Glutaredoxin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

monothiol glutaredoxin, putative

Species:

Leishmania major

UniProt:

Q4QJH1_LEIMA

TriTrypDb:

LmjF.05.0310 , LMJLV39_050008100 , LMJSD75_050008100

Length:

180

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005759	mitochondrial matrix	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJH1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0019725	cellular homeostasis	2	2
GO:0042592	homeostatic process	3	2
GO:0045454	cell redox homeostasis	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	7
GO:0015035	protein-disulfide reductase activity	3	8
GO:0015036	disulfide oxidoreductase activity	4	8
GO:0016491	oxidoreductase activity	2	8
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	8
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0051536	iron-sulfur cluster binding	3	7
GO:0051540	metal cluster binding	2	7
GO:0097573	obsolete glutathione oxidoreductase activity	4	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.684
CLV_PCSK_KEX2_1	21	23	PF00082	0.684
DEG_Nend_UBRbox_1	1	4	PF02207	0.714
DOC_CYCLIN_RxL_1	2	13	PF00134	0.657
DOC_PP1_RVXF_1	88	95	PF00149	0.396
DOC_USP7_MATH_1	36	40	PF00917	0.633
DOC_USP7_MATH_1	42	46	PF00917	0.680
DOC_WW_Pin1_4	20	25	PF00397	0.494
DOC_WW_Pin1_4	44	49	PF00397	0.593
DOC_WW_Pin1_4	95	100	PF00397	0.343
LIG_14-3-3_CanoR_1	103	113	PF00244	0.343
LIG_14-3-3_CanoR_1	22	31	PF00244	0.672
LIG_14-3-3_CanoR_1	56	62	PF00244	0.567
LIG_BRCT_BRCA1_1	57	61	PF00533	0.612
LIG_eIF4E_1	149	155	PF01652	0.397
LIG_FHA_1	105	111	PF00498	0.350
LIG_FHA_1	161	167	PF00498	0.418
LIG_FHA_1	169	175	PF00498	0.398
LIG_FHA_1	62	68	PF00498	0.613
LIG_LIR_Gen_1	122	132	PF02991	0.332
LIG_LIR_LC3C_4	89	93	PF02991	0.520
LIG_LIR_Nem_3	122	126	PF02991	0.332
LIG_LIR_Nem_3	140	145	PF02991	0.343
LIG_LYPXL_yS_3	145	148	PF13949	0.397
LIG_NRBOX	109	115	PF00104	0.391
LIG_SH2_NCK_1	35	39	PF00017	0.604
LIG_SH2_SRC	149	152	PF00017	0.397
LIG_SH2_STAT5	149	152	PF00017	0.397
LIG_SH3_3	140	146	PF00018	0.343
LIG_SH3_3	96	102	PF00018	0.312
LIG_SUMO_SIM_par_1	109	115	PF11976	0.391
MOD_CK1_1	20	26	PF00069	0.649
MOD_CK1_1	44	50	PF00069	0.678
MOD_CK1_1	72	78	PF00069	0.547
MOD_GlcNHglycan	12	15	PF01048	0.645
MOD_GlcNHglycan	31	34	PF01048	0.643
MOD_GlcNHglycan	36	39	PF01048	0.620
MOD_GlcNHglycan	52	55	PF01048	0.611
MOD_GlcNHglycan	57	60	PF01048	0.631
MOD_GSK3_1	137	144	PF00069	0.343
MOD_GSK3_1	23	30	PF00069	0.591
MOD_GSK3_1	42	49	PF00069	0.676
MOD_GSK3_1	93	100	PF00069	0.365
MOD_NEK2_1	10	15	PF00069	0.615
MOD_NEK2_1	166	171	PF00069	0.479
MOD_NEK2_1	17	22	PF00069	0.535
MOD_NEK2_1	31	36	PF00069	0.644
MOD_NEK2_1	50	55	PF00069	0.585
MOD_NEK2_1	61	66	PF00069	0.533
MOD_PIKK_1	97	103	PF00454	0.382
MOD_PKA_2	104	110	PF00069	0.397
MOD_PKA_2	55	61	PF00069	0.637
MOD_Plk_4	119	125	PF00069	0.343
MOD_Plk_4	160	166	PF00069	0.444
MOD_Plk_4	169	175	PF00069	0.475
MOD_ProDKin_1	20	26	PF00069	0.495
MOD_ProDKin_1	44	50	PF00069	0.596
MOD_ProDKin_1	95	101	PF00069	0.343
TRG_ENDOCYTIC_2	121	124	PF00928	0.350
TRG_ENDOCYTIC_2	145	148	PF00928	0.397
TRG_ER_diArg_1	102	105	PF00400	0.397
TRG_ER_diLys_1	175	180	PF00400	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J2P4	Bodo saltans	56%	100%
A0A3S5H4T1	Leishmania donovani	31%	92%
A0A3S7WP17	Leishmania donovani	93%	100%
A4H326	Leishmania braziliensis	31%	92%
A4H476	Leishmania braziliensis	75%	100%
A4HRD2	Leishmania infantum	32%	92%
A4HSF1	Leishmania infantum	93%	100%
D0A4I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AC00	Leishmania major	33%	92%
E9AJ97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	92%
E9AKD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q02784	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q84Y95	Arabidopsis thaliana	33%	100%