LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QJE4_LEIMA
TriTrypDb:
LmjF.05.0580 , LMJLV39_050010600 * , LMJSD75_050010800 *
Length:
784

Annotations

LeishMANIAdb annotations

This Kinetoplastid-unique protein has a 4TM central helical bundle and long cytoplasmic termini with strikingly low complexity. Its function is unknown.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0000123 histone acetyltransferase complex 4 2
GO:0000124 SAGA complex 4 2
GO:0005815 microtubule organizing center 2 2
GO:0016020 membrane 2 7
GO:0031248 protein acetyltransferase complex 3 2
GO:0032991 protein-containing complex 1 2
GO:0036064 ciliary basal body 3 2
GO:0070461 SAGA-type complex 5 2
GO:0110165 cellular anatomical entity 1 7
GO:0140535 intracellular protein-containing complex 2 2
GO:1902493 acetyltransferase complex 4 2
GO:1902494 catalytic complex 2 2
GO:1905368 peptidase complex 3 2
GO:1990234 transferase complex 3 2

Expansion

Sequence features

Q4QJE4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJE4

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 2
GO:0006357 regulation of transcription by RNA polymerase II 7 2
GO:0009889 regulation of biosynthetic process 4 2
GO:0010468 regulation of gene expression 5 2
GO:0010556 regulation of macromolecule biosynthetic process 5 2
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 2
GO:0019222 regulation of metabolic process 3 2
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031326 regulation of cellular biosynthetic process 5 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051252 regulation of RNA metabolic process 5 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065007 biological regulation 1 2
GO:0080090 regulation of primary metabolic process 4 2
GO:1903506 regulation of nucleic acid-templated transcription 7 2
GO:2001141 regulation of RNA biosynthetic process 6 2
Molecular functions
Term Name Level Count
GO:0003712 transcription coregulator activity 2 4
GO:0003713 transcription coactivator activity 3 4
GO:0140110 transcription regulator activity 1 4
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 762 766 PF00656 0.775
CLV_NRD_NRD_1 138 140 PF00675 0.538
CLV_NRD_NRD_1 217 219 PF00675 0.755
CLV_NRD_NRD_1 264 266 PF00675 0.756
CLV_NRD_NRD_1 28 30 PF00675 0.513
CLV_NRD_NRD_1 319 321 PF00675 0.444
CLV_NRD_NRD_1 646 648 PF00675 0.576
CLV_NRD_NRD_1 654 656 PF00675 0.537
CLV_NRD_NRD_1 686 688 PF00675 0.587
CLV_NRD_NRD_1 733 735 PF00675 0.584
CLV_NRD_NRD_1 736 738 PF00675 0.564
CLV_PCSK_FUR_1 652 656 PF00082 0.551
CLV_PCSK_FUR_1 684 688 PF00082 0.589
CLV_PCSK_FUR_1 734 738 PF00082 0.577
CLV_PCSK_KEX2_1 138 140 PF00082 0.538
CLV_PCSK_KEX2_1 263 265 PF00082 0.709
CLV_PCSK_KEX2_1 28 30 PF00082 0.513
CLV_PCSK_KEX2_1 319 321 PF00082 0.444
CLV_PCSK_KEX2_1 495 497 PF00082 0.498
CLV_PCSK_KEX2_1 527 529 PF00082 0.534
CLV_PCSK_KEX2_1 644 646 PF00082 0.588
CLV_PCSK_KEX2_1 654 656 PF00082 0.530
CLV_PCSK_KEX2_1 686 688 PF00082 0.584
CLV_PCSK_KEX2_1 732 734 PF00082 0.671
CLV_PCSK_KEX2_1 736 738 PF00082 0.572
CLV_PCSK_PC1ET2_1 495 497 PF00082 0.493
CLV_PCSK_PC1ET2_1 527 529 PF00082 0.534
CLV_PCSK_PC1ET2_1 644 646 PF00082 0.615
CLV_PCSK_PC7_1 491 497 PF00082 0.472
CLV_PCSK_PC7_1 641 647 PF00082 0.614
CLV_PCSK_PC7_1 682 688 PF00082 0.657
CLV_PCSK_PC7_1 732 738 PF00082 0.563
CLV_PCSK_SKI1_1 264 268 PF00082 0.673
CLV_PCSK_SKI1_1 502 506 PF00082 0.454
CLV_PCSK_SKI1_1 544 548 PF00082 0.507
CLV_PCSK_SKI1_1 702 706 PF00082 0.601
DEG_APCC_DBOX_1 294 302 PF00400 0.324
DEG_APCC_KENBOX_2 676 680 PF00400 0.816
DEG_Nend_UBRbox_2 1 3 PF02207 0.809
DEG_SPOP_SBC_1 232 236 PF00917 0.440
DOC_AGCK_PIF_1 429 434 PF00069 0.407
DOC_CKS1_1 103 108 PF01111 0.734
DOC_CKS1_1 399 404 PF01111 0.642
DOC_CYCLIN_RxL_1 259 269 PF00134 0.472
DOC_CYCLIN_yCln2_LP_2 483 489 PF00134 0.423
DOC_PP1_RVXF_1 392 399 PF00149 0.712
DOC_PP1_RVXF_1 525 532 PF00149 0.695
DOC_PP1_RVXF_1 566 572 PF00149 0.649
DOC_PP2B_LxvP_1 483 486 PF13499 0.423
DOC_PP4_FxxP_1 335 338 PF00568 0.694
DOC_PP4_MxPP_1 578 581 PF00568 0.730
DOC_USP7_MATH_1 243 247 PF00917 0.543
DOC_USP7_MATH_1 257 261 PF00917 0.417
DOC_USP7_MATH_1 330 334 PF00917 0.781
DOC_USP7_MATH_1 622 626 PF00917 0.788
DOC_WW_Pin1_4 102 107 PF00397 0.731
DOC_WW_Pin1_4 133 138 PF00397 0.757
DOC_WW_Pin1_4 233 238 PF00397 0.470
DOC_WW_Pin1_4 338 343 PF00397 0.704
DOC_WW_Pin1_4 349 354 PF00397 0.686
DOC_WW_Pin1_4 36 41 PF00397 0.778
DOC_WW_Pin1_4 398 403 PF00397 0.633
DOC_WW_Pin1_4 43 48 PF00397 0.755
DOC_WW_Pin1_4 582 587 PF00397 0.747
DOC_WW_Pin1_4 6 11 PF00397 0.792
DOC_WW_Pin1_4 617 622 PF00397 0.875
DOC_WW_Pin1_4 626 631 PF00397 0.913
DOC_WW_Pin1_4 89 94 PF00397 0.738
LIG_14-3-3_CanoR_1 227 237 PF00244 0.443
LIG_14-3-3_CanoR_1 28 38 PF00244 0.764
LIG_14-3-3_CanoR_1 331 336 PF00244 0.747
LIG_14-3-3_CanoR_1 491 495 PF00244 0.662
LIG_AP2alpha_2 131 133 PF02296 0.721
LIG_BRCT_BRCA1_1 375 379 PF00533 0.698
LIG_deltaCOP1_diTrp_1 155 159 PF00928 0.418
LIG_FHA_1 155 161 PF00498 0.359
LIG_FHA_1 210 216 PF00498 0.492
LIG_FHA_1 281 287 PF00498 0.393
LIG_FHA_1 295 301 PF00498 0.360
LIG_FHA_1 420 426 PF00498 0.437
LIG_FHA_1 439 445 PF00498 0.286
LIG_FHA_1 44 50 PF00498 0.794
LIG_FHA_1 456 462 PF00498 0.275
LIG_FHA_2 192 198 PF00498 0.492
LIG_FHA_2 233 239 PF00498 0.496
LIG_FHA_2 538 544 PF00498 0.705
LIG_FHA_2 673 679 PF00498 0.744
LIG_LIR_Apic_2 333 338 PF02991 0.698
LIG_LIR_Apic_2 397 402 PF02991 0.647
LIG_LIR_Gen_1 155 164 PF02991 0.372
LIG_LIR_Gen_1 182 193 PF02991 0.446
LIG_LIR_Gen_1 306 315 PF02991 0.405
LIG_LIR_Gen_1 346 353 PF02991 0.686
LIG_LIR_Gen_1 401 412 PF02991 0.614
LIG_LIR_Gen_1 431 437 PF02991 0.401
LIG_LIR_Gen_1 517 526 PF02991 0.639
LIG_LIR_LC3C_4 753 757 PF02991 0.758
LIG_LIR_Nem_3 148 154 PF02991 0.692
LIG_LIR_Nem_3 155 159 PF02991 0.411
LIG_LIR_Nem_3 182 188 PF02991 0.383
LIG_LIR_Nem_3 269 273 PF02991 0.513
LIG_LIR_Nem_3 306 310 PF02991 0.361
LIG_LIR_Nem_3 400 406 PF02991 0.635
LIG_LIR_Nem_3 428 432 PF02991 0.407
LIG_LIR_Nem_3 433 437 PF02991 0.356
LIG_LIR_Nem_3 446 451 PF02991 0.363
LIG_LIR_Nem_3 517 523 PF02991 0.628
LIG_MYND_1 503 507 PF01753 0.662
LIG_Pex14_1 147 151 PF04695 0.691
LIG_Pex14_1 430 434 PF04695 0.379
LIG_Pex14_2 154 158 PF04695 0.566
LIG_Pex14_2 359 363 PF04695 0.660
LIG_Pex14_2 409 413 PF04695 0.535
LIG_Pex14_2 426 430 PF04695 0.332
LIG_Pex14_2 519 523 PF04695 0.624
LIG_SH2_CRK 305 309 PF00017 0.395
LIG_SH2_CRK 312 316 PF00017 0.306
LIG_SH2_GRB2like 280 283 PF00017 0.381
LIG_SH2_NCK_1 399 403 PF00017 0.692
LIG_SH2_STAP1 239 243 PF00017 0.515
LIG_SH2_STAP1 280 284 PF00017 0.494
LIG_SH2_STAP1 312 316 PF00017 0.338
LIG_SH2_STAP1 451 455 PF00017 0.395
LIG_SH2_STAT3 104 107 PF00017 0.751
LIG_SH2_STAT3 15 18 PF00017 0.792
LIG_SH2_STAT5 104 107 PF00017 0.760
LIG_SH2_STAT5 153 156 PF00017 0.696
LIG_SH2_STAT5 203 206 PF00017 0.408
LIG_SH2_STAT5 434 437 PF00017 0.407
LIG_SH2_STAT5 451 454 PF00017 0.334
LIG_SH2_STAT5 513 516 PF00017 0.688
LIG_SH3_3 123 129 PF00018 0.685
LIG_SH3_3 134 140 PF00018 0.689
LIG_SH3_3 208 214 PF00018 0.419
LIG_SH3_3 500 506 PF00018 0.660
LIG_SH3_3 589 595 PF00018 0.785
LIG_SH3_3 706 712 PF00018 0.818
LIG_SH3_3 754 760 PF00018 0.803
LIG_SUMO_SIM_anti_2 306 312 PF11976 0.368
LIG_SUMO_SIM_anti_2 458 463 PF11976 0.441
LIG_SUMO_SIM_anti_2 476 482 PF11976 0.423
LIG_SUMO_SIM_par_1 173 178 PF11976 0.549
LIG_SUMO_SIM_par_1 456 463 PF11976 0.345
LIG_TRAF2_1 140 143 PF00917 0.693
LIG_TRAF2_1 664 667 PF00917 0.713
LIG_TYR_ITIM 310 315 PF00017 0.359
LIG_WRC_WIRS_1 267 272 PF05994 0.487
LIG_WRC_WIRS_1 304 309 PF05994 0.380
LIG_WRC_WIRS_1 416 421 PF05994 0.401
LIG_WRC_WIRS_1 426 431 PF05994 0.330
LIG_WRC_WIRS_1 444 449 PF05994 0.359
MOD_CDK_SPK_2 133 138 PF00069 0.747
MOD_CDK_SPxK_1 133 139 PF00069 0.747
MOD_CK1_1 102 108 PF00069 0.668
MOD_CK1_1 246 252 PF00069 0.485
MOD_CK1_1 306 312 PF00069 0.408
MOD_CK1_1 323 329 PF00069 0.733
MOD_CK1_1 39 45 PF00069 0.786
MOD_CK1_1 4 10 PF00069 0.790
MOD_CK1_1 414 420 PF00069 0.418
MOD_CK1_1 428 434 PF00069 0.470
MOD_CK1_1 626 632 PF00069 0.748
MOD_CK1_1 75 81 PF00069 0.767
MOD_CK1_1 89 95 PF00069 0.698
MOD_CK2_1 232 238 PF00069 0.608
MOD_CK2_1 266 272 PF00069 0.456
MOD_CK2_1 537 543 PF00069 0.674
MOD_CK2_1 661 667 PF00069 0.852
MOD_CK2_1 672 678 PF00069 0.718
MOD_GlcNHglycan 10 13 PF01048 0.597
MOD_GlcNHglycan 322 325 PF01048 0.478
MOD_GlcNHglycan 375 378 PF01048 0.615
MOD_GlcNHglycan 41 44 PF01048 0.661
MOD_GlcNHglycan 413 416 PF01048 0.380
MOD_GlcNHglycan 614 618 PF01048 0.567
MOD_GlcNHglycan 64 67 PF01048 0.625
MOD_GlcNHglycan 666 671 PF01048 0.711
MOD_GlcNHglycan 70 73 PF01048 0.515
MOD_GlcNHglycan 75 78 PF01048 0.494
MOD_GlcNHglycan 750 755 PF01048 0.595
MOD_GlcNHglycan 88 91 PF01048 0.486
MOD_GSK3_1 114 121 PF00069 0.703
MOD_GSK3_1 228 235 PF00069 0.623
MOD_GSK3_1 39 46 PF00069 0.829
MOD_GSK3_1 4 11 PF00069 0.792
MOD_GSK3_1 411 418 PF00069 0.464
MOD_GSK3_1 613 620 PF00069 0.850
MOD_GSK3_1 622 629 PF00069 0.780
MOD_GSK3_1 661 668 PF00069 0.870
MOD_GSK3_1 68 75 PF00069 0.772
MOD_GSK3_1 692 699 PF00069 0.866
MOD_GSK3_1 735 742 PF00069 0.836
MOD_LATS_1 690 696 PF00433 0.809
MOD_LATS_1 735 741 PF00433 0.812
MOD_N-GLC_1 191 196 PF02516 0.626
MOD_N-GLC_1 29 34 PF02516 0.564
MOD_N-GLC_1 623 628 PF02516 0.517
MOD_N-GLC_1 678 683 PF02516 0.688
MOD_N-GLC_1 692 697 PF02516 0.548
MOD_N-GLC_2 80 82 PF02516 0.539
MOD_NEK2_1 1 6 PF00069 0.800
MOD_NEK2_1 154 159 PF00069 0.566
MOD_NEK2_1 266 271 PF00069 0.485
MOD_NEK2_1 303 308 PF00069 0.359
MOD_NEK2_1 419 424 PF00069 0.372
MOD_NEK2_1 425 430 PF00069 0.344
MOD_NEK2_1 455 460 PF00069 0.402
MOD_NEK2_1 529 534 PF00069 0.701
MOD_NEK2_1 574 579 PF00069 0.803
MOD_NEK2_1 613 618 PF00069 0.779
MOD_NEK2_1 665 670 PF00069 0.799
MOD_NEK2_1 672 677 PF00069 0.756
MOD_NEK2_1 68 73 PF00069 0.745
MOD_NEK2_2 146 151 PF00069 0.690
MOD_PIKK_1 105 111 PF00454 0.731
MOD_PIKK_1 114 120 PF00454 0.658
MOD_PIKK_1 29 35 PF00454 0.785
MOD_PIKK_1 378 384 PF00454 0.714
MOD_PIKK_1 505 511 PF00454 0.661
MOD_PIKK_1 559 565 PF00454 0.737
MOD_PIKK_1 707 713 PF00454 0.766
MOD_PKA_1 686 692 PF00069 0.837
MOD_PKA_2 294 300 PF00069 0.324
MOD_PKA_2 330 336 PF00069 0.763
MOD_PKA_2 437 443 PF00069 0.410
MOD_PKA_2 490 496 PF00069 0.669
MOD_PKA_2 686 692 PF00069 0.874
MOD_PKA_2 735 741 PF00069 0.825
MOD_PKB_1 645 653 PF00069 0.765
MOD_PKB_1 684 692 PF00069 0.802
MOD_PKB_1 696 704 PF00069 0.722
MOD_Plk_1 1 7 PF00069 0.797
MOD_Plk_1 118 124 PF00069 0.708
MOD_Plk_1 154 160 PF00069 0.524
MOD_Plk_1 246 252 PF00069 0.634
MOD_Plk_1 455 461 PF00069 0.421
MOD_Plk_1 623 629 PF00069 0.718
MOD_Plk_2-3 551 557 PF00069 0.743
MOD_Plk_4 146 152 PF00069 0.693
MOD_Plk_4 165 171 PF00069 0.418
MOD_Plk_4 286 292 PF00069 0.430
MOD_Plk_4 294 300 PF00069 0.353
MOD_Plk_4 303 309 PF00069 0.335
MOD_Plk_4 331 337 PF00069 0.702
MOD_Plk_4 443 449 PF00069 0.420
MOD_Plk_4 455 461 PF00069 0.349
MOD_Plk_4 574 580 PF00069 0.715
MOD_Plk_4 588 594 PF00069 0.783
MOD_Plk_4 777 783 PF00069 0.675
MOD_Plk_4 99 105 PF00069 0.731
MOD_ProDKin_1 102 108 PF00069 0.730
MOD_ProDKin_1 133 139 PF00069 0.757
MOD_ProDKin_1 233 239 PF00069 0.471
MOD_ProDKin_1 338 344 PF00069 0.701
MOD_ProDKin_1 349 355 PF00069 0.683
MOD_ProDKin_1 36 42 PF00069 0.779
MOD_ProDKin_1 398 404 PF00069 0.627
MOD_ProDKin_1 43 49 PF00069 0.757
MOD_ProDKin_1 582 588 PF00069 0.751
MOD_ProDKin_1 6 12 PF00069 0.793
MOD_ProDKin_1 617 623 PF00069 0.876
MOD_ProDKin_1 626 632 PF00069 0.915
MOD_ProDKin_1 89 95 PF00069 0.735
MOD_SUMO_rev_2 522 529 PF00179 0.708
TRG_DiLeu_BaEn_1 476 481 PF01217 0.423
TRG_ENDOCYTIC_2 151 154 PF00928 0.671
TRG_ENDOCYTIC_2 305 308 PF00928 0.395
TRG_ENDOCYTIC_2 312 315 PF00928 0.306
TRG_ENDOCYTIC_2 404 407 PF00928 0.612
TRG_ENDOCYTIC_2 434 437 PF00928 0.375
TRG_ER_diArg_1 137 139 PF00400 0.748
TRG_ER_diArg_1 263 265 PF00400 0.514
TRG_ER_diArg_1 27 29 PF00400 0.718
TRG_ER_diArg_1 318 320 PF00400 0.639
TRG_ER_diArg_1 645 647 PF00400 0.815
TRG_ER_diArg_1 684 687 PF00400 0.788
TRG_ER_diArg_1 732 734 PF00400 0.871
TRG_NLS_MonoCore_2 643 648 PF00514 0.812
TRG_NLS_MonoExtN_4 641 648 PF00514 0.812

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I288 Leptomonas seymouri 49% 91%
A0A3S7WP32 Leishmania donovani 93% 100%
A4H4A9 Leishmania braziliensis 66% 100%
A4HSI0 Leishmania infantum 93% 100%
E9AKG4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
V5BAT7 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS