SURP motif domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surp module, putative

Species:

Leishmania major

UniProt:

Q4QJE1_LEIMA

TriTrypDb:

LmjF.05.0610 , LMJLV39_050010900 , LMJSD75_050011100 , LMJSD75_050011200

Length:

927

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QJE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJE1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.621
CLV_C14_Caspase3-7	322	326	PF00656	0.600
CLV_C14_Caspase3-7	357	361	PF00656	0.607
CLV_C14_Caspase3-7	461	465	PF00656	0.627
CLV_NRD_NRD_1	238	240	PF00675	0.498
CLV_NRD_NRD_1	301	303	PF00675	0.649
CLV_NRD_NRD_1	365	367	PF00675	0.706
CLV_NRD_NRD_1	661	663	PF00675	0.673
CLV_NRD_NRD_1	668	670	PF00675	0.635
CLV_PCSK_FUR_1	298	302	PF00082	0.626
CLV_PCSK_FUR_1	658	662	PF00082	0.665
CLV_PCSK_KEX2_1	186	188	PF00082	0.303
CLV_PCSK_KEX2_1	238	240	PF00082	0.498
CLV_PCSK_KEX2_1	300	302	PF00082	0.654
CLV_PCSK_KEX2_1	317	319	PF00082	0.770
CLV_PCSK_KEX2_1	660	662	PF00082	0.674
CLV_PCSK_KEX2_1	668	670	PF00082	0.638
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.282
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.714
CLV_PCSK_PC7_1	664	670	PF00082	0.719
CLV_PCSK_SKI1_1	433	437	PF00082	0.526
CLV_PCSK_SKI1_1	483	487	PF00082	0.523
CLV_PCSK_SKI1_1	720	724	PF00082	0.736
CLV_PCSK_SKI1_1	826	830	PF00082	0.644
DEG_APCC_DBOX_1	211	219	PF00400	0.482
DEG_Nend_Nbox_1	1	3	PF02207	0.485
DEG_SCF_FBW7_1	779	786	PF00400	0.646
DEG_SIAH_1	519	527	PF03145	0.533
DEG_SPOP_SBC_1	113	117	PF00917	0.547
DEG_SPOP_SBC_1	750	754	PF00917	0.667
DEG_SPOP_SBC_1	810	814	PF00917	0.683
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	78	81	PF00134	0.707
DOC_MAPK_gen_1	151	160	PF00069	0.453
DOC_MAPK_gen_1	238	244	PF00069	0.459
DOC_MAPK_MEF2A_6	674	683	PF00069	0.468
DOC_MAPK_MEF2A_6	826	833	PF00069	0.518
DOC_PP2B_LxvP_1	143	146	PF13499	0.528
DOC_PP2B_LxvP_1	147	150	PF13499	0.521
DOC_PP2B_LxvP_1	152	155	PF13499	0.482
DOC_PP2B_LxvP_1	417	420	PF13499	0.563
DOC_PP2B_LxvP_1	681	684	PF13499	0.438
DOC_PP2B_LxvP_1	78	81	PF13499	0.653
DOC_PP2B_LxvP_1	839	842	PF13499	0.605
DOC_PP4_FxxP_1	203	206	PF00568	0.482
DOC_PP4_FxxP_1	64	67	PF00568	0.675
DOC_USP7_MATH_1	114	118	PF00917	0.780
DOC_USP7_MATH_1	125	129	PF00917	0.653
DOC_USP7_MATH_1	270	274	PF00917	0.778
DOC_USP7_MATH_1	397	401	PF00917	0.738
DOC_USP7_MATH_1	460	464	PF00917	0.467
DOC_USP7_MATH_1	520	524	PF00917	0.650
DOC_USP7_MATH_1	526	530	PF00917	0.494
DOC_USP7_MATH_1	554	558	PF00917	0.791
DOC_USP7_MATH_1	582	586	PF00917	0.678
DOC_USP7_MATH_1	625	629	PF00917	0.642
DOC_USP7_MATH_1	652	656	PF00917	0.763
DOC_USP7_MATH_1	67	71	PF00917	0.790
DOC_USP7_MATH_1	750	754	PF00917	0.716
DOC_USP7_MATH_1	794	798	PF00917	0.706
DOC_USP7_MATH_1	809	813	PF00917	0.568
DOC_USP7_MATH_1	845	849	PF00917	0.688
DOC_USP7_MATH_1	876	880	PF00917	0.757
DOC_USP7_UBL2_3	737	741	PF12436	0.735
DOC_WW_Pin1_4	117	122	PF00397	0.779
DOC_WW_Pin1_4	23	28	PF00397	0.602
DOC_WW_Pin1_4	392	397	PF00397	0.676
DOC_WW_Pin1_4	550	555	PF00397	0.597
DOC_WW_Pin1_4	602	607	PF00397	0.552
DOC_WW_Pin1_4	626	631	PF00397	0.736
DOC_WW_Pin1_4	637	642	PF00397	0.641
DOC_WW_Pin1_4	645	650	PF00397	0.705
DOC_WW_Pin1_4	653	658	PF00397	0.636
DOC_WW_Pin1_4	667	672	PF00397	0.676
DOC_WW_Pin1_4	779	784	PF00397	0.663
DOC_WW_Pin1_4	788	793	PF00397	0.771
DOC_WW_Pin1_4	841	846	PF00397	0.697
DOC_WW_Pin1_4	85	90	PF00397	0.633
LIG_14-3-3_CanoR_1	214	219	PF00244	0.482
LIG_14-3-3_CanoR_1	427	436	PF00244	0.626
LIG_14-3-3_CanoR_1	662	672	PF00244	0.565
LIG_14-3-3_CanoR_1	90	100	PF00244	0.647
LIG_14-3-3_CanoR_1	922	926	PF00244	0.513
LIG_BRCT_BRCA1_1	923	927	PF00533	0.520
LIG_Clathr_ClatBox_1	891	895	PF01394	0.664
LIG_CSL_BTD_1	242	245	PF09270	0.490
LIG_deltaCOP1_diTrp_1	535	541	PF00928	0.445
LIG_eIF4E_1	905	911	PF01652	0.607
LIG_FHA_1	138	144	PF00498	0.657
LIG_FHA_1	161	167	PF00498	0.502
LIG_FHA_1	169	175	PF00498	0.481
LIG_FHA_1	519	525	PF00498	0.619
LIG_FHA_1	712	718	PF00498	0.604
LIG_FHA_1	755	761	PF00498	0.710
LIG_FHA_1	784	790	PF00498	0.632
LIG_FHA_1	879	885	PF00498	0.676
LIG_FHA_2	103	109	PF00498	0.681
LIG_FHA_2	122	128	PF00498	0.533
LIG_FHA_2	162	168	PF00498	0.321
LIG_FHA_2	177	183	PF00498	0.482
LIG_FHA_2	371	377	PF00498	0.639
LIG_FHA_2	397	403	PF00498	0.734
LIG_FHA_2	459	465	PF00498	0.615
LIG_FHA_2	683	689	PF00498	0.505
LIG_GSK3_LRP6_1	841	846	PF00069	0.578
LIG_IBAR_NPY_1	452	454	PF08397	0.577
LIG_LIR_Apic_2	116	122	PF02991	0.614
LIG_LIR_Apic_2	201	206	PF02991	0.482
LIG_LIR_Apic_2	62	67	PF02991	0.682
LIG_LIR_Apic_2	68	74	PF02991	0.632
LIG_LIR_Gen_1	26	36	PF02991	0.656
LIG_LIR_Gen_1	445	455	PF02991	0.504
LIG_LIR_Gen_1	610	621	PF02991	0.641
LIG_LIR_Gen_1	921	927	PF02991	0.523
LIG_LIR_Nem_3	26	31	PF02991	0.609
LIG_LIR_Nem_3	445	450	PF02991	0.488
LIG_LIR_Nem_3	535	541	PF02991	0.445
LIG_LIR_Nem_3	610	616	PF02991	0.644
LIG_LIR_Nem_3	921	926	PF02991	0.516
LIG_MYND_1	76	80	PF01753	0.683
LIG_NRBOX	164	170	PF00104	0.331
LIG_NRBOX	214	220	PF00104	0.482
LIG_NRBOX	497	503	PF00104	0.427
LIG_PCNA_yPIPBox_3	40	51	PF02747	0.641
LIG_PDZ_Class_2	922	927	PF00595	0.521
LIG_Pex14_1	824	828	PF04695	0.582
LIG_Pex14_2	828	832	PF04695	0.597
LIG_PTB_Apo_2	190	197	PF02174	0.466
LIG_SH2_CRK	119	123	PF00017	0.557
LIG_SH2_CRK	216	220	PF00017	0.523
LIG_SH2_CRK	71	75	PF00017	0.702
LIG_SH2_CRK	905	909	PF00017	0.746
LIG_SH2_CRK	923	927	PF00017	0.445
LIG_SH2_GRB2like	83	86	PF00017	0.665
LIG_SH2_NCK_1	119	123	PF00017	0.557
LIG_SH2_NCK_1	454	458	PF00017	0.572
LIG_SH2_PTP2	241	244	PF00017	0.414
LIG_SH2_SRC	454	457	PF00017	0.447
LIG_SH2_STAP1	923	927	PF00017	0.520
LIG_SH2_STAT3	35	38	PF00017	0.624
LIG_SH2_STAT5	241	244	PF00017	0.414
LIG_SH2_STAT5	510	513	PF00017	0.558
LIG_SH2_STAT5	532	535	PF00017	0.500
LIG_SH2_STAT5	539	542	PF00017	0.404
LIG_SH2_STAT5	83	86	PF00017	0.814
LIG_SH3_2	245	250	PF14604	0.550
LIG_SH3_3	107	113	PF00018	0.737
LIG_SH3_3	239	245	PF00018	0.429
LIG_SH3_3	412	418	PF00018	0.613
LIG_SH3_3	627	633	PF00018	0.739
LIG_SH3_3	721	727	PF00018	0.728
LIG_SH3_3	835	841	PF00018	0.697
LIG_SH3_3	854	860	PF00018	0.668
LIG_SH3_3	86	92	PF00018	0.558
LIG_SUMO_SIM_anti_2	163	171	PF11976	0.411
LIG_SUMO_SIM_anti_2	677	683	PF11976	0.556
LIG_TRAF2_1	179	182	PF00917	0.502
LIG_TRAF2_1	284	287	PF00917	0.649
LIG_TYR_ITIM	537	542	PF00017	0.473
LIG_UBA3_1	821	826	PF00899	0.507
LIG_WW_1	80	83	PF00397	0.798
MOD_CDK_SPK_2	653	658	PF00069	0.666
MOD_CDK_SPK_2	85	90	PF00069	0.548
MOD_CDK_SPxxK_3	653	660	PF00069	0.689
MOD_CDK_SPxxK_3	667	674	PF00069	0.597
MOD_CK1_1	117	123	PF00069	0.700
MOD_CK1_1	226	232	PF00069	0.540
MOD_CK1_1	341	347	PF00069	0.624
MOD_CK1_1	348	354	PF00069	0.637
MOD_CK1_1	356	362	PF00069	0.723
MOD_CK1_1	370	376	PF00069	0.608
MOD_CK1_1	557	563	PF00069	0.811
MOD_CK1_1	585	591	PF00069	0.671
MOD_CK1_1	59	65	PF00069	0.579
MOD_CK1_1	602	608	PF00069	0.525
MOD_CK1_1	640	646	PF00069	0.636
MOD_CK1_1	648	654	PF00069	0.676
MOD_CK1_1	749	755	PF00069	0.707
MOD_CK1_1	790	796	PF00069	0.775
MOD_CK1_1	797	803	PF00069	0.700
MOD_CK1_1	812	818	PF00069	0.542
MOD_CK2_1	102	108	PF00069	0.677
MOD_CK2_1	121	127	PF00069	0.599
MOD_CK2_1	176	182	PF00069	0.482
MOD_CK2_1	316	322	PF00069	0.658
MOD_CK2_1	352	358	PF00069	0.788
MOD_CK2_1	370	376	PF00069	0.594
MOD_CK2_1	396	402	PF00069	0.731
MOD_CK2_1	667	673	PF00069	0.588
MOD_CK2_1	682	688	PF00069	0.503
MOD_GlcNHglycan	110	113	PF01048	0.682
MOD_GlcNHglycan	116	119	PF01048	0.627
MOD_GlcNHglycan	127	130	PF01048	0.513
MOD_GlcNHglycan	18	21	PF01048	0.716
MOD_GlcNHglycan	273	276	PF01048	0.749
MOD_GlcNHglycan	308	311	PF01048	0.669
MOD_GlcNHglycan	336	339	PF01048	0.840
MOD_GlcNHglycan	347	350	PF01048	0.560
MOD_GlcNHglycan	369	372	PF01048	0.695
MOD_GlcNHglycan	373	376	PF01048	0.803
MOD_GlcNHglycan	399	402	PF01048	0.747
MOD_GlcNHglycan	420	423	PF01048	0.533
MOD_GlcNHglycan	5	8	PF01048	0.597
MOD_GlcNHglycan	555	559	PF01048	0.719
MOD_GlcNHglycan	584	587	PF01048	0.700
MOD_GlcNHglycan	588	591	PF01048	0.646
MOD_GlcNHglycan	59	62	PF01048	0.586
MOD_GlcNHglycan	650	653	PF01048	0.691
MOD_GlcNHglycan	748	751	PF01048	0.667
MOD_GlcNHglycan	792	795	PF01048	0.689
MOD_GlcNHglycan	796	799	PF01048	0.727
MOD_GlcNHglycan	814	817	PF01048	0.536
MOD_GlcNHglycan	847	850	PF01048	0.745
MOD_GlcNHglycan	911	914	PF01048	0.528
MOD_GSK3_1	108	115	PF00069	0.696
MOD_GSK3_1	117	124	PF00069	0.709
MOD_GSK3_1	16	23	PF00069	0.732
MOD_GSK3_1	312	319	PF00069	0.615
MOD_GSK3_1	330	337	PF00069	0.684
MOD_GSK3_1	338	345	PF00069	0.647
MOD_GSK3_1	347	354	PF00069	0.756
MOD_GSK3_1	366	373	PF00069	0.688
MOD_GSK3_1	382	389	PF00069	0.677
MOD_GSK3_1	392	399	PF00069	0.817
MOD_GSK3_1	423	430	PF00069	0.648
MOD_GSK3_1	550	557	PF00069	0.685
MOD_GSK3_1	582	589	PF00069	0.717
MOD_GSK3_1	636	643	PF00069	0.779
MOD_GSK3_1	648	655	PF00069	0.655
MOD_GSK3_1	663	670	PF00069	0.538
MOD_GSK3_1	746	753	PF00069	0.651
MOD_GSK3_1	779	786	PF00069	0.672
MOD_GSK3_1	790	797	PF00069	0.583
MOD_GSK3_1	805	812	PF00069	0.804
MOD_GSK3_1	841	848	PF00069	0.663
MOD_LATS_1	304	310	PF00433	0.679
MOD_N-GLC_1	330	335	PF02516	0.639
MOD_N-GLC_1	548	553	PF02516	0.515
MOD_N-GLC_1	566	571	PF02516	0.641
MOD_NEK2_1	160	165	PF00069	0.430
MOD_NEK2_1	168	173	PF00069	0.482
MOD_NEK2_1	3	8	PF00069	0.594
MOD_NEK2_1	548	553	PF00069	0.545
MOD_NEK2_1	751	756	PF00069	0.667
MOD_NEK2_2	764	769	PF00069	0.607
MOD_PIKK_1	226	232	PF00454	0.619
MOD_PIKK_1	386	392	PF00454	0.737
MOD_PIKK_1	663	669	PF00454	0.607
MOD_PIKK_1	69	75	PF00454	0.701
MOD_PIKK_1	703	709	PF00454	0.661
MOD_PIKK_1	895	901	PF00454	0.678
MOD_PKA_1	366	372	PF00069	0.625
MOD_PKA_2	338	344	PF00069	0.568
MOD_PKA_2	663	669	PF00069	0.668
MOD_PKA_2	921	927	PF00069	0.523
MOD_PKB_1	151	159	PF00069	0.430
MOD_PKB_1	212	220	PF00069	0.482
MOD_PKB_1	332	340	PF00069	0.672
MOD_Plk_1	160	166	PF00069	0.422
MOD_Plk_1	67	73	PF00069	0.650
MOD_Plk_1	876	882	PF00069	0.601
MOD_Plk_2-3	161	167	PF00069	0.412
MOD_Plk_2-3	458	464	PF00069	0.525
MOD_Plk_4	161	167	PF00069	0.412
MOD_Plk_4	214	220	PF00069	0.482
MOD_Plk_4	42	48	PF00069	0.613
MOD_Plk_4	496	502	PF00069	0.430
MOD_Plk_4	59	65	PF00069	0.496
MOD_Plk_4	682	688	PF00069	0.509
MOD_Plk_4	860	866	PF00069	0.658
MOD_Plk_4	887	893	PF00069	0.645
MOD_Plk_4	921	927	PF00069	0.523
MOD_ProDKin_1	117	123	PF00069	0.779
MOD_ProDKin_1	23	29	PF00069	0.599
MOD_ProDKin_1	392	398	PF00069	0.675
MOD_ProDKin_1	550	556	PF00069	0.606
MOD_ProDKin_1	602	608	PF00069	0.548
MOD_ProDKin_1	626	632	PF00069	0.732
MOD_ProDKin_1	637	643	PF00069	0.641
MOD_ProDKin_1	645	651	PF00069	0.707
MOD_ProDKin_1	653	659	PF00069	0.636
MOD_ProDKin_1	667	673	PF00069	0.601
MOD_ProDKin_1	779	785	PF00069	0.664
MOD_ProDKin_1	788	794	PF00069	0.771
MOD_ProDKin_1	841	847	PF00069	0.696
MOD_ProDKin_1	85	91	PF00069	0.628
MOD_SUMO_for_1	185	188	PF00179	0.482
MOD_SUMO_rev_2	359	369	PF00179	0.588
MOD_SUMO_rev_2	45	53	PF00179	0.634
TRG_DiLeu_BaEn_1	161	166	PF01217	0.415
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.696
TRG_DiLeu_BaLyEn_6	906	911	PF01217	0.576
TRG_ENDOCYTIC_2	216	219	PF00928	0.519
TRG_ENDOCYTIC_2	241	244	PF00928	0.414
TRG_ENDOCYTIC_2	28	31	PF00928	0.594
TRG_ENDOCYTIC_2	539	542	PF00928	0.468
TRG_ENDOCYTIC_2	613	616	PF00928	0.628
TRG_ENDOCYTIC_2	923	926	PF00928	0.510
TRG_ER_diArg_1	150	153	PF00400	0.463
TRG_ER_diArg_1	298	301	PF00400	0.621
TRG_ER_diArg_1	414	417	PF00400	0.616
TRG_ER_diArg_1	657	660	PF00400	0.694
TRG_ER_diArg_1	661	664	PF00400	0.691
TRG_ER_diArg_1	717	720	PF00400	0.584
TRG_NES_CRM1_1	492	503	PF08389	0.503
TRG_Pf-PMV_PEXEL_1	473	478	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAE1	Leptomonas seymouri	41%	98%
A0A3S7WP43	Leishmania donovani	91%	95%
A4HD48	Leishmania braziliensis	73%	94%
A4HSI3	Leishmania infantum	91%	95%
E9AKG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%