Putative DNA replication licensing factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor MCM8, putative

Species:

Leishmania major

UniProt:

Q4QJG9_LEIMA

TriTrypDb:

LmjF.05.0330 , LMJLV39_050008200 , LMJSD75_050008200

Length:

993

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0032991	protein-containing complex	1	2
GO:0042555	MCM complex	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJG9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0032392	DNA geometric change	7	7
GO:0032508	DNA duplex unwinding	8	7
GO:0051276	chromosome organization	5	7
GO:0071103	DNA conformation change	6	7
GO:0071840	cellular component organization or biogenesis	2	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003697	single-stranded DNA binding	5	2
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	445	449	PF00656	0.533
CLV_C14_Caspase3-7	467	471	PF00656	0.575
CLV_NRD_NRD_1	167	169	PF00675	0.461
CLV_NRD_NRD_1	207	209	PF00675	0.382
CLV_NRD_NRD_1	386	388	PF00675	0.446
CLV_NRD_NRD_1	4	6	PF00675	0.583
CLV_NRD_NRD_1	429	431	PF00675	0.562
CLV_NRD_NRD_1	698	700	PF00675	0.257
CLV_NRD_NRD_1	745	747	PF00675	0.647
CLV_NRD_NRD_1	921	923	PF00675	0.701
CLV_PCSK_KEX2_1	207	209	PF00082	0.382
CLV_PCSK_KEX2_1	386	388	PF00082	0.446
CLV_PCSK_KEX2_1	4	6	PF00082	0.615
CLV_PCSK_KEX2_1	429	431	PF00082	0.562
CLV_PCSK_KEX2_1	745	747	PF00082	0.578
CLV_PCSK_KEX2_1	921	923	PF00082	0.701
CLV_PCSK_SKI1_1	140	144	PF00082	0.382
CLV_PCSK_SKI1_1	218	222	PF00082	0.602
CLV_PCSK_SKI1_1	233	237	PF00082	0.198
CLV_PCSK_SKI1_1	554	558	PF00082	0.307
CLV_PCSK_SKI1_1	602	606	PF00082	0.243
CLV_PCSK_SKI1_1	657	661	PF00082	0.250
CLV_PCSK_SKI1_1	778	782	PF00082	0.353
CLV_PCSK_SKI1_1	965	969	PF00082	0.386
DEG_APCC_DBOX_1	934	942	PF00400	0.473
DEG_SCF_TRCP1_1	835	840	PF00400	0.588
DEG_SPOP_SBC_1	608	612	PF00917	0.507
DOC_ANK_TNKS_1	3	10	PF00023	0.628
DOC_ANK_TNKS_1	472	479	PF00023	0.649
DOC_CKS1_1	105	110	PF01111	0.592
DOC_CKS1_1	363	368	PF01111	0.315
DOC_CYCLIN_RxL_1	775	785	PF00134	0.351
DOC_MAPK_MEF2A_6	554	561	PF00069	0.450
DOC_MAPK_MEF2A_6	574	581	PF00069	0.357
DOC_MAPK_NFAT4_5	554	562	PF00069	0.507
DOC_PP1_RVXF_1	506	512	PF00149	0.594
DOC_PP1_RVXF_1	776	783	PF00149	0.343
DOC_PP2B_LxvP_1	771	774	PF13499	0.482
DOC_PP4_FxxP_1	677	680	PF00568	0.450
DOC_SPAK_OSR1_1	695	699	PF12202	0.407
DOC_SPAK_OSR1_1	715	719	PF12202	0.428
DOC_USP7_MATH_1	211	215	PF00917	0.375
DOC_USP7_MATH_1	279	283	PF00917	0.515
DOC_USP7_MATH_1	405	409	PF00917	0.446
DOC_USP7_MATH_1	502	506	PF00917	0.610
DOC_USP7_MATH_1	507	511	PF00917	0.552
DOC_USP7_MATH_1	608	612	PF00917	0.538
DOC_USP7_MATH_1	725	729	PF00917	0.474
DOC_USP7_MATH_1	821	825	PF00917	0.597
DOC_USP7_MATH_1	902	906	PF00917	0.697
DOC_USP7_UBL2_3	983	987	PF12436	0.461
DOC_WW_Pin1_4	104	109	PF00397	0.573
DOC_WW_Pin1_4	190	195	PF00397	0.599
DOC_WW_Pin1_4	218	223	PF00397	0.588
DOC_WW_Pin1_4	242	247	PF00397	0.450
DOC_WW_Pin1_4	288	293	PF00397	0.473
DOC_WW_Pin1_4	316	321	PF00397	0.447
DOC_WW_Pin1_4	362	367	PF00397	0.314
DOC_WW_Pin1_4	39	44	PF00397	0.494
DOC_WW_Pin1_4	415	420	PF00397	0.584
DOC_WW_Pin1_4	706	711	PF00397	0.468
DOC_WW_Pin1_4	852	857	PF00397	0.471
LIG_14-3-3_CanoR_1	248	256	PF00244	0.533
LIG_14-3-3_CanoR_1	404	410	PF00244	0.494
LIG_14-3-3_CanoR_1	49	55	PF00244	0.412
LIG_14-3-3_CanoR_1	508	518	PF00244	0.594
LIG_14-3-3_CanoR_1	538	544	PF00244	0.450
LIG_14-3-3_CanoR_1	699	703	PF00244	0.457
LIG_14-3-3_CanoR_1	921	927	PF00244	0.572
LIG_14-3-3_CanoR_1	965	974	PF00244	0.372
LIG_APCC_ABBA_1	947	952	PF00400	0.360
LIG_BRCT_BRCA1_1	511	515	PF00533	0.527
LIG_CtBP_PxDLS_1	549	554	PF00389	0.450
LIG_deltaCOP1_diTrp_1	29	36	PF00928	0.427
LIG_deltaCOP1_diTrp_1	56	62	PF00928	0.366
LIG_EH1_1	96	104	PF00400	0.406
LIG_FHA_1	104	110	PF00498	0.641
LIG_FHA_1	139	145	PF00498	0.467
LIG_FHA_1	363	369	PF00498	0.321
LIG_FHA_1	487	493	PF00498	0.551
LIG_FHA_1	49	55	PF00498	0.412
LIG_FHA_1	538	544	PF00498	0.450
LIG_FHA_1	615	621	PF00498	0.450
LIG_FHA_1	665	671	PF00498	0.544
LIG_FHA_1	681	687	PF00498	0.407
LIG_FHA_1	735	741	PF00498	0.454
LIG_FHA_1	799	805	PF00498	0.310
LIG_FHA_1	93	99	PF00498	0.403
LIG_FHA_1	966	972	PF00498	0.363
LIG_FHA_2	219	225	PF00498	0.411
LIG_FHA_2	310	316	PF00498	0.507
LIG_FHA_2	370	376	PF00498	0.367
LIG_FHA_2	55	61	PF00498	0.451
LIG_FHA_2	627	633	PF00498	0.450
LIG_FHA_2	642	648	PF00498	0.457
LIG_FHA_2	877	883	PF00498	0.466
LIG_Integrin_RGD_1	473	475	PF01839	0.655
LIG_LIR_Apic_2	275	279	PF02991	0.507
LIG_LIR_Gen_1	155	165	PF02991	0.367
LIG_LIR_Gen_1	221	231	PF02991	0.305
LIG_LIR_Gen_1	56	66	PF02991	0.388
LIG_LIR_Gen_1	714	722	PF02991	0.450
LIG_LIR_Gen_1	91	102	PF02991	0.413
LIG_LIR_Nem_3	155	160	PF02991	0.347
LIG_LIR_Nem_3	221	226	PF02991	0.424
LIG_LIR_Nem_3	523	529	PF02991	0.250
LIG_LIR_Nem_3	56	62	PF02991	0.396
LIG_LIR_Nem_3	714	719	PF02991	0.450
LIG_LIR_Nem_3	896	900	PF02991	0.466
LIG_LIR_Nem_3	91	97	PF02991	0.416
LIG_PALB2_WD40_1	531	539	PF16756	0.450
LIG_Pex14_1	161	165	PF04695	0.345
LIG_Pex14_2	157	161	PF04695	0.329
LIG_Pex14_2	511	515	PF04695	0.527
LIG_SH2_CRK	210	214	PF00017	0.380
LIG_SH2_NCK_1	210	214	PF00017	0.380
LIG_SH2_STAP1	50	54	PF00017	0.497
LIG_SH2_STAP1	885	889	PF00017	0.450
LIG_SH2_STAT3	803	806	PF00017	0.389
LIG_SH2_STAT3	885	888	PF00017	0.450
LIG_SH2_STAT5	50	53	PF00017	0.414
LIG_SH2_STAT5	803	806	PF00017	0.389
LIG_SH2_STAT5	858	861	PF00017	0.450
LIG_SH2_STAT5	988	991	PF00017	0.344
LIG_SH3_2	105	110	PF14604	0.639
LIG_SH3_3	102	108	PF00018	0.584
LIG_SH3_3	188	194	PF00018	0.541
LIG_SH3_3	317	323	PF00018	0.457
LIG_SH3_3	579	585	PF00018	0.443
LIG_SH3_3	58	64	PF00018	0.427
LIG_SH3_3	836	842	PF00018	0.585
LIG_SUMO_SIM_par_1	149	155	PF11976	0.334
LIG_SUMO_SIM_par_1	357	362	PF11976	0.393
LIG_SUMO_SIM_par_1	578	584	PF11976	0.450
LIG_SUMO_SIM_par_1	658	664	PF11976	0.450
LIG_SUMO_SIM_par_1	72	78	PF11976	0.624
LIG_SUMO_SIM_par_1	954	961	PF11976	0.440
LIG_TRAF2_1	519	522	PF00917	0.441
LIG_UBA3_1	547	554	PF00899	0.450
LIG_WRC_WIRS_1	894	899	PF05994	0.436
MOD_CDC14_SPxK_1	245	248	PF00782	0.450
MOD_CDK_SPK_2	319	324	PF00069	0.627
MOD_CDK_SPK_2	852	857	PF00069	0.450
MOD_CDK_SPxK_1	104	110	PF00069	0.583
MOD_CDK_SPxK_1	242	248	PF00069	0.450
MOD_CK1_1	198	204	PF00069	0.553
MOD_CK1_1	25	31	PF00069	0.430
MOD_CK1_1	319	325	PF00069	0.732
MOD_CK1_1	327	333	PF00069	0.786
MOD_CK1_1	408	414	PF00069	0.538
MOD_CK1_1	415	421	PF00069	0.516
MOD_CK1_1	510	516	PF00069	0.494
MOD_CK1_1	626	632	PF00069	0.450
MOD_CK2_1	516	522	PF00069	0.449
MOD_CK2_1	54	60	PF00069	0.442
MOD_CK2_1	626	632	PF00069	0.450
MOD_Cter_Amidation	2	5	PF01082	0.605
MOD_Cter_Amidation	919	922	PF01082	0.670
MOD_DYRK1A_RPxSP_1	190	194	PF00069	0.599
MOD_GlcNHglycan	15	18	PF01048	0.561
MOD_GlcNHglycan	197	200	PF01048	0.685
MOD_GlcNHglycan	213	216	PF01048	0.332
MOD_GlcNHglycan	24	27	PF01048	0.524
MOD_GlcNHglycan	281	284	PF01048	0.307
MOD_GlcNHglycan	325	329	PF01048	0.677
MOD_GlcNHglycan	344	347	PF01048	0.598
MOD_GlcNHglycan	351	354	PF01048	0.538
MOD_GlcNHglycan	413	417	PF01048	0.585
MOD_GlcNHglycan	437	440	PF01048	0.585
MOD_GlcNHglycan	5	8	PF01048	0.650
MOD_GlcNHglycan	504	507	PF01048	0.597
MOD_GlcNHglycan	512	515	PF01048	0.432
MOD_GlcNHglycan	518	521	PF01048	0.372
MOD_GlcNHglycan	602	605	PF01048	0.243
MOD_GlcNHglycan	625	628	PF01048	0.250
MOD_GlcNHglycan	728	731	PF01048	0.250
MOD_GlcNHglycan	827	830	PF01048	0.575
MOD_GlcNHglycan	835	838	PF01048	0.681
MOD_GlcNHglycan	839	842	PF01048	0.561
MOD_GlcNHglycan	902	905	PF01048	0.563
MOD_GlcNHglycan	913	916	PF01048	0.627
MOD_GlcNHglycan	942	947	PF01048	0.440
MOD_GlcNHglycan	965	968	PF01048	0.401
MOD_GSK3_1	168	175	PF00069	0.528
MOD_GSK3_1	233	240	PF00069	0.452
MOD_GSK3_1	315	322	PF00069	0.505
MOD_GSK3_1	408	415	PF00069	0.592
MOD_GSK3_1	498	505	PF00069	0.569
MOD_GSK3_1	510	517	PF00069	0.685
MOD_GSK3_1	539	546	PF00069	0.450
MOD_GSK3_1	610	617	PF00069	0.468
MOD_GSK3_1	623	630	PF00069	0.526
MOD_GSK3_1	821	828	PF00069	0.581
MOD_GSK3_1	831	838	PF00069	0.572
MOD_GSK3_1	88	95	PF00069	0.443
MOD_GSK3_1	889	896	PF00069	0.451
MOD_N-GLC_1	706	711	PF02516	0.250
MOD_NEK2_1	170	175	PF00069	0.564
MOD_NEK2_1	314	319	PF00069	0.507
MOD_NEK2_1	437	442	PF00069	0.655
MOD_NEK2_1	485	490	PF00069	0.557
MOD_NEK2_1	539	544	PF00069	0.450
MOD_NEK2_1	557	562	PF00069	0.450
