196	202	PF00069	0.353
MOD_PKA_2	205	211	PF00069	0.411
MOD_PKA_2	679	685	PF00069	0.558
MOD_PKA_2	9	15	PF00069	0.568
MOD_Plk_1	512	518	PF00069	0.382
MOD_Plk_1	656	662	PF00069	0.525
MOD_Plk_1	718	724	PF00069	0.485
MOD_Plk_2-3	380	386	PF00069	0.439
MOD_Plk_2-3	524	530	PF00069	0.425
MOD_Plk_2-3	628	634	PF00069	0.621
MOD_Plk_2-3	656	662	PF00069	0.641
MOD_Plk_4	182	188	PF00069	0.400
MOD_Plk_4	446	452	PF00069	0.269
MOD_Plk_4	51	57	PF00069	0.441
MOD_Plk_4	719	725	PF00069	0.585
MOD_ProDKin_1	159	165	PF00069	0.359
MOD_ProDKin_1	405	411	PF00069	0.389
MOD_ProDKin_1	437	443	PF00069	0.271
MOD_ProDKin_1	594	600	PF00069	0.619
MOD_ProDKin_1	742	748	PF00069	0.578
MOD_SUMO_for_1	338	341	PF00179	0.586
MOD_SUMO_for_1	352	355	PF00179	0.621
MOD_SUMO_for_1	377	380	PF00179	0.538
MOD_SUMO_rev_2	133	143	PF00179	0.561
MOD_SUMO_rev_2	154	160	PF00179	0.519
MOD_SUMO_rev_2	211	218	PF00179	0.490
TRG_DiLeu_BaEn_1	156	161	PF01217	0.503
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.381
TRG_ENDOCYTIC_2	417	420	PF00928	0.257
TRG_ENDOCYTIC_2	686	689	PF00928	0.516
TRG_ER_diArg_1	146	148	PF00400	0.336
TRG_ER_diArg_1	456	458	PF00400	0.257
TRG_ER_diArg_1	501	503	PF00400	0.408
TRG_ER_diArg_1	538	540	PF00400	0.381
TRG_ER_diArg_1	697	700	PF00400	0.482
TRG_ER_diArg_1	706	708	PF00400	0.496
TRG_ER_diArg_1	9	11	PF00400	0.405
TRG_NLS_MonoCore_2	707	712	PF00514	0.524
TRG_NLS_MonoExtN_4	706	713	PF00514	0.547
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	647	651	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	767	771	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S3	Leptomonas seymouri	75%	100%
A0A3S5H5G5	Leishmania donovani	94%	100%
A0A422NYH3	Trypanosoma rangeli	51%	100%
A4H466	Leishmania braziliensis	85%	100%
A4HSD4	Leishmania infantum	94%	100%
C9ZPW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	97%
E9AKC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q2YDM7	Bos taurus	36%	100%
Q4R8L2	Macaca fascicularis	34%	100%
Q9H089	Homo sapiens	34%	100%