LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Dual specificity phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dual specificity phosphatase-like protein
Gene product:
dual specificity phosphatase-like protein
Species:
Leishmania major
UniProt:
Q4QJI1_LEIMA
TriTrypDb:
LmjF.05.0220 * , LMJLV39_050007100 * , LMJSD75_050007100 *
Length:
665

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QJI1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJI1

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009966 regulation of signal transduction 4 2
GO:0009968 negative regulation of signal transduction 5 2
GO:0009987 cellular process 1 6
GO:0010646 regulation of cell communication 4 2
GO:0010648 negative regulation of cell communication 5 2
GO:0016311 dephosphorylation 5 6
GO:0019538 protein metabolic process 3 6
GO:0023051 regulation of signaling 3 2
GO:0023057 negative regulation of signaling 4 2
GO:0036211 protein modification process 4 6
GO:0043170 macromolecule metabolic process 3 6
GO:0043408 regulation of MAPK cascade 6 2
GO:0043409 negative regulation of MAPK cascade 7 2
GO:0043412 macromolecule modification 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0048519 negative regulation of biological process 3 2
GO:0048523 negative regulation of cellular process 4 2
GO:0048583 regulation of response to stimulus 3 2
GO:0048585 negative regulation of response to stimulus 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0071704 organic substance metabolic process 2 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:1902531 regulation of intracellular signal transduction 5 2
GO:1902532 negative regulation of intracellular signal transduction 6 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0004721 phosphoprotein phosphatase activity 3 6
GO:0004725 protein tyrosine phosphatase activity 4 6
GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4 6
GO:0016787 hydrolase activity 2 6
GO:0016788 hydrolase activity, acting on ester bonds 3 6
GO:0016791 phosphatase activity 5 6
GO:0042578 phosphoric ester hydrolase activity 4 6
GO:0140096 catalytic activity, acting on a protein 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 246 250 PF00656 0.553
CLV_C14_Caspase3-7 501 505 PF00656 0.755
CLV_C14_Caspase3-7 538 542 PF00656 0.560
CLV_C14_Caspase3-7 86 90 PF00656 0.526
CLV_NRD_NRD_1 167 169 PF00675 0.526
CLV_NRD_NRD_1 199 201 PF00675 0.526
CLV_NRD_NRD_1 366 368 PF00675 0.845
CLV_NRD_NRD_1 434 436 PF00675 0.815
CLV_NRD_NRD_1 454 456 PF00675 0.509
