ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJH7_LEIMA

TriTrypDb:

LmjF.05.0260 , LMJLV39_050007500 , LMJSD75_050007500

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.549
CLV_C14_Caspase3-7	380	384	PF00656	0.685
CLV_C14_Caspase3-7	389	393	PF00656	0.565
CLV_C14_Caspase3-7	58	62	PF00656	0.580
CLV_NRD_NRD_1	312	314	PF00675	0.450
CLV_NRD_NRD_1	33	35	PF00675	0.450
CLV_NRD_NRD_1	330	332	PF00675	0.498
CLV_NRD_NRD_1	336	338	PF00675	0.504
CLV_NRD_NRD_1	353	355	PF00675	0.556
CLV_PCSK_KEX2_1	155	157	PF00082	0.454
CLV_PCSK_KEX2_1	224	226	PF00082	0.470
CLV_PCSK_KEX2_1	312	314	PF00082	0.591
CLV_PCSK_KEX2_1	325	327	PF00082	0.384
CLV_PCSK_KEX2_1	329	331	PF00082	0.382
CLV_PCSK_KEX2_1	33	35	PF00082	0.450
CLV_PCSK_KEX2_1	336	338	PF00082	0.484
CLV_PCSK_KEX2_1	353	355	PF00082	0.556
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.504
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.470
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.468
CLV_PCSK_PC7_1	326	332	PF00082	0.436
CLV_PCSK_SKI1_1	101	105	PF00082	0.497
CLV_PCSK_SKI1_1	155	159	PF00082	0.391
CLV_PCSK_SKI1_1	260	264	PF00082	0.564
CLV_PCSK_SKI1_1	47	51	PF00082	0.445
DEG_Nend_UBRbox_3	1	3	PF02207	0.535
DOC_MAPK_MEF2A_6	178	187	PF00069	0.600
DOC_SPAK_OSR1_1	246	250	PF12202	0.503
DOC_USP7_MATH_1	108	112	PF00917	0.587
DOC_USP7_MATH_1	206	210	PF00917	0.604
DOC_USP7_MATH_1	363	367	PF00917	0.649
DOC_WW_Pin1_4	179	184	PF00397	0.523
DOC_WW_Pin1_4	228	233	PF00397	0.388
DOC_WW_Pin1_4	282	287	PF00397	0.447
DOC_WW_Pin1_4	33	38	PF00397	0.540
LIG_14-3-3_CanoR_1	164	168	PF00244	0.435
LIG_14-3-3_CanoR_1	178	183	PF00244	0.531
LIG_14-3-3_CanoR_1	279	285	PF00244	0.438
LIG_CtBP_PxDLS_1	184	188	PF00389	0.477
LIG_CtBP_PxDLS_1	78	83	PF00389	0.469
LIG_FHA_1	15	21	PF00498	0.410
LIG_FHA_1	180	186	PF00498	0.526
LIG_FHA_1	254	260	PF00498	0.391
LIG_FHA_1	296	302	PF00498	0.570
LIG_FHA_2	122	128	PF00498	0.556
LIG_LIR_Gen_1	317	327	PF02991	0.522
LIG_LIR_Nem_3	188	193	PF02991	0.434
LIG_LIR_Nem_3	317	323	PF02991	0.522
LIG_SH2_CRK	154	158	PF00017	0.397
LIG_SH2_CRK	190	194	PF00017	0.416
LIG_SH2_STAT5	123	126	PF00017	0.563
LIG_SH2_STAT5	334	337	PF00017	0.562
LIG_SUMO_SIM_anti_2	298	303	PF11976	0.435
LIG_SUMO_SIM_par_1	297	303	PF11976	0.423
LIG_TRAF2_1	115	118	PF00917	0.572
LIG_TRAF2_1	139	142	PF00917	0.433
LIG_TRAF2_1	314	317	PF00917	0.445
LIG_TRAF2_1	384	387	PF00917	0.688
LIG_TRAF2_1	77	80	PF00917	0.497
LIG_TYR_ITIM	152	157	PF00017	0.409
MOD_CDK_SPxK_1	282	288	PF00069	0.543
MOD_CK1_1	209	215	PF00069	0.649
MOD_CK1_1	223	229	PF00069	0.367
MOD_CK1_1	295	301	PF00069	0.460
MOD_CK1_1	366	372	PF00069	0.672
MOD_CK2_1	112	118	PF00069	0.608
MOD_CK2_1	163	169	PF00069	0.493
MOD_CK2_1	192	198	PF00069	0.541
MOD_CK2_1	374	380	PF00069	0.688
MOD_CK2_1	74	80	PF00069	0.463
MOD_Cter_Amidation	31	34	PF01082	0.447
MOD_GlcNHglycan	114	117	PF01048	0.587
MOD_GlcNHglycan	30	33	PF01048	0.583
MOD_GlcNHglycan	368	371	PF01048	0.779
MOD_GlcNHglycan	373	379	PF01048	0.747
MOD_GlcNHglycan	41	45	PF01048	0.421
MOD_GlcNHglycan	76	79	PF01048	0.449
MOD_GSK3_1	108	115	PF00069	0.565
MOD_GSK3_1	206	213	PF00069	0.620
MOD_N-GLC_1	292	297	PF02516	0.461
MOD_N-GLC_1	366	371	PF02516	0.654
MOD_NEK2_1	177	182	PF00069	0.480
MOD_NEK2_2	241	246	PF00069	0.455
MOD_PIKK_1	121	127	PF00454	0.567
MOD_PKA_2	163	169	PF00069	0.427
MOD_PKA_2	177	183	PF00069	0.526
MOD_Plk_1	185	191	PF00069	0.544
MOD_Plk_1	209	215	PF00069	0.645
MOD_Plk_4	185	191	PF00069	0.544
MOD_ProDKin_1	179	185	PF00069	0.521
MOD_ProDKin_1	228	234	PF00069	0.387
MOD_ProDKin_1	282	288	PF00069	0.453
MOD_ProDKin_1	33	39	PF00069	0.542
TRG_DiLeu_BaEn_1	80	85	PF01217	0.450
TRG_DiLeu_BaEn_2	315	321	PF01217	0.529
TRG_DiLeu_BaEn_3	316	322	PF01217	0.481
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.502
TRG_ENDOCYTIC_2	154	157	PF00928	0.402
TRG_ENDOCYTIC_2	190	193	PF00928	0.418
TRG_ER_diArg_1	225	228	PF00400	0.457
TRG_ER_diArg_1	329	331	PF00400	0.537
TRG_ER_diArg_1	335	337	PF00400	0.487
TRG_NLS_MonoExtN_4	222	228	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHU8	Leptomonas seymouri	45%	94%
A0A3S7WP15	Leishmania donovani	88%	100%
A4H470	Leishmania braziliensis	72%	100%
A4HSE5	Leishmania infantum	88%	100%
E9AKD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%