Tudor domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJH6_LEIMA

TriTrypDb:

LmjF.05.0270 , LMJLV39_050007600 , LMJSD75_050007600

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	316	318	PF00675	0.643
CLV_PCSK_FUR_1	269	273	PF00082	0.522
CLV_PCSK_KEX2_1	271	273	PF00082	0.585
CLV_PCSK_KEX2_1	314	316	PF00082	0.589
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.577
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.606
CLV_PCSK_PC7_1	267	273	PF00082	0.444
CLV_PCSK_SKI1_1	285	289	PF00082	0.495
DEG_Kelch_Keap1_1	87	92	PF01344	0.525
DEG_SPOP_SBC_1	215	219	PF00917	0.541
DEG_SPOP_SBC_1	228	232	PF00917	0.539
DOC_ANK_TNKS_1	22	29	PF00023	0.525
DOC_CKS1_1	75	80	PF01111	0.565
DOC_USP7_MATH_1	173	177	PF00917	0.533
DOC_USP7_MATH_1	216	220	PF00917	0.700
DOC_USP7_MATH_1	224	228	PF00917	0.683
DOC_USP7_MATH_1	262	266	PF00917	0.407
DOC_USP7_UBL2_3	82	86	PF12436	0.585
DOC_WW_Pin1_4	108	113	PF00397	0.553
DOC_WW_Pin1_4	222	227	PF00397	0.620
DOC_WW_Pin1_4	74	79	PF00397	0.486
DOC_WW_Pin1_4	84	89	PF00397	0.546
LIG_14-3-3_CanoR_1	18	23	PF00244	0.538
LIG_14-3-3_CanoR_1	201	205	PF00244	0.419
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BIR_III_4	37	41	PF00653	0.603
LIG_DLG_GKlike_1	18	25	PF00625	0.515
LIG_EH1_1	154	162	PF00400	0.355
LIG_FHA_1	132	138	PF00498	0.360
LIG_FHA_1	173	179	PF00498	0.504
LIG_FHA_1	205	211	PF00498	0.386
LIG_FHA_1	229	235	PF00498	0.477
LIG_FHA_1	75	81	PF00498	0.425
LIG_FHA_1	88	94	PF00498	0.542
LIG_FHA_2	2	8	PF00498	0.535
LIG_FHA_2	201	207	PF00498	0.538
LIG_FHA_2	254	260	PF00498	0.481
LIG_GBD_Chelix_1	25	33	PF00786	0.542
LIG_LIR_Apic_2	96	102	PF02991	0.526
LIG_LIR_Gen_1	291	301	PF02991	0.459
LIG_LIR_Nem_3	127	132	PF02991	0.378
LIG_LIR_Nem_3	21	25	PF02991	0.393
LIG_LIR_Nem_3	291	296	PF02991	0.438
LIG_LYPXL_yS_3	129	132	PF13949	0.457
LIG_MYND_1	112	116	PF01753	0.470
LIG_NRBOX	63	69	PF00104	0.498
LIG_PCNA_yPIPBox_3	288	301	PF02747	0.591
LIG_RPA_C_Plants	274	285	PF08784	0.511
LIG_SH2_CRK	247	251	PF00017	0.525
LIG_SH2_SRC	194	197	PF00017	0.517
LIG_SH2_STAP1	119	123	PF00017	0.438
LIG_SH2_STAP1	162	166	PF00017	0.441
LIG_SH2_STAT5	194	197	PF00017	0.517
LIG_SH3_1	99	105	PF00018	0.475
LIG_SH3_3	133	139	PF00018	0.457
LIG_SH3_3	165	171	PF00018	0.392
LIG_SH3_3	183	189	PF00018	0.495
LIG_SH3_3	207	213	PF00018	0.507
LIG_SH3_3	231	237	PF00018	0.533
LIG_SH3_3	99	105	PF00018	0.597
LIG_TRAF2_1	14	17	PF00917	0.448
LIG_TRAF2_1	203	206	PF00917	0.496
LIG_TRAF2_1	256	259	PF00917	0.486
LIG_TRAF2_1	5	8	PF00917	0.698
MOD_CDK_SPxxK_3	108	115	PF00069	0.528
MOD_CK1_1	217	223	PF00069	0.623
MOD_CK1_1	227	233	PF00069	0.556
MOD_CK1_1	87	93	PF00069	0.555
MOD_CK2_1	1	7	PF00069	0.725
MOD_CK2_1	11	17	PF00069	0.467
MOD_CK2_1	18	24	PF00069	0.442
MOD_CK2_1	200	206	PF00069	0.566
MOD_CK2_1	253	259	PF00069	0.486
MOD_GlcNHglycan	222	225	PF01048	0.720
MOD_GlcNHglycan	226	229	PF01048	0.517
MOD_GlcNHglycan	304	307	PF01048	0.649
MOD_GSK3_1	104	111	PF00069	0.729
MOD_GSK3_1	169	176	PF00069	0.597
MOD_GSK3_1	200	207	PF00069	0.400
MOD_GSK3_1	214	221	PF00069	0.521
MOD_GSK3_1	224	231	PF00069	0.588
MOD_GSK3_1	232	239	PF00069	0.441
MOD_GSK3_1	70	77	PF00069	0.469
MOD_NEK2_1	1	6	PF00069	0.705
MOD_NEK2_1	204	209	PF00069	0.410
MOD_NEK2_2	180	185	PF00069	0.501
MOD_PIKK_1	245	251	PF00454	0.537
MOD_PKA_2	200	206	PF00069	0.412
MOD_PKB_1	251	259	PF00069	0.617
MOD_Plk_1	204	210	PF00069	0.420
MOD_Plk_1	70	76	PF00069	0.474
MOD_Plk_2-3	200	206	PF00069	0.442
MOD_Plk_4	204	210	PF00069	0.402
MOD_Plk_4	93	99	PF00069	0.483
MOD_ProDKin_1	108	114	PF00069	0.538
MOD_ProDKin_1	222	228	PF00069	0.616
MOD_ProDKin_1	74	80	PF00069	0.486
MOD_ProDKin_1	84	90	PF00069	0.545
MOD_SUMO_for_1	254	257	PF00179	0.526
MOD_SUMO_for_1	270	273	PF00179	0.338
TRG_DiLeu_BaEn_1	205	210	PF01217	0.442
TRG_DiLeu_BaEn_1	8	13	PF01217	0.529
TRG_ENDOCYTIC_2	119	122	PF00928	0.422
TRG_ENDOCYTIC_2	129	132	PF00928	0.350
TRG_ENDOCYTIC_2	22	25	PF00928	0.393
TRG_ENDOCYTIC_2	247	250	PF00928	0.464
TRG_ER_diArg_1	250	253	PF00400	0.494
TRG_ER_diArg_1	267	270	PF00400	0.461
TRG_ER_diArg_1	315	317	PF00400	0.635
TRG_NES_CRM1_1	48	60	PF08389	0.538
TRG_NLS_MonoCore_2	313	318	PF00514	0.636
TRG_NLS_MonoExtC_3	310	315	PF00514	0.603
TRG_NLS_MonoExtN_4	311	318	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H6	Leptomonas seymouri	67%	100%
A0A0S4J6H5	Bodo saltans	31%	100%
A0A1X0P0L2	Trypanosomatidae	41%	100%
A0A3R7LUJ2	Trypanosoma rangeli	42%	100%
A0A3S5H5G9	Leishmania donovani	95%	100%
A4H471	Leishmania braziliensis	84%	99%
A4HSE6	Leishmania infantum	96%	80%
D0A4J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AKD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BBA9	Trypanosoma cruzi	40%	99%