CLV_NRD_NRD_1 569 571 PF00675 0.761
CLV_PCSK_KEX2_1 167 169 PF00082 0.526
CLV_PCSK_KEX2_1 199 201 PF00082 0.526
CLV_PCSK_KEX2_1 305 307 PF00082 0.572
CLV_PCSK_KEX2_1 366 368 PF00082 0.845
CLV_PCSK_KEX2_1 37 39 PF00082 0.712
CLV_PCSK_KEX2_1 434 436 PF00082 0.815
CLV_PCSK_PC1ET2_1 305 307 PF00082 0.572
CLV_PCSK_PC1ET2_1 37 39 PF00082 0.712
CLV_PCSK_SKI1_1 102 106 PF00082 0.526
CLV_PCSK_SKI1_1 194 198 PF00082 0.526
CLV_PCSK_SKI1_1 290 294 PF00082 0.672
CLV_PCSK_SKI1_1 37 41 PF00082 0.428
CLV_PCSK_SKI1_1 434 438 PF00082 0.720
DEG_APCC_DBOX_1 433 441 PF00400 0.815
DEG_SCF_FBW7_2 403 410 PF00400 0.742
DEG_SPOP_SBC_1 2 6 PF00917 0.639
DEG_SPOP_SBC_1 292 296 PF00917 0.768
DEG_SPOP_SBC_1 376 380 PF00917 0.594
DEG_SPOP_SBC_1 445 449 PF00917 0.690
DOC_CKS1_1 404 409 PF01111 0.598
DOC_CYCLIN_yClb1_LxF_4 190 196 PF00134 0.364
DOC_MAPK_gen_1 199 207 PF00069 0.378
DOC_MAPK_MEF2A_6 199 207 PF00069 0.526
DOC_PP2B_LxvP_1 284 287 PF13499 0.707
DOC_PP4_FxxP_1 223 226 PF00568 0.661
DOC_USP7_MATH_1 243 247 PF00917 0.812
DOC_USP7_MATH_1 25 29 PF00917 0.713
DOC_USP7_MATH_1 267 271 PF00917 0.829
DOC_USP7_MATH_1 301 305 PF00917 0.699
DOC_USP7_MATH_1 309 313 PF00917 0.794
DOC_USP7_MATH_1 376 380 PF00917 0.594
DOC_USP7_MATH_1 443 447 PF00917 0.699
DOC_USP7_MATH_1 514 518 PF00917 0.752
DOC_USP7_MATH_1 544 548 PF00917 0.612
DOC_USP7_MATH_1 83 87 PF00917 0.461
DOC_WW_Pin1_4 23 28 PF00397 0.710
DOC_WW_Pin1_4 238 243 PF00397 0.775
DOC_WW_Pin1_4 330 335 PF00397 0.540
DOC_WW_Pin1_4 403 408 PF00397 0.684
DOC_WW_Pin1_4 424 429 PF00397 0.729
DOC_WW_Pin1_4 510 515 PF00397 0.657
DOC_WW_Pin1_4 523 528 PF00397 0.821
DOC_WW_Pin1_4 552 557 PF00397 0.744
DOC_WW_Pin1_4 601 606 PF00397 0.768
DOC_WW_Pin1_4 640 645 PF00397 0.841
LIG_14-3-3_CanoR_1 154 163 PF00244 0.399
LIG_14-3-3_CanoR_1 199 207 PF00244 0.421
LIG_14-3-3_CanoR_1 212 218 PF00244 0.464
LIG_14-3-3_CanoR_1 300 309 PF00244 0.794
LIG_14-3-3_CanoR_1 386 396 PF00244 0.796
LIG_14-3-3_CanoR_1 460 469 PF00244 0.706
LIG_14-3-3_CanoR_1 508 514 PF00244 0.562
LIG_14-3-3_CanoR_1 659 664 PF00244 0.720
LIG_Actin_WH2_2 36 53 PF00022 0.711
LIG_BIR_II_1 1 5 PF00653 0.644
LIG_BRCT_BRCA1_1 218 222 PF00533 0.690
LIG_FHA_1 136 142 PF00498 0.441
LIG_FHA_1 351 357 PF00498 0.558
LIG_FHA_1 378 384 PF00498 0.733
LIG_FHA_1 474 480 PF00498 0.816
LIG_FHA_1 77 83 PF00498 0.522
LIG_FHA_2 346 352 PF00498 0.832
LIG_FHA_2 459 465 PF00498 0.552
LIG_FHA_2 57 63 PF00498 0.648
LIG_LIR_Apic_2 220 226 PF02991 0.640
LIG_MLH1_MIPbox_1 219 223 PF16413 0.607
LIG_PCNA_yPIPBox_3 118 131 PF02747 0.526
LIG_RPA_C_Fungi 163 175 PF08784 0.526
LIG_SH2_GRB2like 189 192 PF00017 0.246
LIG_SH2_SRC 189 192 PF00017 0.526
LIG_SH2_STAP1 189 193 PF00017 0.526
LIG_SH2_STAT3 628 631 PF00017 0.757
LIG_SH2_STAT5 103 106 PF00017 0.526
LIG_SH2_STAT5 144 147 PF00017 0.252
LIG_SH2_STAT5 180 183 PF00017 0.501
LIG_SH3_2 24 29 PF14604 0.668
LIG_SH3_3 12 18 PF00018 0.704
LIG_SH3_3 21 27 PF00018 0.674
LIG_SH3_3 419 425 PF00018 0.811
LIG_SH3_3 524 530 PF00018 0.754
LIG_SUMO_SIM_par_1 282 288 PF11976 0.526
LIG_SUMO_SIM_par_1 79 86 PF11976 0.579
LIG_TRAF2_1 113 116 PF00917 0.526
LIG_TRAF2_1 208 211 PF00917 0.433
LIG_TRAF2_1 275 278 PF00917 0.608
LIG_TRAF2_1 463 466 PF00917 0.685
LIG_TRAF2_1 498 501 PF00917 0.798
LIG_TRAF2_1 52 55 PF00917 0.697
LIG_TRAF2_2 275 280 PF00917 0.745
LIG_Vh1_VBS_1 468 486 PF01044 0.542
MOD_CDC14_SPxK_1 26 29 PF00782 0.663
MOD_CDK_SPK_2 523 528 PF00069 0.852
MOD_CDK_SPxK_1 23 29 PF00069 0.670
MOD_CK1_1 157 163 PF00069 0.485
MOD_CK1_1 201 207 PF00069 0.526
MOD_CK1_1 241 247 PF00069 0.828
MOD_CK1_1 28 34 PF00069 0.699
MOD_CK1_1 291 297 PF00069 0.746
MOD_CK1_1 299 305 PF00069 0.601
MOD_CK1_1 327 333 PF00069 0.810
MOD_CK1_1 341 347 PF00069 0.613
MOD_CK1_1 384 390 PF00069 0.695
MOD_CK1_1 411 417 PF00069 0.842
MOD_CK1_1 446 452 PF00069 0.825
MOD_CK1_1 510 516 PF00069 0.825
MOD_CK1_1 574 580 PF00069 0.813
MOD_CK1_1 613 619 PF00069 0.644
MOD_CK1_1 658 664 PF00069 0.710
MOD_CK1_1 76 82 PF00069 0.492
MOD_CK2_1 345 351 PF00069 0.758
MOD_CK2_1 458 464 PF00069 0.765
MOD_CK2_1 537 543 PF00069 0.794
MOD_CK2_1 56 62 PF00069 0.639
MOD_CK2_1 580 586 PF00069 0.759
MOD_CK2_1 88 94 PF00069 0.433
MOD_Cter_Amidation 432 435 PF01082 0.814
MOD_GlcNHglycan 172 175 PF01048 0.373
MOD_GlcNHglycan 243 246 PF01048 0.783
MOD_GlcNHglycan 263 266 PF01048 0.572
MOD_GlcNHglycan 326 329 PF01048 0.730
MOD_GlcNHglycan 340 343 PF01048 0.577
MOD_GlcNHglycan 368 371 PF01048 0.766
MOD_GlcNHglycan 383 386 PF01048 0.632
MOD_GlcNHglycan 397 400 PF01048 0.604
MOD_GlcNHglycan 448 451 PF01048 0.835
MOD_GlcNHglycan 534 537 PF01048 0.860
MOD_GlcNHglycan 545 549 PF01048 0.658
MOD_GlcNHglycan 573 576 PF01048 0.779
MOD_GlcNHglycan 631 634 PF01048 0.712
MOD_GSK3_1 135 142 PF00069 0.509
MOD_GSK3_1 181 188 PF00069 0.526
MOD_GSK3_1 194 201 PF00069 0.444
MOD_GSK3_1 241 248 PF00069 0.698
MOD_GSK3_1 288 295 PF00069 0.800
MOD_GSK3_1 296 303 PF00069 0.694
MOD_GSK3_1 320 327 PF00069 0.731
MOD_GSK3_1 330 337 PF00069 0.713
MOD_GSK3_1 341 348 PF00069 0.656
MOD_GSK3_1 362 369 PF00069 0.716
MOD_GSK3_1 377 384 PF00069 0.630
MOD_GSK3_1 444 451 PF00069 0.777
MOD_GSK3_1 473 480 PF00069 0.736
MOD_GSK3_1 509 516 PF00069 0.775
MOD_GSK3_1 528 535 PF00069 0.608
MOD_GSK3_1 546 553 PF00069 0.765
MOD_GSK3_1 571 578 PF00069 0.756
MOD_GSK3_1 601 608 PF00069 0.839
MOD_GSK3_1 623 630 PF00069 0.778
MOD_GSK3_1 638 645 PF00069 0.645
MOD_GSK3_1 654 661 PF00069 0.710
MOD_GSK3_1 73 80 PF00069 0.528
MOD_N-GLC_1 133 138 PF02516 0.246
MOD_N-GLC_1 267 272 PF02516 0.719
MOD_N-GLC_1 514 519 PF02516 0.741
MOD_N-GLC_1 575 580 PF02516 0.790
MOD_N-GLC_1 587 592 PF02516 0.722
MOD_N-GLC_1 601 606 PF02516 0.612
MOD_N-GLC_2 487 489 PF02516 0.693
MOD_NEK2_1 133 138 PF00069 0.516
MOD_NEK2_1 350 355 PF00069 0.600
MOD_NEK2_1 375 380 PF00069 0.738
MOD_NEK2_1 473 478 PF00069 0.746
MOD_PIKK_1 135 141 PF00454 0.464
MOD_PIKK_1 225 231 PF00454 0.767
MOD_PIKK_1 268 274 PF00454 0.764
MOD_PIKK_1 307 313 PF00454 0.845
MOD_PIKK_1 528 534 PF00454 0.572
MOD_PIKK_1 560 566 PF00454 0.752
MOD_PIKK_1 627 633 PF00454 0.849
MOD_PIKK_1 638 644 PF00454 0.664
MOD_PK_1 320 326 PF00069 0.685
MOD_PKA_1 366 372 PF00069 0.743
MOD_PKA_2 198 204 PF00069 0.526
MOD_PKA_2 211 217 PF00069 0.232
MOD_PKA_2 28 34 PF00069 0.699
MOD_PKA_2 299 305 PF00069 0.792
MOD_PKA_2 337 343 PF00069 0.761
MOD_PKA_2 366 372 PF00069 0.831
MOD_PKA_2 381 387 PF00069 0.552
MOD_PKA_2 507 513 PF00069 0.756
MOD_PKA_2 532 538 PF00069 0.836
MOD_PKA_2 658 664 PF00069 0.721
MOD_PKB_1 601 609 PF00069 0.723
MOD_Plk_1 157 163 PF00069 0.433
MOD_Plk_1 350 356 PF00069 0.555
MOD_Plk_1 62 68 PF00069 0.741
MOD_Plk_1 76 82 PF00069 0.356
MOD_Plk_2-3 185 191 PF00069 0.526
MOD_Plk_4 247 253 PF00069 0.677
MOD_Plk_4 320 326 PF00069 0.713
MOD_Plk_4 479 485 PF00069 0.725
MOD_Plk_4 56 62 PF00069 0.639
MOD_Plk_4 648 654 PF00069 0.688
MOD_Plk_4 77 83 PF00069 0.522
MOD_ProDKin_1 23 29 PF00069 0.707
MOD_ProDKin_1 238 244 PF00069 0.774
MOD_ProDKin_1 330 336 PF00069 0.540
MOD_ProDKin_1 403 409 PF00069 0.680
MOD_ProDKin_1 424 430 PF00069 0.728
MOD_ProDKin_1 510 516 PF00069 0.657
MOD_ProDKin_1 523 529 PF00069 0.819
MOD_ProDKin_1 552 558 PF00069 0.743
MOD_ProDKin_1 601 607 PF00069 0.769
MOD_ProDKin_1 640 646 PF00069 0.840
MOD_SUMO_rev_2 110 120 PF00179 0.526
TRG_DiLeu_BaEn_1 115 120 PF01217 0.246
TRG_DiLeu_BaEn_4 464 470 PF01217 0.543
TRG_DiLeu_BaLyEn_6 279 284 PF01217 0.725
TRG_ER_diArg_1 567 570 PF00400 0.748

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H5G7 Leishmania donovani 90% 100%
A4H479 Leishmania braziliensis 57% 76%
A4HSF4 Leishmania infantum 90% 99%
E9AKC6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS