LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
STE/STE11 serine/threonine-protein kinase, putative
Species:
Leishmania major
UniProt:
Q4QJG3_LEIMA
TriTrypDb:
LmjF.05.0390 * , LMJLV39_050008800 * , LMJSD75_050008800 *
Length:
719

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QJG3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJG3

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 163 167 PF00656 0.350
CLV_C14_Caspase3-7 184 188 PF00656 0.473
CLV_C14_Caspase3-7 255 259 PF00656 0.449
CLV_C14_Caspase3-7 316 320 PF00656 0.653
CLV_C14_Caspase3-7 333 337 PF00656 0.500
CLV_NRD_NRD_1 377 379 PF00675 0.704
CLV_NRD_NRD_1 404 406 PF00675 0.740
CLV_NRD_NRD_1 501 503 PF00675 0.398
CLV_PCSK_KEX2_1 377 379 PF00082 0.704
CLV_PCSK_KEX2_1 501 503 PF00082 0.328
CLV_PCSK_SKI1_1 186 190 PF00082 0.383
CLV_PCSK_SKI1_1 572 576 PF00082 0.328
DEG_Nend_UBRbox_3 1 3 PF02207 0.496
DEG_SCF_FBW7_1 329 335 PF00400 0.698
DOC_CKS1_1 329 334 PF01111 0.699
DOC_CKS1_1 612 617 PF01111 0.328
DOC_CYCLIN_yCln2_LP_2 230 236 PF00134 0.590
DOC_CYCLIN_yCln2_LP_2 706 712 PF00134 0.385
DOC_MAPK_gen_1 492 499 PF00069 0.328
DOC_MAPK_gen_1 518 525 PF00069 0.306
DOC_MAPK_gen_1 572 581 PF00069 0.328
DOC_MAPK_HePTP_8 515 527 PF00069 0.413
DOC_MAPK_MEF2A_6 518 527 PF00069 0.328
DOC_MAPK_MEF2A_6 575 583 PF00069 0.328
DOC_PP2B_LxvP_1 434 437 PF13499 0.678
DOC_USP7_MATH_1 332 336 PF00917 0.708
DOC_USP7_MATH_1 36 40 PF00917 0.798
DOC_USP7_MATH_1 396 400 PF00917 0.746
DOC_USP7_MATH_1 426 430 PF00917 0.582
DOC_USP7_MATH_1 53 57 PF00917 0.612
DOC_USP7_UBL2_3 290 294 PF12436 0.413
DOC_USP7_UBL2_3 453 457 PF12436 0.328
DOC_WW_Pin1_4 328 333 PF00397 0.700
DOC_WW_Pin1_4 447 452 PF00397 0.579
DOC_WW_Pin1_4 611 616 PF00397 0.328
LIG_14-3-3_CanoR_1 401 405 PF00244 0.692
LIG_14-3-3_CanoR_1 469 475 PF00244 0.449
LIG_14-3-3_CanoR_1 54 62 PF00244 0.785
LIG_Actin_WH2_2 456 471 PF00022 0.449
LIG_APCC_ABBA_1 286 291 PF00400 0.449
LIG_APCC_ABBA_1 523 528 PF00400 0.328
LIG_BIR_III_4 187 191 PF00653 0.385
LIG_BIR_III_4 336 340 PF00653 0.701
LIG_BRCT_BRCA1_1 426 430 PF00533 0.592
LIG_BRCT_BRCA1_1 706 710 PF00533 0.398
LIG_Clathr_ClatBox_1 580 584 PF01394 0.328
LIG_deltaCOP1_diTrp_1 300 307 PF00928 0.331
LIG_eIF4E_1 104 110 PF01652 0.573
LIG_FHA_1 15 21 PF00498 0.719
LIG_FHA_1 463 469 PF00498 0.449
LIG_FHA_1 520 526 PF00498 0.341
LIG_FHA_1 534 540 PF00498 0.307
LIG_FHA_1 57 63 PF00498 0.558
LIG_FHA_1 713 719 PF00498 0.713
LIG_FHA_2 124 130 PF00498 0.381
LIG_FHA_2 161 167 PF00498 0.363
LIG_FHA_2 253 259 PF00498 0.363
LIG_FHA_2 420 426 PF00498 0.698
LIG_FHA_2 640 646 PF00498 0.328
LIG_FHA_2 82 88 PF00498 0.706
