Metallophos domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJF9_LEIMA

TriTrypDb:

LmjF.05.0430 , LMJLV39_050009200 , LMJSD75_050009400

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJF9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.488
CLV_C14_Caspase3-7	496	500	PF00656	0.393
CLV_NRD_NRD_1	10	12	PF00675	0.330
CLV_NRD_NRD_1	153	155	PF00675	0.493
CLV_NRD_NRD_1	279	281	PF00675	0.406
CLV_NRD_NRD_1	3	5	PF00675	0.519
CLV_NRD_NRD_1	517	519	PF00675	0.466
CLV_NRD_NRD_1	611	613	PF00675	0.513
CLV_PCSK_FUR_1	8	12	PF00082	0.445
CLV_PCSK_KEX2_1	10	12	PF00082	0.332
CLV_PCSK_KEX2_1	152	154	PF00082	0.491
CLV_PCSK_KEX2_1	279	281	PF00082	0.441
CLV_PCSK_KEX2_1	3	5	PF00082	0.517
CLV_PCSK_KEX2_1	517	519	PF00082	0.543
CLV_PCSK_KEX2_1	611	613	PF00082	0.513
CLV_PCSK_KEX2_1	671	673	PF00082	0.597
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.491
CLV_PCSK_PC1ET2_1	671	673	PF00082	0.620
CLV_PCSK_SKI1_1	146	150	PF00082	0.416
CLV_PCSK_SKI1_1	216	220	PF00082	0.539
CLV_PCSK_SKI1_1	623	627	PF00082	0.467
DEG_APCC_DBOX_1	279	287	PF00400	0.423
DEG_Nend_Nbox_1	1	3	PF02207	0.548
DEG_SCF_FBW7_1	393	400	PF00400	0.464
DEG_SPOP_SBC_1	590	594	PF00917	0.510
DOC_ANK_TNKS_1	573	580	PF00023	0.442
DOC_CYCLIN_RxL_1	143	150	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	196	199	PF00134	0.409
DOC_MAPK_gen_1	152	161	PF00069	0.490
DOC_MAPK_gen_1	517	525	PF00069	0.506
DOC_MAPK_MEF2A_6	154	163	PF00069	0.485
DOC_MAPK_MEF2A_6	340	348	PF00069	0.408
DOC_MAPK_MEF2A_6	518	527	PF00069	0.368
DOC_PP1_RVXF_1	117	123	PF00149	0.482
DOC_PP1_RVXF_1	31	38	PF00149	0.325
DOC_PP2B_LxvP_1	196	199	PF13499	0.482
DOC_PP4_FxxP_1	439	442	PF00568	0.401
DOC_PP4_FxxP_1	527	530	PF00568	0.424
DOC_USP7_MATH_1	42	46	PF00917	0.715
DOC_USP7_MATH_1	49	53	PF00917	0.586
DOC_USP7_MATH_1	500	504	PF00917	0.339
DOC_USP7_MATH_1	546	550	PF00917	0.547
DOC_USP7_MATH_1	590	594	PF00917	0.522
DOC_USP7_MATH_1	637	641	PF00917	0.548
DOC_USP7_MATH_1	68	72	PF00917	0.762
DOC_USP7_UBL2_3	667	671	PF12436	0.709
DOC_WW_Pin1_4	182	187	PF00397	0.436
DOC_WW_Pin1_4	237	242	PF00397	0.731
DOC_WW_Pin1_4	393	398	PF00397	0.631
DOC_WW_Pin1_4	482	487	PF00397	0.394
LIG_14-3-3_CanoR_1	10	15	PF00244	0.346
LIG_14-3-3_CanoR_1	205	210	PF00244	0.499
LIG_14-3-3_CanoR_1	611	617	PF00244	0.593
LIG_14-3-3_CanoR_1	623	630	PF00244	0.433
LIG_BRCT_BRCA1_1	593	597	PF00533	0.492
LIG_BRCT_BRCA1_1	77	81	PF00533	0.767
LIG_CaM_IQ_9	610	625	PF13499	0.422
LIG_CSL_BTD_1	383	386	PF09270	0.481
LIG_DLG_GKlike_1	205	213	PF00625	0.473
LIG_FHA_1	199	205	PF00498	0.629
LIG_FHA_1	401	407	PF00498	0.373
LIG_FHA_1	483	489	PF00498	0.385
