Putative hydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrogenase, putative

Species:

Leishmania major

UniProt:

Q4QJI0_LEIMA

TriTrypDb:

LmjF.05.0230 , LMJLV39_050007200 , LMJSD75_050007200

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJI0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0051536	iron-sulfur cluster binding	3	2
GO:0051539	4 iron, 4 sulfur cluster binding	4	2
GO:0051540	metal cluster binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	517	521	PF00656	0.353
CLV_C14_Caspase3-7	562	566	PF00656	0.551
CLV_C14_Caspase3-7	611	615	PF00656	0.567
CLV_NRD_NRD_1	227	229	PF00675	0.285
CLV_NRD_NRD_1	295	297	PF00675	0.237
CLV_NRD_NRD_1	580	582	PF00675	0.663
CLV_PCSK_FUR_1	225	229	PF00082	0.335
CLV_PCSK_KEX2_1	225	227	PF00082	0.280
CLV_PCSK_KEX2_1	278	280	PF00082	0.255
CLV_PCSK_KEX2_1	40	42	PF00082	0.728
CLV_PCSK_KEX2_1	445	447	PF00082	0.237
CLV_PCSK_KEX2_1	481	483	PF00082	0.251
CLV_PCSK_KEX2_1	579	581	PF00082	0.666
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.255
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.710
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.232
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.251
CLV_PCSK_PC7_1	477	483	PF00082	0.331
CLV_PCSK_SKI1_1	477	481	PF00082	0.248
DEG_APCC_DBOX_1	113	121	PF00400	0.383
DEG_Nend_UBRbox_2	1	3	PF02207	0.567
DEG_SPOP_SBC_1	101	105	PF00917	0.653
DEG_SPOP_SBC_1	306	310	PF00917	0.410
DEG_SPOP_SBC_1	427	431	PF00917	0.542
DEG_SPOP_SBC_1	544	548	PF00917	0.491
DOC_ANK_TNKS_1	416	423	PF00023	0.485
DOC_CKS1_1	434	439	PF01111	0.569
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.385
DOC_MAPK_gen_1	579	588	PF00069	0.521
DOC_PP2B_LxvP_1	199	202	PF13499	0.385
DOC_USP7_MATH_1	101	105	PF00917	0.592
DOC_USP7_MATH_1	108	112	PF00917	0.424
DOC_USP7_MATH_1	265	269	PF00917	0.531
DOC_USP7_MATH_1	29	33	PF00917	0.628
DOC_USP7_MATH_1	301	305	PF00917	0.537
DOC_USP7_MATH_1	388	392	PF00917	0.540
DOC_USP7_MATH_1	425	429	PF00917	0.545
DOC_USP7_MATH_1	485	489	PF00917	0.500
DOC_USP7_MATH_1	544	548	PF00917	0.697
DOC_USP7_MATH_1	561	565	PF00917	0.735
DOC_WW_Pin1_4	382	387	PF00397	0.477
DOC_WW_Pin1_4	428	433	PF00397	0.540
DOC_WW_Pin1_4	540	545	PF00397	0.680
DOC_WW_Pin1_4	556	561	PF00397	0.656
LIG_14-3-3_CanoR_1	148	156	PF00244	0.494
LIG_14-3-3_CanoR_1	487	492	PF00244	0.457
LIG_14-3-3_CanoR_1	618	622	PF00244	0.548
LIG_BRCT_BRCA1_1	390	394	PF00533	0.485
LIG_BRCT_BRCA1_1	487	491	PF00533	0.435
LIG_deltaCOP1_diTrp_1	594	600	PF00928	0.522
LIG_deltaCOP1_diTrp_1	614	621	PF00928	0.438
LIG_eIF4E_1	489	495	PF01652	0.437
LIG_FHA_1	151	157	PF00498	0.532
LIG_FHA_1	191	197	PF00498	0.410
LIG_FHA_1	322	328	PF00498	0.437
LIG_FHA_1	602	608	PF00498	0.575
LIG_FHA_1	79	85	PF00498	0.424
LIG_FHA_2	217	223	PF00498	0.437
LIG_FHA_2	488	494	PF00498	0.437
LIG_FHA_2	589	595	PF00498	0.568
LIG_FHA_2	618	624	PF00498	0.525
LIG_FHA_2	63	69	PF00498	0.432
LIG_FHA_2	75	81	PF00498	0.386
LIG_GBD_Chelix_1	128	136	PF00786	0.367
LIG_LIR_Apic_2	2	6	PF02991	0.499
LIG_LIR_Gen_1	488	498	PF02991	0.437
LIG_LIR_Gen_1	625	632	PF02991	0.531
LIG_LIR_Nem_3	488	494	PF02991	0.437
LIG_LIR_Nem_3	594	600	PF02991	0.602
LIG_MYND_1	261	265	PF01753	0.451
LIG_MYND_1	46	50	PF01753	0.635
LIG_Pex14_1	617	621	PF04695	0.409
LIG_SH2_NCK_1	140	144	PF00017	0.410
LIG_SH2_PTP2	3	6	PF00017	0.492
LIG_SH2_STAP1	140	144	PF00017	0.451
LIG_SH2_STAP1	276	280	PF00017	0.422
LIG_SH2_STAP1	323	327	PF00017	0.437
LIG_SH2_STAP1	526	530	PF00017	0.521
LIG_SH2_STAT3	467	470	PF00017	0.437
LIG_SH2_STAT5	131	134	PF00017	0.375
LIG_SH2_STAT5	204	207	PF00017	0.421
LIG_SH2_STAT5	251	254	PF00017	0.437
LIG_SH2_STAT5	3	6	PF00017	0.492
LIG_SH2_STAT5	323	326	PF00017	0.437
LIG_SH2_STAT5	489	492	PF00017	0.437
LIG_SH3_2	342	347	PF14604	0.535
LIG_SH3_3	23	29	PF00018	0.616
LIG_SH3_3	339	345	PF00018	0.531
LIG_SH3_3	431	437	PF00018	0.521
LIG_SH3_3	44	50	PF00018	0.677
LIG_SH3_3	604	610	PF00018	0.531
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.437
LIG_SUMO_SIM_par_1	116	122	PF11976	0.338
LIG_SUMO_SIM_par_1	188	198	PF11976	0.552
LIG_SUMO_SIM_par_1	204	209	PF11976	0.521
LIG_SUMO_SIM_par_1	238	243	PF11976	0.531
LIG_SUMO_SIM_par_1	602	608	PF11976	0.443
LIG_TRAF2_1	219	222	PF00917	0.444
LIG_UBA3_1	333	338	PF00899	0.527
LIG_WW_1	201	204	PF00397	0.485
LIG_WW_3	169	173	PF00397	0.372
MOD_CK1_1	119	125	PF00069	0.332
MOD_CK1_1	18	24	PF00069	0.583
MOD_CK1_1	181	187	PF00069	0.560
MOD_CK1_1	304	310	PF00069	0.487
MOD_CK1_1	428	434	PF00069	0.546
MOD_CK1_1	547	553	PF00069	0.732
MOD_CK1_1	99	105	PF00069	0.638
MOD_CK2_1	194	200	PF00069	0.485
MOD_CK2_1	216	222	PF00069	0.437
MOD_CK2_1	326	332	PF00069	0.437
MOD_CK2_1	487	493	PF00069	0.443
MOD_CK2_1	588	594	PF00069	0.577
MOD_CK2_1	74	80	PF00069	0.462
MOD_CK2_1	85	91	PF00069	0.371
MOD_GlcNHglycan	110	113	PF01048	0.533
MOD_GlcNHglycan	17	20	PF01048	0.715
MOD_GlcNHglycan	178	183	PF01048	0.332
MOD_GlcNHglycan	214	217	PF01048	0.331
MOD_GlcNHglycan	229	232	PF01048	0.331
MOD_GlcNHglycan	242	245	PF01048	0.224
MOD_GlcNHglycan	267	270	PF01048	0.316
MOD_GlcNHglycan	31	34	PF01048	0.642
MOD_GlcNHglycan	390	393	PF01048	0.334
MOD_GlcNHglycan	405	408	PF01048	0.157
MOD_GlcNHglycan	547	550	PF01048	0.707
MOD_GlcNHglycan	7	10	PF01048	0.605
MOD_GlcNHglycan	72	75	PF01048	0.462
MOD_GlcNHglycan	93	96	PF01048	0.553
MOD_GlcNHglycan	99	102	PF01048	0.614
MOD_GSK3_1	11	18	PF00069	0.624
MOD_GSK3_1	178	185	PF00069	0.560
MOD_GSK3_1	186	193	PF00069	0.500
MOD_GSK3_1	212	219	PF00069	0.445
MOD_GSK3_1	27	34	PF00069	0.700
MOD_GSK3_1	301	308	PF00069	0.544
MOD_GSK3_1	367	374	PF00069	0.523
MOD_GSK3_1	426	433	PF00069	0.525
MOD_GSK3_1	540	547	PF00069	0.737
MOD_GSK3_1	556	563	PF00069	0.683
MOD_GSK3_1	601	608	PF00069	0.531
MOD_GSK3_1	70	77	PF00069	0.402
MOD_GSK3_1	91	98	PF00069	0.490
MOD_GSK3_1	99	106	PF00069	0.625
MOD_NEK2_1	132	137	PF00069	0.393
MOD_NEK2_1	147	152	PF00069	0.340
MOD_NEK2_1	15	20	PF00069	0.653
MOD_NEK2_1	240	245	PF00069	0.437
MOD_NEK2_1	403	408	PF00069	0.437
MOD_NEK2_1	555	560	PF00069	0.690
MOD_NEK2_1	588	593	PF00069	0.631
MOD_NEK2_1	70	75	PF00069	0.413
MOD_NEK2_1	96	101	PF00069	0.434
MOD_NEK2_2	171	176	PF00069	0.372
MOD_NEK2_2	617	622	PF00069	0.563
MOD_PIKK_1	119	125	PF00454	0.451
MOD_PIKK_1	367	373	PF00454	0.505
MOD_PK_1	116	122	PF00069	0.454
MOD_PKA_1	227	233	PF00069	0.385
MOD_PKA_2	11	17	PF00069	0.470
MOD_PKA_2	147	153	PF00069	0.430
MOD_PKA_2	171	177	PF00069	0.469
MOD_PKA_2	227	233	PF00069	0.510
MOD_PKA_2	301	307	PF00069	0.495
MOD_PKA_2	371	377	PF00069	0.472
MOD_PKA_2	588	594	PF00069	0.601
MOD_PKA_2	617	623	PF00069	0.549
MOD_PKB_1	114	122	PF00069	0.466
MOD_PKB_1	225	233	PF00069	0.385
MOD_PKB_1	347	355	PF00069	0.460
MOD_Plk_1	189	195	PF00069	0.409
MOD_Plk_1	601	607	PF00069	0.545
MOD_Plk_4	11	17	PF00069	0.665
MOD_Plk_4	190	196	PF00069	0.385
MOD_Plk_4	487	493	PF00069	0.437
MOD_Plk_4	78	84	PF00069	0.432
MOD_ProDKin_1	382	388	PF00069	0.477
MOD_ProDKin_1	428	434	PF00069	0.540
MOD_ProDKin_1	540	546	PF00069	0.677
MOD_ProDKin_1	556	562	PF00069	0.658
MOD_SUMO_for_1	175	178	PF00179	0.460
MOD_SUMO_rev_2	289	298	PF00179	0.437
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.535
TRG_ENDOCYTIC_2	131	134	PF00928	0.404
TRG_ENDOCYTIC_2	140	143	PF00928	0.394
TRG_ENDOCYTIC_2	489	492	PF00928	0.437
TRG_ER_diArg_1	113	116	PF00400	0.518
TRG_ER_diArg_1	225	228	PF00400	0.480
TRG_ER_diArg_1	346	349	PF00400	0.471
TRG_ER_diArg_1	579	581	PF00400	0.736
TRG_NLS_MonoExtC_3	479	484	PF00514	0.527
TRG_NLS_MonoExtN_4	477	484	PF00514	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2B2	Leptomonas seymouri	54%	100%
A0A0S4J2N1	Bodo saltans	34%	100%
A0A1X0P0T4	Trypanosomatidae	39%	100%
A0A3S7WP18	Leishmania donovani	89%	100%
A0A422NE31	Trypanosoma rangeli	38%	100%
A1CWD8	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	26%	100%
A2Q9A9	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	27%	100%
A4FV58	Bos taurus	29%	100%
A4H468	Leishmania braziliensis	74%	100%
A4HSF5	Leishmania infantum	89%	100%
A5DKC0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	100%
A5DSI2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	26%	100%
A6ZRK3	Saccharomyces cerevisiae (strain YJM789)	23%	100%
A7E7C4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	27%	100%
A7SDA8	Nematostella vectensis	26%	100%
A7TQP0	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	23%	100%
B0WU52	Culex quinquefasciatus	27%	100%
B3N018	Drosophila ananassae	27%	100%
B3NKH7	Drosophila erecta	26%	100%
B4GXC8	Drosophila persimilis	27%	100%
B4IMH3	Drosophila sechellia	26%	100%
B4ISL0	Drosophila yakuba	28%	100%
B4JBE6	Drosophila grimshawi	27%	100%
B4KFU7	Drosophila mojavensis	28%	100%
B4LQR5	Drosophila virilis	28%	100%
B4MUM8	Drosophila willistoni	28%	100%
B4NSS7	Drosophila simulans	26%	100%
B5DK31	Drosophila pseudoobscura pseudoobscura	27%	100%
B6HUC4	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	26%	100%
B6K2N0	Schizosaccharomyces japonicus (strain yFS275 / FY16936)	25%	100%
B6QQH9	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	27%	100%
B8N122	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	27%	100%
D0A4K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AKC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P23503	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P53998	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q0UM75	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	29%	100%
Q16ML2	Aedes aegypti	27%	100%
Q1E736	Coccidioides immitis (strain RS)	27%	100%
Q2UJY8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	27%	100%
Q2YDU6	Rattus norvegicus	27%	100%
Q5APK7	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q5B748	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
Q5BK18	Rattus norvegicus	29%	100%
Q5RF36	Pongo abelii	29%	100%
Q6BUI4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	100%
Q6CFR3	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	100%
Q6DHP6	Danio rerio	25%	100%
Q6GP25	Xenopus laevis	25%	100%
Q75E78	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	100%
Q7PWB8	Anopheles gambiae	26%	100%
Q7SGW5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	100%
Q8SYS7	Drosophila melanogaster	26%	100%
Q94CL6	Arabidopsis thaliana	28%	100%
Q9CYQ7	Mus musculus	27%	100%
Q9H6Q4	Homo sapiens	29%	100%
Q9N392	Caenorhabditis elegans	27%	100%
Q9UHQ1	Homo sapiens	27%	100%
Q9Y7N7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
V5DC01	Trypanosoma cruzi	39%	100%