Phosphate carrier protein, mitochondrial-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate carrier protein, mitochondrial precursor-like protein

Species:

Leishmania major

UniProt:

Q4QJH3_LEIMA

TriTrypDb:

LmjF.05.0290 , LMJLV39_050007900 , LMJSD75_050007900

Length:

485

Annotations

LeishMANIAdb annotations

Forms a well-defined channel with 6 helices. Some paralogs tend to have an additional hydrophobic segment that might be a transit or signal peptide. It is unclear if the N-peptide is a signal or transit peptide. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	9
GO:0005743	mitochondrial inner membrane	5	7
GO:0016020	membrane	2	7
GO:0019866	organelle inner membrane	4	7
GO:0031090	organelle membrane	3	7
GO:0031966	mitochondrial membrane	4	7

Expansion

Sequence features

Q4QJH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJH3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0006811	monoatomic ion transport	4	9
GO:0006817	phosphate ion transport	7	9
GO:0006820	monoatomic anion transport	5	9
GO:0009987	cellular process	1	9
GO:0015698	inorganic anion transport	6	9
GO:0034220	monoatomic ion transmembrane transport	3	9
GO:0035435	phosphate ion transmembrane transport	6	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0055085	transmembrane transport	2	9
GO:0098656	monoatomic anion transmembrane transport	4	9
GO:0098660	inorganic ion transmembrane transport	4	9
GO:0098661	inorganic anion transmembrane transport	5	9
GO:1990542	mitochondrial transmembrane transport	3	9
GO:1990547	mitochondrial phosphate ion transmembrane transport	4	9

