Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJD7_LEIMA

TriTrypDb:

LmjF.05.0650 , LMJLV39_050011300 , LMJSD75_050011600

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

Q4QJD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.592
CLV_C14_Caspase3-7	183	187	PF00656	0.612
CLV_C14_Caspase3-7	369	373	PF00656	0.541
CLV_C14_Caspase3-7	480	484	PF00656	0.542
CLV_C14_Caspase3-7	544	548	PF00656	0.664
CLV_C14_Caspase3-7	806	810	PF00656	0.626
CLV_NRD_NRD_1	472	474	PF00675	0.628
CLV_NRD_NRD_1	511	513	PF00675	0.690
CLV_NRD_NRD_1	568	570	PF00675	0.664
CLV_NRD_NRD_1	761	763	PF00675	0.663
CLV_NRD_NRD_1	790	792	PF00675	0.831
CLV_PCSK_KEX2_1	472	474	PF00082	0.628
CLV_PCSK_KEX2_1	510	512	PF00082	0.692
CLV_PCSK_KEX2_1	567	569	PF00082	0.657
CLV_PCSK_KEX2_1	681	683	PF00082	0.735
CLV_PCSK_KEX2_1	760	762	PF00082	0.722
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.740
CLV_PCSK_SKI1_1	220	224	PF00082	0.473
CLV_PCSK_SKI1_1	350	354	PF00082	0.554
CLV_PCSK_SKI1_1	472	476	PF00082	0.557
CLV_PCSK_SKI1_1	512	516	PF00082	0.569
CLV_PCSK_SKI1_1	772	776	PF00082	0.623
DEG_APCC_DBOX_1	18	26	PF00400	0.522
DEG_APCC_DBOX_1	219	227	PF00400	0.480
DEG_APCC_DBOX_1	510	518	PF00400	0.551
DEG_APCC_DBOX_1	566	574	PF00400	0.671
DEG_Nend_UBRbox_2	1	3	PF02207	0.616
DEG_ODPH_VHL_1	134	146	PF01847	0.399
DEG_SCF_FBW7_1	514	519	PF00400	0.613
DEG_SPOP_SBC_1	59	63	PF00917	0.686
DOC_CDC14_PxL_1	141	149	PF14671	0.390
DOC_CKS1_1	513	518	PF01111	0.615
DOC_CKS1_1	539	544	PF01111	0.631
DOC_CKS1_1	550	555	PF01111	0.572
DOC_CKS1_1	650	655	PF01111	0.545
DOC_CYCLIN_RxL_1	115	128	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	621	627	PF00134	0.572
DOC_MAPK_DCC_7	567	575	PF00069	0.597
DOC_MAPK_gen_1	115	124	PF00069	0.470
DOC_MAPK_gen_1	500	509	PF00069	0.683
DOC_MAPK_gen_1	567	575	PF00069	0.678
DOC_MAPK_gen_1	708	715	PF00069	0.708
DOC_MAPK_gen_1	760	771	PF00069	0.681
DOC_MAPK_MEF2A_6	118	126	PF00069	0.466
DOC_MAPK_MEF2A_6	142	149	PF00069	0.475
DOC_MAPK_MEF2A_6	24	33	PF00069	0.575
DOC_MAPK_MEF2A_6	248	256	PF00069	0.504
DOC_MAPK_MEF2A_6	708	715	PF00069	0.708
DOC_MAPK_NFAT4_5	708	716	PF00069	0.713
DOC_PP1_RVXF_1	797	804	PF00149	0.714
DOC_PP2B_LxvP_1	437	440	PF13499	0.579
DOC_PP2B_LxvP_1	621	624	PF13499	0.561
DOC_PP4_FxxP_1	550	553	PF00568	0.566
DOC_PP4_FxxP_1	850	853	PF00568	0.561
DOC_USP7_MATH_1	244	248	PF00917	0.526
DOC_USP7_MATH_1	34	38	PF00917	0.533
DOC_USP7_MATH_1	419	423	PF00917	0.657
DOC_USP7_MATH_1	463	467	PF00917	0.677
DOC_USP7_MATH_1	516	520	PF00917	0.613
DOC_USP7_MATH_1	583	587	PF00917	0.725
DOC_USP7_MATH_1	59	63	PF00917	0.652
DOC_USP7_MATH_1	704	708	PF00917	0.763
DOC_USP7_MATH_1	773	777	PF00917	0.601
DOC_USP7_MATH_1	787	791	PF00917	0.634
DOC_USP7_MATH_1	805	809	PF00917	0.515
DOC_USP7_MATH_1	853	857	PF00917	0.622
DOC_USP7_UBL2_3	775	779	PF12436	0.676
DOC_WW_Pin1_4	127	132	PF00397	0.401
DOC_WW_Pin1_4	350	355	PF00397	0.523
DOC_WW_Pin1_4	456	461	PF00397	0.719
DOC_WW_Pin1_4	501	506	PF00397	0.684
DOC_WW_Pin1_4	512	517	PF00397	0.554
DOC_WW_Pin1_4	522	527	PF00397	0.704
DOC_WW_Pin1_4	538	543	PF00397	0.542
DOC_WW_Pin1_4	549	554	PF00397	0.583
DOC_WW_Pin1_4	649	654	PF00397	0.531
DOC_WW_Pin1_4	686	691	PF00397	0.802
DOC_WW_Pin1_4	97	102	PF00397	0.526
LIG_14-3-3_CanoR_1	230	235	PF00244	0.526
LIG_14-3-3_CanoR_1	292	298	PF00244	0.546
LIG_14-3-3_CanoR_1	500	505	PF00244	0.659
LIG_14-3-3_CanoR_1	654	658	PF00244	0.744
LIG_14-3-3_CanoR_1	764	770	PF00244	0.679
LIG_14-3-3_CanoR_1	828	832	PF00244	0.652
LIG_14-3-3_CanoR_1	9	15	PF00244	0.696
LIG_Actin_WH2_2	137	153	PF00022	0.381
LIG_APCC_ABBA_1	80	85	PF00400	0.543
LIG_EH1_1	216	224	PF00400	0.415
LIG_FHA_1	128	134	PF00498	0.394
LIG_FHA_1	175	181	PF00498	0.559
LIG_FHA_1	234	240	PF00498	0.410
LIG_FHA_1	319	325	PF00498	0.631
LIG_FHA_1	43	49	PF00498	0.675
LIG_FHA_1	513	519	PF00498	0.690
LIG_FHA_1	598	604	PF00498	0.686
LIG_FHA_1	740	746	PF00498	0.578
LIG_FHA_1	766	772	PF00498	0.627
LIG_FHA_2	539	545	PF00498	0.580
LIG_FHA_2	804	810	PF00498	0.680
LIG_FHA_2	860	866	PF00498	0.653
LIG_GBD_Chelix_1	252	260	PF00786	0.357
LIG_LIR_Apic_2	547	553	PF02991	0.656
LIG_LIR_Apic_2	848	853	PF02991	0.558
LIG_LIR_Gen_1	107	113	PF02991	0.458
LIG_LIR_Gen_1	123	134	PF02991	0.296
LIG_LIR_Gen_1	631	641	PF02991	0.669
LIG_LIR_Gen_1	666	675	PF02991	0.487
LIG_LIR_Nem_3	107	112	PF02991	0.464
LIG_LIR_Nem_3	123	129	PF02991	0.292
LIG_LIR_Nem_3	631	636	PF02991	0.681
LIG_LIR_Nem_3	666	672	PF02991	0.509
LIG_MAD2	619	627	PF02301	0.571
LIG_SH2_CRK	669	673	PF00017	0.529
LIG_SH2_CRK	844	848	PF00017	0.571
LIG_SH2_NCK_1	844	848	PF00017	0.571
LIG_SH2_STAP1	283	287	PF00017	0.455
LIG_SH2_STAT5	197	200	PF00017	0.407
LIG_SH2_STAT5	366	369	PF00017	0.581
LIG_SH2_STAT5	736	739	PF00017	0.488
LIG_SH3_1	536	542	PF00018	0.543
LIG_SH3_3	130	136	PF00018	0.480
LIG_SH3_3	28	34	PF00018	0.464
LIG_SH3_3	373	379	PF00018	0.529
LIG_SH3_3	391	397	PF00018	0.690
LIG_SH3_3	486	492	PF00018	0.675
LIG_SH3_3	520	526	PF00018	0.654
LIG_SH3_3	536	542	PF00018	0.505
LIG_SH3_3	608	614	PF00018	0.661
LIG_SH3_3	621	627	PF00018	0.543
LIG_SH3_3	698	704	PF00018	0.711
LIG_SH3_3	723	729	PF00018	0.606
LIG_SH3_3	98	104	PF00018	0.494
LIG_SUMO_SIM_anti_2	107	114	PF11976	0.467
LIG_SUMO_SIM_par_1	120	125	PF11976	0.366
