LeishMANIAdb
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Putative viscerotropic leishmaniasis antigen

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative viscerotropic leishmaniasis antigen
Gene product:
viscerotropic leishmaniasis antigen, putative
Species:
Leishmania major
UniProt:
Q4QJH9_LEIMA
TriTrypDb:
LmjF.05.0240 * , LMJLV39_050007300 * , LMJSD75_050007300 *
Length:
1239

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

Q4QJH9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJH9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 264 268 PF00656 0.673
CLV_NRD_NRD_1 1027 1029 PF00675 0.387
CLV_NRD_NRD_1 105 107 PF00675 0.426
CLV_NRD_NRD_1 1176 1178 PF00675 0.551
CLV_NRD_NRD_1 1199 1201 PF00675 0.542
CLV_NRD_NRD_1 201 203 PF00675 0.442
CLV_NRD_NRD_1 98 100 PF00675 0.430
CLV_PCSK_FUR_1 1143 1147 PF00082 0.505
CLV_PCSK_KEX2_1 1027 1029 PF00082 0.387
CLV_PCSK_KEX2_1 105 107 PF00082 0.415
CLV_PCSK_KEX2_1 1145 1147 PF00082 0.504
CLV_PCSK_KEX2_1 1176 1178 PF00082 0.551
CLV_PCSK_KEX2_1 1199 1201 PF00082 0.542
CLV_PCSK_KEX2_1 296 298 PF00082 0.456
CLV_PCSK_PC1ET2_1 1145 1147 PF00082 0.504
CLV_PCSK_PC1ET2_1 296 298 PF00082 0.456
CLV_PCSK_SKI1_1 100 104 PF00082 0.333
CLV_PCSK_SKI1_1 1045 1049 PF00082 0.382
CLV_PCSK_SKI1_1 106 110 PF00082 0.371
CLV_PCSK_SKI1_1 1186 1190 PF00082 0.533
DEG_SCF_FBW7_1 133 139 PF00400 0.631
DEG_SPOP_SBC_1 138 142 PF00917 0.696
DOC_CKS1_1 133 138 PF01111 0.667
DOC_MAPK_DCC_7 68 78 PF00069 0.387
DOC_MAPK_gen_1 1143 1152 PF00069 0.722
DOC_MAPK_gen_1 68 78 PF00069 0.458
DOC_MAPK_MEF2A_6 1028 1037 PF00069 0.553
DOC_MAPK_MEF2A_6 1065 1073 PF00069 0.581
DOC_MAPK_MEF2A_6 71 80 PF00069 0.342
DOC_PP1_RVXF_1 6 13 PF00149 0.405
DOC_PP2B_LxvP_1 254 257 PF13499 0.659
DOC_PP2B_LxvP_1 31 34 PF13499 0.353
DOC_USP7_MATH_1 1156 1160 PF00917 0.722
DOC_USP7_MATH_1 1198 1202 PF00917 0.704
DOC_USP7_MATH_1 120 124 PF00917 0.717
DOC_USP7_MATH_1 136 140 PF00917 0.682
DOC_USP7_MATH_1 255 259 PF00917 0.683
DOC_USP7_UBL2_3 103 107 PF12436 0.560
DOC_WW_Pin1_4 1020 1025 PF00397 0.655
DOC_WW_Pin1_4 109 114 PF00397 0.684
DOC_WW_Pin1_4 116 121 PF00397 0.727
DOC_WW_Pin1_4 1161 1166 PF00397 0.693
DOC_WW_Pin1_4 1171 1176 PF00397 0.628
DOC_WW_Pin1_4 1227 1232 PF00397 0.738
DOC_WW_Pin1_4 132 137 PF00397 0.628
DOC_WW_Pin1_4 248 253 PF00397 0.686
LIG_14-3-3_CanoR_1 1155 1165 PF00244 0.641
LIG_14-3-3_CanoR_1 1199 1203 PF00244 0.670
LIG_14-3-3_CanoR_1 137 146 PF00244 0.675
LIG_14-3-3_CanoR_1 184 191 PF00244 0.708
LIG_14-3-3_CanoR_1 226 236 PF00244 0.754
LIG_14-3-3_CanoR_1 28 34 PF00244 0.379
LIG_14-3-3_CanoR_1 297 301 PF00244 0.654
LIG_14-3-3_CterR_2 1236 1239 PF00244 0.705
LIG_BIR_II_1 1 5 PF00653 0.384
LIG_EVH1_2 190 194 PF00568 0.642
LIG_FHA_1 1162 1168 PF00498 0.668
LIG_FHA_1 237 243 PF00498 0.764
LIG_FHA_1 281 287 PF00498 0.665
LIG_FHA_1 40 46 PF00498 0.356
LIG_FHA_1 55 61 PF00498 0.330
LIG_FHA_1 64 70 PF00498 0.421
LIG_FHA_2 1215 1221 PF00498 0.679
LIG_FHA_2 228 234 PF00498 0.706
LIG_FHA_2 262 268 PF00498 0.672
LIG_LIR_Gen_1 44 55 PF02991 0.381
LIG_LIR_LC3C_4 166 171 PF02991 0.637
LIG_LIR_Nem_3 123 129 PF02991 0.714
LIG_LIR_Nem_3 44 50 PF02991 0.378
LIG_NRBOX 76 82 PF00104 0.249
LIG_SH2_CRK 1229 1233 PF00017 0.737
LIG_SH2_NCK_1 1229 1233 PF00017 0.737
LIG_SH2_NCK_1 47 51 PF00017 0.402
LIG_SH2_STAP1 1110 1114 PF00017 0.597
LIG_SH2_STAT5 1115 1118 PF00017 0.541
LIG_SH2_STAT5 1128 1131 PF00017 0.505
LIG_SH2_STAT5 1194 1197 PF00017 0.739
LIG_SH2_STAT5 1229 1232 PF00017 0.733
LIG_SH2_STAT5 235 238 PF00017 0.664
LIG_SH2_STAT5 40 43 PF00017 0.365
LIG_SH2_STAT5 97 100 PF00017 0.557
LIG_SH3_3 1162 1168 PF00018 0.693
LIG_SH3_3 130 136 PF00018 0.674
LIG_SH3_3 16 22 PF00018 0.387
LIG_SH3_3 167 173 PF00018 0.705
LIG_SH3_3 210 216 PF00018 0.769
LIG_SH3_3 239 245 PF00018 0.679
LIG_SH3_3 249 255 PF00018 0.681
LIG_SH3_3 269 275 PF00018 0.628
LIG_SH3_3 69 75 PF00018 0.356
LIG_SUMO_SIM_anti_2 1046 1051 PF11976 0.500
LIG_SUMO_SIM_anti_2 166 173 PF11976 0.634
LIG_SUMO_SIM_par_1 1046 1051 PF11976 0.589
LIG_SUMO_SIM_par_1 1098 1104 PF11976 0.538
LIG_SUMO_SIM_par_1 916 922 PF11976 0.585
LIG_TRAF2_1 1217 1220 PF00917 0.681
LIG_TRAF2_1 302 305 PF00917 0.737
LIG_TRAF2_1 315 318 PF00917 0.636
LIG_TRAF2_1 335 338 PF00917 0.666
LIG_TRAF2_1 355 358 PF00917 0.659
LIG_TRAF2_1 375 378 PF00917 0.582
LIG_TRAF2_1 388 391 PF00917 0.573
LIG_TRAF2_1 408 411 PF00917 0.548
LIG_TRAF2_1 428 431 PF00917 0.619
LIG_TRAF2_1 441 444 PF00917 0.584
LIG_TRAF2_1 461 464 PF00917 0.627
LIG_TRAF2_1 474 477 PF00917 0.593
LIG_TRAF2_1 494 497 PF00917 0.547
LIG_TRAF2_1 507 510 PF00917 0.624
LIG_TRAF2_1 527 530 PF00917 0.639
LIG_TRAF2_1 540 543 PF00917 0.606
LIG_TRAF2_1 560 563 PF00917 0.680
LIG_TRAF2_1 573 576 PF00917 0.622
LIG_TRAF2_1 593 596 PF00917 0.547
LIG_TRAF2_1 606 609 PF00917 0.634
LIG_TRAF2_1 626 629 PF00917 0.583
LIG_TRAF2_1 646 649 PF00917 0.679
LIG_TRAF2_1 659 662 PF00917 0.612
LIG_TRAF2_1 679 682 PF00917 0.643
LIG_TRAF2_1 699 702 PF00917 0.682
LIG_TRAF2_1 712 715 PF00917 0.588
LIG_TRAF2_1 732 735 PF00917 0.546
LIG_TRAF2_1 745 748 PF00917 0.575
LIG_TRAF2_1 765 768 PF00917 0.667
LIG_TRAF2_1 778 781 PF00917 0.578
LIG_TRAF2_1 798 801 PF00917 0.631
LIG_TRAF2_1 811 814 PF00917 0.625
LIG_TRAF2_1 831 834 PF00917 0.666
LIG_TRAF2_1 844 847 PF00917 0.534
LIG_TRAF2_1 864 867 PF00917 0.541
LIG_TRAF2_1 877 880 PF00917 0.584
LIG_TRAF2_1 897 900 PF00917 0.622
LIG_TRAF2_1 930 933 PF00917 0.662
LIG_TRAF2_1 943 946 PF00917 0.582
LIG_TRAF2_1 963 966 PF00917 0.552
LIG_TRAF2_1 983 986 PF00917 0.652
LIG_TRAF2_1 996 999 PF00917 0.705
LIG_TYR_ITIM 45 50 PF00017 0.381
LIG_WW_3 181 185 PF00397 0.636
MOD_CDK_SPK_2 1171 1176 PF00069 0.672
MOD_CDK_SPK_2 132 137 PF00069 0.671
MOD_CDK_SPxK_1 1171 1177 PF00069 0.674
MOD_CDK_SPxxK_3 1020 1027 PF00069 0.629
MOD_CK1_1 1023 1029 PF00069 0.678
MOD_CK1_1 1157 1163 PF00069 0.720
MOD_CK1_1 1184 1190 PF00069 0.733
MOD_CK1_1 1193 1199 PF00069 0.673
MOD_CK1_1 1201 1207 PF00069 0.632
MOD_CK1_1 1209 1215 PF00069 0.649
MOD_CK1_1 139 145 PF00069 0.742
MOD_CK1_1 280 286 PF00069 0.664
MOD_CK1_1 32 38 PF00069 0.409
MOD_CK2_1 1035 1041 PF00069 0.623
MOD_CK2_1 1201 1207 PF00069 0.753
MOD_CK2_1 1214 1220 PF00069 0.659
MOD_CK2_1 195 201 PF00069 0.656
MOD_Cter_Amidation 1143 1146 PF01082 0.523
MOD_GlcNHglycan 1159 1162 PF01048 0.458
MOD_GlcNHglycan 1183 1186 PF01048 0.537
MOD_GlcNHglycan 1196 1199 PF01048 0.444
MOD_GlcNHglycan 1213 1216 PF01048 0.430
MOD_GlcNHglycan 15 18 PF01048 0.593
MOD_GlcNHglycan 186 189 PF01048 0.483
MOD_GlcNHglycan 31 34 PF01048 0.503
MOD_GSK3_1 1157 1164 PF00069 0.706
MOD_GSK3_1 116 123 PF00069 0.740
MOD_GSK3_1 1176 1183 PF00069 0.698
MOD_GSK3_1 1189 1196 PF00069 0.643
MOD_GSK3_1 1206 1213 PF00069 0.643
MOD_GSK3_1 132 139 PF00069 0.626
MOD_GSK3_1 150 157 PF00069 0.620
MOD_GSK3_1 234 241 PF00069 0.770
MOD_GSK3_1 257 264 PF00069 0.695
MOD_GSK3_1 50 57 PF00069 0.354
MOD_LATS_1 1135 1141 PF00433 0.643
MOD_N-GLC_1 10 15 PF02516 0.623
MOD_N-GLC_1 277 282 PF02516 0.489
MOD_N-GLC_1 286 291 PF02516 0.484
MOD_N-GLC_1 29 34 PF02516 0.477
MOD_N-GLC_1 50 55 PF02516 0.603
MOD_N-GLC_2 54 56 PF02516 0.544
MOD_NEK2_1 1170 1175 PF00069 0.694
MOD_NEK2_1 1181 1186 PF00069 0.712
MOD_NEK2_1 1189 1194 PF00069 0.649
MOD_NEK2_1 261 266 PF00069 0.771
MOD_NEK2_1 286 291 PF00069 0.700
MOD_NEK2_1 29 34 PF00069 0.371
MOD_NEK2_2 238 243 PF00069 0.667
MOD_PIKK_1 150 156 PF00454 0.645
MOD_PIKK_1 287 293 PF00454 0.730
MOD_PK_1 1176 1182 PF00069 0.661
MOD_PK_1 15 21 PF00069 0.386
MOD_PK_1 296 302 PF00069 0.652
MOD_PKA_1 1176 1182 PF00069 0.750
MOD_PKA_1 296 302 PF00069 0.652
MOD_PKA_2 1154 1160 PF00069 0.640
MOD_PKA_2 1170 1176 PF00069 0.675
MOD_PKA_2 1198 1204 PF00069 0.704
MOD_PKA_2 1209 1215 PF00069 0.724
MOD_PKA_2 136 142 PF00069 0.631
MOD_PKA_2 225 231 PF00069 0.758
MOD_PKA_2 296 302 PF00069 0.652
MOD_PKB_1 1208 1216 PF00069 0.744
MOD_Plk_1 1043 1049 PF00069 0.553
MOD_Plk_1 261 267 PF00069 0.730
MOD_Plk_2-3 214 220 PF00069 0.664
MOD_Plk_4 1176 1182 PF00069 0.688
MOD_Plk_4 1190 1196 PF00069 0.698
MOD_ProDKin_1 1020 1026 PF00069 0.652
MOD_ProDKin_1 109 115 PF00069 0.687
MOD_ProDKin_1 116 122 PF00069 0.727
MOD_ProDKin_1 1161 1167 PF00069 0.695
MOD_ProDKin_1 1171 1177 PF00069 0.630
MOD_ProDKin_1 1227 1233 PF00069 0.740
MOD_ProDKin_1 132 138 PF00069 0.626
MOD_ProDKin_1 248 254 PF00069 0.687
MOD_SUMO_rev_2 196 205 PF00179 0.650
TRG_DiLeu_BaEn_1 1044 1049 PF01217 0.606
TRG_DiLeu_BaEn_1 913 918 PF01217 0.584
TRG_DiLeu_BaEn_4 1219 1225 PF01217 0.665
TRG_DiLeu_BaEn_4 304 310 PF01217 0.713
TRG_DiLeu_BaEn_4 317 323 PF01217 0.623
TRG_DiLeu_BaEn_4 337 343 PF01217 0.663
TRG_DiLeu_BaEn_4 357 363 PF01217 0.656
TRG_DiLeu_BaEn_4 377 383 PF01217 0.574
TRG_DiLeu_BaEn_4 390 396 PF01217 0.580
TRG_DiLeu_BaEn_4 410 416 PF01217 0.638
TRG_DiLeu_BaEn_4 430 436 PF01217 0.538
TRG_DiLeu_BaEn_4 443 449 PF01217 0.587
TRG_DiLeu_BaEn_4 463 469 PF01217 0.625
TRG_DiLeu_BaEn_4 476 482 PF01217 0.599
TRG_DiLeu_BaEn_4 496 502 PF01217 0.608
TRG_DiLeu_BaEn_4 509 515 PF01217 0.629
TRG_DiLeu_BaEn_4 529 535 PF01217 0.632
TRG_DiLeu_BaEn_4 542 548 PF01217 0.595
TRG_DiLeu_BaEn_4 562 568 PF01217 0.678
TRG_DiLeu_BaEn_4 575 581 PF01217 0.629
TRG_DiLeu_BaEn_4 595 601 PF01217 0.547
TRG_DiLeu_BaEn_4 608 614 PF01217 0.626
TRG_DiLeu_BaEn_4 628 634 PF01217 0.586
TRG_DiLeu_BaEn_4 648 654 PF01217 0.681
TRG_DiLeu_BaEn_4 661 667 PF01217 0.581
TRG_DiLeu_BaEn_4 681 687 PF01217 0.681
TRG_DiLeu_BaEn_4 701 707 PF01217 0.678
TRG_DiLeu_BaEn_4 714 720 PF01217 0.577
TRG_DiLeu_BaEn_4 734 740 PF01217 0.540
TRG_DiLeu_BaEn_4 747 753 PF01217 0.566
TRG_DiLeu_BaEn_4 767 773 PF01217 0.664
TRG_DiLeu_BaEn_4 780 786 PF01217 0.567
TRG_DiLeu_BaEn_4 800 806 PF01217 0.664
TRG_DiLeu_BaEn_4 813 819 PF01217 0.636
TRG_DiLeu_BaEn_4 833 839 PF01217 0.659
TRG_DiLeu_BaEn_4 846 852 PF01217 0.539
TRG_DiLeu_BaEn_4 866 872 PF01217 0.536
TRG_DiLeu_BaEn_4 879 885 PF01217 0.543
TRG_DiLeu_BaEn_4 899 905 PF01217 0.609
TRG_DiLeu_BaEn_4 932 938 PF01217 0.663
TRG_DiLeu_BaEn_4 945 951 PF01217 0.585
TRG_DiLeu_BaEn_4 965 971 PF01217 0.556
TRG_DiLeu_BaEn_4 985 991 PF01217 0.655
TRG_DiLeu_BaLyEn_6 1165 1170 PF01217 0.671
TRG_ENDOCYTIC_2 178 181 PF00928 0.640
TRG_ENDOCYTIC_2 47 50 PF00928 0.403
TRG_ER_diArg_1 1027 1029 PF00400 0.629
TRG_ER_diArg_1 1175 1177 PF00400 0.745
TRG_ER_diArg_1 1235 1238 PF00400 0.701
TRG_ER_diArg_1 183 186 PF00400 0.646
TRG_NES_CRM1_1 1068 1079 PF08389 0.580
TRG_Pf-PMV_PEXEL_1 99 104 PF00026 0.368

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H5G8 Leishmania donovani 68% 100%
A4HFE2 Leishmania braziliensis 49% 100%
A4HSF6 Leishmania infantum 66% 100%
E9AKC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 63% 90%
E9AKC9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 88%
E9AYS6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS