MSP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJE6_LEIMA

TriTrypDb:

LmjF.05.0560 , LMJLV39_050010400 , LMJSD75_050010600

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QJE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.571
CLV_C14_Caspase3-7	249	253	PF00656	0.628
CLV_NRD_NRD_1	223	225	PF00675	0.438
CLV_NRD_NRD_1	265	267	PF00675	0.510
CLV_NRD_NRD_1	283	285	PF00675	0.503
CLV_NRD_NRD_1	381	383	PF00675	0.611
CLV_NRD_NRD_1	416	418	PF00675	0.629
CLV_PCSK_KEX2_1	223	225	PF00082	0.438
CLV_PCSK_KEX2_1	265	267	PF00082	0.493
CLV_PCSK_KEX2_1	283	285	PF00082	0.510
CLV_PCSK_KEX2_1	381	383	PF00082	0.611
CLV_PCSK_SKI1_1	238	242	PF00082	0.464
CLV_PCSK_SKI1_1	382	386	PF00082	0.735
DEG_SCF_FBW7_1	68	73	PF00400	0.489
DEG_SPOP_SBC_1	103	107	PF00917	0.681
DEG_SPOP_SBC_1	330	334	PF00917	0.591
DOC_CKS1_1	28	33	PF01111	0.642
DOC_MAPK_gen_1	14	23	PF00069	0.510
DOC_MAPK_MEF2A_6	358	367	PF00069	0.447
DOC_MAPK_NFAT4_5	362	370	PF00069	0.341
DOC_MAPK_RevD_3	366	382	PF00069	0.231
DOC_PP1_RVXF_1	20	26	PF00149	0.517
DOC_PP2B_LxvP_1	215	218	PF13499	0.607
DOC_SPAK_OSR1_1	125	129	PF12202	0.528
DOC_USP7_MATH_1	196	200	PF00917	0.596
DOC_USP7_MATH_1	218	222	PF00917	0.692
DOC_USP7_MATH_1	234	238	PF00917	0.674
DOC_USP7_MATH_1	330	334	PF00917	0.709
DOC_USP7_MATH_1	34	38	PF00917	0.505
DOC_USP7_MATH_1	70	74	PF00917	0.569
DOC_USP7_UBL2_3	358	362	PF12436	0.632
DOC_WW_Pin1_4	113	118	PF00397	0.669
DOC_WW_Pin1_4	241	246	PF00397	0.769
DOC_WW_Pin1_4	27	32	PF00397	0.608
DOC_WW_Pin1_4	285	290	PF00397	0.686
DOC_WW_Pin1_4	299	304	PF00397	0.718
DOC_WW_Pin1_4	66	71	PF00397	0.676
DOC_WW_Pin1_4	91	96	PF00397	0.760
LIG_14-3-3_CanoR_1	111	120	PF00244	0.624
LIG_14-3-3_CanoR_1	152	160	PF00244	0.511
LIG_14-3-3_CanoR_1	223	229	PF00244	0.708
LIG_14-3-3_CanoR_1	298	303	PF00244	0.798
LIG_14-3-3_CanoR_1	381	390	PF00244	0.417
LIG_APCC_ABBA_1	182	187	PF00400	0.519
LIG_BIR_II_1	1	5	PF00653	0.470
LIG_BIR_III_4	63	67	PF00653	0.527
LIG_BRCT_BRCA1_1	260	264	PF00533	0.657
LIG_BRCT_BRCA1_1	36	40	PF00533	0.492
LIG_EH1_1	363	371	PF00400	0.360
LIG_eIF4E_1	364	370	PF01652	0.360
LIG_FHA_1	152	158	PF00498	0.580
LIG_FHA_1	203	209	PF00498	0.613
LIG_FHA_1	258	264	PF00498	0.705
LIG_FHA_1	267	273	PF00498	0.578
LIG_FHA_1	34	40	PF00498	0.572
LIG_FHA_1	63	69	PF00498	0.608
LIG_FHA_1	73	79	PF00498	0.533
LIG_FHA_2	28	34	PF00498	0.597
LIG_FHA_2	383	389	PF00498	0.461
LIG_GBD_Chelix_1	365	373	PF00786	0.289
LIG_LIR_Gen_1	129	138	PF02991	0.540
LIG_LIR_Gen_1	332	342	PF02991	0.700
LIG_LIR_Nem_3	129	133	PF02991	0.514
LIG_LIR_Nem_3	332	338	PF02991	0.703
LIG_MYND_1	239	243	PF01753	0.669
LIG_SH2_CRK	56	60	PF00017	0.474
LIG_SH2_GRB2like	335	338	PF00017	0.582
LIG_SH2_PTP2	130	133	PF00017	0.546
LIG_SH2_PTP2	364	367	PF00017	0.357
LIG_SH2_PTP2	374	377	PF00017	0.429
LIG_SH2_STAP1	335	339	PF00017	0.695
LIG_SH2_STAP1	405	409	PF00017	0.431
LIG_SH2_STAT3	405	408	PF00017	0.431
LIG_SH2_STAT5	11	14	PF00017	0.495
LIG_SH2_STAT5	130	133	PF00017	0.464
LIG_SH2_STAT5	364	367	PF00017	0.331
LIG_SH2_STAT5	374	377	PF00017	0.317
LIG_SH3_3	10	16	PF00018	0.512
LIG_SH3_3	114	120	PF00018	0.697
LIG_SH3_3	187	193	PF00018	0.645
LIG_SH3_3	205	211	PF00018	0.492
LIG_SH3_3	228	234	PF00018	0.778
LIG_SH3_3	28	34	PF00018	0.607
LIG_Sin3_3	213	220	PF02671	0.551
LIG_SxIP_EBH_1	162	171	PF03271	0.469
LIG_TRAF2_1	121	124	PF00917	0.606
LIG_TRAF2_1	400	403	PF00917	0.392
LIG_TYR_ITIM	128	133	PF00017	0.510
LIG_UBA3_1	39	43	PF00899	0.466
MOD_CDK_SPK_2	241	246	PF00069	0.704
MOD_CDK_SPxxK_3	304	311	PF00069	0.690
MOD_CK1_1	110	116	PF00069	0.580
MOD_CK1_1	301	307	PF00069	0.757
MOD_CK1_1	72	78	PF00069	0.635
MOD_CK1_1	99	105	PF00069	0.738
MOD_CK2_1	27	33	PF00069	0.602
MOD_CK2_1	330	336	PF00069	0.656
MOD_CK2_1	382	388	PF00069	0.453
MOD_CK2_1	407	413	PF00069	0.452
MOD_CK2_1	78	84	PF00069	0.610
MOD_GlcNHglycan	113	116	PF01048	0.463
MOD_GlcNHglycan	166	169	PF01048	0.386
MOD_GlcNHglycan	198	201	PF01048	0.460
MOD_GlcNHglycan	248	251	PF01048	0.524
MOD_GlcNHglycan	290	293	PF01048	0.515
MOD_GlcNHglycan	393	396	PF01048	0.693
MOD_GSK3_1	107	114	PF00069	0.654
MOD_GSK3_1	159	166	PF00069	0.535
MOD_GSK3_1	284	291	PF00069	0.650
MOD_GSK3_1	293	300	PF00069	0.679
MOD_GSK3_1	62	69	PF00069	0.635
MOD_GSK3_1	70	77	PF00069	0.599
MOD_GSK3_1	78	85	PF00069	0.512
MOD_GSK3_1	99	106	PF00069	0.773
MOD_N-GLC_1	298	303	PF02516	0.565
MOD_N-GLC_1	34	39	PF02516	0.369
MOD_N-GLC_1	391	396	PF02516	0.712
MOD_NEK2_1	163	168	PF00069	0.569
MOD_NEK2_1	257	262	PF00069	0.751
MOD_NEK2_1	3	8	PF00069	0.528
MOD_NEK2_1	82	87	PF00069	0.725
MOD_NEK2_2	259	264	PF00069	0.611
MOD_PIKK_1	70	76	PF00454	0.511
MOD_PIKK_1	82	88	PF00454	0.605
MOD_PK_1	224	230	PF00069	0.599
MOD_PKA_1	266	272	PF00069	0.736
MOD_PKA_1	283	289	PF00069	0.681
MOD_PKA_2	107	113	PF00069	0.633
MOD_PKA_2	151	157	PF00069	0.523
MOD_PKA_2	283	289	PF00069	0.698
MOD_PKA_2	297	303	PF00069	0.739
MOD_PKA_2	82	88	PF00069	0.668
MOD_PKA_2	99	105	PF00069	0.783
MOD_Plk_1	34	40	PF00069	0.567
MOD_Plk_4	259	265	PF00069	0.685
MOD_Plk_4	34	40	PF00069	0.500
MOD_ProDKin_1	113	119	PF00069	0.663
MOD_ProDKin_1	241	247	PF00069	0.769
MOD_ProDKin_1	27	33	PF00069	0.602
MOD_ProDKin_1	285	291	PF00069	0.689
MOD_ProDKin_1	299	305	PF00069	0.718
MOD_ProDKin_1	66	72	PF00069	0.679
MOD_ProDKin_1	91	97	PF00069	0.762
MOD_SUMO_for_1	133	136	PF00179	0.561
TRG_ENDOCYTIC_2	130	133	PF00928	0.470
TRG_ENDOCYTIC_2	335	338	PF00928	0.698
TRG_ENDOCYTIC_2	364	367	PF00928	0.393
TRG_ENDOCYTIC_2	374	377	PF00928	0.393
TRG_ENDOCYTIC_2	56	59	PF00928	0.493
TRG_ER_diArg_1	223	226	PF00400	0.671
TRG_ER_diArg_1	236	239	PF00400	0.755
TRG_ER_diArg_1	264	266	PF00400	0.788
TRG_ER_diArg_1	282	284	PF00400	0.638
TRG_ER_diArg_1	380	382	PF00400	0.401
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2J2	Leptomonas seymouri	51%	100%
A0A1X0NKC1	Trypanosomatidae	33%	100%
A0A3S5H5I5	Leishmania donovani	92%	100%
A0A422ND80	Trypanosoma rangeli	31%	100%
A4H4A2	Leishmania braziliensis	70%	100%
A4HSH8	Leishmania infantum	91%	100%
E9AKG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BAR1	Trypanosoma cruzi	29%	100%