LIG_SUMO_SIM_par_1	332	337	PF11976	0.649
LIG_SUMO_SIM_par_1	711	716	PF11976	0.564
LIG_TRAF2_1	37	40	PF00917	0.633
LIG_TRAF2_1	541	544	PF00917	0.584
LIG_TRAF2_1	752	755	PF00917	0.602
LIG_TRAF2_1	82	85	PF00917	0.514
LIG_TRAF2_2	492	497	PF00917	0.659
LIG_TRFH_1	610	614	PF08558	0.543
LIG_TYR_ITIM	667	672	PF00017	0.514
LIG_TYR_ITIM	842	847	PF00017	0.578
LIG_UBA3_1	146	151	PF00899	0.453
LIG_WRC_WIRS_1	106	111	PF05994	0.506
MOD_CDK_SPK_2	649	654	PF00069	0.612
MOD_CDK_SPxK_1	549	555	PF00069	0.651
MOD_CK1_1	108	114	PF00069	0.431
MOD_CK1_1	125	131	PF00069	0.287
MOD_CK1_1	159	165	PF00069	0.538
MOD_CK1_1	293	299	PF00069	0.549
MOD_CK1_1	318	324	PF00069	0.603
MOD_CK1_1	519	525	PF00069	0.810
MOD_CK1_1	58	64	PF00069	0.672
MOD_CK1_1	657	663	PF00069	0.619
MOD_CK1_1	780	786	PF00069	0.656
MOD_CK1_1	827	833	PF00069	0.704
MOD_CK2_1	165	171	PF00069	0.576
MOD_CK2_1	34	40	PF00069	0.540
MOD_CK2_1	538	544	PF00069	0.586
MOD_CK2_1	728	734	PF00069	0.662
MOD_CK2_1	859	865	PF00069	0.654
MOD_Cter_Amidation	758	761	PF01082	0.608
MOD_GlcNHglycan	10	13	PF01048	0.557
MOD_GlcNHglycan	152	155	PF01048	0.371
MOD_GlcNHglycan	158	161	PF01048	0.478
MOD_GlcNHglycan	223	226	PF01048	0.483
MOD_GlcNHglycan	248	251	PF01048	0.517
MOD_GlcNHglycan	292	295	PF01048	0.543
MOD_GlcNHglycan	300	303	PF01048	0.593
MOD_GlcNHglycan	305	308	PF01048	0.618
MOD_GlcNHglycan	316	320	PF01048	0.558
MOD_GlcNHglycan	326	329	PF01048	0.567
MOD_GlcNHglycan	36	39	PF01048	0.549
MOD_GlcNHglycan	419	422	PF01048	0.654
MOD_GlcNHglycan	432	436	PF01048	0.556
MOD_GlcNHglycan	452	455	PF01048	0.520
MOD_GlcNHglycan	466	469	PF01048	0.513
MOD_GlcNHglycan	527	530	PF01048	0.689
MOD_GlcNHglycan	57	60	PF01048	0.683
MOD_GlcNHglycan	589	592	PF01048	0.710
MOD_GlcNHglycan	593	596	PF01048	0.630
MOD_GlcNHglycan	63	66	PF01048	0.608
MOD_GlcNHglycan	747	750	PF01048	0.719
MOD_GlcNHglycan	779	782	PF01048	0.607
MOD_GlcNHglycan	787	790	PF01048	0.630
MOD_GlcNHglycan	850	853	PF01048	0.698
MOD_GlcNHglycan	88	91	PF01048	0.422
MOD_GSK3_1	104	111	PF00069	0.383
MOD_GSK3_1	229	236	PF00069	0.482
MOD_GSK3_1	318	325	PF00069	0.703
MOD_GSK3_1	415	422	PF00069	0.727
MOD_GSK3_1	446	453	PF00069	0.706
MOD_GSK3_1	512	519	PF00069	0.661
MOD_GSK3_1	55	62	PF00069	0.684
MOD_GSK3_1	583	590	PF00069	0.640
MOD_GSK3_1	591	598	PF00069	0.685
MOD_GSK3_1	649	656	PF00069	0.622
MOD_GSK3_1	686	693	PF00069	0.760
MOD_GSK3_1	773	780	PF00069	0.550
MOD_GSK3_1	801	808	PF00069	0.697
MOD_GSK3_1	810	817	PF00069	0.589
MOD_GSK3_1	826	833	PF00069	0.630
MOD_LATS_1	228	234	PF00433	0.534
MOD_N-GLC_1	165	170	PF02516	0.607
MOD_N-GLC_1	230	235	PF02516	0.526
MOD_N-GLC_1	261	266	PF02516	0.431
MOD_N-GLC_1	464	469	PF02516	0.630
MOD_N-GLC_1	704	709	PF02516	0.622
MOD_N-GLC_1	801	806	PF02516	0.553
MOD_N-GLC_2	362	364	PF02516	0.593
MOD_NEK2_1	122	127	PF00069	0.366
MOD_NEK2_1	150	155	PF00069	0.459
MOD_NEK2_1	156	161	PF00069	0.635
MOD_NEK2_1	237	242	PF00069	0.494
MOD_NEK2_1	260	265	PF00069	0.468
MOD_NEK2_1	371	376	PF00069	0.547
MOD_NEK2_1	713	718	PF00069	0.569
MOD_NEK2_1	745	750	PF00069	0.541
MOD_NEK2_1	765	770	PF00069	0.466
MOD_NEK2_1	801	806	PF00069	0.668
MOD_NEK2_1	814	819	PF00069	0.575
MOD_NEK2_1	826	831	PF00069	0.636
MOD_NEK2_1	86	91	PF00069	0.455
MOD_NEK2_2	663	668	PF00069	0.471
MOD_PIKK_1	274	280	PF00454	0.600
MOD_PIKK_1	674	680	PF00454	0.477
MOD_PIKK_1	713	719	PF00454	0.655
MOD_PKA_2	114	120	PF00069	0.402
MOD_PKA_2	229	235	PF00069	0.536
MOD_PKA_2	415	421	PF00069	0.623
MOD_PKA_2	653	659	PF00069	0.740
MOD_PKA_2	765	771	PF00069	0.677
MOD_PKA_2	8	14	PF00069	0.716
MOD_PKA_2	827	833	PF00069	0.748
MOD_PKB_1	762	770	PF00069	0.632
MOD_Plk_1	104	110	PF00069	0.349
MOD_Plk_1	122	128	PF00069	0.358
MOD_Plk_1	173	179	PF00069	0.495
MOD_Plk_1	230	236	PF00069	0.443
MOD_Plk_1	261	267	PF00069	0.431
MOD_Plk_1	642	648	PF00069	0.502
MOD_Plk_1	94	100	PF00069	0.363
MOD_Plk_2-3	332	338	PF00069	0.597
MOD_Plk_4	105	111	PF00069	0.543
MOD_Plk_4	293	299	PF00069	0.579
MOD_Plk_4	810	816	PF00069	0.668
MOD_ProDKin_1	127	133	PF00069	0.395
MOD_ProDKin_1	350	356	PF00069	0.519
MOD_ProDKin_1	456	462	PF00069	0.720
MOD_ProDKin_1	501	507	PF00069	0.683
MOD_ProDKin_1	512	518	PF00069	0.553
MOD_ProDKin_1	522	528	PF00069	0.708
MOD_ProDKin_1	538	544	PF00069	0.539
MOD_ProDKin_1	549	555	PF00069	0.582
MOD_ProDKin_1	649	655	PF00069	0.537
MOD_ProDKin_1	686	692	PF00069	0.802
MOD_ProDKin_1	97	103	PF00069	0.534
MOD_SUMO_rev_2	51	58	PF00179	0.637
TRG_DiLeu_BaEn_1	74	79	PF01217	0.618
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.377
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.403
TRG_DiLeu_BaLyEn_6	709	714	PF01217	0.713
TRG_DiLeu_BaLyEn_6	796	801	PF01217	0.570
TRG_ENDOCYTIC_2	669	672	PF00928	0.503
TRG_ENDOCYTIC_2	844	847	PF00928	0.573
TRG_ER_diArg_1	118	121	PF00400	0.430
TRG_ER_diArg_1	363	366	PF00400	0.525
TRG_ER_diArg_1	472	474	PF00400	0.553
TRG_ER_diArg_1	499	502	PF00400	0.747
TRG_ER_diArg_1	509	512	PF00400	0.617
TRG_ER_diArg_1	566	569	PF00400	0.653
TRG_ER_diArg_1	760	762	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE62	Leptomonas seymouri	37%	100%
A0A3S5H5I9	Leishmania donovani	89%	100%
A4HD44	Leishmania braziliensis	68%	96%
A4HSI7	Leishmania infantum	90%	100%
E9AKH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%