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0005315	inorganic phosphate transmembrane transporter activity	4	9
GO:0015291	secondary active transmembrane transporter activity	4	9
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	9
GO:0022804	active transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.717
CLV_C14_Caspase3-7	409	413	PF00656	0.466
CLV_C14_Caspase3-7	46	50	PF00656	0.571
CLV_C14_Caspase3-7	479	483	PF00656	0.302
CLV_PCSK_SKI1_1	166	170	PF00082	0.266
CLV_PCSK_SKI1_1	217	221	PF00082	0.243
CLV_PCSK_SKI1_1	298	302	PF00082	0.334
DEG_APCC_DBOX_1	192	200	PF00400	0.534
DEG_APCC_DBOX_1	297	305	PF00400	0.534
DEG_SPOP_SBC_1	397	401	PF00917	0.489
DEG_SPOP_SBC_1	56	60	PF00917	0.651
DOC_AGCK_PIF_2	332	337	PF00069	0.412
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	61	64	PF00134	0.706
DOC_MAPK_gen_1	166	175	PF00069	0.488
DOC_MAPK_MEF2A_6	448	456	PF00069	0.516
DOC_PP1_RVXF_1	83	89	PF00149	0.624
DOC_PP2B_LxvP_1	2	5	PF13499	0.600
DOC_PP2B_LxvP_1	61	64	PF13499	0.706
DOC_PP4_FxxP_1	75	78	PF00568	0.637
DOC_USP7_MATH_1	180	184	PF00917	0.478
DOC_USP7_MATH_1	246	250	PF00917	0.655
DOC_USP7_MATH_1	251	255	PF00917	0.659
DOC_USP7_MATH_1	398	402	PF00917	0.489
DOC_USP7_MATH_1	414	418	PF00917	0.454
DOC_USP7_MATH_1	425	429	PF00917	0.410
DOC_USP7_MATH_1	478	482	PF00917	0.288
DOC_WW_Pin1_4	287	292	PF00397	0.534
DOC_WW_Pin1_4	74	79	PF00397	0.692
LIG_14-3-3_CanoR_1	126	131	PF00244	0.363
LIG_14-3-3_CanoR_1	286	291	PF00244	0.516
LIG_14-3-3_CanoR_1	32	36	PF00244	0.704
LIG_14-3-3_CanoR_1	394	398	PF00244	0.569
LIG_BRCT_BRCA1_1	206	210	PF00533	0.516
LIG_BRCT_BRCA1_1	289	293	PF00533	0.489
LIG_BRCT_BRCA1_1	333	337	PF00533	0.450
LIG_Clathr_ClatBox_1	175	179	PF01394	0.489
LIG_deltaCOP1_diTrp_1	440	447	PF00928	0.501
LIG_eIF4E_1	185	191	PF01652	0.489
LIG_FHA_1	111	117	PF00498	0.399
LIG_FHA_1	120	126	PF00498	0.419
LIG_FHA_1	305	311	PF00498	0.581
LIG_FHA_1	56	62	PF00498	0.694
LIG_FHA_1	99	105	PF00498	0.385
LIG_FHA_2	407	413	PF00498	0.489
LIG_FHA_2	46	52	PF00498	0.690
LIG_FHA_2	477	483	PF00498	0.429
LIG_GBD_Chelix_1	364	372	PF00786	0.335
LIG_GBD_Chelix_1	96	104	PF00786	0.221
LIG_LIR_Apic_2	72	78	PF02991	0.634
LIG_LIR_Gen_1	129	138	PF02991	0.252
LIG_LIR_Gen_1	170	180	PF02991	0.516
LIG_LIR_Gen_1	211	221	PF02991	0.534
LIG_LIR_Gen_1	254	264	PF02991	0.506
LIG_LIR_Gen_1	333	342	PF02991	0.297
LIG_LIR_Gen_1	344	354	PF02991	0.335
LIG_LIR_LC3C_4	101	106	PF02991	0.253
LIG_LIR_Nem_3	129	135	PF02991	0.252
LIG_LIR_Nem_3	164	168	PF02991	0.463
LIG_LIR_Nem_3	170	175	PF02991	0.436
LIG_LIR_Nem_3	183	188	PF02991	0.377
LIG_LIR_Nem_3	207	213	PF02991	0.491
LIG_LIR_Nem_3	254	260	PF02991	0.574
LIG_LIR_Nem_3	290	296	PF02991	0.398
LIG_LIR_Nem_3	333	338	PF02991	0.297
LIG_LIR_Nem_3	344	349	PF02991	0.321
LIG_LIR_Nem_3	467	471	PF02991	0.371
LIG_NRBOX	371	377	PF00104	0.380
LIG_Pex14_2	133	137	PF04695	0.329
LIG_Pex14_2	168	172	PF04695	0.527
LIG_Pex14_2	191	195	PF04695	0.498
LIG_Pex14_2	260	264	PF04695	0.534
LIG_REV1ctd_RIR_1	189	196	PF16727	0.489
LIG_SH2_CRK	135	139	PF00017	0.386
LIG_SH2_CRK	185	189	PF00017	0.489
LIG_SH2_CRK	314	318	PF00017	0.465
LIG_SH2_PTP2	218	221	PF00017	0.489
LIG_SH2_SRC	213	216	PF00017	0.466
LIG_SH2_STAT3	108	111	PF00017	0.371
LIG_SH2_STAT3	202	205	PF00017	0.475
LIG_SH2_STAT5	108	111	PF00017	0.409
LIG_SH2_STAT5	132	135	PF00017	0.294
LIG_SH2_STAT5	202	205	PF00017	0.489
LIG_SH2_STAT5	218	221	PF00017	0.371
LIG_SH2_STAT5	296	299	PF00017	0.453
LIG_SH2_STAT5	327	330	PF00017	0.294
LIG_SH3_3	288	294	PF00018	0.567
LIG_SH3_3	377	383	PF00018	0.301
LIG_SUMO_SIM_anti_2	101	107	PF11976	0.253
LIG_SUMO_SIM_par_1	101	107	PF11976	0.343
LIG_SUMO_SIM_par_1	453	459	PF11976	0.386
LIG_TYR_ITIM	216	221	PF00017	0.524
LIG_WRC_WIRS_1	165	170	PF05994	0.534
LIG_WRC_WIRS_1	332	337	PF05994	0.312
MOD_CK1_1	17	23	PF00069	0.788
MOD_CK1_1	396	402	PF00069	0.526
MOD_CK1_1	74	80	PF00069	0.689
MOD_CK2_1	164	170	PF00069	0.398
MOD_CK2_1	208	214	PF00069	0.551
MOD_CK2_1	330	336	PF00069	0.386
MOD_GlcNHglycan	113	116	PF01048	0.635
MOD_GlcNHglycan	248	251	PF01048	0.424
MOD_GlcNHglycan	253	256	PF01048	0.385
MOD_GlcNHglycan	298	301	PF01048	0.318
MOD_GlcNHglycan	395	398	PF01048	0.334
MOD_GlcNHglycan	400	403	PF01048	0.180
MOD_GlcNHglycan	427	430	PF01048	0.282
MOD_GlcNHglycan	53	56	PF01048	0.463
MOD_GSK3_1	204	211	PF00069	0.534
MOD_GSK3_1	341	348	PF00069	0.413
MOD_GSK3_1	392	399	PF00069	0.541
MOD_GSK3_1	51	58	PF00069	0.712
MOD_N-GLC_1	17	22	PF02516	0.558
MOD_NEK2_1	104	109	PF00069	0.335
MOD_NEK2_1	244	249	PF00069	0.698
MOD_NEK2_1	262	267	PF00069	0.446
MOD_NEK2_1	330	335	PF00069	0.451
MOD_NEK2_1	345	350	PF00069	0.342
MOD_NEK2_1	363	368	PF00069	0.286
MOD_NEK2_1	406	411	PF00069	0.504
MOD_NEK2_1	456	461	PF00069	0.337
MOD_NEK2_1	92	97	PF00069	0.327
MOD_NEK2_2	180	185	PF00069	0.489
MOD_NEK2_2	341	346	PF00069	0.494
MOD_PKA_2	12	18	PF00069	0.780
MOD_PKA_2	31	37	PF00069	0.566
MOD_PKA_2	393	399	PF00069	0.534
MOD_Plk_1	30	36	PF00069	0.668
MOD_Plk_2-3	164	170	PF00069	0.534
MOD_Plk_4	104	110	PF00069	0.365
MOD_Plk_4	180	186	PF00069	0.493
MOD_Plk_4	219	225	PF00069	0.522
MOD_Plk_4	31	37	PF00069	0.707
MOD_Plk_4	325	331	PF00069	0.294
MOD_Plk_4	341	347	PF00069	0.382
MOD_Plk_4	363	369	PF00069	0.327
MOD_Plk_4	383	389	PF00069	0.371
MOD_Plk_4	57	63	PF00069	0.699
MOD_Plk_4	71	77	PF00069	0.648
MOD_ProDKin_1	287	293	PF00069	0.534
MOD_ProDKin_1	74	80	PF00069	0.688
MOD_SUMO_rev_2	226	234	PF00179	0.592
TRG_DiLeu_BaLyEn_6	450	455	PF01217	0.386
TRG_ENDOCYTIC_2	135	138	PF00928	0.336
TRG_ENDOCYTIC_2	165	168	PF00928	0.475
TRG_ENDOCYTIC_2	185	188	PF00928	0.341
TRG_ENDOCYTIC_2	213	216	PF00928	0.450
TRG_ENDOCYTIC_2	218	221	PF00928	0.450
TRG_ENDOCYTIC_2	257	260	PF00928	0.597
TRG_ENDOCYTIC_2	314	317	PF00928	0.465
TRG_ENDOCYTIC_2	327	330	PF00928	0.254
TRG_ENDOCYTIC_2	468	471	PF00928	0.263

