Sm domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

u6 snrna-associated sm-like protein lsm3

Species:

Leishmania major

UniProt:

Q4QJE8_LEIMA

TriTrypDb:

LmjF.05.0540 , LMJLV39_050010200 , LMJSD75_050010400

Length:

135

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005688	U6 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QJE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJE8

Function

Biological processes
Term	Name	Level	Count
GO:0000365	mRNA trans splicing, via spliceosome	9	2
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0045291	mRNA trans splicing, SL addition	10	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0017069	snRNA binding	5	2
GO:0017070	U6 snRNA binding	6	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.682
CLV_NRD_NRD_1	101	103	PF00675	0.637
CLV_PCSK_KEX2_1	103	105	PF00082	0.794
CLV_PCSK_KEX2_1	44	46	PF00082	0.389
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.759
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.466
DEG_APCC_DBOX_1	62	70	PF00400	0.524
DEG_Nend_UBRbox_2	1	3	PF02207	0.607
DEG_SPOP_SBC_1	23	27	PF00917	0.639
DOC_MAPK_gen_1	120	130	PF00069	0.535
DOC_MAPK_gen_1	44	50	PF00069	0.383
DOC_MAPK_MEF2A_6	123	132	PF00069	0.531
DOC_USP7_MATH_1	115	119	PF00917	0.538
LIG_14-3-3_CanoR_1	45	51	PF00244	0.388
LIG_AP2alpha_2	33	35	PF02296	0.479
LIG_BIR_III_4	108	112	PF00653	0.658
LIG_Clathr_ClatBox_1	50	54	PF01394	0.439
LIG_Clathr_ClatBox_1	66	70	PF01394	0.402
LIG_FHA_2	84	90	PF00498	0.611
LIG_Integrin_isoDGR_2	94	96	PF01839	0.758
LIG_LIR_Nem_3	32	38	PF02991	0.476
LIG_PDZ_Class_2	130	135	PF00595	0.483
LIG_SH2_STAT5	37	40	PF00017	0.565
LIG_SH3_2	31	36	PF14604	0.517
LIG_SH3_3	28	34	PF00018	0.516
LIG_SUMO_SIM_anti_2	129	134	PF11976	0.411
LIG_SUMO_SIM_par_1	126	131	PF11976	0.526
LIG_SUMO_SIM_par_1	65	71	PF11976	0.411
MOD_CK1_1	26	32	PF00069	0.622
MOD_GlcNHglycan	2	6	PF01048	0.756
MOD_GlcNHglycan	28	31	PF01048	0.661
MOD_GSK3_1	22	29	PF00069	0.719
MOD_GSK3_1	79	86	PF00069	0.459
MOD_NEK2_1	1	6	PF00069	0.760
MOD_NEK2_1	13	18	PF00069	0.515
MOD_NEK2_1	88	93	PF00069	0.750
MOD_NEK2_2	115	120	PF00069	0.479
MOD_PKA_2	62	68	PF00069	0.523
MOD_Plk_1	115	121	PF00069	0.673
MOD_Plk_1	88	94	PF00069	0.569
MOD_Plk_4	62	68	PF00069	0.405
TRG_DiLeu_BaEn_1	117	122	PF01217	0.454
TRG_DiLeu_LyEn_5	117	122	PF01217	0.454
TRG_ER_diArg_1	101	104	PF00400	0.782
TRG_NLS_MonoExtC_3	101	106	PF00514	0.629
TRG_NLS_MonoExtN_4	101	107	PF00514	0.630
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTA2	Leptomonas seymouri	53%	100%
A0A3S7WP36	Leishmania donovani	96%	100%
A4H4A0	Leishmania braziliensis	80%	71%
A4HSH6	Leishmania infantum	96%	100%
E9AKG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%