Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJF8_LEIMA

TriTrypDb:

LmjF.05.0440 , LMJLV39_050009300 , LMJSD75_050009500

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.656
CLV_C14_Caspase3-7	586	590	PF00656	0.449
CLV_C14_Caspase3-7	663	667	PF00656	0.497
CLV_NRD_NRD_1	266	268	PF00675	0.452
CLV_NRD_NRD_1	341	343	PF00675	0.488
CLV_NRD_NRD_1	632	634	PF00675	0.393
CLV_NRD_NRD_1	755	757	PF00675	0.474
CLV_PCSK_FUR_1	339	343	PF00082	0.498
CLV_PCSK_FUR_1	505	509	PF00082	0.474
CLV_PCSK_FUR_1	752	756	PF00082	0.441
CLV_PCSK_KEX2_1	266	268	PF00082	0.452
CLV_PCSK_KEX2_1	341	343	PF00082	0.522
CLV_PCSK_KEX2_1	507	509	PF00082	0.472
CLV_PCSK_KEX2_1	632	634	PF00082	0.393
CLV_PCSK_KEX2_1	752	754	PF00082	0.423
CLV_PCSK_KEX2_1	755	757	PF00082	0.470
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.472
CLV_PCSK_SKI1_1	303	307	PF00082	0.434
CLV_PCSK_SKI1_1	349	353	PF00082	0.485
DEG_APCC_DBOX_1	302	310	PF00400	0.416
DEG_APCC_DBOX_1	682	690	PF00400	0.466
DEG_APCC_KENBOX_2	773	777	PF00400	0.522
DEG_SCF_FBW7_2	757	764	PF00400	0.522
DEG_SCF_TRCP1_1	809	815	PF00400	0.369
DEG_SPOP_SBC_1	208	212	PF00917	0.593
DOC_CDC14_PxL_1	533	541	PF14671	0.419
DOC_CKS1_1	608	613	PF01111	0.588
DOC_CKS1_1	758	763	PF01111	0.528
DOC_CYCLIN_RxL_1	683	693	PF00134	0.442
DOC_MAPK_gen_1	486	496	PF00069	0.517
DOC_MAPK_gen_1	632	640	PF00069	0.459
DOC_MAPK_gen_1	752	759	PF00069	0.380
DOC_MAPK_MEF2A_6	534	541	PF00069	0.424
DOC_MAPK_MEF2A_6	736	745	PF00069	0.397
DOC_MAPK_RevD_3	741	755	PF00069	0.369
DOC_PP1_SILK_1	423	428	PF00149	0.426
DOC_PP2B_LxvP_1	343	346	PF13499	0.436
DOC_PP4_FxxP_1	553	556	PF00568	0.418
DOC_USP7_MATH_1	131	135	PF00917	0.755
DOC_USP7_MATH_1	166	170	PF00917	0.416
DOC_USP7_MATH_1	208	212	PF00917	0.593
DOC_USP7_MATH_1	246	250	PF00917	0.354
DOC_USP7_MATH_1	565	569	PF00917	0.402
DOC_USP7_MATH_1	646	650	PF00917	0.467
DOC_USP7_MATH_1	660	664	PF00917	0.349
DOC_USP7_MATH_1	695	699	PF00917	0.423
DOC_USP7_MATH_1	798	802	PF00917	0.515
DOC_USP7_MATH_1	807	811	PF00917	0.368
DOC_USP7_MATH_1	82	86	PF00917	0.399
DOC_USP7_MATH_1	837	841	PF00917	0.441
DOC_USP7_MATH_1	93	97	PF00917	0.569
DOC_WW_Pin1_4	124	129	PF00397	0.595
DOC_WW_Pin1_4	16	21	PF00397	0.488
DOC_WW_Pin1_4	181	186	PF00397	0.402
DOC_WW_Pin1_4	188	193	PF00397	0.435
DOC_WW_Pin1_4	455	460	PF00397	0.559
DOC_WW_Pin1_4	607	612	PF00397	0.612
DOC_WW_Pin1_4	757	762	PF00397	0.525
LIG_14-3-3_CanoR_1	361	371	PF00244	0.548
LIG_14-3-3_CanoR_1	469	477	PF00244	0.553
LIG_14-3-3_CanoR_1	493	497	PF00244	0.477
LIG_14-3-3_CanoR_1	58	62	PF00244	0.472
LIG_14-3-3_CanoR_1	683	687	PF00244	0.467
LIG_14-3-3_CanoR_1	826	836	PF00244	0.451
LIG_APCC_ABBAyCdc20_2	715	721	PF00400	0.465
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_BIR_III_2	278	282	PF00653	0.506
LIG_BIR_III_2	49	53	PF00653	0.445
LIG_BIR_III_4	385	389	PF00653	0.520
LIG_Clathr_ClatBox_1	196	200	PF01394	0.413
LIG_deltaCOP1_diTrp_1	268	274	PF00928	0.453
LIG_deltaCOP1_diTrp_1	430	439	PF00928	0.436
LIG_FHA_1	118	124	PF00498	0.642
LIG_FHA_1	294	300	PF00498	0.488
LIG_FHA_1	496	502	PF00498	0.454
LIG_FHA_1	533	539	PF00498	0.426
LIG_FHA_1	633	639	PF00498	0.395
LIG_FHA_1	779	785	PF00498	0.400
LIG_FHA_2	64	70	PF00498	0.433
LIG_FHA_2	683	689	PF00498	0.443
LIG_FHA_2	706	712	PF00498	0.434
LIG_FHA_2	758	764	PF00498	0.523
LIG_Integrin_RGD_1	664	666	PF01839	0.439
LIG_LIR_Gen_1	372	380	PF02991	0.448
LIG_LIR_Gen_1	430	440	PF02991	0.512
LIG_LIR_Gen_1	545	554	PF02991	0.426
LIG_LIR_Gen_1	56	64	PF02991	0.421
LIG_LIR_Gen_1	649	658	PF02991	0.342
LIG_LIR_Gen_1	717	727	PF02991	0.380
LIG_LIR_Nem_3	253	258	PF02991	0.520
LIG_LIR_Nem_3	372	377	PF02991	0.443
LIG_LIR_Nem_3	430	436	PF02991	0.523
LIG_LIR_Nem_3	545	550	PF02991	0.349
LIG_LIR_Nem_3	56	62	PF02991	0.410
LIG_LIR_Nem_3	649	654	PF02991	0.351
LIG_LIR_Nem_3	717	722	PF02991	0.384
LIG_LIR_Nem_3	810	816	PF02991	0.344
LIG_NRBOX	151	157	PF00104	0.453
LIG_NRBOX	653	659	PF00104	0.371
LIG_PCNA_TLS_4	368	375	PF02747	0.445
LIG_PCNA_yPIPBox_3	732	741	PF02747	0.411
LIG_Pex14_2	699	703	PF04695	0.497
LIG_SH2_CRK	178	182	PF00017	0.382
LIG_SH2_CRK	533	537	PF00017	0.387
LIG_SH2_CRK	90	94	PF00017	0.530
LIG_SH2_NCK_1	81	85	PF00017	0.453
LIG_SH2_NCK_1	90	94	PF00017	0.500
LIG_SH2_STAP1	651	655	PF00017	0.376
LIG_SH2_STAP1	747	751	PF00017	0.437
LIG_SH2_STAP1	791	795	PF00017	0.562
LIG_SH2_STAT5	374	377	PF00017	0.442
LIG_SH2_STAT5	544	547	PF00017	0.350
LIG_SH3_1	755	761	PF00018	0.464
LIG_SH3_2	608	613	PF14604	0.588
LIG_SH3_3	189	195	PF00018	0.421
LIG_SH3_3	456	462	PF00018	0.546
LIG_SH3_3	605	611	PF00018	0.646
LIG_SH3_3	698	704	PF00018	0.442
LIG_SH3_3	755	761	PF00018	0.464
LIG_SUMO_SIM_anti_2	738	745	PF11976	0.306
LIG_SUMO_SIM_par_1	193	201	PF11976	0.411
LIG_SUMO_SIM_par_1	653	659	PF11976	0.415
LIG_SxIP_EBH_1	167	177	PF03271	0.415
LIG_UBA3_1	422	427	PF00899	0.416
LIG_WRC_WIRS_1	696	701	PF05994	0.442
MOD_CDK_SPK_2	455	460	PF00069	0.542
MOD_CDK_SPxK_1	607	613	PF00069	0.593
MOD_CK1_1	117	123	PF00069	0.622
MOD_CK1_1	134	140	PF00069	0.538
MOD_CK1_1	147	153	PF00069	0.553
MOD_CK1_1	210	216	PF00069	0.622
MOD_CK1_1	218	224	PF00069	0.489
MOD_CK1_1	450	456	PF00069	0.559
MOD_CK1_1	473	479	PF00069	0.474
MOD_CK1_1	690	696	PF00069	0.410
MOD_CK2_1	682	688	PF00069	0.416
MOD_CK2_1	705	711	PF00069	0.448
MOD_CK2_1	819	825	PF00069	0.426
MOD_GlcNHglycan	104	107	PF01048	0.671
MOD_GlcNHglycan	133	136	PF01048	0.626
MOD_GlcNHglycan	141	144	PF01048	0.509
MOD_GlcNHglycan	173	176	PF01048	0.481
MOD_GlcNHglycan	217	220	PF01048	0.608
MOD_GlcNHglycan	324	327	PF01048	0.515
MOD_GlcNHglycan	362	365	PF01048	0.542
MOD_GlcNHglycan	398	403	PF01048	0.511
MOD_GlcNHglycan	42	45	PF01048	0.531
MOD_GlcNHglycan	563	566	PF01048	0.531
MOD_GlcNHglycan	658	661	PF01048	0.425
MOD_GlcNHglycan	668	671	PF01048	0.383
MOD_GlcNHglycan	808	812	PF01048	0.411
MOD_GlcNHglycan	829	832	PF01048	0.465
MOD_GlcNHglycan	839	842	PF01048	0.408
MOD_GSK3_1	113	120	PF00069	0.635
MOD_GSK3_1	129	136	PF00069	0.762
MOD_GSK3_1	200	207	PF00069	0.531
MOD_GSK3_1	208	215	PF00069	0.536
MOD_GSK3_1	246	253	PF00069	0.402