MOD_NEK2_1	587	592	PF00069	0.453
MOD_NEK2_1	616	621	PF00069	0.499
MOD_NEK2_1	675	680	PF00069	0.450
MOD_NEK2_1	782	787	PF00069	0.350
MOD_NEK2_1	833	838	PF00069	0.610
MOD_NEK2_1	850	855	PF00069	0.325
MOD_NEK2_1	889	894	PF00069	0.450
MOD_NEK2_1	900	905	PF00069	0.538
MOD_NEK2_2	405	410	PF00069	0.456
MOD_NMyristoyl	1	7	PF02799	0.618
MOD_OFUCOSY	607	614	PF10250	0.250
MOD_PIKK_1	170	176	PF00454	0.526
MOD_PIKK_1	327	333	PF00454	0.695
MOD_PIKK_1	344	350	PF00454	0.504
MOD_PIKK_1	408	414	PF00454	0.590
MOD_PIKK_1	587	593	PF00454	0.450
MOD_PIKK_1	782	788	PF00454	0.352
MOD_PKA_1	168	174	PF00069	0.515
MOD_PKA_1	921	927	PF00069	0.499
MOD_PKA_2	237	243	PF00069	0.457
MOD_PKA_2	247	253	PF00069	0.440
MOD_PKA_2	3	9	PF00069	0.645
MOD_PKA_2	48	54	PF00069	0.422
MOD_PKA_2	507	513	PF00069	0.633
MOD_PKA_2	537	543	PF00069	0.450
MOD_PKA_2	573	579	PF00069	0.450
MOD_PKA_2	681	687	PF00069	0.533
MOD_PKA_2	698	704	PF00069	0.379
MOD_PKA_2	921	927	PF00069	0.566
MOD_Plk_1	308	314	PF00069	0.450
MOD_Plk_1	627	633	PF00069	0.450
MOD_Plk_1	850	856	PF00069	0.367
MOD_Plk_2-3	309	315	PF00069	0.507
MOD_Plk_2-3	369	375	PF00069	0.375
MOD_Plk_4	237	243	PF00069	0.452
MOD_Plk_4	309	315	PF00069	0.552
MOD_Plk_4	54	60	PF00069	0.465
MOD_Plk_4	543	549	PF00069	0.450
MOD_Plk_4	557	563	PF00069	0.450
MOD_Plk_4	681	687	PF00069	0.458
MOD_ProDKin_1	104	110	PF00069	0.583
MOD_ProDKin_1	190	196	PF00069	0.599
MOD_ProDKin_1	218	224	PF00069	0.592
MOD_ProDKin_1	242	248	PF00069	0.450
MOD_ProDKin_1	288	294	PF00069	0.473
MOD_ProDKin_1	316	322	PF00069	0.447
MOD_ProDKin_1	362	368	PF00069	0.313
MOD_ProDKin_1	39	45	PF00069	0.504
MOD_ProDKin_1	415	421	PF00069	0.578
MOD_ProDKin_1	706	712	PF00069	0.468
MOD_ProDKin_1	852	858	PF00069	0.471
MOD_SUMO_for_1	870	873	PF00179	0.450
MOD_SUMO_rev_2	650	659	PF00179	0.452
TRG_DiLeu_BaEn_1	300	305	PF01217	0.507
TRG_DiLeu_BaEn_1	655	660	PF01217	0.450
TRG_DiLeu_BaEn_1	976	981	PF01217	0.387
TRG_DiLeu_BaEn_4	300	306	PF01217	0.507
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.395
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.576
TRG_ENDOCYTIC_2	210	213	PF00928	0.370
TRG_ER_diArg_1	206	208	PF00400	0.380
TRG_ER_diArg_1	401	404	PF00400	0.383
TRG_ER_diArg_1	429	432	PF00400	0.564
TRG_ER_diArg_1	921	923	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	657	661	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	972	976	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM6	Leptomonas seymouri	64%	98%
A0A3S5H5H2	Leishmania donovani	92%	100%
A4H477	Leishmania braziliensis	80%	100%
A4HSF2	Leishmania infantum	91%	100%
E9AKD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
E9AMM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
F4KAB8	Arabidopsis thaliana	26%	100%