LIG_Integrin_isoDGR_2 272 274 PF01839 0.449
LIG_Integrin_isoDGR_2 470 472 PF01839 0.413
LIG_LIR_Apic_2 614 620 PF02991 0.328
LIG_LIR_Gen_1 409 418 PF02991 0.686
LIG_LIR_Gen_1 658 667 PF02991 0.328
LIG_LIR_Nem_3 103 107 PF02991 0.586
LIG_LIR_Nem_3 409 415 PF02991 0.737
LIG_LIR_Nem_3 447 452 PF02991 0.470
LIG_LIR_Nem_3 459 463 PF02991 0.309
LIG_LIR_Nem_3 540 545 PF02991 0.384
LIG_LIR_Nem_3 658 663 PF02991 0.328
LIG_MYND_1 696 700 PF01753 0.449
LIG_NRBOX 683 689 PF00104 0.449
LIG_Pex14_1 660 664 PF04695 0.328
LIG_Pex14_2 538 542 PF04695 0.328
LIG_PTB_Apo_2 43 50 PF02174 0.666
LIG_SH2_CRK 104 108 PF00017 0.580
LIG_SH2_CRK 464 468 PF00017 0.420
LIG_SH2_CRK 555 559 PF00017 0.385
LIG_SH2_STAP1 464 468 PF00017 0.328
LIG_SH2_STAT5 104 107 PF00017 0.543
LIG_SH2_STAT5 123 126 PF00017 0.166
LIG_SH2_STAT5 162 165 PF00017 0.396
LIG_SH2_STAT5 174 177 PF00017 0.328
LIG_SH2_STAT5 192 195 PF00017 0.218
LIG_SH2_STAT5 277 280 PF00017 0.344
LIG_SH2_STAT5 285 288 PF00017 0.344
LIG_SH2_STAT5 464 467 PF00017 0.449
LIG_SH2_STAT5 529 532 PF00017 0.445
LIG_SH2_STAT5 563 566 PF00017 0.315
LIG_SH3_3 326 332 PF00018 0.691
LIG_SH3_3 364 370 PF00018 0.702
LIG_SH3_3 380 386 PF00018 0.683
LIG_SH3_3 47 53 PF00018 0.546
LIG_SH3_3 609 615 PF00018 0.328
LIG_SH3_3 648 654 PF00018 0.328
LIG_SH3_3 71 77 PF00018 0.799
LIG_SH3_3 95 101 PF00018 0.651
LIG_SUMO_SIM_anti_2 496 501 PF11976 0.328
LIG_SUMO_SIM_par_1 477 483 PF11976 0.333
LIG_SUMO_SIM_par_1 579 584 PF11976 0.344
LIG_SUMO_SIM_par_1 75 81 PF11976 0.571
LIG_TRAF2_1 422 425 PF00917 0.594
LIG_TRAF2_1 486 489 PF00917 0.449
LIG_TYR_ITIM 102 107 PF00017 0.593
LIG_UBA3_1 684 690 PF00899 0.428
LIG_WRC_WIRS_1 535 540 PF05994 0.344
MOD_CDK_SPxK_1 447 453 PF00069 0.582
MOD_CK1_1 143 149 PF00069 0.376
MOD_CK1_1 320 326 PF00069 0.718
MOD_CK1_1 353 359 PF00069 0.753
MOD_CK1_1 360 366 PF00069 0.693
MOD_CK1_1 399 405 PF00069 0.694
MOD_CK1_1 531 537 PF00069 0.337
MOD_CK1_1 56 62 PF00069 0.803
MOD_CK1_1 81 87 PF00069 0.789
MOD_CK2_1 123 129 PF00069 0.344
MOD_CK2_1 419 425 PF00069 0.622
MOD_CK2_1 441 447 PF00069 0.570
MOD_CK2_1 483 489 PF00069 0.348
MOD_CK2_1 639 645 PF00069 0.328
MOD_GlcNHglycan 10 13 PF01048 0.762
MOD_GlcNHglycan 142 145 PF01048 0.395
MOD_GlcNHglycan 226 229 PF01048 0.452
MOD_GlcNHglycan 392 395 PF01048 0.738
MOD_GlcNHglycan 414 418 PF01048 0.670
MOD_GlcNHglycan 530 533 PF01048 0.328
MOD_GlcNHglycan 56 59 PF01048 0.583
MOD_GlcNHglycan 602 605 PF01048 0.449
MOD_GSK3_1 186 193 PF00069 0.344
MOD_GSK3_1 32 39 PF00069 0.792
MOD_GSK3_1 328 335 PF00069 0.754
MOD_GSK3_1 353 360 PF00069 0.761
MOD_GSK3_1 386 393 PF00069 0.676
MOD_GSK3_1 396 403 PF00069 0.665
MOD_GSK3_1 4 11 PF00069 0.766
MOD_GSK3_1 426 433 PF00069 0.552
MOD_GSK3_1 447 454 PF00069 0.624
MOD_GSK3_1 533 540 PF00069 0.242
MOD_GSK3_1 602 609 PF00069 0.348
MOD_GSK3_1 631 638 PF00069 0.328
MOD_GSK3_1 667 674 PF00069 0.328
MOD_N-GLC_1 1 6 PF02516 0.759
MOD_N-GLC_1 390 395 PF02516 0.677
MOD_N-GLC_1 406 411 PF02516 0.681
MOD_N-GLC_1 54 59 PF02516 0.765
MOD_N-GLC_1 667 672 PF02516 0.413
MOD_NEK2_1 1 6 PF00069 0.757
MOD_NEK2_1 359 364 PF00069 0.720
MOD_NEK2_1 400 405 PF00069 0.662
MOD_NEK2_1 430 435 PF00069 0.623
MOD_NEK2_1 592 597 PF00069 0.328
MOD_NEK2_1 78 83 PF00069 0.571
MOD_NEK2_2 396 401 PF00069 0.756
MOD_NEK2_2 546 551 PF00069 0.449
MOD_PIKK_1 317 323 PF00454 0.642
MOD_PK_1 541 547 PF00069 0.427
MOD_PKA_1 405 411 PF00069 0.684
MOD_PKA_2 273 279 PF00069 0.449
MOD_PKA_2 353 359 PF00069 0.749
MOD_PKA_2 400 406 PF00069 0.742
MOD_PKA_2 53 59 PF00069 0.795
MOD_PKA_2 698 704 PF00069 0.344
MOD_Plk_1 1 7 PF00069 0.749
MOD_Plk_2-3 338 344 PF00069 0.728
MOD_Plk_2-3 480 486 PF00069 0.370
MOD_Plk_4 273 279 PF00069 0.363
MOD_Plk_4 325 331 PF00069 0.745
MOD_Plk_4 426 432 PF00069 0.587
MOD_Plk_4 45 51 PF00069 0.548
MOD_Plk_4 534 540 PF00069 0.344
MOD_Plk_4 607 613 PF00069 0.327
MOD_Plk_4 639 645 PF00069 0.324
MOD_Plk_4 655 661 PF00069 0.328
MOD_ProDKin_1 328 334 PF00069 0.699
MOD_ProDKin_1 447 453 PF00069 0.582
MOD_ProDKin_1 611 617 PF00069 0.328
MOD_SUMO_for_1 623 626 PF00179 0.344
MOD_SUMO_rev_2 180 188 PF00179 0.449
MOD_SUMO_rev_2 514 519 PF00179 0.421
MOD_SUMO_rev_2 675 685 PF00179 0.283
MOD_SUMO_rev_2 693 698 PF00179 0.283
TRG_DiLeu_BaEn_4 488 494 PF01217 0.385
TRG_DiLeu_BaLyEn_6 105 110 PF01217 0.486
TRG_DiLeu_BaLyEn_6 74 79 PF01217 0.570
TRG_ENDOCYTIC_2 104 107 PF00928 0.579
TRG_ENDOCYTIC_2 204 207 PF00928 0.437
TRG_ENDOCYTIC_2 285 288 PF00928 0.449
TRG_ENDOCYTIC_2 412 415 PF00928 0.742
TRG_ENDOCYTIC_2 464 467 PF00928 0.348
TRG_ENDOCYTIC_2 512 515 PF00928 0.449
TRG_ENDOCYTIC_2 555 558 PF00928 0.385
TRG_ER_diArg_1 175 178 PF00400 0.475
TRG_ER_diArg_1 376 378 PF00400 0.700
TRG_ER_diArg_1 500 502 PF00400 0.398
TRG_Pf-PMV_PEXEL_1 377 381 PF00026 0.621
TRG_Pf-PMV_PEXEL_1 562 566 PF00026 0.475

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZR8 Leptomonas seymouri 73% 90%
A0A0S4J7Q1 Bodo saltans 55% 100%
A0A1X0P0R3 Trypanosomatidae 64% 100%
A0A3S7WP16 Leishmania donovani 95% 91%
A0A422N0Q9 Trypanosoma rangeli 62% 100%
A4H485 Leishmania braziliensis 83% 98%
A4HSG1 Leishmania infantum 95% 91%
D0A4H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 100%
E9AKE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 98%
V5D179 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS