Conserved oligomeric Golgi complex subunit 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COG4 transport protein, putative

Species:

Leishmania major

UniProt:

Q4QJE2_LEIMA

TriTrypDb:

LmjF.05.0600 , LMJLV39_050010800 , LMJSD75_050011000

Length:

902

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005794	Golgi apparatus	5	12
GO:0016020	membrane	2	12
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QJE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJE2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.618
CLV_C14_Caspase3-7	334	338	PF00656	0.472
CLV_C14_Caspase3-7	429	433	PF00656	0.421
CLV_MEL_PAP_1	812	818	PF00089	0.535
CLV_NRD_NRD_1	252	254	PF00675	0.324
CLV_NRD_NRD_1	26	28	PF00675	0.523
CLV_NRD_NRD_1	321	323	PF00675	0.415
CLV_NRD_NRD_1	366	368	PF00675	0.328
CLV_NRD_NRD_1	390	392	PF00675	0.475
CLV_NRD_NRD_1	650	652	PF00675	0.717
CLV_NRD_NRD_1	801	803	PF00675	0.397
CLV_NRD_NRD_1	812	814	PF00675	0.399
CLV_NRD_NRD_1	88	90	PF00675	0.550
CLV_NRD_NRD_1	892	894	PF00675	0.456
CLV_PCSK_FUR_1	86	90	PF00082	0.647
CLV_PCSK_KEX2_1	25	27	PF00082	0.517
CLV_PCSK_KEX2_1	321	323	PF00082	0.328
CLV_PCSK_KEX2_1	366	368	PF00082	0.328
CLV_PCSK_KEX2_1	398	400	PF00082	0.437
CLV_PCSK_KEX2_1	649	651	PF00082	0.723
CLV_PCSK_KEX2_1	801	803	PF00082	0.388
CLV_PCSK_KEX2_1	814	816	PF00082	0.390
CLV_PCSK_KEX2_1	85	87	PF00082	0.519
CLV_PCSK_KEX2_1	88	90	PF00082	0.507
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.437
CLV_PCSK_PC1ET2_1	814	816	PF00082	0.482
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.643
CLV_PCSK_PC7_1	21	27	PF00082	0.587
CLV_PCSK_SKI1_1	195	199	PF00082	0.353
CLV_PCSK_SKI1_1	323	327	PF00082	0.358
CLV_PCSK_SKI1_1	398	402	PF00082	0.483
CLV_PCSK_SKI1_1	674	678	PF00082	0.529
CLV_PCSK_SKI1_1	802	806	PF00082	0.468
CLV_PCSK_SKI1_1	832	836	PF00082	0.386
CLV_PCSK_SKI1_1	847	851	PF00082	0.391
CLV_PCSK_SKI1_1	883	887	PF00082	0.394
DEG_Nend_Nbox_1	1	3	PF02207	0.636
DOC_CKS1_1	512	517	PF01111	0.242
DOC_CKS1_1	660	665	PF01111	0.562
DOC_CYCLIN_RxL_1	881	891	PF00134	0.508
DOC_CYCLIN_yClb5_NLxxxL_5	850	859	PF00134	0.410
DOC_MAPK_gen_1	801	812	PF00069	0.479
DOC_MAPK_gen_1	893	900	PF00069	0.519
DOC_MAPK_HePTP_8	890	902	PF00069	0.538
DOC_MAPK_MEF2A_6	893	902	PF00069	0.541
DOC_PP1_RVXF_1	887	893	PF00149	0.434
DOC_PP2B_LxvP_1	44	47	PF13499	0.424
DOC_PP4_FxxP_1	660	663	PF00568	0.505
DOC_USP7_MATH_1	115	119	PF00917	0.598
DOC_USP7_MATH_1	156	160	PF00917	0.710
DOC_USP7_MATH_1	226	230	PF00917	0.442
DOC_USP7_MATH_1	267	271	PF00917	0.399
DOC_USP7_MATH_1	279	283	PF00917	0.385
DOC_USP7_MATH_1	408	412	PF00917	0.468
DOC_USP7_MATH_1	531	535	PF00917	0.397
DOC_USP7_MATH_1	558	562	PF00917	0.475
DOC_USP7_MATH_1	605	609	PF00917	0.359
DOC_USP7_MATH_1	640	644	PF00917	0.742
DOC_USP7_MATH_1	747	751	PF00917	0.467
DOC_USP7_MATH_1	75	79	PF00917	0.512
DOC_USP7_MATH_1	80	84	PF00917	0.482
DOC_USP7_MATH_1	830	834	PF00917	0.517
DOC_WW_Pin1_4	144	149	PF00397	0.619
DOC_WW_Pin1_4	344	349	PF00397	0.308
DOC_WW_Pin1_4	511	516	PF00397	0.276
DOC_WW_Pin1_4	659	664	PF00397	0.561
DOC_WW_Pin1_4	694	699	PF00397	0.582
DOC_WW_Pin1_4	841	846	PF00397	0.532
LIG_14-3-3_CanoR_1	189	193	PF00244	0.396
LIG_14-3-3_CanoR_1	306	314	PF00244	0.376
LIG_14-3-3_CanoR_1	344	348	PF00244	0.393
LIG_14-3-3_CanoR_1	391	400	PF00244	0.475
LIG_14-3-3_CanoR_1	436	443	PF00244	0.475
LIG_14-3-3_CanoR_1	674	679	PF00244	0.500
LIG_14-3-3_CanoR_1	813	819	PF00244	0.463
LIG_14-3-3_CanoR_1	829	835	PF00244	0.307
LIG_14-3-3_CanoR_1	838	846	PF00244	0.401
LIG_14-3-3_CanoR_1	96	104	PF00244	0.586
LIG_APCC_ABBAyCdc20_2	35	41	PF00400	0.636
LIG_BH_BH3_1	671	687	PF00452	0.521
LIG_EH1_1	849	857	PF00400	0.484
LIG_FHA_1	214	220	PF00498	0.335
LIG_FHA_1	856	862	PF00498	0.362
LIG_FHA_1	864	870	PF00498	0.421
LIG_FHA_1	98	104	PF00498	0.547
LIG_FHA_2	325	331	PF00498	0.242
LIG_FHA_2	385	391	PF00498	0.482
LIG_FHA_2	392	398	PF00498	0.435
LIG_FHA_2	575	581	PF00498	0.344
LIG_FHA_2	660	666	PF00498	0.556
LIG_FHA_2	695	701	PF00498	0.567
LIG_FHA_2	715	721	PF00498	0.498
LIG_FHA_2	837	843	PF00498	0.316
LIG_FHA_2	876	882	PF00498	0.430
LIG_FHA_2	886	892	PF00498	0.377
LIG_GBD_Chelix_1	244	252	PF00786	0.449
LIG_LIR_Gen_1	285	296	PF02991	0.398
LIG_LIR_Gen_1	728	738	PF02991	0.445
LIG_LIR_Gen_1	744	753	PF02991	0.423
LIG_LIR_Gen_1	848	857	PF02991	0.402
LIG_LIR_Nem_3	285	291	PF02991	0.447
LIG_LIR_Nem_3	458	463	PF02991	0.395
LIG_LIR_Nem_3	566	570	PF02991	0.409
LIG_LIR_Nem_3	580	586	PF02991	0.263
LIG_LIR_Nem_3	702	707	PF02991	0.571
LIG_LIR_Nem_3	728	733	PF02991	0.440
LIG_LIR_Nem_3	744	749	PF02991	0.427
LIG_LIR_Nem_3	755	761	PF02991	0.385
LIG_LIR_Nem_3	817	822	PF02991	0.383
LIG_LIR_Nem_3	848	853	PF02991	0.391
LIG_LRP6_Inhibitor_1	29	35	PF00058	0.564
LIG_NRBOX	89	95	PF00104	0.486
LIG_PCNA_PIPBox_1	521	530	PF02747	0.344
LIG_PCNA_yPIPBox_3	186	200	PF02747	0.482
LIG_PDZ_Class_2	897	902	PF00595	0.413
LIG_Pex14_1	726	730	PF04695	0.406
LIG_PTB_Apo_2	50	57	PF02174	0.634
LIG_PTB_Phospho_1	50	56	PF10480	0.634
LIG_REV1ctd_RIR_1	581	591	PF16727	0.363
LIG_REV1ctd_RIR_1	832	842	PF16727	0.399
LIG_RPA_C_Fungi	184	196	PF08784	0.321
LIG_SH2_NCK_1	136	140	PF00017	0.463
LIG_SH2_PTP2	453	456	PF00017	0.449
LIG_SH2_STAP1	232	236	PF00017	0.413
LIG_SH2_STAP1	396	400	PF00017	0.449
LIG_SH2_STAP1	465	469	PF00017	0.475
LIG_SH2_STAT3	781	784	PF00017	0.525
LIG_SH2_STAT5	385	388	PF00017	0.383
LIG_SH2_STAT5	453	456	PF00017	0.336
LIG_SH2_STAT5	460	463	PF00017	0.293
LIG_SH2_STAT5	569	572	PF00017	0.432
LIG_SH2_STAT5	62	65	PF00017	0.603
LIG_SH2_STAT5	678	681	PF00017	0.476
LIG_SH2_STAT5	781	784	PF00017	0.467
LIG_SH3_3	449	455	PF00018	0.350
LIG_SH3_3	573	579	PF00018	0.421
LIG_Sin3_3	358	365	PF02671	0.242
LIG_Sin3_3	792	799	PF02671	0.428
LIG_Sin3_3	849	856	PF02671	0.276
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.363
LIG_SUMO_SIM_anti_2	264	270	PF11976	0.349
LIG_SUMO_SIM_par_1	857	863	PF11976	0.380
LIG_TRAF2_1	282	285	PF00917	0.437
LIG_TRAF2_1	560	563	PF00917	0.437
LIG_TRAF2_1	868	871	PF00917	0.564
LIG_TRFH_1	56	60	PF08558	0.602
LIG_TYR_ITSM	456	463	PF00017	0.398
LIG_UBA3_1	818	826	PF00899	0.517
LIG_UBA3_1	855	864	PF00899	0.439
LIG_WRC_WIRS_1	385	390	PF05994	0.385
LIG_WRC_WIRS_1	564	569	PF05994	0.398
LIG_WRC_WIRS_1	831	836	PF05994	0.432
MOD_CDK_SPxK_1	841	847	PF00069	0.559
MOD_CK1_1	147	153	PF00069	0.669
MOD_CK1_1	176	182	PF00069	0.622
MOD_CK1_1	305	311	PF00069	0.344
MOD_CK1_1	340	346	PF00069	0.377
MOD_CK1_1	513	519	PF00069	0.371
MOD_CK1_1	641	647	PF00069	0.738
MOD_CK2_1	279	285	PF00069	0.437
MOD_CK2_1	324	330	PF00069	0.242
MOD_CK2_1	384	390	PF00069	0.463
MOD_CK2_1	391	397	PF00069	0.393
MOD_CK2_1	408	414	PF00069	0.288
MOD_CK2_1	659	665	PF00069	0.573
MOD_CK2_1	75	81	PF00069	0.520
MOD_CK2_1	756	762	PF00069	0.496
MOD_CK2_1	875	881	PF00069	0.455
MOD_CK2_1	885	891	PF00069	0.403
MOD_Cter_Amidation	647	650	PF01082	0.779
MOD_DYRK1A_RPxSP_1	344	348	PF00069	0.376
MOD_GlcNHglycan	122	125	PF01048	0.529
MOD_GlcNHglycan	144	147	PF01048	0.587
MOD_GlcNHglycan	169	172	PF01048	0.675
MOD_GlcNHglycan	256	260	PF01048	0.455
MOD_GlcNHglycan	333	336	PF01048	0.366
MOD_GlcNHglycan	339	342	PF01048	0.326
MOD_GlcNHglycan	363	366	PF01048	0.437
MOD_GlcNHglycan	410	413	PF01048	0.369
MOD_GlcNHglycan	507	510	PF01048	0.349
MOD_GlcNHglycan	515	518	PF01048	0.335
MOD_GlcNHglycan	521	524	PF01048	0.309
MOD_GlcNHglycan	533	536	PF01048	0.259
MOD_GlcNHglycan	547	550	PF01048	0.437
MOD_GlcNHglycan	556	559	PF01048	0.406
MOD_GlcNHglycan	597	600	PF01048	0.346
MOD_GlcNHglycan	602	605	PF01048	0.310
MOD_GlcNHglycan	607	610	PF01048	0.303
MOD_GlcNHglycan	643	646	PF01048	0.749
MOD_GlcNHglycan	65	68	PF01048	0.476
MOD_GlcNHglycan	694	697	PF01048	0.523
MOD_GSK3_1	116	123	PF00069	0.598
MOD_GSK3_1	156	163	PF00069	0.724
MOD_GSK3_1	173	180	PF00069	0.514
MOD_GSK3_1	226	233	PF00069	0.435
MOD_GSK3_1	257	264	PF00069	0.449
MOD_GSK3_1	340	347	PF00069	0.381
MOD_GSK3_1	373	380	PF00069	0.342
MOD_GSK3_1	455	462	PF00069	0.437
MOD_GSK3_1	554	561	PF00069	0.488
MOD_GSK3_1	690	697	PF00069	0.541
MOD_GSK3_1	710	717	PF00069	0.482
MOD_GSK3_1	855	862	PF00069	0.415
MOD_N-GLC_1	176	181	PF02516	0.596
MOD_N-GLC_1	505	510	PF02516	0.404
MOD_N-GLC_1	641	646	PF02516	0.782
MOD_N-GLC_1	75	80	PF02516	0.594
MOD_NEK2_1	213	218	PF00069	0.369
MOD_NEK2_1	255	260	PF00069	0.398
MOD_NEK2_1	442	447	PF00069	0.344
MOD_NEK2_1	456	461	PF00069	0.344
MOD_NEK2_1	538	543	PF00069	0.388