LIG_FHA_1	590	596	PF00498	0.382
LIG_FHA_1	88	94	PF00498	0.709
LIG_FHA_2	14	20	PF00498	0.313
LIG_FHA_2	243	249	PF00498	0.733
LIG_FHA_2	494	500	PF00498	0.525
LIG_FHA_2	624	630	PF00498	0.398
LIG_FHA_2	652	658	PF00498	0.577
LIG_GBD_Chelix_1	658	666	PF00786	0.412
LIG_LIR_Apic_2	524	530	PF02991	0.402
LIG_LIR_Gen_1	106	115	PF02991	0.581
LIG_LIR_Gen_1	19	29	PF02991	0.412
LIG_LIR_Gen_1	337	346	PF02991	0.225
LIG_LIR_Gen_1	578	588	PF02991	0.501
LIG_LIR_Nem_3	106	112	PF02991	0.613
LIG_LIR_Nem_3	19	25	PF02991	0.373
LIG_LIR_Nem_3	337	341	PF02991	0.230
LIG_LIR_Nem_3	563	567	PF02991	0.473
LIG_LIR_Nem_3	578	584	PF02991	0.455
LIG_LIR_Nem_3	64	69	PF02991	0.605
LIG_LYPXL_S_1	173	177	PF13949	0.488
LIG_LYPXL_S_1	435	439	PF13949	0.496
LIG_LYPXL_yS_3	174	177	PF13949	0.494
LIG_MYND_3	366	370	PF01753	0.429
LIG_Pex14_1	264	268	PF04695	0.393
LIG_Pex14_2	151	155	PF04695	0.481
LIG_Pex14_2	511	515	PF04695	0.527
LIG_PTAP_UEV_1	73	78	PF05743	0.653
LIG_SH2_CRK	109	113	PF00017	0.436
LIG_SH2_CRK	9	13	PF00017	0.414
LIG_SH2_PTP2	338	341	PF00017	0.230
LIG_SH2_PTP2	434	437	PF00017	0.474
LIG_SH2_PTP2	458	461	PF00017	0.349
LIG_SH2_SRC	105	108	PF00017	0.521
LIG_SH2_SRC	336	339	PF00017	0.363
LIG_SH2_SRC	434	437	PF00017	0.427
LIG_SH2_STAP1	315	319	PF00017	0.382
LIG_SH2_STAP1	374	378	PF00017	0.366
LIG_SH2_STAT3	374	377	PF00017	0.492
LIG_SH2_STAT3	466	469	PF00017	0.392
LIG_SH2_STAT5	109	112	PF00017	0.501
LIG_SH2_STAT5	14	17	PF00017	0.384
LIG_SH2_STAT5	24	27	PF00017	0.213
LIG_SH2_STAT5	338	341	PF00017	0.299
LIG_SH2_STAT5	434	437	PF00017	0.454
LIG_SH2_STAT5	458	461	PF00017	0.348
LIG_SH2_STAT5	466	469	PF00017	0.349
LIG_SH2_STAT5	504	507	PF00017	0.418
LIG_SH2_STAT5	575	578	PF00017	0.418
LIG_SH3_3	45	51	PF00018	0.579
LIG_SH3_3	450	456	PF00018	0.413
LIG_SH3_3	542	548	PF00018	0.616
LIG_SH3_3	579	585	PF00018	0.481
LIG_SH3_3	71	77	PF00018	0.630
LIG_SUMO_SIM_par_1	111	116	PF11976	0.529
LIG_TRAF2_1	389	392	PF00917	0.509
LIG_TRAF2_1	654	657	PF00917	0.545
LIG_TRFH_1	194	198	PF08558	0.549
LIG_TYR_ITIM	334	339	PF00017	0.287
MOD_CK1_1	13	19	PF00069	0.476
MOD_CK1_1	140	146	PF00069	0.485
MOD_CK1_1	200	206	PF00069	0.601
MOD_CK1_1	208	214	PF00069	0.478
MOD_CK1_1	246	252	PF00069	0.657
MOD_CK1_1	324	330	PF00069	0.449
MOD_CK1_1	52	58	PF00069	0.581
MOD_CK1_1	593	599	PF00069	0.708
MOD_CK2_1	13	19	PF00069	0.310
MOD_CK2_1	370	376	PF00069	0.414
MOD_CK2_1	595	601	PF00069	0.567
MOD_CK2_1	623	629	PF00069	0.424
MOD_CK2_1	651	657	PF00069	0.503
MOD_GlcNHglycan	248	252	PF01048	0.691
MOD_GlcNHglycan	400	403	PF01048	0.512
MOD_GlcNHglycan	44	47	PF01048	0.630
MOD_GlcNHglycan	469	472	PF01048	0.353
MOD_GlcNHglycan	51	54	PF01048	0.627
MOD_GlcNHglycan	597	600	PF01048	0.682
MOD_GlcNHglycan	639	642	PF01048	0.555
MOD_GlcNHglycan	77	80	PF01048	0.744
MOD_GSK3_1	200	207	PF00069	0.575
MOD_GSK3_1	242	249	PF00069	0.754
MOD_GSK3_1	365	372	PF00069	0.501
MOD_GSK3_1	393	400	PF00069	0.623
MOD_GSK3_1	467	474	PF00069	0.431
MOD_GSK3_1	49	56	PF00069	0.580
MOD_GSK3_1	586	593	PF00069	0.537
MOD_GSK3_1	619	626	PF00069	0.504
MOD_GSK3_1	637	644	PF00069	0.415
MOD_GSK3_1	68	75	PF00069	0.751
MOD_GSK3_1	92	99	PF00069	0.774
MOD_N-GLC_1	358	363	PF02516	0.461
MOD_N-GLC_1	56	61	PF02516	0.750
MOD_NEK2_1	369	374	PF00069	0.510
MOD_NEK2_1	467	472	PF00069	0.319
MOD_NEK2_1	595	600	PF00069	0.429
MOD_NEK2_1	93	98	PF00069	0.636
MOD_NEK2_2	548	553	PF00069	0.398
MOD_PIKK_1	225	231	PF00454	0.419
MOD_PIKK_1	610	616	PF00454	0.557
MOD_PIKK_1	87	93	PF00454	0.579
MOD_PKA_1	10	16	PF00069	0.388
MOD_PKA_2	10	16	PF00069	0.334
MOD_PKA_2	204	210	PF00069	0.419
MOD_PKA_2	610	616	PF00069	0.523
MOD_PKA_2	651	657	PF00069	0.530
MOD_PKB_1	223	231	PF00069	0.370
MOD_PKB_1	8	16	PF00069	0.411
MOD_Plk_1	113	119	PF00069	0.472
MOD_Plk_1	140	146	PF00069	0.398
MOD_Plk_1	369	375	PF00069	0.514
MOD_Plk_1	500	506	PF00069	0.404
MOD_Plk_1	619	625	PF00069	0.597
MOD_Plk_2-3	370	376	PF00069	0.513
MOD_Plk_4	257	263	PF00069	0.297
MOD_Plk_4	321	327	PF00069	0.348
MOD_Plk_4	342	348	PF00069	0.368
MOD_Plk_4	446	452	PF00069	0.408
MOD_Plk_4	459	465	PF00069	0.468
MOD_ProDKin_1	182	188	PF00069	0.436
MOD_ProDKin_1	237	243	PF00069	0.732
MOD_ProDKin_1	393	399	PF00069	0.633
MOD_ProDKin_1	482	488	PF00069	0.391
TRG_ENDOCYTIC_2	109	112	PF00928	0.577
TRG_ENDOCYTIC_2	174	177	PF00928	0.494
TRG_ENDOCYTIC_2	215	218	PF00928	0.469
TRG_ENDOCYTIC_2	336	339	PF00928	0.287
TRG_ENDOCYTIC_2	436	439	PF00928	0.448
TRG_ENDOCYTIC_2	458	461	PF00928	0.398
TRG_ENDOCYTIC_2	9	12	PF00928	0.426
TRG_ER_diArg_1	153	155	PF00400	0.493
TRG_ER_diArg_1	2	4	PF00400	0.528
TRG_ER_diArg_1	610	612	PF00400	0.472
TRG_ER_diArg_1	9	11	PF00400	0.371
TRG_ER_diLys_1	669	673	PF00400	0.709
TRG_NES_CRM1_1	337	349	PF08389	0.453
TRG_NLS_MonoExtC_3	151	156	PF00514	0.488
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P332	Leptomonas seymouri	54%	98%
A0A0S4IZM9	Bodo saltans	29%	100%
A0A0S4J2Q8	Bodo saltans	30%	100%
A0A1X0P0G0	Trypanosomatidae	34%	100%
A0A3S5H5H7	Leishmania donovani	91%	100%
A0A422N0S3	Trypanosoma rangeli	37%	100%
A4H489	Leishmania braziliensis	78%	99%
A4HSG5	Leishmania infantum	91%	100%
D0A4G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AKE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B0Z2	Trypanosoma cruzi	37%	100%