Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJE0_LEIMA

TriTrypDb:

LmjF.05.0620 , LMJLV39_050011000 , LMJSD75_050011300

Length:

874

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	791	795	PF00656	0.604
CLV_MEL_PAP_1	341	347	PF00089	0.675
CLV_NRD_NRD_1	104	106	PF00675	0.723
CLV_NRD_NRD_1	120	122	PF00675	0.567
CLV_NRD_NRD_1	126	128	PF00675	0.608
CLV_NRD_NRD_1	219	221	PF00675	0.701
CLV_NRD_NRD_1	279	281	PF00675	0.644
CLV_NRD_NRD_1	311	313	PF00675	0.668
CLV_NRD_NRD_1	53	55	PF00675	0.671
CLV_NRD_NRD_1	599	601	PF00675	0.705
CLV_NRD_NRD_1	659	661	PF00675	0.713
CLV_NRD_NRD_1	788	790	PF00675	0.705
CLV_NRD_NRD_1	806	808	PF00675	0.807
CLV_PCSK_FUR_1	102	106	PF00082	0.676
CLV_PCSK_FUR_1	118	122	PF00082	0.560
CLV_PCSK_FUR_1	309	313	PF00082	0.670
CLV_PCSK_KEX2_1	104	106	PF00082	0.723
CLV_PCSK_KEX2_1	118	120	PF00082	0.599
CLV_PCSK_KEX2_1	125	127	PF00082	0.605
CLV_PCSK_KEX2_1	219	221	PF00082	0.653
CLV_PCSK_KEX2_1	279	281	PF00082	0.644
CLV_PCSK_KEX2_1	311	313	PF00082	0.668
CLV_PCSK_KEX2_1	334	336	PF00082	0.598
CLV_PCSK_KEX2_1	53	55	PF00082	0.577
CLV_PCSK_KEX2_1	599	601	PF00082	0.705
CLV_PCSK_KEX2_1	659	661	PF00082	0.713
CLV_PCSK_KEX2_1	788	790	PF00082	0.699
CLV_PCSK_KEX2_1	806	808	PF00082	0.807
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.598
CLV_PCSK_PC7_1	114	120	PF00082	0.601
CLV_PCSK_PC7_1	121	127	PF00082	0.567
CLV_PCSK_PC7_1	275	281	PF00082	0.578
CLV_PCSK_SKI1_1	174	178	PF00082	0.653
CLV_PCSK_SKI1_1	42	46	PF00082	0.563
CLV_PCSK_SKI1_1	632	636	PF00082	0.585
CLV_PCSK_SKI1_1	747	751	PF00082	0.622
CLV_PCSK_SKI1_1	807	811	PF00082	0.718
CLV_PCSK_SKI1_1	90	94	PF00082	0.667
CLV_Separin_Metazoa	50	54	PF03568	0.601
DEG_APCC_DBOX_1	694	702	PF00400	0.496
DEG_SCF_FBW7_1	411	418	PF00400	0.598
DEG_SPOP_SBC_1	367	371	PF00917	0.597
DOC_ANK_TNKS_1	139	146	PF00023	0.672
DOC_ANK_TNKS_1	343	350	PF00023	0.686
DOC_CKS1_1	356	361	PF01111	0.581
DOC_CYCLIN_RxL_1	629	638	PF00134	0.580
DOC_CYCLIN_RxL_1	692	705	PF00134	0.594
DOC_CYCLIN_yCln2_LP_2	182	188	PF00134	0.621
DOC_CYCLIN_yCln2_LP_2	715	721	PF00134	0.566
DOC_MAPK_DCC_7	174	184	PF00069	0.591
DOC_MAPK_gen_1	334	341	PF00069	0.605
DOC_MAPK_gen_1	659	666	PF00069	0.714
DOC_MAPK_MEF2A_6	334	341	PF00069	0.605
DOC_PP1_RVXF_1	815	822	PF00149	0.635
DOC_PP2B_LxvP_1	182	185	PF13499	0.675
DOC_PP2B_LxvP_1	191	194	PF13499	0.629
DOC_PP2B_LxvP_1	288	291	PF13499	0.687
