Probable eukaryotic initiation factor 4A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania major

UniProt:

Q4QJG6_LEIMA

TriTrypDb:

LmjF.05.0360 , LMJLV39_050008500 , LMJSD75_050008500

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJG6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003724	RNA helicase activity	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0008186	ATP-dependent activity, acting on RNA	2	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.465
CLV_NRD_NRD_1	182	184	PF00675	0.232
CLV_NRD_NRD_1	505	507	PF00675	0.536
CLV_NRD_NRD_1	523	525	PF00675	0.500
CLV_NRD_NRD_1	558	560	PF00675	0.565
CLV_NRD_NRD_1	595	597	PF00675	0.675
CLV_NRD_NRD_1	617	619	PF00675	0.727
CLV_PCSK_FUR_1	180	184	PF00082	0.158
CLV_PCSK_FUR_1	521	525	PF00082	0.593
CLV_PCSK_FUR_1	556	560	PF00082	0.598
CLV_PCSK_KEX2_1	182	184	PF00082	0.232
CLV_PCSK_KEX2_1	523	525	PF00082	0.496
CLV_PCSK_KEX2_1	555	557	PF00082	0.665
CLV_PCSK_KEX2_1	558	560	PF00082	0.660
CLV_PCSK_KEX2_1	595	597	PF00082	0.746
CLV_PCSK_KEX2_1	619	621	PF00082	0.611
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.665
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.611
CLV_PCSK_SKI1_1	100	104	PF00082	0.248
CLV_PCSK_SKI1_1	132	136	PF00082	0.260
CLV_PCSK_SKI1_1	182	186	PF00082	0.223
CLV_PCSK_SKI1_1	559	563	PF00082	0.649
CLV_PCSK_SKI1_1	576	580	PF00082	0.573
CLV_PCSK_SKI1_1	596	600	PF00082	0.572
CLV_PCSK_SKI1_1	602	606	PF00082	0.550
CLV_PCSK_SKI1_1	619	623	PF00082	0.627
CLV_Separin_Metazoa	349	353	PF03568	0.417
DEG_APCC_DBOX_1	346	354	PF00400	0.481
DEG_SCF_FBW7_2	74	81	PF00400	0.406
DOC_CDC14_PxL_1	319	327	PF14671	0.386
DOC_CKS1_1	22	27	PF01111	0.473
DOC_CKS1_1	75	80	PF01111	0.406
DOC_CYCLIN_RxL_1	129	136	PF00134	0.483
DOC_CYCLIN_RxL_1	144	158	PF00134	0.407
DOC_CYCLIN_RxL_1	180	190	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	175	178	PF00134	0.473
DOC_MAPK_DCC_7	397	406	PF00069	0.417
DOC_MAPK_gen_1	130	137	PF00069	0.497
DOC_MAPK_gen_1	180	187	PF00069	0.429
DOC_MAPK_gen_1	428	438	PF00069	0.485
DOC_MAPK_gen_1	452	460	PF00069	0.338
DOC_MAPK_gen_1	98	105	PF00069	0.405
DOC_MAPK_HePTP_8	394	406	PF00069	0.417
DOC_MAPK_MEF2A_6	347	355	PF00069	0.406
DOC_MAPK_MEF2A_6	397	406	PF00069	0.417
DOC_PP1_RVXF_1	181	188	PF00149	0.382
DOC_PP2B_LxvP_1	175	178	PF13499	0.451
DOC_PP2B_LxvP_1	198	201	PF13499	0.541
DOC_PP2B_LxvP_1	314	317	PF13499	0.316
DOC_PP2B_LxvP_1	399	402	PF13499	0.406
DOC_PP4_FxxP_1	303	306	PF00568	0.539
DOC_PP4_FxxP_1	56	59	PF00568	0.406
DOC_PP4_FxxP_1	93	96	PF00568	0.473
DOC_USP7_MATH_1	218	222	PF00917	0.474
DOC_USP7_MATH_1	275	279	PF00917	0.710
DOC_USP7_MATH_1	287	291	PF00917	0.750
DOC_USP7_MATH_1	361	365	PF00917	0.406
DOC_USP7_MATH_1	402	406	PF00917	0.452
DOC_USP7_MATH_1	466	470	PF00917	0.484
DOC_USP7_MATH_1	47	51	PF00917	0.430
DOC_USP7_MATH_1	516	520	PF00917	0.484
DOC_USP7_MATH_1	538	542	PF00917	0.675
DOC_USP7_MATH_1	557	561	PF00917	0.750
DOC_USP7_MATH_1	591	595	PF00917	0.617
DOC_USP7_MATH_1	604	608	PF00917	0.480
DOC_USP7_UBL2_3	576	580	PF12436	0.574
DOC_WW_Pin1_4	124	129	PF00397	0.406
DOC_WW_Pin1_4	21	26	PF00397	0.355
DOC_WW_Pin1_4	224	229	PF00397	0.607
DOC_WW_Pin1_4	460	465	PF00397	0.493
DOC_WW_Pin1_4	544	549	PF00397	0.738
DOC_WW_Pin1_4	612	617	PF00397	0.642
DOC_WW_Pin1_4	74	79	PF00397	0.406
LIG_14-3-3_CanoR_1	11	20	PF00244	0.334
LIG_14-3-3_CanoR_1	159	166	PF00244	0.420
LIG_14-3-3_CanoR_1	194	199	PF00244	0.518
LIG_14-3-3_CanoR_1	217	223	PF00244	0.473
LIG_14-3-3_CanoR_1	299	304	PF00244	0.605
LIG_14-3-3_CanoR_1	352	356	PF00244	0.417
LIG_14-3-3_CanoR_1	556	562	PF00244	0.648
LIG_14-3-3_CanoR_1	595	603	PF00244	0.596
LIG_14-3-3_CanoR_1	98	103	PF00244	0.405
LIG_APCC_ABBA_1	406	411	PF00400	0.417
LIG_BIR_II_1	1	5	PF00653	0.317
LIG_BIR_III_4	67	71	PF00653	0.452
LIG_eIF4E_1	69	75	PF01652	0.406
LIG_FHA_1	186	192	PF00498	0.425
LIG_FHA_1	195	201	PF00498	0.415
LIG_FHA_1	256	262	PF00498	0.443
LIG_FHA_1	352	358	PF00498	0.426
LIG_FHA_1	455	461	PF00498	0.362
LIG_FHA_2	110	116	PF00498	0.465
LIG_FHA_2	159	165	PF00498	0.426
LIG_FHA_2	194	200	PF00498	0.454
LIG_FHA_2	438	444	PF00498	0.310
LIG_FHA_2	497	503	PF00498	0.413
LIG_FHA_2	560	566	PF00498	0.611
LIG_LIR_Apic_2	301	306	PF02991	0.574
LIG_LIR_Apic_2	459	464	PF02991	0.420
LIG_LIR_Apic_2	53	59	PF02991	0.406
LIG_LIR_Gen_1	18	27	PF02991	0.475
LIG_LIR_Gen_1	243	253	PF02991	0.439
LIG_LIR_Gen_1	3	9	PF02991	0.362
LIG_LIR_Gen_1	310	320	PF02991	0.425
LIG_LIR_Gen_1	81	92	PF02991	0.406
LIG_LIR_Nem_3	18	22	PF02991	0.476
LIG_LIR_Nem_3	243	248	PF02991	0.467
LIG_LIR_Nem_3	3	7	PF02991	0.346
LIG_LIR_Nem_3	310	316	PF02991	0.430
LIG_LIR_Nem_3	67	72	PF02991	0.408
LIG_LIR_Nem_3	81	87	PF02991	0.415
LIG_LIR_Nem_3	88	93	PF02991	0.406
LIG_LYPXL_SIV_4	323	331	PF13949	0.452
LIG_NRBOX	130	136	PF00104	0.473
LIG_NRBOX	364	370	PF00104	0.510
LIG_PDZ_Class_3	620	625	PF00595	0.540
LIG_RPA_C_Plants	496	507	PF08784	0.514
LIG_SH2_CRK	410	414	PF00017	0.406
LIG_SH2_GRB2like	341	344	PF00017	0.510
LIG_SH2_SRC	341	344	PF00017	0.510
LIG_SH2_SRC	84	87	PF00017	0.430
LIG_SH2_STAP1	442	446	PF00017	0.359
LIG_SH2_STAT5	151	154	PF00017	0.516
LIG_SH2_STAT5	313	316	PF00017	0.300
LIG_SH2_STAT5	324	327	PF00017	0.406
LIG_SH2_STAT5	341	344	PF00017	0.406
LIG_SH2_STAT5	419	422	PF00017	0.421
LIG_SH3_2	294	299	PF14604	0.573
LIG_SH3_3	134	140	PF00018	0.457
LIG_SH3_3	291	297	PF00018	0.581
LIG_SH3_3	317	323	PF00018	0.448
LIG_SH3_3	72	78	PF00018	0.435
LIG_SUMO_SIM_anti_2	260	265	PF11976	0.493
LIG_SUMO_SIM_anti_2	434	441	PF11976	0.345
LIG_SUMO_SIM_anti_2	443	448	PF11976	0.329
LIG_SUMO_SIM_par_1	468	477	PF11976	0.475
LIG_TRAF2_1	213	216	PF00917	0.476
LIG_TRAF2_1	267	270	PF00917	0.477
LIG_TYR_ITIM	149	154	PF00017	0.510
LIG_TYR_ITIM	82	87	PF00017	0.406
LIG_WRC_WIRS_1	378	383	PF05994	0.426
MOD_CDC14_SPxK_1	615	618	PF00782	0.627
MOD_CDK_SPxK_1	124	130	PF00069	0.406
MOD_CDK_SPxK_1	612	618	PF00069	0.633
MOD_CDK_SPxK_1	74	80	PF00069	0.406
MOD_CDK_SPxxK_3	460	467	PF00069	0.495
MOD_CDK_SPxxK_3	612	619	PF00069	0.611
MOD_CK1_1	221	227	PF00069	0.542
MOD_CK1_1	278	284	PF00069	0.678
MOD_CK1_1	289	295	PF00069	0.741
MOD_CK1_1	364	370	PF00069	0.406
MOD_CK1_1	50	56	PF00069	0.420
MOD_CK1_1	547	553	PF00069	0.605
MOD_CK1_1	560	566	PF00069	0.646
MOD_CK1_1	594	600	PF00069	0.593
MOD_CK1_1	612	618	PF00069	0.723
MOD_CK2_1	193	199	PF00069	0.548
MOD_CK2_1	254	260	PF00069	0.507
MOD_CK2_1	496	502	PF00069	0.416
MOD_CK2_1	559	565	PF00069	0.711
MOD_GlcNHglycan	207	210	PF01048	0.589
MOD_GlcNHglycan	277	280	PF01048	0.678
MOD_GlcNHglycan	289	292	PF01048	0.755
MOD_GlcNHglycan	468	471	PF01048	0.424
MOD_GlcNHglycan	479	482	PF01048	0.354
MOD_GlcNHglycan	49	52	PF01048	0.212
MOD_GlcNHglycan	532	535	PF01048	0.754
MOD_GlcNHglycan	551	554	PF01048	0.683
MOD_GlcNHglycan	562	565	PF01048	0.681
MOD_GlcNHglycan	596	599	PF01048	0.688
MOD_GlcNHglycan	606	609	PF01048	0.776
MOD_GSK3_1	11	18	PF00069	0.491
MOD_GSK3_1	218	225	PF00069	0.539
MOD_GSK3_1	251	258	PF00069	0.499
MOD_GSK3_1	285	292	PF00069	0.718
MOD_GSK3_1	456	463	PF00069	0.506
MOD_GSK3_1	466	473	PF00069	0.539
MOD_GSK3_1	538	545	PF00069	0.638
MOD_LATS_1	192	198	PF00433	0.620
MOD_N-GLC_1	536	541	PF02516	0.630
MOD_N-GLC_2	343	345	PF02516	0.206
MOD_NEK2_1	185	190	PF00069	0.438
MOD_NEK2_1	207	212	PF00069	0.481
MOD_NEK2_1	222	227	PF00069	0.648
MOD_NEK2_1	542	547	PF00069	0.781
MOD_PIKK_1	109	115	PF00454	0.461
MOD_PIKK_1	307	313	PF00454	0.357
MOD_PIKK_1	367	373	PF00454	0.417
MOD_PIKK_1	566	572	PF00454	0.722
MOD_PIKK_1	596	602	PF00454	0.616
MOD_PKA_2	158	164	PF00069	0.406
MOD_PKA_2	193	199	PF00069	0.548
MOD_PKA_2	298	304	PF00069	0.599
MOD_PKA_2	351	357	PF00069	0.417
MOD_PKA_2	517	523	PF00069	0.611
MOD_PKA_2	557	563	PF00069	0.638
MOD_PKA_2	594	600	PF00069	0.685
MOD_Plk_1	254	260	PF00069	0.422
MOD_Plk_1	334	340	PF00069	0.421
MOD_Plk_1	442	448	PF00069	0.400
MOD_Plk_2-3	158	164	PF00069	0.456
MOD_Plk_2-3	255	261	PF00069	0.479
MOD_Plk_4	15	21	PF00069	0.399
MOD_Plk_4	168	174	PF00069	0.467
MOD_Plk_4	335	341	PF00069	0.406
MOD_Plk_4	364	370	PF00069	0.406
MOD_Plk_4	402	408	PF00069	0.452
MOD_Plk_4	415	421	PF00069	0.430
MOD_Plk_4	442	448	PF00069	0.384
MOD_Plk_4	456	462	PF00069	0.299
MOD_Plk_4	470	476	PF00069	0.344
MOD_ProDKin_1	124	130	PF00069	0.406
MOD_ProDKin_1	21	27	PF00069	0.355
MOD_ProDKin_1	224	230	PF00069	0.607
MOD_ProDKin_1	460	466	PF00069	0.492
MOD_ProDKin_1	544	550	PF00069	0.736
MOD_ProDKin_1	612	618	PF00069	0.643
MOD_ProDKin_1	74	80	PF00069	0.406
MOD_SUMO_rev_2	445	454	PF00179	0.366
TRG_DiLeu_BaEn_1	243	248	PF01217	0.467
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.516
TRG_ENDOCYTIC_2	151	154	PF00928	0.516
TRG_ENDOCYTIC_2	19	22	PF00928	0.370
TRG_ENDOCYTIC_2	313	316	PF00928	0.300
TRG_ENDOCYTIC_2	69	72	PF00928	0.407
TRG_ENDOCYTIC_2	84	87	PF00928	0.401
TRG_ER_diArg_1	180	183	PF00400	0.467
TRG_ER_diArg_1	521	524	PF00400	0.585
TRG_ER_diArg_1	556	559	PF00400	0.586
TRG_ER_diArg_1	618	621	PF00400	0.635
TRG_ER_diArg_1	97	100	PF00400	0.405
TRG_NLS_Bipartite_1	558	580	PF00514	0.684
TRG_NLS_Bipartite_1	605	622	PF00514	0.617
TRG_NLS_MonoExtC_3	554	559	PF00514	0.562
TRG_NLS_MonoExtC_3	575	580	PF00514	0.615
TRG_NLS_MonoExtC_3	617	622	PF00514	0.613
TRG_NLS_MonoExtN_4	616	622	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.206
TRG_Pf-PMV_PEXEL_1	585	590	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	80	85	PF00026	0.206

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2T9	Leptomonas seymouri	72%	100%
A0A0S4J5D6	Bodo saltans	49%	100%
A0A0S4KKU4	Bodo saltans	30%	90%
A0A1X0NVK0	Trypanosomatidae	28%	87%
A0A1X0P0F9	Trypanosomatidae	56%	100%
A0A3R7KKL1	Trypanosoma rangeli	31%	87%
A0A3R7M1K3	Trypanosoma rangeli	29%	87%
A0A3S5H5H4	Leishmania donovani	95%	100%
A0A3S5H6T7	Leishmania donovani	29%	100%
A0A3S7X5R1	Leishmania donovani	28%	81%
A0A422NDK5	Trypanosoma rangeli	56%	100%
A2XVF7	Oryza sativa subsp. indica	30%	75%
A3AVH5	Oryza sativa subsp. japonica	30%	75%
A4H481	Leishmania braziliensis	79%	99%
A4HKL3	Leishmania braziliensis	27%	81%
A4HSF8	Leishmania infantum	95%	100%
A4HWB0	Leishmania infantum	29%	100%
A4I846	Leishmania infantum	28%	81%
A4R5B8	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	33%	68%
A4REU9	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	31%	82%
A7ESL7	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	33%	68%
A7TJ71	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	28%	81%
C9ZNU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
D0A4H6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
D0A6Z3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0AAB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	86%
E9AKE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AQ10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	96%
P26802	Drosophila melanogaster	29%	91%
Q0DLB9	Oryza sativa subsp. japonica	26%	100%
Q4HZ42	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	33%	70%
Q4IJH1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	30%	100%
Q4Q552	Leishmania major	28%	81%
Q4QFH1	Leishmania major	32%	100%
Q6C835	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	78%
Q6FU81	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	94%
Q76PD3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q7FGZ2	Arabidopsis thaliana	29%	100%
Q7XJN0	Arabidopsis thaliana	28%	100%
Q8W4E1	Arabidopsis thaliana	27%	100%
Q93Y39	Arabidopsis thaliana	33%	76%
V5CZW7	Trypanosoma cruzi	58%	100%
V5DCA1	Trypanosoma cruzi	27%	87%