MOD_GSK3_1	394	401	PF00069	0.458
MOD_GSK3_1	450	457	PF00069	0.625
MOD_GSK3_1	520	527	PF00069	0.472
MOD_GSK3_1	557	564	PF00069	0.561
MOD_GSK3_1	583	590	PF00069	0.573
MOD_GSK3_1	656	663	PF00069	0.415
MOD_GSK3_1	91	98	PF00069	0.602
MOD_N-GLC_1	117	122	PF02516	0.600
MOD_N-GLC_1	16	21	PF02516	0.532
MOD_N-GLC_1	454	459	PF02516	0.646
MOD_N-GLC_1	602	607	PF02516	0.591
MOD_N-GLC_2	411	413	PF02516	0.577
MOD_N-GLC_2	573	575	PF02516	0.399
MOD_NEK2_1	1	6	PF00069	0.490
MOD_NEK2_1	186	191	PF00069	0.479
MOD_NEK2_1	520	525	PF00069	0.403
MOD_NEK2_1	532	537	PF00069	0.380
MOD_NEK2_1	640	645	PF00069	0.378
MOD_NEK2_2	295	300	PF00069	0.416
MOD_NEK2_2	682	687	PF00069	0.489
MOD_NEK2_2	695	700	PF00069	0.311
MOD_NEK2_2	747	752	PF00069	0.439
MOD_PIKK_1	200	206	PF00454	0.409
MOD_PIKK_1	594	600	PF00454	0.608
MOD_PIKK_1	730	736	PF00454	0.483
MOD_PK_1	421	427	PF00069	0.444
MOD_PKA_1	632	638	PF00069	0.315
MOD_PKA_2	102	108	PF00069	0.543
MOD_PKA_2	360	366	PF00069	0.570
MOD_PKA_2	492	498	PF00069	0.489
MOD_PKA_2	557	563	PF00069	0.543
MOD_PKA_2	566	572	PF00069	0.391
MOD_PKA_2	57	63	PF00069	0.480
MOD_PKA_2	583	589	PF00069	0.357
MOD_PKA_2	612	618	PF00069	0.496
MOD_PKA_2	632	638	PF00069	0.268
MOD_PKA_2	682	688	PF00069	0.416
MOD_PKB_1	452	460	PF00069	0.530
MOD_Plk_1	147	153	PF00069	0.490
MOD_Plk_1	398	404	PF00069	0.471
MOD_Plk_1	473	479	PF00069	0.514
MOD_Plk_1	687	693	PF00069	0.425
MOD_Plk_2-3	634	640	PF00069	0.456
MOD_Plk_4	1	7	PF00069	0.491
MOD_Plk_4	136	142	PF00069	0.623
MOD_Plk_4	147	153	PF00069	0.405
MOD_Plk_4	370	376	PF00069	0.504
MOD_Plk_4	421	427	PF00069	0.491
MOD_Plk_4	497	503	PF00069	0.488
MOD_Plk_4	621	627	PF00069	0.411
MOD_Plk_4	695	701	PF00069	0.438
MOD_ProDKin_1	124	130	PF00069	0.595
MOD_ProDKin_1	16	22	PF00069	0.480
MOD_ProDKin_1	181	187	PF00069	0.398
MOD_ProDKin_1	188	194	PF00069	0.429
MOD_ProDKin_1	455	461	PF00069	0.562
MOD_ProDKin_1	607	613	PF00069	0.607
MOD_ProDKin_1	757	763	PF00069	0.523
MOD_SUMO_for_1	479	482	PF00179	0.423
MOD_SUMO_rev_2	586	593	PF00179	0.437
TRG_DiLeu_BaEn_1	193	198	PF01217	0.408
TRG_DiLeu_BaEn_1	739	744	PF01217	0.352
TRG_DiLeu_BaLyEn_6	182	187	PF01217	0.403
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.420
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.535
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.536
TRG_ENDOCYTIC_2	374	377	PF00928	0.442
TRG_ENDOCYTIC_2	533	536	PF00928	0.382
TRG_ENDOCYTIC_2	651	654	PF00928	0.338
TRG_ER_diArg_1	26	29	PF00400	0.369
TRG_ER_diArg_1	265	267	PF00400	0.462
TRG_ER_diArg_1	311	314	PF00400	0.457
TRG_ER_diArg_1	339	342	PF00400	0.534
TRG_ER_diArg_1	631	633	PF00400	0.392
TRG_ER_diArg_1	751	754	PF00400	0.408
TRG_ER_diArg_1	755	757	PF00400	0.470
TRG_NES_CRM1_1	148	158	PF08389	0.466
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I264	Leptomonas seymouri	45%	96%
A0A3S7WP37	Leishmania donovani	92%	100%
A4H490	Leishmania braziliensis	78%	100%
A4HSG6	Leishmania infantum	93%	100%
E9AKF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%