MOD_NEK2_1	666	671	PF00069	0.395
MOD_NEK2_1	69	74	PF00069	0.518
MOD_NEK2_1	714	719	PF00069	0.470
MOD_NEK2_1	855	860	PF00069	0.418
MOD_NEK2_2	830	835	PF00069	0.493
MOD_PIKK_1	226	232	PF00454	0.418
MOD_PIKK_1	267	273	PF00454	0.449
MOD_PIKK_1	324	330	PF00454	0.380
MOD_PIKK_1	836	842	PF00454	0.457
MOD_PKA_1	391	397	PF00069	0.449
MOD_PKA_1	814	820	PF00069	0.447
MOD_PKA_2	188	194	PF00069	0.376
MOD_PKA_2	305	311	PF00069	0.357
MOD_PKA_2	34	40	PF00069	0.631
MOD_PKA_2	343	349	PF00069	0.406
MOD_PKA_2	435	441	PF00069	0.453
MOD_PKA_2	81	87	PF00069	0.507
MOD_PKA_2	814	820	PF00069	0.450
MOD_Plk_1	176	182	PF00069	0.533
MOD_Plk_1	237	243	PF00069	0.328
MOD_Plk_1	284	290	PF00069	0.488
MOD_Plk_1	373	379	PF00069	0.329
MOD_Plk_1	414	420	PF00069	0.359
MOD_Plk_1	690	696	PF00069	0.572
MOD_Plk_1	699	705	PF00069	0.535
MOD_Plk_1	75	81	PF00069	0.594
MOD_Plk_2-3	284	290	PF00069	0.398
MOD_Plk_4	116	122	PF00069	0.554
MOD_Plk_4	384	390	PF00069	0.420
MOD_Plk_4	456	462	PF00069	0.350
MOD_Plk_4	516	522	PF00069	0.363
MOD_Plk_4	563	569	PF00069	0.475
MOD_Plk_4	622	628	PF00069	0.561
MOD_Plk_4	674	680	PF00069	0.522
MOD_Plk_4	734	740	PF00069	0.480
MOD_Plk_4	806	812	PF00069	0.400
MOD_Plk_4	814	820	PF00069	0.372
MOD_Plk_4	855	861	PF00069	0.385
MOD_ProDKin_1	144	150	PF00069	0.626
MOD_ProDKin_1	344	350	PF00069	0.308
MOD_ProDKin_1	511	517	PF00069	0.276
MOD_ProDKin_1	659	665	PF00069	0.558
MOD_ProDKin_1	694	700	PF00069	0.575
MOD_ProDKin_1	841	847	PF00069	0.535
MOD_SUMO_rev_2	750	756	PF00179	0.326
MOD_SUMO_rev_2	880	885	PF00179	0.500
TRG_DiLeu_BaEn_3	373	379	PF01217	0.475
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.449
TRG_DiLeu_BaLyEn_6	613	618	PF01217	0.449
TRG_ENDOCYTIC_2	288	291	PF00928	0.398
TRG_ENDOCYTIC_2	385	388	PF00928	0.330
TRG_ENDOCYTIC_2	453	456	PF00928	0.385
TRG_ENDOCYTIC_2	460	463	PF00928	0.385
TRG_ENDOCYTIC_2	56	59	PF00928	0.605
TRG_ER_diArg_1	24	27	PF00400	0.515
TRG_ER_diArg_1	649	651	PF00400	0.706
TRG_ER_diArg_1	801	803	PF00400	0.398
TRG_ER_diArg_1	812	815	PF00400	0.468
TRG_ER_diArg_1	86	89	PF00400	0.525
TRG_NLS_Bipartite_1	801	817	PF00514	0.498
TRG_NLS_MonoExtC_3	84	89	PF00514	0.642
TRG_NLS_MonoExtN_4	82	89	PF00514	0.642
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	616	620	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	716	720	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU85	Leptomonas seymouri	66%	97%
A0A0S4IPR3	Bodo saltans	29%	100%
A0A1X0NK43	Trypanosomatidae	37%	93%
A0A3R7LU72	Trypanosoma rangeli	36%	100%
A0A3S7WP44	Leishmania donovani	93%	100%
A4HD49	Leishmania braziliensis	81%	100%
A4HSI2	Leishmania infantum	94%	100%
C9ZUC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	89%
E9AKG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
V5BAR5	Trypanosoma cruzi	35%	98%