DOC_PP2B_LxvP_1	800	803	PF13499	0.609
DOC_USP7_MATH_1	158	162	PF00917	0.641
DOC_USP7_MATH_1	163	167	PF00917	0.645
DOC_USP7_MATH_1	226	230	PF00917	0.801
DOC_USP7_MATH_1	258	262	PF00917	0.682
DOC_USP7_MATH_1	278	282	PF00917	0.576
DOC_USP7_MATH_1	3	7	PF00917	0.565
DOC_USP7_MATH_1	394	398	PF00917	0.690
DOC_USP7_MATH_1	409	413	PF00917	0.586
DOC_USP7_MATH_1	430	434	PF00917	0.653
DOC_USP7_MATH_1	447	451	PF00917	0.413
DOC_USP7_MATH_1	469	473	PF00917	0.499
DOC_USP7_MATH_1	584	588	PF00917	0.683
DOC_USP7_MATH_1	630	634	PF00917	0.549
DOC_USP7_MATH_1	704	708	PF00917	0.594
DOC_USP7_MATH_1	729	733	PF00917	0.623
DOC_USP7_MATH_1	77	81	PF00917	0.650
DOC_USP7_MATH_1	777	781	PF00917	0.644
DOC_USP7_MATH_1	812	816	PF00917	0.618
DOC_USP7_MATH_1	835	839	PF00917	0.635
DOC_USP7_MATH_1	96	100	PF00917	0.533
DOC_WW_Pin1_4	151	156	PF00397	0.721
DOC_WW_Pin1_4	167	172	PF00397	0.687
DOC_WW_Pin1_4	246	251	PF00397	0.740
DOC_WW_Pin1_4	291	296	PF00397	0.756
DOC_WW_Pin1_4	355	360	PF00397	0.711
DOC_WW_Pin1_4	368	373	PF00397	0.576
DOC_WW_Pin1_4	375	380	PF00397	0.480
DOC_WW_Pin1_4	407	412	PF00397	0.695
DOC_WW_Pin1_4	53	58	PF00397	0.654
DOC_WW_Pin1_4	587	592	PF00397	0.513
DOC_WW_Pin1_4	600	605	PF00397	0.692
DOC_WW_Pin1_4	607	612	PF00397	0.629
DOC_WW_Pin1_4	63	68	PF00397	0.618
DOC_WW_Pin1_4	635	640	PF00397	0.741
DOC_WW_Pin1_4	653	658	PF00397	0.608
DOC_WW_Pin1_4	72	77	PF00397	0.537
DOC_WW_Pin1_4	749	754	PF00397	0.656
DOC_WW_Pin1_4	780	785	PF00397	0.643
DOC_WW_Pin1_4	90	95	PF00397	0.554
LIG_14-3-3_CanoR_1	222	226	PF00244	0.679
LIG_14-3-3_CanoR_1	279	287	PF00244	0.569
LIG_14-3-3_CanoR_1	318	324	PF00244	0.605
LIG_14-3-3_CanoR_1	632	638	PF00244	0.612
LIG_14-3-3_CanoR_1	768	778	PF00244	0.672
LIG_14-3-3_CanoR_1	788	796	PF00244	0.567
LIG_14-3-3_CanoR_1	806	812	PF00244	0.644
LIG_Actin_WH2_2	512	528	PF00022	0.438
LIG_BIR_II_1	1	5	PF00653	0.710
LIG_BRCT_BRCA1_1	496	500	PF00533	0.422
LIG_BRCT_BRCA1_1	706	710	PF00533	0.535
LIG_EVH1_1	800	804	PF00568	0.644
LIG_FHA_1	33	39	PF00498	0.630
LIG_FHA_1	375	381	PF00498	0.667
LIG_FHA_1	396	402	PF00498	0.675
LIG_FHA_1	57	63	PF00498	0.666
LIG_FHA_1	596	602	PF00498	0.800
LIG_FHA_1	683	689	PF00498	0.680
LIG_FHA_1	9	15	PF00498	0.661
LIG_FHA_2	311	317	PF00498	0.664
LIG_FHA_2	490	496	PF00498	0.618
LIG_FHA_2	513	519	PF00498	0.530
LIG_FHA_2	616	622	PF00498	0.567
LIG_Integrin_RGD_1	127	129	PF01839	0.735
LIG_LIR_Gen_1	35	44	PF02991	0.533
LIG_LIR_Gen_1	497	508	PF02991	0.392
LIG_LIR_Gen_1	810	819	PF02991	0.597
LIG_LIR_Nem_3	35	39	PF02991	0.547
LIG_LIR_Nem_3	497	503	PF02991	0.409
LIG_LIR_Nem_3	576	581	PF02991	0.604
LIG_LIR_Nem_3	810	816	PF02991	0.596
LIG_MYND_1	291	295	PF01753	0.688
LIG_NRBOX	187	193	PF00104	0.582
LIG_NRBOX	630	636	PF00104	0.593
LIG_SH2_CRK	538	542	PF00017	0.486
LIG_SH2_SRC	620	623	PF00017	0.586
LIG_SH2_STAP1	460	464	PF00017	0.537
LIG_SH2_STAP1	538	542	PF00017	0.486
LIG_SH2_STAT3	384	387	PF00017	0.622
LIG_SH2_STAT5	384	387	PF00017	0.676
LIG_SH2_STAT5	491	494	PF00017	0.620
LIG_SH2_STAT5	700	703	PF00017	0.751
LIG_SH2_STAT5	86	89	PF00017	0.783
LIG_SH3_2	300	305	PF14604	0.592
LIG_SH3_2	742	747	PF14604	0.574
LIG_SH3_2	784	789	PF14604	0.603
LIG_SH3_2	801	806	PF14604	0.650
LIG_SH3_3	104	110	PF00018	0.648
LIG_SH3_3	152	158	PF00018	0.675
LIG_SH3_3	297	303	PF00018	0.757
LIG_SH3_3	336	342	PF00018	0.583
LIG_SH3_3	34	40	PF00018	0.613
LIG_SH3_3	353	359	PF00018	0.570
LIG_SH3_3	446	452	PF00018	0.512
LIG_SH3_3	578	584	PF00018	0.496
LIG_SH3_3	605	611	PF00018	0.635
LIG_SH3_3	636	642	PF00018	0.782
LIG_SH3_3	64	70	PF00018	0.710
LIG_SH3_3	655	661	PF00018	0.550
LIG_SH3_3	736	742	PF00018	0.673
LIG_SH3_3	781	787	PF00018	0.612
LIG_SH3_3	798	804	PF00018	0.595
LIG_SH3_3	806	812	PF00018	0.617
LIG_SUMO_SIM_anti_2	440	445	PF11976	0.478
LIG_SUMO_SIM_par_1	633	638	PF11976	0.623
LIG_TRAF2_1	213	216	PF00917	0.644
LIG_TYR_ITIM	536	541	PF00017	0.460
LIG_TYR_ITIM	811	816	PF00017	0.725
LIG_WRC_WIRS_1	386	391	PF05994	0.618
LIG_WW_1	83	86	PF00397	0.647
LIG_WW_3	603	607	PF00397	0.635
LIG_WW_3	656	660	PF00397	0.660
LIG_WW_3	785	789	PF00397	0.589
LIG_WW_3	82	86	PF00397	0.646
MOD_CDC14_SPxK_1	603	606	PF00782	0.687
MOD_CDC14_SPxK_1	638	641	PF00782	0.630
MOD_CDC14_SPxK_1	656	659	PF00782	0.571
MOD_CDC14_SPxK_1	752	755	PF00782	0.634
MOD_CDK_SPK_2	167	172	PF00069	0.623
MOD_CDK_SPK_2	246	251	PF00069	0.593
MOD_CDK_SPxK_1	600	606	PF00069	0.695
MOD_CDK_SPxK_1	635	641	PF00069	0.630
MOD_CDK_SPxK_1	653	659	PF00069	0.583
MOD_CDK_SPxK_1	749	755	PF00069	0.640
MOD_CDK_SPxxK_3	167	174	PF00069	0.598
MOD_CDK_SPxxK_3	246	253	PF00069	0.730
MOD_CDK_SPxxK_3	375	382	PF00069	0.668
MOD_CDK_SPxxK_3	53	60	PF00069	0.658
MOD_CDK_SPxxK_3	653	660	PF00069	0.711
MOD_CK1_1	10	16	PF00069	0.582
MOD_CK1_1	134	140	PF00069	0.817
MOD_CK1_1	165	171	PF00069	0.635
MOD_CK1_1	19	25	PF00069	0.554
MOD_CK1_1	2	8	PF00069	0.622
MOD_CK1_1	249	255	PF00069	0.668
MOD_CK1_1	388	394	PF00069	0.803
MOD_CK1_1	410	416	PF00069	0.665
MOD_CK1_1	56	62	PF00069	0.702
MOD_CK1_1	586	592	PF00069	0.624
MOD_CK1_1	633	639	PF00069	0.594
MOD_CK1_1	669	675	PF00069	0.816
MOD_CK1_1	780	786	PF00069	0.704
MOD_CK1_1	815	821	PF00069	0.636
MOD_CK1_1	855	861	PF00069	0.681
MOD_CK1_1	863	869	PF00069	0.586
MOD_CK2_1	447	453	PF00069	0.628
MOD_CK2_1	699	705	PF00069	0.596
MOD_Cter_Amidation	102	105	PF01082	0.734
MOD_DYRK1A_RPxSP_1	246	250	PF00069	0.647
MOD_DYRK1A_RPxSP_1	251	255	PF00069	0.653
MOD_GlcNHglycan	1	4	PF01048	0.638
MOD_GlcNHglycan	21	24	PF01048	0.572
MOD_GlcNHglycan	227	231	PF01048	0.675
MOD_GlcNHglycan	242	246	PF01048	0.607
MOD_GlcNHglycan	256	259	PF01048	0.687
MOD_GlcNHglycan	351	354	PF01048	0.652
MOD_GlcNHglycan	359	362	PF01048	0.628
MOD_GlcNHglycan	424	427	PF01048	0.755
MOD_GlcNHglycan	475	478	PF01048	0.688
MOD_GlcNHglycan	495	499	PF01048	0.441
MOD_GlcNHglycan	553	556	PF01048	0.619
MOD_GlcNHglycan	571	574	PF01048	0.593
MOD_GlcNHglycan	586	589	PF01048	0.614
MOD_GlcNHglycan	773	776	PF01048	0.727
MOD_GlcNHglycan	779	782	PF01048	0.705
MOD_GlcNHglycan	99	102	PF01048	0.640
MOD_GSK3_1	110	117	PF00069	0.631
MOD_GSK3_1	12	19	PF00069	0.638
MOD_GSK3_1	130	137	PF00069	0.727
MOD_GSK3_1	158	165	PF00069	0.771
MOD_GSK3_1	170	177	PF00069	0.673
MOD_GSK3_1	254	261	PF00069	0.807
MOD_GSK3_1	3	10	PF00069	0.690
MOD_GSK3_1	363	370	PF00069	0.609
MOD_GSK3_1	407	414	PF00069	0.659
MOD_GSK3_1	469	476	PF00069	0.627
MOD_GSK3_1	583	590	PF00069	0.618
MOD_GSK3_1	666	673	PF00069	0.801
MOD_GSK3_1	674	681	PF00069	0.688
MOD_GSK3_1	776	783	PF00069	0.579
MOD_GSK3_1	817	824	PF00069	0.711
MOD_GSK3_1	831	838	PF00069	0.707
MOD_GSK3_1	852	859	PF00069	0.803
MOD_GSK3_1	92	99	PF00069	0.616
MOD_N-GLC_1	266	271	PF02516	0.645
MOD_N-GLC_1	669	674	PF02516	0.740
MOD_N-GLC_1	860	865	PF02516	0.540
MOD_N-GLC_2	207	209	PF02516	0.650
MOD_N-GLC_2	473	475	PF02516	0.621
MOD_NEK2_1	14	19	PF00069	0.654
MOD_NEK2_1	286	291	PF00069	0.635
MOD_NEK2_1	374	379	PF00069	0.646
MOD_NEK2_1	569	574	PF00069	0.578
MOD_NEK2_1	666	671	PF00069	0.698
MOD_NEK2_1	699	704	PF00069	0.567
MOD_NEK2_1	769	774	PF00069	0.658
MOD_NEK2_1	860	865	PF00069	0.661
MOD_NEK2_2	812	817	PF00069	0.630
MOD_PIKK_1	165	171	PF00454	0.653
MOD_PIKK_1	221	227	PF00454	0.700
MOD_PIKK_1	233	239	PF00454	0.598
MOD_PIKK_1	416	422	PF00454	0.691
MOD_PIKK_1	641	647	PF00454	0.566
MOD_PIKK_1	825	831	PF00454	0.635
MOD_PKA_2	129	135	PF00069	0.689
MOD_PKA_2	221	227	PF00069	0.702
MOD_PKA_2	278	284	PF00069	0.569
MOD_PKA_2	310	316	PF00069	0.664
MOD_PKA_2	363	369	PF00069	0.616
MOD_PKA_2	595	601	PF00069	0.702
MOD_PKA_2	787	793	PF00069	0.571
MOD_PKB_1	119	127	PF00069	0.661
MOD_PKB_1	641	649	PF00069	0.625
MOD_Plk_1	395	401	PF00069	0.695
MOD_Plk_1	615	621	PF00069	0.627
MOD_Plk_1	852	858	PF00069	0.677
MOD_Plk_1	860	866	PF00069	0.585
MOD_Plk_4	32	38	PF00069	0.607
MOD_Plk_4	395	401	PF00069	0.653
MOD_Plk_4	852	858	PF00069	0.677
MOD_ProDKin_1	151	157	PF00069	0.723
MOD_ProDKin_1	167	173	PF00069	0.688
MOD_ProDKin_1	246	252	PF00069	0.739
MOD_ProDKin_1	291	297	PF00069	0.759
MOD_ProDKin_1	355	361	PF00069	0.712
MOD_ProDKin_1	368	374	PF00069	0.575
MOD_ProDKin_1	375	381	PF00069	0.478
MOD_ProDKin_1	407	413	PF00069	0.696
MOD_ProDKin_1	53	59	PF00069	0.654
MOD_ProDKin_1	587	593	PF00069	0.518
MOD_ProDKin_1	600	606	PF00069	0.695
MOD_ProDKin_1	607	613	PF00069	0.629
MOD_ProDKin_1	63	69	PF00069	0.618
MOD_ProDKin_1	635	641	PF00069	0.744
MOD_ProDKin_1	653	659	PF00069	0.609
MOD_ProDKin_1	72	78	PF00069	0.533
MOD_ProDKin_1	749	755	PF00069	0.654
MOD_ProDKin_1	780	786	PF00069	0.642
MOD_ProDKin_1	90	96	PF00069	0.558
MOD_SUMO_for_1	519	522	PF00179	0.499
TRG_DiLeu_BaEn_1	396	401	PF01217	0.673
TRG_DiLeu_BaLyEn_6	694	699	PF01217	0.488
TRG_ENDOCYTIC_2	460	463	PF00928	0.567
TRG_ENDOCYTIC_2	538	541	PF00928	0.544
TRG_ENDOCYTIC_2	577	580	PF00928	0.521
TRG_ENDOCYTIC_2	813	816	PF00928	0.778
TRG_ER_diArg_1	102	105	PF00400	0.592
TRG_ER_diArg_1	118	121	PF00400	0.571
TRG_ER_diArg_1	125	127	PF00400	0.595
TRG_ER_diArg_1	309	312	PF00400	0.671
TRG_ER_diArg_1	52	54	PF00400	0.577
TRG_ER_diArg_1	599	601	PF00400	0.705
TRG_ER_diArg_1	640	643	PF00400	0.617
TRG_ER_diArg_1	658	660	PF00400	0.607
TRG_ER_diArg_1	695	698	PF00400	0.608
TRG_ER_diArg_1	765	768	PF00400	0.590
TRG_ER_diArg_1	787	789	PF00400	0.705
TRG_ER_diArg_1	805	807	PF00400	0.799
TRG_ER_diArg_1	87	90	PF00400	0.657
TRG_NES_CRM1_1	495	507	PF08389	0.453
TRG_NES_CRM1_1	691	705	PF08389	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5I7	Leishmania donovani	82%	98%
A4HD47	Leishmania braziliensis	50%	96%
E9AKG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%