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H8	Leptomonas seymouri	53%	100%
A0A0S4JBC4	Bodo saltans	41%	100%
A0A0S4JNX4	Bodo saltans	32%	100%
A0A3S7WP13	Leishmania donovani	93%	100%
A0A3S7WVJ8	Leishmania donovani	21%	100%
A4H474	Leishmania braziliensis	72%	97%
A4HSE9	Leishmania infantum	93%	100%
A4HYC8	Leishmania infantum	21%	100%
A4IA82	Leishmania infantum	23%	100%
A4RPU0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	22%	100%
B4F8I5	Zea mays	25%	100%
D0A4I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AFR9	Leishmania major	31%	93%
E9AKD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AS62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	100%
O04619	Arabidopsis thaliana	23%	100%
O61703	Choristoneura fumiferana	35%	100%
O94502	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
P12234	Bos taurus	35%	100%
P16036	Rattus norvegicus	33%	100%
P40614	Caenorhabditis elegans	38%	100%
Q00325	Homo sapiens	34%	100%
Q287T7	Danio rerio	23%	100%
Q2H608	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	21%	100%
Q4QDA4	Leishmania major	22%	100%
Q54S10	Dictyostelium discoideum	21%	100%
Q552L9	Dictyostelium discoideum	23%	100%
Q5R7W2	Pongo abelii	33%	100%
Q7S2H8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	100%
Q7T292	Danio rerio	23%	100%
Q8R0Z5	Mus musculus	22%	100%
Q8RXZ9	Arabidopsis thaliana	21%	100%
Q8VEM8	Mus musculus	34%	100%
Q96A46	Homo sapiens	22%	100%
Q96U08	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	22%	100%
Q9FI73	Arabidopsis thaliana	22%	100%
Q9FLS8	Arabidopsis thaliana	22%	100%
Q9FMU6	Arabidopsis thaliana	33%	100%
Q9M2Z8	Arabidopsis thaliana	33%	100%
Q9NYZ2	Homo sapiens	23%	100%
Q9Z2B2	Mus musculus	23%	100%