Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJH2_LEIMA

TriTrypDb:

LmjF.05.0300 , LMJLV39_050008000 , LMJSD75_050008000

Length:

881

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.573
CLV_C14_Caspase3-7	376	380	PF00656	0.537
CLV_C14_Caspase3-7	501	505	PF00656	0.696
CLV_C14_Caspase3-7	683	687	PF00656	0.712
CLV_C14_Caspase3-7	780	784	PF00656	0.595
CLV_NRD_NRD_1	141	143	PF00675	0.482
CLV_NRD_NRD_1	270	272	PF00675	0.722
CLV_NRD_NRD_1	44	46	PF00675	0.480
CLV_NRD_NRD_1	467	469	PF00675	0.799
CLV_NRD_NRD_1	519	521	PF00675	0.699
CLV_NRD_NRD_1	529	531	PF00675	0.725
CLV_NRD_NRD_1	576	578	PF00675	0.678
CLV_NRD_NRD_1	663	665	PF00675	0.840
CLV_PCSK_FUR_1	41	45	PF00082	0.478
CLV_PCSK_KEX2_1	141	143	PF00082	0.482
CLV_PCSK_KEX2_1	270	272	PF00082	0.796
CLV_PCSK_KEX2_1	43	45	PF00082	0.479
CLV_PCSK_KEX2_1	467	469	PF00082	0.799
CLV_PCSK_KEX2_1	519	521	PF00082	0.699
CLV_PCSK_KEX2_1	528	530	PF00082	0.722
CLV_PCSK_KEX2_1	576	578	PF00082	0.678
CLV_PCSK_KEX2_1	663	665	PF00082	0.830
CLV_PCSK_PC7_1	39	45	PF00082	0.477
CLV_PCSK_PC7_1	515	521	PF00082	0.758
CLV_PCSK_SKI1_1	15	19	PF00082	0.480
CLV_PCSK_SKI1_1	177	181	PF00082	0.550
CLV_PCSK_SKI1_1	303	307	PF00082	0.659
CLV_PCSK_SKI1_1	843	847	PF00082	0.706
CLV_PCSK_SKI1_1	854	858	PF00082	0.591
CLV_PCSK_SKI1_1	864	868	PF00082	0.608
DEG_APCC_DBOX_1	14	22	PF00400	0.480
DEG_APCC_DBOX_1	93	101	PF00400	0.485
DEG_COP1_1	783	793	PF00400	0.545
DEG_SCF_FBW7_1	7	14	PF00400	0.470
DEG_SPOP_SBC_1	638	642	PF00917	0.622
DEG_SPOP_SBC_1	751	755	PF00917	0.584
DOC_CKS1_1	66	71	PF01111	0.496
DOC_CKS1_1	8	13	PF01111	0.465
DOC_CYCLIN_RxL_1	65	78	PF00134	0.503
DOC_CYCLIN_RxL_1	840	849	PF00134	0.703
DOC_CYCLIN_RxL_1	859	872	PF00134	0.441
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.720
DOC_CYCLIN_yCln2_LP_2	631	637	PF00134	0.746
DOC_MAPK_gen_1	41	50	PF00069	0.482
DOC_MAPK_gen_1	467	475	PF00069	0.788
DOC_MAPK_gen_1	859	868	PF00069	0.654
DOC_MAPK_MEF2A_6	15	23	PF00069	0.462
DOC_PP1_RVXF_1	862	869	PF00149	0.681
DOC_PP2B_LxvP_1	205	208	PF13499	0.710
DOC_PP2B_LxvP_1	249	252	PF13499	0.690
DOC_PP2B_LxvP_1	488	491	PF13499	0.713
DOC_PP2B_LxvP_1	631	634	PF13499	0.718
DOC_PP2B_LxvP_1	728	731	PF13499	0.808
DOC_PP2B_LxvP_1	788	791	PF13499	0.546
DOC_PP2B_LxvP_1	839	842	PF13499	0.650
DOC_PP2B_LxvP_1	850	853	PF13499	0.716
DOC_PP4_FxxP_1	593	596	PF00568	0.681
DOC_USP7_MATH_1	102	106	PF00917	0.532
DOC_USP7_MATH_1	131	135	PF00917	0.494
DOC_USP7_MATH_1	168	172	PF00917	0.676
DOC_USP7_MATH_1	193	197	PF00917	0.613
DOC_USP7_MATH_1	214	218	PF00917	0.816
DOC_USP7_MATH_1	243	247	PF00917	0.725
DOC_USP7_MATH_1	258	262	PF00917	0.655
DOC_USP7_MATH_1	284	288	PF00917	0.735
DOC_USP7_MATH_1	433	437	PF00917	0.684
DOC_USP7_MATH_1	466	470	PF00917	0.674
DOC_USP7_MATH_1	49	53	PF00917	0.489
DOC_USP7_MATH_1	507	511	PF00917	0.807
DOC_USP7_MATH_1	638	642	PF00917	0.739
DOC_USP7_MATH_1	703	707	PF00917	0.587
DOC_USP7_MATH_1	751	755	PF00917	0.584
DOC_USP7_MATH_1	778	782	PF00917	0.786
DOC_USP7_MATH_1	789	793	PF00917	0.588
DOC_WW_Pin1_4	115	120	PF00397	0.613
DOC_WW_Pin1_4	122	127	PF00397	0.597
DOC_WW_Pin1_4	152	157	PF00397	0.627
DOC_WW_Pin1_4	222	227	PF00397	0.722
DOC_WW_Pin1_4	349	354	PF00397	0.747
DOC_WW_Pin1_4	356	361	PF00397	0.674
DOC_WW_Pin1_4	383	388	PF00397	0.696
DOC_WW_Pin1_4	410	415	PF00397	0.691
DOC_WW_Pin1_4	518	523	PF00397	0.802
DOC_WW_Pin1_4	585	590	PF00397	0.764
DOC_WW_Pin1_4	610	615	PF00397	0.707
DOC_WW_Pin1_4	65	70	PF00397	0.518
DOC_WW_Pin1_4	696	701	PF00397	0.664
DOC_WW_Pin1_4	7	12	PF00397	0.468
DOC_WW_Pin1_4	753	758	PF00397	0.798
DOC_WW_Pin1_4	765	770	PF00397	0.577
DOC_WW_Pin1_4	82	87	PF00397	0.463
DOC_WW_Pin1_4	837	842	PF00397	0.692
DOC_WW_Pin1_4	844	849	PF00397	0.627
LIG_14-3-3_CanoR_1	124	130	PF00244	0.550
LIG_14-3-3_CanoR_1	218	223	PF00244	0.755
LIG_14-3-3_CanoR_1	228	232	PF00244	0.574
LIG_14-3-3_CanoR_1	467	475	PF00244	0.650
LIG_14-3-3_CanoR_1	616	621	PF00244	0.578
LIG_14-3-3_CanoR_1	864	869	PF00244	0.620
LIG_14-3-3_CanoR_1	99	106	PF00244	0.527
LIG_BRCT_BRCA1_1	13	17	PF00533	0.474
LIG_EVH1_1	7	11	PF00568	0.450
LIG_FHA_1	178	184	PF00498	0.548
LIG_FHA_1	267	273	PF00498	0.559
LIG_FHA_1	369	375	PF00498	0.705
LIG_FHA_1	411	417	PF00498	0.811
LIG_FHA_1	519	525	PF00498	0.690
LIG_FHA_1	586	592	PF00498	0.677
LIG_FHA_1	621	627	PF00498	0.640
LIG_FHA_1	745	751	PF00498	0.700
LIG_FHA_1	8	14	PF00498	0.466
LIG_FHA_2	315	321	PF00498	0.762
LIG_FHA_2	673	679	PF00498	0.604
LIG_FHA_2	778	784	PF00498	0.787
LIG_FHA_2	812	818	PF00498	0.698
LIG_FHA_2	865	871	PF00498	0.681
LIG_GSK3_LRP6_1	115	120	PF00069	0.519
LIG_Integrin_RGD_1	676	678	PF01839	0.599
LIG_LIR_Apic_2	481	487	PF02991	0.692
LIG_LIR_Apic_2	590	596	PF02991	0.774
LIG_LIR_Apic_2	665	671	PF02991	0.609
LIG_LIR_Gen_1	217	226	PF02991	0.703
LIG_LIR_Gen_1	647	656	PF02991	0.655
LIG_LIR_Nem_3	217	222	PF02991	0.675
LIG_LIR_Nem_3	590	595	PF02991	0.775
LIG_LIR_Nem_3	647	652	PF02991	0.671
LIG_LIR_Nem_3	706	712	PF02991	0.588
LIG_LIR_Nem_3	773	777	PF02991	0.763
LIG_LIR_Nem_3	830	835	PF02991	0.791
LIG_MYND_1	210	214	PF01753	0.698
LIG_PDZ_Class_3	876	881	PF00595	0.655
LIG_Pex14_1	708	712	PF04695	0.619
LIG_Pex14_2	571	575	PF04695	0.674
LIG_PTAP_UEV_1	550	555	PF05743	0.618
LIG_SH2_CRK	649	653	PF00017	0.660
LIG_SH2_NCK_1	582	586	PF00017	0.765
LIG_SH2_SRC	431	434	PF00017	0.754
LIG_SH2_STAP1	189	193	PF00017	0.648
LIG_SH2_STAP1	649	653	PF00017	0.660
LIG_SH2_STAP1	79	83	PF00017	0.479
LIG_SH2_STAT5	158	161	PF00017	0.557
LIG_SH2_STAT5	36	39	PF00017	0.495
LIG_SH2_STAT5	431	434	PF00017	0.762
LIG_SH2_STAT5	444	447	PF00017	0.519
LIG_SH2_STAT5	454	457	PF00017	0.654
LIG_SH2_STAT5	582	585	PF00017	0.698
LIG_SH2_STAT5	651	654	PF00017	0.645
LIG_SH2_STAT5	774	777	PF00017	0.637
LIG_SH3_1	412	418	PF00018	0.803
LIG_SH3_1	5	11	PF00018	0.481
LIG_SH3_2	119	124	PF14604	0.525
LIG_SH3_3	111	117	PF00018	0.632
LIG_SH3_3	120	126	PF00018	0.582
LIG_SH3_3	412	418	PF00018	0.803
LIG_SH3_3	5	11	PF00018	0.481
LIG_SH3_3	537	543	PF00018	0.819
LIG_SH3_3	545	551	PF00018	0.828
LIG_SH3_3	623	629	PF00018	0.649
LIG_SH3_3	63	69	PF00018	0.520
LIG_SH3_3	632	638	PF00018	0.675
LIG_SH3_3	697	703	PF00018	0.736
LIG_SH3_3	714	720	PF00018	0.617
LIG_SH3_3	828	834	PF00018	0.788
LIG_SUMO_SIM_anti_2	344	350	PF11976	0.624
LIG_SUMO_SIM_par_1	17	22	PF11976	0.463
LIG_SUMO_SIM_par_1	240	246	PF11976	0.748
LIG_SUMO_SIM_par_1	46	52	PF11976	0.486
LIG_TRAF2_1	170	173	PF00917	0.682
LIG_TRAF2_1	723	726	PF00917	0.656
LIG_TRAF2_1	876	879	PF00917	0.671
LIG_TRFH_1	837	841	PF08558	0.656
LIG_WRC_WIRS_1	244	249	PF05994	0.758
LIG_WW_3	121	125	PF00397	0.608
LIG_WW_3	840	844	PF00397	0.764
LIG_WW_3	859	863	PF00397	0.453
MOD_CDC14_SPxK_1	225	228	PF00782	0.671
MOD_CDC14_SPxK_1	613	616	PF00782	0.569
MOD_CDC14_SPxK_1	840	843	PF00782	0.691
MOD_CDK_SPK_2	518	523	PF00069	0.802
MOD_CDK_SPK_2	65	70	PF00069	0.501
MOD_CDK_SPxK_1	222	228	PF00069	0.676
MOD_CDK_SPxK_1	610	616	PF00069	0.573
MOD_CDK_SPxK_1	837	843	PF00069	0.702
MOD_CDK_SPxxK_3	349	356	PF00069	0.672
MOD_CK1_1	125	131	PF00069	0.556
MOD_CK1_1	151	157	PF00069	0.541
MOD_CK1_1	181	187	PF00069	0.632
MOD_CK1_1	260	266	PF00069	0.796
MOD_CK1_1	344	350	PF00069	0.625
MOD_CK1_1	352	358	PF00069	0.669
MOD_CK1_1	434	440	PF00069	0.768
MOD_CK1_1	597	603	PF00069	0.753
MOD_CK1_1	612	618	PF00069	0.550
MOD_CK1_1	647	653	PF00069	0.768
MOD_CK1_1	680	686	PF00069	0.848
MOD_CK1_1	699	705	PF00069	0.474
MOD_CK1_1	752	758	PF00069	0.735
MOD_CK1_1	844	850	PF00069	0.677
MOD_CK2_1	23	29	PF00069	0.457
MOD_CK2_1	261	267	PF00069	0.707
MOD_CK2_1	314	320	PF00069	0.674
MOD_CK2_1	507	513	PF00069	0.805
MOD_CK2_1	621	627	PF00069	0.640
MOD_CK2_1	864	870	PF00069	0.532
MOD_DYRK1A_RPxSP_1	356	360	PF00069	0.711
MOD_GlcNHglycan	129	132	PF01048	0.511
MOD_GlcNHglycan	25	28	PF01048	0.456
MOD_GlcNHglycan	281	284	PF01048	0.719
MOD_GlcNHglycan	285	289	PF01048	0.763
MOD_GlcNHglycan	311	314	PF01048	0.714
MOD_GlcNHglycan	437	440	PF01048	0.671
MOD_GlcNHglycan	456	459	PF01048	0.706
MOD_GlcNHglycan	464	467	PF01048	0.765
MOD_GlcNHglycan	470	473	PF01048	0.612
MOD_GlcNHglycan	481	484	PF01048	0.684
MOD_GlcNHglycan	500	503	PF01048	0.546
MOD_GlcNHglycan	551	554	PF01048	0.856
MOD_GlcNHglycan	646	649	PF01048	0.787
MOD_GlcNHglycan	691	694	PF01048	0.671
MOD_GlcNHglycan	703	706	PF01048	0.609
MOD_GlcNHglycan	780	783	PF01048	0.777
MOD_GlcNHglycan	785	788	PF01048	0.713
MOD_GlcNHglycan	791	794	PF01048	0.534
MOD_GlcNHglycan	824	827	PF01048	0.587
MOD_GSK3_1	127	134	PF00069	0.552
MOD_GSK3_1	148	155	PF00069	0.641
MOD_GSK3_1	17	24	PF00069	0.462
MOD_GSK3_1	175	182	PF00069	0.658
MOD_GSK3_1	195	202	PF00069	0.630
MOD_GSK3_1	214	221	PF00069	0.711
MOD_GSK3_1	257	264	PF00069	0.605
MOD_GSK3_1	305	312	PF00069	0.646
MOD_GSK3_1	352	359	PF00069	0.674
MOD_GSK3_1	427	434	PF00069	0.640
MOD_GSK3_1	462	469	PF00069	0.620
MOD_GSK3_1	583	590	PF00069	0.720
MOD_GSK3_1	602	609	PF00069	0.640
MOD_GSK3_1	612	619	PF00069	0.780
MOD_GSK3_1	647	654	PF00069	0.687
MOD_GSK3_1	699	706	PF00069	0.566
MOD_GSK3_1	7	14	PF00069	0.470
MOD_GSK3_1	749	756	PF00069	0.763
MOD_GSK3_1	778	785	PF00069	0.720
MOD_GSK3_1	837	844	PF00069	0.745
MOD_GSK3_1	98	105	PF00069	0.518
MOD_N-GLC_1	688	693	PF02516	0.782
MOD_N-GLC_2	695	697	PF02516	0.560
MOD_NEK2_1	17	22	PF00069	0.479
MOD_NEK2_1	179	184	PF00069	0.613
MOD_NEK2_1	23	28	PF00069	0.461
MOD_NEK2_1	242	247	PF00069	0.657
MOD_NEK2_1	257	262	PF00069	0.659
MOD_NEK2_1	305	310	PF00069	0.642
MOD_NEK2_1	368	373	PF00069	0.724
MOD_NEK2_1	498	503	PF00069	0.590
MOD_NEK2_1	750	755	PF00069	0.764
MOD_NEK2_1	777	782	PF00069	0.761
MOD_PIKK_1	168	174	PF00454	0.624
MOD_PIKK_1	181	187	PF00454	0.536
MOD_PIKK_1	541	547	PF00454	0.625
MOD_PK_1	218	224	PF00069	0.801
MOD_PKA_2	227	233	PF00069	0.586
MOD_PKA_2	261	267	PF00069	0.685
MOD_PKA_2	279	285	PF00069	0.564
MOD_PKA_2	466	472	PF00069	0.654
MOD_PKA_2	479	485	PF00069	0.733
MOD_PKA_2	615	621	PF00069	0.544
MOD_PKA_2	662	668	PF00069	0.758
MOD_PKA_2	98	104	PF00069	0.482
MOD_PKB_1	862	870	PF00069	0.639
MOD_Plk_1	284	290	PF00069	0.578
MOD_Plk_1	677	683	PF00069	0.765
MOD_Plk_4	132	138	PF00069	0.529
MOD_Plk_4	227	233	PF00069	0.644
MOD_Plk_4	341	347	PF00069	0.650
MOD_Plk_4	363	369	PF00069	0.729
MOD_Plk_4	399	405	PF00069	0.580
MOD_Plk_4	427	433	PF00069	0.631
MOD_Plk_4	587	593	PF00069	0.698
MOD_Plk_4	594	600	PF00069	0.744
MOD_Plk_4	621	627	PF00069	0.640
MOD_Plk_4	647	653	PF00069	0.768
MOD_Plk_4	770	776	PF00069	0.656
MOD_ProDKin_1	115	121	PF00069	0.616
MOD_ProDKin_1	122	128	PF00069	0.595
MOD_ProDKin_1	152	158	PF00069	0.630
MOD_ProDKin_1	222	228	PF00069	0.725
MOD_ProDKin_1	349	355	PF00069	0.745
MOD_ProDKin_1	356	362	PF00069	0.675
MOD_ProDKin_1	383	389	PF00069	0.694
MOD_ProDKin_1	410	416	PF00069	0.691
MOD_ProDKin_1	518	524	PF00069	0.804
MOD_ProDKin_1	585	591	PF00069	0.763
MOD_ProDKin_1	610	616	PF00069	0.707
MOD_ProDKin_1	65	71	PF00069	0.519
MOD_ProDKin_1	696	702	PF00069	0.660
MOD_ProDKin_1	7	13	PF00069	0.470
MOD_ProDKin_1	753	759	PF00069	0.797
MOD_ProDKin_1	765	771	PF00069	0.574
MOD_ProDKin_1	82	88	PF00069	0.464
MOD_ProDKin_1	837	843	PF00069	0.697
MOD_ProDKin_1	844	850	PF00069	0.635
MOD_SUMO_for_1	374	377	PF00179	0.680
TRG_DiLeu_BaEn_1	627	632	PF01217	0.712
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.693
TRG_ENDOCYTIC_2	649	652	PF00928	0.665
TRG_ENDOCYTIC_2	774	777	PF00928	0.764
TRG_ER_diArg_1	270	272	PF00400	0.566
TRG_ER_diArg_1	41	44	PF00400	0.475
TRG_ER_diArg_1	518	520	PF00400	0.802
TRG_ER_diArg_1	527	530	PF00400	0.672
TRG_ER_diArg_1	575	577	PF00400	0.784
TRG_ER_diArg_1	663	666	PF00400	0.833
TRG_ER_diArg_1	861	864	PF00400	0.758
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ8	Leptomonas seymouri	33%	100%
A0A3S7WP11	Leishmania donovani	77%	93%
A4H475	Leishmania braziliensis	68%	100%
A4HSF0	Leishmania infantum	83%	100%
E9AKD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%